About The Study: Evidence from this systematic review and meta-analysis indicates that paternal mental distress is a potentially modifiable predictor of child development. Reducing mental distress in fathers perinatally is thus an important target for preventative interventions aiming to support fathers during the transition to parenthood and promote the health and well-being of next-generation offspring.
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: This longitudinal cohort study found that large life expectancy differences between American Indian and Alaska Native individuals and other U.S. residents have been underestimated due to racial misclassification on death certificates, resulting in the statistical erasure of Indigenous people in routine vital statistics.
Corresponding Author: To contact the corresponding author, Jacob Bor, SD, email jbor@bu.edu.
(doi:10.1001/jama.2025.8126)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, daily walking volume and walking intensity were inversely associated with the risk of chronic low back pain. The findings suggest that walking volume may have a more pronounced benefit than walking intensity.
Corresponding Author: To contact the corresponding author, Rayane Haddadj, MS, email rayane.haddadj@ntnu.no.
(doi:10.1001/jamanetworkopen.2025.15592)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: The results of this cohort study suggest that medical cannabis laws and recreational cannabis laws enactment was associated with greater opioid use disorder (OUD) prevalence in Veterans Health Administration patients over time, with the greatest increases among middle-aged and older patients and those with chronic pain. The findings did not support state cannabis legalization as a means of reducing the burden of OUD during the ongoing opioid epidemic.
Corresponding Author: To contact the corresponding author, Deborah S. Hasin, PhD, email dsh2@cumc.columbia.edu.
(doi:10.1001/jamahealthforum.2025.1369)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: The observed sensitivity and specificity measures for computed tomography perfusion and computed tomography angiography as an ancillary test for death by neurologic criteria did not meet the prespecified validation threshold of greater than 98%. Clinical examination remains the cornerstone of death by neurologic criteria, and ancillary imaging should be interpreted cautiously within a comprehensive clinical assessment.
Corresponding Author: To contact the corresponding author, Michael Chasse, MD, PhD, email michael.chasse@umontreal.ca.
(doi:10.1001/jamaneurol.2025.2375)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: In adult patients receiving mechanical ventilation and supplemental oxygen in the intensive care unit, minimizing oxygen exposure through conservative oxygen therapy did not significantly reduce all-cause mortality at 90 days.
Corresponding Author: To contact the corresponding author, Daniel S. Martin, PhD, email daniel.martin@plymouth.ac.uk.
(doi:10.1001/jama.2025.9663)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study, U.S. drug overdose death rates entered a new wave of sustained deceleration in 2023 after 2 decades of increase. This shift may reflect changes in drug markets, treatment access, harm reduction efforts, and population-level risk. Although the decline is encouraging, persistent disparities highlight the need for targeted interventions and improved understanding of the underlying drivers.
Corresponding Author: To contact the corresponding author, Lori Ann Post, PhD, email lori.post@northwestern.edu.
(doi:10.1001/jamanetworkopen.2025.14997)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: This study found that initiating fecal immunochemical test screening at age 40 to 49 was associated with further reduction in colorectal cancer (CRC) mortality and incidence compared with starting screening at age 50. These results provide strong empirical support for lowering the CRC screening age, with substantial public health implications.
Corresponding Author: To contact the corresponding author, Tony Hsiu-Hsi Chen, PhD, email chenlin@ntu.edu.tw.
(doi:10.1001/jamaoncol.2025.1433)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Article: This Viewpoint, from Martin A. Makary, MD, MPH, and Vinay Prasad, MD, MPH, of the Food and Drug Administration (FDA), outlines new priorities of the FDA.
Corresponding Author: To contact the corresponding author, Martin A. Makary, MD, MPH, email CommissionersOffice@fda.hhs.gov.
(doi:10.1001/jama.2025.10116)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study using data from the Centers for Disease Control and Prevention Wide Ranging Online Data for Epidemiologic Research database, alcohol-associated liver disease mortality increased significantly across demographic groups, with particularly concerning trends among women, younger adults, and American Indian and Alaska Native populations. These findings highlight the urgent need for targeted public health interventions and enhanced surveillance, especially given the sustained impact of COVID-19 pandemic–related changes in alcohol consumption patterns.
Corresponding Author: To contact the corresponding author, Robert J. Wong, MD, MS, email rwong123@stanford.edu.
(doi:10.1001/jamanetworkopen.2025.14857)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This survey study found that after Dobbs, 42% of survey respondents who provided abortions in states banning abortion relocated to another state. Almost all clinicians who relocated from any policy context relocated to states not banning abortion.
Corresponding Author: To contact the corresponding author, Dana Howard, PhD, email dana.howard@osumc.edu.
(doi:10.1001/jamanetworkopen.2025.14884)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: Augmenting enteral protein during critical illness did not improve number of days free of the index hospital and alive at day 90.
Corresponding Author: To contact the corresponding author, Adam M. Deane, PhD, email Adam.deane@mh.org.au.
(doi:10.1001/jama.2025.9110)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This study found that parent-reported firearm storage may be a poor estimator of teen perceived firearm access, regardless of teen gender, parental education, and urbanicity. Strictly focusing safety efforts on locked and unloaded firearm storage may not fully negate teen’s perceptions that they can access and load household firearms. Storing additional firearms securely may not prevent teen access if at least 1 household firearm remains unlocked.
Corresponding Author: To contact the corresponding author, Katherine G. Hastings, MPH, email katiegh@student.ubc.ca.
(doi:10.1001/jamanetworkopen.2025.14443)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cross-sectional study revealed high attrition rates among lesbian, gay, and bisexual (LGB) medical students, with the highest observed among LGB Hispanic male and female students. Our findings highlight the importance of intersectionality in understanding attrition from medical school. Although future studies need to examine the cause of these disparities in attrition, LGB students experience discrimination within medical training environments, which may lead to risk of attrition.
Corresponding Author: To contact the corresponding author, Mytien Nguyen, MS, email mytien.nguyen@yale.edu.
(doi:10.1001/jamanetworkopen.2025.14515)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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EMBARGOED FOR RELEASE: 2:15 P.M. (ET), TUESDAY, JUNE 10, 2025
Media advisory: The full study is linked to this news release. This study is being presented at the Society for Pediatric and Perinatal Epidemiologic Research Annual Meeting.
About The Study: Findings from this cohort study suggest that severe neonatal morbidity may be a significant risk factor for childhood mortality. Efforts to prevent severe neonatal morbidity, as well as early identification and long-term follow-up care, may help further reduce mortality.
Corresponding Author: To contact the corresponding author, Hillary Graham, MS, email hillary.graham@ki.se.
(doi:10.1001/jamapediatrics.2025.1873)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: The results of this study demonstrate that permissive firearm laws contributed to thousands of excess firearm deaths among children living in states with permissive policies. Future work should focus on determining which types of laws conferred the most harm and which offered the most protection.
Corresponding Author: To contact the corresponding author, Jeremy Samuel Faust, MD, MS, email jsfaust@bwh.harvard.edu.
(doi:10.1001/jamapediatrics.2025.1363)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this cross-sectional study suggest that although 988 has been contacted more than 16 million times since its launch in July 2022, there remains opportunity to increase 988 use.
Corresponding Author: To contact the corresponding author, Jonathan Purtle, DrPH, MSc, email jonathan.purtle@nyu.edu.
(doi:10.1001/jamanetworkopen.2025.14323)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: The findings of this cross-sectional study suggest substantial cost shifting in veterans’ surgical care from Medicare Advantage to Veterans Health Administration among high-veteran Medicare Advantage plans, underscoring the urgent need for policy reforms to improve the efficiency of veterans’ care.
Corresponding Author: To contact the corresponding author, Jose F. Figueroa, MD, MPH, email jfigueroa@hsph.harvard.edu.
(doi:10.1001/jamahealthforum.2025.0827)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This study found that nearly 1 in 5 firearm suicides in the U.S. occurred outside the home, highlighting the potential to enhance intervention strategies by extending them to broader community settings.
Corresponding Author: To contact the corresponding author, Camerin A. Rencken, PhD, ScM, email crencken@uw.edu.
(doi:10.1001/jamanetworkopen.2025.14423)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Article: This Viewpoint, by Vinay Prasad, MD, MPH, of the Center for Biologics Evaluation and Research, Food and Drug Administration, and colleagues discusses a safety communication recommending a pause in the use of live attenuated chikungunya virus vaccine.
Corresponding Author: To contact the corresponding author, Vinay Prasad, MD, MPH, email vinayak.prasad@fda.gov.
(doi:10.1001/jama.2025.9393)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: The results of this cohort study suggest that, despite some differences by political affiliation, there is high support of policies to support the adult care economy, suggesting a policy window to advance legislation and executive action to address the care needs of aging populations and populations with disabilities.
Corresponding Author: To contact the corresponding author, Katherine E. M. Miller, PhD, email kmill177@jh.edu.
(doi:10.1001/jamahealthforum.2025.1204)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study, poor mental health among workers varied significantly by sociodemographic categories; significant differences among industry and occupation groups remained after adjustment. More research is needed on the effects of work-related factors on mental health, which may inform tailored treatment and prevention strategies.
Corresponding Author: To contact the corresponding author, Aaron L. Sussell, PhD, email als7@cdc.gov.
(doi:10.1001/jamanetworkopen.2025.14212)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: In this cohort study, state Medigap guaranteed issue protections were associated with higher rates of switching to traditional Medicare among Medicare Advantage beneficiaries newly diagnosed with cancer. These findings underscore the protective association of state Medigap regulations in facilitating a switch to traditional Medicare (especially among beneficiaries who likely desired more flexibility in accessing and receiving care) and illuminate potential disparities in switching that may reflect unequal abilities to compare and afford plans.
Corresponding Author: To contact the corresponding author, Youngmin Kwon, PhD, email youngmin.kwon@vumc.org.
(doi:10.1001/jamahealthforum.2025.2018)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: Health care employment growth decreased amid the pandemic but fully recovered by 2024. This recovery contrasts with non–health care employment trends and may result from health care financing via insurance coverage shielding health care employment from macroeconomic fluctuations.
Corresponding Author: To contact the corresponding author, Thuy Nguyen, PhD, email thuydn@umich.edu.
(doi:10.1001/jama.2025.8588)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: In this cohort study, the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) among patients with diabetes was associated with a 2-fold higher risk of incident neovascular age-related macular degeneration development than among similar patients with diabetes who did not receive a GLP-1 RA. Further research is needed to elucidate the exact pathophysiological mechanisms involved and to understand the trade-offs between the benefits and risks of GLP-1 RAs.
Corresponding Author: To contact the corresponding author, Rajeev H. Muni, MD, MSc, email rajeev.muni@utoronto.ca.
(doi:10.1001/jamaophthalmol.2025.1455)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: Among childhood cancer survivors in this cohort study, obesity was associated with an increased risk for multiple subsequent neoplasm types, while higher physical activity was associated with reduced subsequent neoplasm risk. Lifestyle interventions should be considered in future subsequent neoplasm prevention research.
Corresponding Author: To contact the corresponding author, Lenat Joffe, MD, MS, email ljoffe@northwell.edu.
(doi:10.1001/jamaoncol.2025.1340)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: The proportion of U.S. adults who were unaware of having hypertension increased significantly over the study period (2013 to 2023), particularly in young adults and women, while diabetes and high cholesterol level unawareness remained stable. By the 2021 to 2023 cycle, approximately 1 in 6 adults with hypertension and 3 in 10 with diabetes were unaware of their condition.
Corresponding Author: To contact the corresponding author, Rishi K. Wadhera, MD, MPP, MPhil, email rwadhera@bidmc.harvard.edu.
(doi:10.1001/jamacardio.2025.1536)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of schools, a COVID-19–related decline in youth physical fitness was observed. Compared with pre-pandemic and post-pandemic periods, cardiorespiratory fitness and musculoskeletal fitness healthy fitness zone achievement were significantly lower during the pandemic, but the reduction did not appear to be associated with extended remote or hybrid environments.
Corresponding Author: To contact the corresponding author, Andjelka Pavlovic, PhD, email andjelka.pavlovic@ttuhsc.edu.
(doi:10.1001/jamanetworkopen.2025.13721)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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EMBARGOED FOR RELEASE: 5:30 P.M. (ET), SUNDAY, JUNE 1, 2025
Media advisory: The full study and editor’s note are linked to this news release. This study is being presented at the 2025 American Society of Clinical Oncology Annual Meeting.
About The Study: Although phase 3 trials are often interpreted as demonstrating superiority, overall survival and quality of life (QOL), which may be the most relevant end points to patients, are uncommonly improved. To increase the meaningfulness of late-phase research, future trial designs and regulatory processes should be refocused toward overall survival and QOL improvements.
Corresponding Author: To contact the corresponding author, Alexander D. Sherry, MD, email alexanderdsherry@gmail.com.
(doi:10.1001/jamaoncol.2025.1002)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of 3.26 million individuals in the U.S., results highlighted the dual burden of incarceration on health outcomes. Individuals who were incarcerated faced significantly higher risks of death, particularly from overdoses, and elevated county incarceration rates exacerbated individual-level mortality risks. These findings suggest the need for reforms in criminal justice and public health policies to address these elevated risks and their widespread implications.
Corresponding author: To contact the corresponding author, Utsha G. Khatri, M.D., M.S., email utsha.khatri@mountsinai.org.
(doi: 10.1001/jamanetworkopen.2025.13537)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study of births among individuals with a prior cesarean birth, patterns of severe maternal morbidity (SMM) by birth mode varied by race and ethnicity, with elevated rates of SMM among those from marginalized racial and ethnic groups with planned cesarean births. Future work should identify interventions to improve quality of care and promote equity for this population.
Corresponding author: To contact the corresponding author, Laura B. Attanasio, Ph.D., email lattanasio@umass.edu.
(doi: 10.1001/jamanetworkopen.2025.13578)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: In an average-risk colorectal cancer screening population, a blood-based test demonstrated acceptable accuracy for colorectal cancer detection, but detection of advanced precancerous lesions remains a challenge, and ongoing efforts are needed to improve test sensitivity.
Corresponding Author: To contact the corresponding author, Theodore R. Levin, MD, email theodore.levin@kp.org.
(doi:10.1001/jama.2025.7515)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: The finding of a slightly lower prevalence of any adenoma in the younger compared with the older age group (35.4% vs 40.8%) in the current study is consistent with an evaluation of 2001 screening colonoscopies from a university-based medical center between 2019 and 2021, which reported slightly lower rates of adenoma detection in those ages 45 to 49 vs 50 to 54 (34.3% vs 38.2%) and with a large study of adenoma detection rates in those ages 45 to 49 vs 50 to 54 (28.6% vs 31.8%) who underwent a screening colonoscopy before the change in guidelines (i.e., 2014-2020).
Corresponding Author: To contact the corresponding author, Jeffrey K. Lee, MD, MPH, email jeffrey.k.lee@kp.org.
(doi:10.1001/jama.2025.7494)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: This county-level dataset complements the state and national-level Centers for Disease Control and Prevention data, confirming a widespread decline in measles-mumps-rubella (MMR) vaccination rates in the U.S. after the COVID-19 pandemic while revealing significant heterogeneity in vaccination patterns within and across states. This dataset can be used in spatial and statistical analyses to identify factors associated with low or declining MMR rates in U.S. counties and help inform targeted vaccination strategies to reduce the risk of measles outbreaks.
Corresponding Author: To contact the corresponding author, Lauren M. Gardner, PhD, email l.gardner@jhu.edu.
(doi:10.1001/jama.2025.8952)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: Between 2021 and 2023, prevalence of current cannabis use increased among adults age 65 or older nationally, with key demographic subgroups experiencing marked increases. Adults with the highest incomes initially had the lowest prevalence of cannabis use vs other income levels, but by 2023, they had the highest prevalence, which may indicate better access to medical cannabis given its costs.
Corresponding Author: To contact the corresponding author, Benjamin H. Han, MD, email b2han@health.ucsd.edu.
(doi:10.1001/jamainternmed.2025.1156)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: This cross-sectional study found that chronic cannabis smoking and tetrahydrocannabinol (THC) ingestion were associated with endothelial dysfunction similar to that observed in tobacco smokers, although apparently occurring via distinct mechanisms.
Corresponding author: To contact the corresponding author, Matthew L. Springer, Ph.D., email matt.springer@ucsf.edu.
(doi: 10.1001/jamacardio.2025.1399)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About The Study: This study demonstrates that the artificial sweetener neotame was a ubiquitous constituent of popular disposable e-cigarettes sold in the U.S. in 2024, including those containing no nicotine or the nicotine analogue 6-methylnicotine. Neotame is 7,000 to 13,000 times sweeter than table sugar and is 35 to 65 times sweeter than aspartame.
Corresponding Author: To contact the corresponding author, Sven E. Jordt, PhD, email sven.jordt@duke.edu.
(doi:10.1001/jama.2025.7398)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This cost-effectiveness analysis found that cessation of public water fluoridation would increase tooth decay and health system costs in the U.S. Despite concerns regarding toxic effects associated with high levels of fluoride, this model demonstrates the substantial ongoing benefits of water fluoridation at safe levels currently recommended by the U.S. Environmental Protection Agency, the National Toxicity Program, and the Centers for Disease Control and Prevention.
Corresponding Author: To contact the corresponding author, Lisa Simon, MD, DMD, email lsimon@bwh.harvard.edu.
(doi:10.1001/jamahealthforum.2025.1166)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of middle-aged and older adults across 4 countries, both higher maternal and paternal education were generally associated with slower cognitive decline, and these associations were mediated by participants’ own education. These findings highlight the long-term relevance of parental education for offspring cognitive health across diverse cultural or socioeconomic contexts, and support the potential benefits of improving educational attainment to reduce intergenerational disparities in late-life cognitive health.
Corresponding Author: To contact the corresponding author, Vivian Yawei Guo, PhD, email guoyw23@mail.sysu.edu.cn.
(doi:10.1001/jamanetworkopen.2025.13036)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this national survey of internal medicine physicians, experiencing sacred moments —meaningful, memorable, and sometimes spiritual moments of connection— is common; discussing them with colleagues is not. These findings suggest that frequently experiencing sacred moments and discussing them with colleagues could bolster physician well-being.
Corresponding Author: To contact the corresponding author, Jessica Ameling, MPH, email jameling@med.umich.edu.
(doi:10.1001/jamanetworkopen.2025.13159)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About The Study: In this pilot trial, acupuncture produced greater reductions in nocturia (waking up 1 or more times to urinate) relative to usual care in survivors of prostate cancer. The nocturia reduction was comparable to other treatments, such as desmopressin, α-blockers, and antimuscarinic medications; however, acupuncture was associated with fewer adverse events. Nocturia affects more than half of survivors of prostate cancer.
Corresponding Author: To contact the corresponding author, Kevin T. Liou, MD, email liouk@mskcc.org.
(doi:10.1001/jamaoncol.2025.1199)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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About The Study: The findings of this study that fewer than half of U.S. adults are aware and about one-fifth are unsure of their awareness of the association between alcohol and cancer emphasize the need to implement the recently updated Surgeon General’s recommendation to reduce the alcohol-related cancer burden in the U.S.
Corresponding Author: To contact the corresponding author, Sanjay Shete, PhD, email sshete@mdanderson.org.
(doi:10.1001/jamaoncol.2025.1146)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study assessing early life low lead level and children’s and adolescents’ academic achievement, a 1-unit increase in lead levels in the range currently considered low for further interventions was associated with worse academic performance throughout school grades comparable to that for lead levels in the range recommended for additional interventions. These findings support the need to reconsider and potentially lower current blood lead reference values for recommending further interventions.
Corresponding author: To contact the corresponding author, George L. Wehby, M.P.H., Ph.D., email george-wehby@uiowa.edu.
(doi: 10.1001/jamanetworkopen.2025.12796)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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