Breast Cancer Incidence After a False-Positive Mammography Result

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, NOVEMBER 2, 2023

Media advisory: The full study is linked to this news release.

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About The Study: The findings of this study suggest that the risk of developing breast cancer after a false-positive mammography result differs by individual characteristics and follow-up. These findings can be used to develop individualized risk-based breast cancer screening after a false-positive result. 

Authors: Xinhe Mao, M.Sc., of the Karolinska Institutet in Stockholm, is the corresponding author. 

 

(doi:10.1001/jamaoncol.2023.4519)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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PTSD Symptoms and Cardiovascular and Brain Health in Women

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, NOVEMBER 2, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of 274 midlife women, greater posttraumatic stress disorder (PTSD) symptoms were associated with higher carotid atherosclerosis and, among women who were APOEɛ4 carriers, greater brain small vessel disease and poorer cognitive performance. These findings point to the adverse implications of PTSD symptoms for cardiovascular and neurocognitive health among women in midlife, particularly for women who are APOEɛ4 carriers. 

Authors: Rebecca C. Thurston, Ph.D., of the University of Pittsburgh, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.41388)

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Genetic Liability to PTSD Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes

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Adverse Life Experiences and Brain Function

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, NOVEMBER 1, 2023

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this meta-analysis of 83 neuroimaging studies of adversity exposure and brain function, prior adversity exposure was associated with altered adult brain reactivity to diverse challenges. These results might better identify how adversity diminishes the ability to cope with later stressors and produces enduring susceptibility to mental health problems. 

Authors: Niki Hosseini-Kamkar, Ph.D., of the Royal Ottawa Hospital in Ottawa, Ontario, Canada, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.40018)

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Prevalence, Awareness, and Treatment of Elevated LDL Cholesterol in Adults, 1999-2020

JAMA Cardiology

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, NOVEMBER 1, 2023

Media advisory: The full study is linked to this news release.

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About The Study: Although the prevalence of severely elevated low-density lipoprotein cholesterol (LDL-C) has declined, 1 in 17 U.S. adults still have LDL-C levels of 160 to 189 mg/dL and 1 in 48 adults have LDL-C levels of 190 mg/dL or greater. Among those with an LDL-C of 190 mg/dL or greater, 1 in 4 are unaware and untreated, with a higher proportion for an LDL-C of 160 to 189 mg/dL. These gaps disproportionately affect non-Hispanic Black, Hispanic, and socioeconomically disadvantaged persons, contributing to disparities in outcomes.  

Authors: Salim S. Virani, M.D., Ph.D., of Aga Khan University in Karachi, Pakistan, is the corresponding author.

 

(doi:10.1001/jamacardio.2023.3931)

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Interpregnancy Interval After Clinical Pregnancy Loss and Outcomes of the Next Frozen Embryo Transfer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 31, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study of 2,433 women who received in vitro fertilization treatment suggest that delaying frozen embryo transfer for at least six months after a preceding clinical pregnancy loss was associated with beneficial pregnancy outcomes. Further prospective studies are needed to confirm these findings. 

Authors: Daimin Wei, M.D., Ph.D., of Shandong University in Jinan, China, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.40709)

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Masks During Pandemics Caused by Respiratory Pathogens— Evidence and Implications for Action

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 31, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

  

About The Study: Robust available data support the use of face masks in community settings to reduce transmission of SARS-CoV-2 and should inform future responses to epidemics and pandemics caused by respiratory viruses. 

Authors: Shama Cash-Goldwasser, M.D., M.P.H., of Resolve to Save Lives in New York, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.39443)

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Personalized Multilevel Intervention for Improving Appropriate Use of Colorectal Cancer Screening in Older Adults

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Bone Mineral Density in Transgender Adolescents Treated With Puberty Suppression and Subsequent Gender-Affirming Hormones

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Sociodemographic Disparities and Hearing-Related Quality of Life in Children With Hearing Loss

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 30, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that race and ethnicity and neighborhood disadvantage are associated with hearing-related quality of life in deaf or hard-of-hearing children. The neighborhood association was seen most broadly in children older than 13 years. 

Authors: Dylan K. Chan, M.D., Ph.D., of the University of California, San Francisco, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.40934)

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Imaging Brain Injury in Former National Football League Players

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 30, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this imaging study that included 54 athletes, higher levels of 18 kDa translocator protein (TSPO) that mark brain injury and repair were found in former National Football League (NFL) players compared with former non-collision sport athletes. The NFL players also had lower performance in learning and memory. These findings suggest that further tracking of TSPO levels in relation to neuropsychological performance over time is needed to understand whether these signs persist, progress, and/or warrant neuroimmune-modulating interventions.

Authors: Jennifer M. Coughlin, M.D., of the Johns Hopkins University School of Medicine in Baltimore, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.40580)

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Year-by-Year Blood Pressure Variability From Midlife to Death and Lifetime Dementia Risk

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 30, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: High blood pressure variability indicated increased lifetime dementia risk in late life but not in midlife in this study that included 820 adults monitored for an average time of 32 years. This result suggests that high blood pressure variability may indicate increased dementia risk in older age but might be less viable as a midlife dementia prevention target. 

Authors: Jan Willem van Dalen, Ph.D., of the Radboud University Medical Center in Nijmegen, the Netherlands, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.40249)

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Use of Telemedicine and Quality of Care Among Medicare Enrollees With Serious Mental Illness

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2023.3648?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=102723

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Transparency in Coverage Data and Variation in Prices for Common Health Care Services

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Medication Abortion Safety and Effectiveness With Misoprostol Alone

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, OCTOBER 27, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings in this study of 637 callers to safe abortion hotlines and accompaniment groups in Argentina, Nigeria, and Southeast Asia suggest that misoprostol alone is a highly effective method of pregnancy termination. Future research should explore strategies to maximize the effectiveness of misoprostol alone in clinical and nonclinical settings. 

Authors: Ruvani Jayaweera, Ph.D., of Ibis Reproductive Health in Oakland, California, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.40042)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Effect of Time-Restricted Eating on Weight Loss in Adults With Type 2 Diabetes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, OCTOBER 27, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This 6-month randomized clinical trial involving 75 adults with type 2 diabetes found that a time-restricted eating diet strategy without calorie counting was effective for weight loss and lowering of hemoglobin A1c levels compared with daily calorie counting. These findings will need to be confirmed by larger RCTs with longer follow-up. 

Authors: Krista A. Varady, Ph.D., of the University of Illinois Chicago, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.39337)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Risk Model–Based Lung Cancer Screening and Racial and Ethnic Disparities in the US

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Machine Learning Models for Predicting Long-Term Visual Acuity in Highly Myopic Eyes

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Neurodevelopmental Outcomes in Infants Screened for Retinopathy of Prematurity

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Admissions for Bronchiolitis at Children’s Hospitals Before and During the Pandemic

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, OCTOBER 26, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study of 41 large U.S. children’s hospitals suggest that bronchiolitis hospitalizations decreased transiently and then increased markedly during the COVID-19 pandemic era. Patients admitted during the pandemic era were older and were more likely to be admitted to an intensive care unit. These findings suggest that bronchiolitis seasonality has not yet returned to pre-pandemic patterns, and hospitals should prepare for the possibility of atypical timing again in 2023. 

Authors: Jonathan H. Pelletier, M.D., of Akron Children’s Hospital in Akron, Ohio, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.39884

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Parent-Perceived Benefits and Harms Associated With Internet Use by Adolescent Offspring

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, OCTOBER 26, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This survey study of attitudes of 1,005 parents of children and adolescents ages 9 to 15 revealed both perceived benefits (e.g., family connectedness) and concerns (e.g., cyberbullying, addiction) of internet use. Twice as many parents reported specific concerns about internet addiction than substance addiction. 

Authors: Michael Peter Milham, M.D., Ph.D., of the Child Mind Institute in New York, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.39851

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Age, Body Mass Index, Tumor Subtype, and Racial and Ethnic Disparities in Breast Cancer Survival

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, OCTOBER 25, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study with 9,479 participants, racial and ethnic survival disparities were identified in patients with early-stage breast cancer receiving standardized initial care, and potentially at-risk subgroups, for whom focused interventions may improve outcomes, were found. 

Authors: Erica T. Warner, Sc.D., of Massachusetts General Hospital in Boston, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.39584

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Metformin Cessation and Dementia Incidence

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, OCTOBER 25, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Terminating metformin treatment was associated with increased dementia incidence in this study of 12,000 early terminators and 29,000 routine users of metformin. This finding may have important implications for clinical treatment of adults with diabetes and provides additional evidence that metformin is associated with reduced dementia risk. 

Authors: Sarah F. Ackley, Ph.D., of Boston University, Boston, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.39723)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Landiolol and Organ Failure in Patients With Septic Shock

JAMA

EMBARGOED FOR RELEASE: 8 A.M. (ET), WEDNESDAY, OCTOBER 25, 2023

Media advisory: The full study and editorial are linked to this news release. This study is being released to coincide with presentation at the European Society of Intensive Care Medicine Lives 2023 36th Annual Congress.

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About The Study: The results of this randomized clinical trial involving 126 patients do not support the use of the very short-acting beta-blocker landiolol for managing patients with tachycardia treated with norepinephrine for established septic shock. 

Authors: Tony Whitehouse, M.D., of Queen Elizabeth Hospital in Birmingham, United Kingdom, is the corresponding author.

 

(doi:10.1001/jama.2023.20134)

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Intravenous Vitamin C for Patients Hospitalized With COVID-19

JAMA

EMBARGOED FOR RELEASE: 8 A.M. (ET), WEDNESDAY, OCTOBER 25, 2023

Media advisory: The full study and editorial are linked to this news release. This study is being released to coincide with presentation at the European Society of Intensive Care Medicine Lives 2023 36th Annual Congress.

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About The Study: In hospitalized patients with COVID-19, vitamin C had low probability of improving the primary composite outcome of organ support–free days and hospital survival in two harmonized randomized clinical trials. 

Authors: Neill K. J. Adhikari, M.D.C.M., M.Sc., of the Sunnybrook Health Sciences Centre in Toronto, and Francois Lamontagne, M.D., M.Sc., of the Universite de Sherbrooke in Sherbrooke, Canada, are the corresponding authors.

 

(doi:10.1001/jama.2023.21407)

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Sigh Ventilation in Patients With Trauma

JAMA

EMBARGOED FOR RELEASE: 8 A.M. (ET), WEDNESDAY, OCTOBER 25, 2023

Media advisory: The full study and editorial are linked to this news release. This study is being released to coincide with presentation at the European Society of Intensive Care Medicine Lives 2023 36th Annual Congress.

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About The Study: In a randomized clinical trial including 524 trauma patients receiving mechanical ventilation with risk factors for developing acute respiratory distress syndrome, the addition of sigh breaths did not significantly increase ventilator-free days. Prespecified secondary outcome data suggest that sighs are well-tolerated and may improve clinical outcomes. 

Authors: Richard K. Albert, M.D., of the University of Colorado, Denver, is the corresponding author.

 

(doi:10.1001/jama.2023.21739)

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Multitarget Stool RNA Test for Colorectal Cancer Screening

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 23, 2023

Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the American College of Gastroenterology 2023 Annual Scientific Meeting.

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https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2023.22231?guestAccessKey=a43a7e6d-f8f7-4c6d-b106-8aac7b27149c&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=102323

 

About The Study: In a clinical trial that included 8,920 participants, a noninvasive, multitarget stool RNA test (ColoSense) for colorectal cancer screening showed high sensitivity for colorectal neoplasia (colorectal cancer and advanced adenoma) with significant improvement in sensitivity relative to the fecal immunochemical test. Specificity for no lesions on colonoscopy was comparable to existing molecular diagnostic tests. 

Authors: Erica K. Barnell, M.D., Ph.D., of the Washington University School of Medicine in St. Louis, is the corresponding author.

 

(doi:10.1001/jama.2023.22231)

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Nirmatrelvir and Molnupiravir and Post–COVID-19 Condition in Older Patients

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Hospital Admissions for Abusive Head Trauma Before and During the Pandemic

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Newborn and Early Infant Outcomes Following Maternal COVID-19 Vaccination During Pregnancy

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 23, 2023

Media advisory: The full study and editorial are linked to this news release.

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About The Study: In this study of 142,000 live births in Ontario, Canada, maternal mRNA COVID-19 vaccination during pregnancy was associated with lower risks of severe neonatal morbidity, neonatal death, and neonatal intensive care unit admission and no increase in neonatal readmission or hospital admission up to age six months, compared with no maternal COVID-19 vaccination before delivery. 

Authors: Jeffrey C. Kwong, M.D., M.Sc., of ICES in Toronto, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2023.4499)

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Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 23, 2023

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of 2,361 mother-child pairs followed up prenatally to child age of approximately two years, prenatal lead exposure was associated with an increased risk of cognitive developmental delay (CDD) in children, especially in those with a high genetic risk. These findings suggest that prenatal lead exposure and genetic background may jointly contribute to an increased risk of CDD for children and indicate the possibility for an integrated strategy to assess CDD risk and improve children’s cognitive ability. 

Authors: Yuanyuan Li, Ph.D., of the Huazhong University of Science and Technology in Wuhan, Hubei, China, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.39108)

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Traditional Chinese Medicine Compound (Tongxinluo) and Clinical Outcomes of Patients With Acute Myocardial Infarction

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 24, 2023

Media advisory: The full study, editorial and editor’s note are linked to this news release.

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About The Study: In this randomized clinical trial of 3,777 patients with ST-segment elevation myocardial infarction (STEMI; a type of heart attack), the Chinese patent medicine Tongxinluo, as an adjunctive therapy in addition to STEMI guideline-directed treatments, significantly improved both 30-day and 1-year clinical outcomes. Further research is needed to determine the mechanism of action of Tongxinluo in STEMI. 

Authors: Yuejin Yang, M.D., Ph.D., and Runlin Gao, M.D., of the Chinese Academy of Medical Sciences and Peking Union Medical College in Beijing, are the corresponding authors.

 

(doi:10.1001/jama.2023.19524)

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Removal of Medicaid Prior Authorization Requirements and Buprenorphine Treatment for Opioid Use Disorder

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Specialty Palliative Care and Symptom Severity and Control in Adolescents and Young Adults With Cancer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, OCTOBER 20, 2023

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.38699?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=102023

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of 5,435 adolescents and young adults with cancer, those reporting moderate or severe symptoms through a screening program were more likely to subsequently receive specialty palliative care. These findings suggest that specialty palliative care was associated with a subsequent decrease in pain severity but did not affect other symptoms. New interventions targeting other symptoms during treatment and particularly at the end of life are needed. 

Authors: Sumit Gupta, M.D., Ph.D., of the Hospital for Sick Children in Toronto, is the corresponding author.

  

(doi:10.1001/jamanetworkopen.2023.38699)

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Noninvasive Bioelectronic Treatment of Postcesarean Pain

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, OCTOBER 20, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this randomized clinical trial of 134 individuals who underwent a cesarean delivery, use of a high-frequency electrical stimulation device as part of a multimodal analgesia protocol decreased opioid use in the immediate postoperative period and opioids prescribed at discharge. These findings suggest that the use of this device may be a helpful adjunct to decrease opioid use without compromising pain control after cesarean delivery. 

Authors: Jennifer L. Grasch, M.D., of the Ohio State University Wexner Medical Center in Columbus, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.38188)

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Neurodevelopmental Outcomes Among Offspring Exposed to Corticosteroid and B2-Adrenergic Agonists In Utero

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 24, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.39347?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=102423

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: The results of this study of 91,460 mother-offspring pairs found no association between in utero corticosteroid and β2-adrenergic agonist exposure and offspring neurodevelopmental outcomes, regardless of the timing of exposure. Despite the limitations and low power of the study, the findings suggest that corticosteroids and β2-adrenergic agonists are safe for pregnant individuals with asthma and the neurodevelopment of their offspring.

Authors: Abir Nagata, Ph.D., of Osaka University in Osaka, Japan, and Toshio Masumoto, Ph.D., of Tottori University in Tottori, Japan, are the corresponding authors.

 

(doi: 10.1001/jamanetworkopen.2023.39347)

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Incidence and Transmission of SARS-CoV-2 in Child Care Centers After COVID-19 Vaccines

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 24, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this examination of SARS-CoV-2 incidence and transmission in child care centers (CCCs) and students’ households, transmission within CCCs and from children infected at CCCs into households was low in this study that included 83 children in 11 CCCs. These findings suggest that current testing and exclusion recommendations for SARS-CoV-2 in CCCs should be aligned with those for other respiratory viruses with similar morbidity and greater transmission to households.

Authors: Timothy R. Shope, M.D., M.P.H., of UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, is the corresponding author.

 

(doi: 10.1001/jamanetworkopen.2023.39355)

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Diverse Research Teams and Underrepresented Groups in Clinical Studies

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COVID-19 Vaccination Willingness and Reasons for Vaccine Refusal

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, OCTOBER 19, 2023

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.37909?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=101923

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study that involved the use of data from Hong Kong and Singapore suggest that trust in health authorities was fundamental to overcoming COVID-19 vaccine hesitancy. As such, engendering trust in health care professionals, experts, and public health agencies should be incorporated into pandemic preparedness and response. 

Authors: Michael Y. Ni, M.D., of the University of Hong Kong, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.37909)

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Developmental Trajectory of Body Weight in Youths at Risk for Major Mood Disorders

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, OCTOBER 19, 2023

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of 394 individuals, females with a family history of mood disorders were prone to weight gain starting around puberty and predating mood disorder onset. Early interventions aiming to prevent adverse mental and physical outcomes in this vulnerable group need to start in childhood. 

Authors: Rudolf Uher, M.D., Ph.D., of Dalhousie University in Halifax, Nova Scotia, Canada, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.38540)

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Deep Learning of Electrocardiograms in Sinus Rhythm From Veterans to Predict Atrial Fibrillation

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Barriers and Facilitators to Clinical Practice Development in Men and Women Surgeons

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Treatment Rates for Mental Disorders Among Children and Adolescents

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, OCTOBER 18, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.38174?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=101823

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this meta-analysis of 40 studies including 310,000 children and adolescents suggest that, in general, the treatment rates for mental disorders among children and adolescents were low, especially for depression and anxiety. Targeted intervention policies and effective measures should be designed and implemented to improve treatment rates of psychiatric disorders among youths. 

Authors: Yuanyuan Xiao, Ph.D., of Kunming Medical University in Kunming, Yunnan, China, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.38174)

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Association of Antepartum and Postpartum Air Pollution Exposure With Postpartum Depression in Southern California

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, OCTOBER 18, 2023

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.38315?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=101823

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study including 340,000 pregnant women suggest that long-term exposure to antepartum and postpartum air pollution was associated with higher postpartum depression risks. Identifying the modifiable environmental risk factors and developing interventions are important public health issues to improve maternal mental health and alleviate the disease burden of postpartum depression. 

Authors: Jun Wu, Ph.D., of the University of California, Irvine, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.38315)

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Trends, Outcomes of Assisted Reproductive Technology Cycles Using a Gestational Carrier

JAMA

EMBARGOED FOR RELEASE: 12:30 P.M. (ET), WEDNESDAY, OCTOBER 18, 2023

Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the American Society for Reproductive Medicine 2023 Scientific Congress & Expo. 

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About The Study: There was an increased likelihood of live birth among assisted reproductive technology cycles with a gestational carrier versus those without a gestational carrier in this analysis of 2014 to 2020 national surveillance data. Gestational carrier use was a risk factor for twins, even after adjusting for the number of embryos transferred. More than one-quarter of embryo transfers to gestational carriers involved two or more embryos despite national recommendations of single embryo transfer. 

Authors: Lisa M. Shandley, M.D, M.Sc., of the Emory University School of Medicine in Atlanta, is the corresponding author.

 

(doi:10.1001/jama.2023.11023)

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Variations in State Laws on Mental Health–Related Firearm Prohibition

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Patterns of Social Determinants of Health and Child Mental Health, Cognition, and Physical Health

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Early Childhood Education and Midlife Ideal Cardiovascular Health in a Prospective Urban Cohort

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