Paxlovid and COVID-19 Mortality and Hospitalization Among Patients With Vulnerability to COVID-19 Complications

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 2, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of 6,866 individuals with COVID-19, nirmatrelvir and ritonavir (Paxlovid [Pfizer]) treatment was associated with reduced risk of COVID-19 hospitalization or death in clinically extremely vulnerable individuals, with the greatest benefit observed in severely immunocompromised individuals. No reduction in the primary outcome (death from any cause or emergency hospitalization with COVID-19 within 28 days) was observed in lower-risk individuals, including those age 70 or older without serious comorbidities. 

Authors: Colin R. Dormuth, Sc.D., of the University of British Columbia in Vancouver, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.36678)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Loneliness and Risk of Parkinson Disease

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 2, 2023

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About The Study: This study of 491,000 participants followed up for up to 15 years found that loneliness was associated with risk of incident Parkinson disease across demographic groups and independent of depression and other prominent risk factors and genetic risk. The findings add to the evidence that loneliness is a substantial psychosocial determinant of health.

Authors: Antonio Terracciano, Ph.D., of the Florida State University College of Medicine in Tallahassee, is the corresponding author.

 

(doi:10.1001/jamaneurol.2023.3382)

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Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 3, 2023

Media advisory: The full study is linked to this news release.

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About The Study: The results of this meta-analysis indicate that adherence to continuous positive airway pressure (CPAP) was associated with a reduced major adverse cardiac and cerebrovascular event recurrence risk, suggesting that treatment adherence is a key factor in secondary cardiovascular prevention in patients with obstructive sleep apnea.

Authors: Ferran Barbé, M.D., of the Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES) in Madrid, is the corresponding author.

 

(doi:10.1001/jama.2023.17465)

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Use of Electronic Clinical Data to Track Incidence and Mortality for SARS-CoV-2–Associated Sepsis

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, SEPTEMBER 29, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study of 431,000 inpatient encounters at five Massachusetts hospitals suggest that SARS-CoV-2–associated sepsis was common and had higher mortality than presumed bacterial sepsis early in the COVID-19 pandemic. These findings highlight the high burden of SARS-CoV-2–associated sepsis and demonstrate the utility of electronic health record-based algorithms to conduct surveillance for viral and bacterial sepsis. 

Authors: Claire N. Shappell, M.D., M.P.H., of Brigham and Women’s Hospital in Boston, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.35728)

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Neighborhood Factors, Individual Stressors, and Cardiovascular Health Among Black and White Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, SEPTEMBER 29, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of Black and white U.S. adults ages 45 and older, neighborhood-level factors, including safety and physical and social environments, and individual-level factors, including discrimination, attenuated racial disparities in cardiovascular health. Interventional approaches to improve ideal cardiovascular health that separately target neighborhood context and discrimination by gender and race are warranted. 

Authors: Anika L. Hines, Ph.D., M.P.H., of the Virginia Commonwealth University School of Medicine in Richmond, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.36207)

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Psychotropic Medication Use in Children and Adolescents With Type 1 Diabetes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 3, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: This study found an increasing trend in psychotropic medication dispensation among Swedish children and adolescents with type 1 diabetes from 2006 to 2019, persistently higher than those without type 1 diabetes. These findings call for further in-depth investigations into the benefits and risks of psychotropic medications within this population and highlight the importance of integrating pediatric diabetes care and mental health care for early detection of psychological needs and careful monitoring of medication use.

Authors: Shengxin Liu, M.Sc., of the Karolinska Institutet in Solna, Sweden is the corresponding author.

 

(doi: 10.1001/jamanetworkopen.2023.36621)

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Utilization and Spending on Mental Health Services Among Children and Youths With Commercial Insurance

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 3, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: After comparing mental health care service utilization and spending rates for children and youths with commercial insurance across three periods from January 2019 through August 2022, this study found differences between periods as well as different rates of change within each period for both visit types (in-person and telehealth), even after accounting for state and patient sex. Utilization and spending increased over the entire timeframe. Attention-deficit/hyperactivity disorder, anxiety disorders, and adjustment disorder accounted for most visits and spending in all phases.

Authors: Mariah M. Kalmin, Ph.D., of the RAND Corporation in Santa Monica, California is the corresponding author.

 

(doi: 10.1001/jamanetworkopen.2023.36979)

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Misinformation, Trust, and Use of Ivermectin and Hydroxychloroquine for COVID-19

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, SEPTEMBER 29, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: In this 50-state survey study of 13,438 adults who reported probable or definite COVID-19 infection, endorsement of misinformation about the COVID-19 pandemic, lack of trust in physicians or scientists, conspiracy-mindedness, and the nature of news sources were associated with receiving non–evidence-based treatment for COVID-19. These results suggest that the potential harms of misinformation may extend to the use of ineffective and potentially toxic treatments in addition to avoidance of health-promoting behaviors. 

Authors: Roy H. Perlis, M.D., M.Sc., of Massachusetts General Hospital in Boston, is the corresponding author.

 

(doi:10.1001/jamahealthforum.2023.3257)

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Virtual Tumor Board to Foster Interinstitutional Head and Neck Cancer Subspecialty Care

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Pharmacist-Led Diabetes Control Intervention and Health Outcomes in Hispanic Patients With Diabetes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 28, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study that included 931 Hispanic adults suggest that a pharmacist-led intervention may be a strategy for improving some outcomes among Hispanic patients with type 2 diabetes. 

Authors: Kimberly Danae Cauley Narain, M.D., Ph.D., M.P.H., of the University of California, Los Angeles, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.35409)

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Developing an Electroencephalography-Based Model for Predicting Response to Antidepressant Medication

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 28, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that the use of electroencephalography can provide a reliable method for predicting response to specific antidepressant medications and may help match patients with depression to optimized treatment. 

Authors: Faranak Farzan, Ph.D., of Simon Fraser University in Surrey, British Columbia, Canada, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.36094)

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Barriers to Care Among Sexual and Gender Minority Individuals With Chronic Inflammatory Skin Diseases

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Antidepressant Use and Risk of Manic Episodes in Children and Adolescents With Unipolar Depression

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One-Year Association of Drug Possession Law Change With Fatal Drug Overdose in Oregon and Washington

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Cannabis Use Frequency and Cannabis-Related Consequences in High-Risk Young Adults Across Cannabis Legalization

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 27, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In a study of 619 high-risk young adults in Ontario, Canada, individuals using cannabis frequently pre-legalization showed significant reductions in use and consequences over time, reflecting an aging out pattern. Small increases in use among participants with no pre-legalization use were observed over time, but without parallel changes in cannabis-related consequences. The results did not reveal substantive adverse near-term outcomes across the legalization period, although a within-participants design cannot rule out the possibility of alternative trajectories in the absence of legalization. 

Authors: Amanda Doggett, Ph.D., of McMaster University/St. Joseph’s Healthcare in Hamilton, Ontario, Canada, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.36035)

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Community Mobility and Depressive Symptoms During the Pandemic

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 27, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Depressive symptoms were greater in locales and times with diminished community mobility in this survey study with 192,000 respondents. Strategies to understand the potential public health consequences of pandemic responses are needed. 

Authors: Roy H. Perlis, M.D., M.Sc., of Massachusetts General Hospital in Boston, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.34945)

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Mental Health Symptoms in Oral Contraceptive Users During Short-Term Hormone Withdrawal

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 27, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of long-term combined oral contraceptive users, withdrawal from contraceptive steroids during the pill pause (short-term hormone withdrawal) was associated with adverse mental health symptoms similar to those experienced by women during menses with withdrawal from endogenous steroids. These results question the use of the pill pause from a mental health perspective. 

Authors: Belinda Pletzer, Ph.D., of the University of Salzburg in Salzburg, Austria, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.35957)

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Changes in Diagnoses and Site of Care for Patients Receiving Hospice Care From Agencies Acquired by Private Equity Firms and Publicly Traded Companies

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Childhood and Adolescence Gender Role Nonconformity and Gender and Sexuality Diversity in Young Adulthood

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Racial, Ethnic, and Sex Diversity in Academic Medical Leadership

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 25, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

  

About The Study: The results of this study suggest that select specialties in academic medicine have bridged diversity gaps in academic medical leadership whereas others continue to lag behind.

Authors: Charles S. Day, M.D., M.B.A., of Henry Ford Health in Detroit, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.35529)

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Racial Disparities in Emergency Department Physical Restraint Use

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 25, 2023

Media advisory: The full study is linked to this news release.

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About The Study: In this systematic review and meta-analysis of 10 studies, physical restraint was uncommon, occurring in less than 1% of encounters, but adult Black patients experienced a significantly higher risk of physical restraint in emergency department settings compared with other racial groups. Emergency departments should carefully consider, and take steps to address, how racism may affect disparate use of restraints among adult patients. 

Authors: Vidya Eswaran, M.D., of the Baylor College of Medicine in Houston, is the corresponding author.

 

(doi:10.1001/jamainternmed.2023.4832)

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Access to Marijuana by Minors Via Online Dispensaries

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 25, 2023

Media advisory: The full study is linked to this news release.

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About The Study: This analysis of 80 online marijuana dispensaries based in 32 states found that most lacked adequate age verification features and most accepted nontraceable payment methods, enabling youth to hide their transactions. Almost 1 in 5 online dispensaries required no formal age verification at any stage of the purchasing process. 

Authors: Ruth L. Milanaik, D.O., of Steven and Alexandra Cohen Children’s Medical Center of New York in Lake Success, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2023.3656)

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Premorbid Sociodemographic Status and Multiple Sclerosis Outcomes With Universal Health Care

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 26, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this study of working-age adults with multiple sclerosis (MS), premorbid income, education, and marital status correlated with disability and symptom severity in relapse onset and progressive-onset MS, independent of treatment. These findings suggest that socioeconomic status may reflect both structural and individual determinants of health in MS.

Authors: Anna He, M.B.B.S., of the Karolinska Institute in Stockholm, Sweden is the corresponding author.

 

(doi: 10.1001/jamanetworkopen.2023.34675)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Alcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 26, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this study of 69,000 adults with hepatitis C virus (HCV) infection, there was no difference in sustained virologic response across alcohol use categories, even for patients with high-risk consumption or alcohol use disorder, after adjusting for potential confounding variables. These findings suggest that restricting access to direct-acting antiviral therapy on the basis of alcohol use creates an unnecessary barrier for patients and challenges HCV elimination goals.

Authors: Emily J. Cartwright, M.D., of the Emory University School of Medicine in Atlanta, and Christopher T. Rentsch, Ph.D., of the London School of Hygiene & Tropical Medicine in London, are the corresponding authors.

 

(doi: 10.1001/jamanetworkopen.2023.35715)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Suicide Risks of Health Care Workers in the US

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 26, 2023

Media advisory: The full study is linked to this news release.

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About The Study: From a nationally representative cohort of approximately 1.84 million employed adults observed from 2008 through 2019, relative to non–health care workers, registered nurses, health technicians, and health care support workers in the U.S. were at increased risk of suicide. New programmatic efforts are needed to protect the mental health of these U.S. health care workers.

Authors: Mark Olfson, M.D., M.P.H., of Columbia University in New York, is the corresponding author.

 

(doi:10.1001/jama.2023.15787)

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Impairment and Disability Identity and Perceptions of Trust, Respect, and Fairness

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2023.3180?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092223

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Medicaid Value-Based Payments and Health Care Use for Patients With Mental Illness

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Vulnerability of Older Adults to Government Impersonation Scams

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, SEPTEMBER 22, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.35319?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092223

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study using a behavioral experiment designed to mimic a real-world imposter scam among 644 older adults, a sizable number of older adults engaged without skepticism. The results suggest that many older adults, including those without cognitive impairment, are vulnerable to fraud and scams. 

Authors: Lei Yu, Ph.D., of Rush University Medical Center in Chicago, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.35319)

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Cardiovascular Disease Burden, Outcomes Among American Indian and Alaska Native Medicare Beneficiaries

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, SEPTEMBER 22, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study of 220,000 American Indian and Alaska Native patients with Medicare insurance suggest a significant burden of cardiovascular disease and cardiometabolic risk factors. These findings highlight the critical need for future efforts to prioritize the cardiovascular health of this population. 

Authors: Lauren A. Eberly, M.D., M.P.H., of the Indian Health Service in Gallup, New Mexico, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.34923)

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Paxlovid or Lagevrio Use and Severe Outcomes From Omicron Infections

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 21, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study of 68,000 patients who received a diagnosis of COVID-19 and who were at high risk of progressing to severe COVID-19 suggest that the use of either nirmatrelvir (Paxlovid) or molnupiravir (Lagevrio) is associated with reductions in mortality and hospitalization in patients infected with Omicron, regardless of age, race and ethnicity, virus strain, vaccination status, previous infection status, or coexisting conditions. Both drugs can, therefore, be used to treat non-hospitalized patients who are at high risk of progressing to severe COVID-19. 

Authors: Dan-Yu Lin, Ph.D., of the University of North Carolina in Chapel Hill, and Xiaofeng Wang, Ph.D., of the Cleveland Clinic, are the corresponding authors. 

 

(doi:10.1001/jamanetworkopen.2023.35077)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Incidence of Diabetes Among Youth Before and During the Pandemic

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 21, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study that included data from Kaiser Permanente Southern California of individuals age 19 and younger, the incidence of type 1 diabetes slightly increased overall and type 2 diabetes significantly increased after the beginning of the COVID-19 pandemic, in particular among non-Hispanic Black and Hispanic youth. These findings suggest the need for further evaluation of physiologic and behavioral risk factors preceding new-onset diabetes during the pandemic. 

Authors: Matthew T. Mefford, Ph.D., of Kaiser Permanente Southern California in Pasadena, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.34953)

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Disparities in Emergency Medicine Residents’ Performance Assessments by Race, Ethnicity, and Sex

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 21, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.30847?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092123

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This analysis of assessments of 2,708 emergency medicine residents found evidence of sex-specific ethnoracial disparities in ratings on the Milestones assessments. These disparities increased over time across multiple Milestones assessments and were most severe for female residents of ethnoracial groups that are underrepresented in medicine. 

Authors: Elle Lett, Ph.D., M.A., M.Biostat., of the University of Washington School of Public Health in Seattle, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.30847)

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Prenatal Exposure to Nonpersistent Environmental Chemicals and Postpartum Depression

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Consumption of Ultraprocessed Food and Risk of Depression

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 20, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that greater ultraprocessed food (UPF; i.e., energy-dense, palatable, and ready-to-eat items) intake, particularly artificial sweeteners and artificially sweetened beverages, is associated with increased risk of depression. Although the mechanism associating UPF to depression is unknown, recent experimental data suggests that artificial sweeteners elicit purinergic transmission in the brain, which may be involved in the etiopathogenesis of depression. 

Authors: Raaj S. Mehta, M.D., M.P.H., and Andrew T. Chan, M.D., M.P.H., of Massachusetts General Hospital and Harvard Medical School in Boston, are corresponding authors. 

 

(doi:10.1001/jamanetworkopen.2023.34770)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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County-Level Sociodemographic Characteristics and Availability of COVID-19 Therapeutic Drugs

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 20, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.34763?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092023

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study showed sociodemographic-based disparities in geographic clustering of COVID-19 therapeutic drugs, highlighting disparities in access to these drugs. With the end of the COVID-19 Public Health Emergency, these findings highlight an important gap in treatment access. 

Authors: Kosuke Tamura, Ph.D., of the National Institutes of Health in Bethesda, Maryland, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.34763)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Surrogate Adiposity Markers and Mortality

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 20, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Waist-to-hip ratio had the strongest and most consistent association with mortality irrespective of body mass index in this study consisting of 387,000 UK adult participants from the UK Biobank. Clinical recommendations should consider focusing on adiposity distribution compared with mass. 

Authors: Guillaume Pare, M.D., M.Sc., of the Vascular and Stroke Research Institute in Hamilton, Ontario, Canada, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.34836)

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Treatment Failure and Adverse Events After Amoxicillin-Clavulanate vs Amoxicillin for Pediatric Acute Sinusitis

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Comparison of Hospital Online Price and Telephone Price for Shoppable Services

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Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times

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Effect of Extracurricular After-School Physical Activities on Academic Performance of Schoolchildren

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Economic Burden of US Youth Violence Injuries

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 18, 2023

Media advisory: The full study is linked to this news release.

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About The Study: This economic evaluation’s findings indicate that the economic burden of youth violence, including medical care, lost productivity, reduced quality of life from injury morbidity, and avoidable mortality, reached $122 billion in 2020, dominated by male firearm homicides. Prevention strategies can reduce this substantial burden. 

Authors: Cora Peterson, Ph.D., of the Centers for Disease Control and Prevention in Atlanta, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2023.3235)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Screen Time and Developmental Performance Among Children at 1-3 Years of Age

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 18, 2023

Media advisory: The full study is linked to this news release.

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About The Study: Increased TV/DVD screen time from age 1 year negatively affected later development in this study of 57,980 children. To reduce the negative consequences of excessive media use, researchers and health care professionals should encourage family media management and recommend social support for parents who tend to rely on the media. 

Authors: Midori Yamamoto, Ph.D., of Chiba University in Chiba, Japan, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2023.3643)

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Buprenorphine Dose and Time to Discontinuation Among Patients With Opioid Use Disorder in the Era of Fentanyl

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 18, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.34540?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091823

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study of 6,499 patients initiating buprenorphine treatment between 2016 and 2020 suggest that the value of higher buprenorphine doses than currently recommended needs to be considered for improving retention in treatment. 

Authors: Laura C. Chambers, Ph.D., M.P.H., of Brown University in Providence, Rhode Island, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.34540)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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School-Based Health Centers, Access to Care, and Income-Based Disparities

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 18, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.34532?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091823

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study using nationally representative survey data with difference-in-differences analysis of school-based health center (SBHC) adoption, SBHCs were associated with access to care and reduced income-based disparities. These findings support additional SBHC expansion. 

Authors: Michel Boudreaux, Ph.D., of the University of Maryland in College Park, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.34532)

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USPSTF Recommendation on Screening for Hypertensive Disorders of Pregnancy

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 19, 2023

Media advisory: To contact the U.S. Preventive Services Task Force, email the Media Coordinator at Newsroom@USPSTF.net or call 301-951-9203. The full report and related articles are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time and all USPSTF articles remain free indefinitely https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2023.16991?guestAccessKey=9b2150f1-559c-4c9f-8de1-2ceda03caf64&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091923

 

Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends screening for hypertensive disorders in pregnant persons with blood pressure measurements throughout pregnancy. Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality in the U.S. The rate has been increasing from approximately 500 cases per 10,000 deliveries in 1993 to 1,021 cases per 10,000 deliveries in 2016 to 2017. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this recommendation is consistent with its 2017 recommendation statement.

 

(doi:10.1001/jama.2023.16991)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Note: More information about the U.S. Preventive Services Task Force, its process, and its recommendations can be found on the newsroom page of its website.

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Racial and Ethnic Disparities in Long-Acting Injectable Antipsychotic Use in a National Sample of Medicare Beneficiaries With Schizophrenia

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Receipt of BNT162b2 Vaccine and COVID-19 Ambulatory Visits in Young US Children

JAMA

EMBARGOED FOR RELEASE: 10 A.M. (ET), FRIDAY, SEPTEMBER 15, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2023.17473?guestAccessKey=3c77918c-2e4c-42f9-b7e9-84eed4b3aa00&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091523

 

About The Study: Receiving at least two doses of wild-type BNT162b2 vaccine (Pfizer) was associated with a reduced risk of COVID-19 emergency department or urgent care and outpatient visits in children younger than five years. The risk of SARS-CoV-2 encounters appeared lower for those with two versus three doses of BNT162b2, albeit with wide CIs, which is likely due to more immune-evasive Omicron sublineages (e.g., BQ.1-related and XBB-related strains) becoming dominant by the time young children received their third dose and longer median time since dose three compared with dose two.

Authors: Sara Y. Tartof, Ph.D., M.P.H., of the Kaiser Permanente Southern California Department of Research & Evaluation in Pasadena, is the corresponding author.

 

(doi:10.1001/jama.2023.17473)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Cost of Public Health Insurance for US-Born and Immigrant Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, SEPTEMBER 15, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study of 44,000 low-income, working-age adults suggest that the direct cost of providing public health insurance to immigrants is less than that for the U.S. born, and immigrants’ health care utilization, upon coverage, remains comparatively modest, thus refuting the notion that providing insurance to immigrants imposes a heavy fiscal burden. 

Authors: Felix M. Muchomba, Ph.D., of the State University of New Jersey in New Brunswick, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2023.34008)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Premenstrual Disorders, Timing of Menopause, and Severity of Vasomotor Symptoms

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 19, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.34545?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091923

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this study of 3,635 female participants in the U.S., premenstrual disorders (PMDs) were associated with increased risks of early menopause and moderate or severe vasomotor symptoms (VMS). PMDs may be indicative of underlying physiology linked to early menopause and VMS, suggesting a phenotype observable during the reproductive years that may allow clinicians to target women at risk of earlier menopause and subsequent health risks later in the life course.

Authors: Yihui Yang, M.P.H., and Donghao Lu, M.D., Ph.D., of the Karolinska Institutet in Stockholm, Sweden are the corresponding authors.

 

(doi: 10.1001/jamanetworkopen.2023.34545)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Interventions for Physical Capacity and Quality of Life in Adults With Post–COVID-19 Condition

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 19, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.33838?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091923

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: The findings of this systematic review and meta-analysis suggest that rehabilitation interventions in adults with post–COVID-19 condition are associated with improvements in functional exercise capacity, dyspnea, and quality of life, with a high probability of improvement compared with the current standard care. The certainty of evidence was moderate for functional exercise capacity and quality of life and low for other outcomes.

Authors: Dimitra V. Pouliopoulou, M.Sc., of Western University in London, Ontario, Canada, is the corresponding author.

 

(doi: 10.1001/jamanetworkopen.2023.33838)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Temporal Association Among Influenza-Like Illness, Cardiovascular Events, and Vaccine Dose in Patients With High-Risk Cardiovascular Disease

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Remotely Delivered Cancer Genetic Testing in the Making Genetic Testing Accessible Trial

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Gender Bias and Ophthalmology Accreditation Council for Graduate Medical Education Milestones Evaluations

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Use of Physical Therapy and Subsequent Falls Among Patients With Dizziness

JAMA Otolaryngology–Head & Neck Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 14, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2023.2840?guestAccessKey=620b8450-97c8-43e7-ae4b-f9f84cdc7716&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091423

 

About The Study: The findings of this study of 805,000 patients ages 18 or older suggest that receipt of physical therapy (PT) after presentation for dizziness was associated with a reduction in fall risk during the subsequent 12 months; thus, timely PT referral for dizziness may be beneficial for these patients. Future research, ideally with a clinical trial design, is needed to explore the independent impact of PT on subsequent falls for adults with dizziness. 

Authors: Meredith E. Adams, M.D., M.S., of the University of Minnesota in Minneapolis, is the corresponding author. 

 

(doi:10.1001/jamaoto.2023.2840)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Geographical Variation in Social Determinants of Female Breast Cancer Mortality Across US Counties

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 14, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.33618?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091423

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study of 2,176 counties suggest that breast cancer mortality in the U.S. can be affected by where individuals live, and that more comprehensive and geographically targeted interventions may lead to healthier communities. 

Authors: Taylor Anderson, Ph.D., of George Mason University in Fairfax, Virginia, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.33618)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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