JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 2, 2023
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study of 6,866 individuals with COVID-19, nirmatrelvir and ritonavir (Paxlovid [Pfizer]) treatment was associated with reduced risk of COVID-19 hospitalization or death in clinically extremely vulnerable individuals, with the greatest benefit observed in severely immunocompromised individuals. No reduction in the primary outcome (death from any cause or emergency hospitalization with COVID-19 within 28 days) was observed in lower-risk individuals, including those age 70 or older without serious comorbidities.
Authors: Colin R. Dormuth, Sc.D., of the University of British Columbia in Vancouver, is the corresponding author.
(doi:10.1001/jamanetworkopen.2023.36678)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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