Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock

JAMA Cardiology

EMBARGOED FOR RELEASE: 5 A.M. ET, SATURDAY, AUGUST 30, 2025

Media advisory: This study is being presented at the European Society of Cardiology Congress 2025. The full study and editorial are linked to this news release.

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About The Study: Randomization systolic blood pressure (SBP) was associated with the survival benefit of microaxial flow pump treatment, with the most hypotensive patients deriving the largest survival benefit. Early SBP may help identify patients most likely to gain a net benefit from microaxial flow pump treatment. Findings are hypothesis generating.

Corresponding Author: To contact the corresponding author, Astrid Duus Mikkelsen, MD, email astrid.duus.mikkelsen@reigonh.dk.

 

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine

JAMA Network Open

EMBARGOED FOR RELEASE: 8 A.M. ET, SATURDAY, AUGUST 30, 2025

Media advisory: This study is being presented at the European Society of Cardiology Congress 2025. The full study is linked to this news release.

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About The Study: In this prespecified analysis of the DANFLU-2 trial, the risk of incident myocarditis or pericarditis was lower among individuals randomized to high-dose inactivated influenza vaccine vs standard-dose- inactivated influenza vaccine. Despite sporadic reports of myocarditis and pericarditis associated with influenza vaccination, the consistency of our results with vs without inclusion of events occurring immediately after vaccination negates a dose-response association and a causal link.

Corresponding Author: To contact the corresponding author, Tor Biering-Sørensen, MD, MSc, MPH, PhD, email tor.biering@gmail.com.

 

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Bivalent RSV Prefusion F Protein–Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults

JAMA

EMBARGOED FOR RELEASE: 8:15 A.M. ET, SATURDAY, AUGUST 30, 2025

Media advisory: This study is being presented at the European Society of Cardiology Congress 2025. The full study and related article are linked to this news release.

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About The Study: In adults age 60 or older, all-cause cardiorespiratory hospitalization was significantly lower with respiratory syncytial virus (RSV) prefusion F protein than with no vaccine. The findings suggest potential downstream cardiorespiratory benefits of RSV immunization, although the effect on all-cause cardiovascular hospitalization was not statistically significant. 

Corresponding Author: To contact the corresponding author, Tor Biering-Sørensen, MD, MSc, MPH, PhD, email tor.biering@gmail.com.

 

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Physiology-Guided Complete Revascularization in Older Patients With Myocardial Infarction

JAMA Cardiology

EMBARGOED FOR RELEASE: 8:45 A.M. ET, FRIDAY, AUGUST 29, 2025

Media advisory: This study is being presented at the European Society of Cardiology Congress 2025. The full study is linked to this news release.

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About The Study: In patients 75 years or older with myocardial infarction and multivessel disease, the benefit of physiology-guided complete revascularization over culprit-lesion–only treatment was sustained at 3 years. 

Corresponding Author: To contact the corresponding author, Simone Biscaglia, MD, email bscsmn@unife.it.

 

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Remote Screening for Asymptomatic Atrial Fibrillation

JAMA

EMBARGOED FOR RELEASE: 5:15 A.M. ET, FRIDAY, AUGUST 29, 2025

Media advisory: This study is being presented at the European Society of Cardiology Congress 2025. The full study is linked to this news release.

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About The Study: In this remote randomized clinical trial, mail-based atrial fibrillation (AF) screening with an electrocardiogram patch in older patients at moderate to high risk of stroke led to a modest long-term increase in AF diagnosis at 2.5 years.

Corresponding Authors: To contact the corresponding authors, email Rohan Wijesurendra, DPhil, rohan.wijesurendra@ndph.ox.ac.uk and Barbara Casadei, DPhil, b.casadei@imperial.ac.uk.

 

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Extreme Heat and Calls to Law Enforcement Related to Domestic Violence

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Adolescent Treatment Landscape of Depression, Suicidality, and Substance Use Disorder in the US

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

ADHD Diagnosis and Timing of Medication Initiation Among Children Ages 3 to 5

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, AUGUST 29, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this retrospective cohort study of preschool-age children with attention-deficit/hyperactivity disorder (ADHD) seen in primary care in 8 large pediatric health systems, many children were prescribed medications at or shortly after the first documented diagnosis. Analysis of clinical documentation is needed to understand early prescription patterns.

Corresponding Author: To contact the corresponding author, Yair Bannett, MD, MS, email ybannett@stanford.edu.

 

(doi:10.1001/jamanetworkopen.2025.29610)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Food Insecurity Prevalence Among US Medical Students

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, AUGUST 29, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this survey study, more than 1 in 5 U.S. medical students reported food insecurity, nearly double the level of U.S. households. These findings call for institutional and policy interventions to address medical students’ basic needs, ensuring the success of future physicians.

Corresponding Authors: To contact the corresponding authors, email Bassel M. Shanab, BA,  (bassel.shanab@yale.edu) and Pavan Khosla, BA, (pavan.khosla@yale.edu).

 

(doi:10.1001/jamanetworkopen.2025.29926)

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Coverage and Prior Authorization Policies for Semaglutide and Tirzepatide in Medicare Part D Plans

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, AUGUST 29, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This analysis found a substantial expansion in coverage for injectable semaglutide, injectable tirzepatide, and oral semaglutide from 2020 to 2024, accompanied by a sharp rise in prior authorization requirements, from below 15% in 2023 Q3 to over 80% in 2024 Q3. Although coverage for these glucagon-like peptide-1 (GLP-1) receptor agonists remained consistently higher among Medicare Advantage Part Ds than standalone prescription drug plans, both plan types rapidly adopted prior authorization requirements beginning in late 2023.

Corresponding Author: To contact the corresponding author, Changchuan Jiang, MD, MPH, email changchuan.jiang@utsouthwestern.edu.

 

(doi:10.1001/jamanetworkopen.2025.29842)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Contributing Factors to the Nonpublication of Head and Neck Cancer Clinical Trials

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Health Care Setting and Minimally Adequate Depression Treatment Among Publicly Insured Children

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Adverse Childhood Experiences and Health at Age 50 Years in the National Child Development Study

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Perspectives on Health-Related Social Needs Screening in Primary Care Among Black and Latine Patients

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Glucagon-Like Peptide-1 Receptor Agonists and Risk of Uveitis

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, AUGUST 28, 2025

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2025.2822?guestAccessKey=6c01b25d-c594-444b-bc35-c0c92f4791b3&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=082825

 

About The Study: This cohort study found that glucagon-like peptide-1 receptor agonist (GLP-1RA) prescriptions were associated with a lower risk of uveitis compared with controls. These findings suggest potential anti-inflammatory benefits beyond glycemic control, warranting further investigation into their role in ocular inflammatory diseases.

Corresponding Author: To contact the corresponding author, Sumit Sharma, MD, email sumitsharma.md@gmail.com.

 

(doi:10.1001/jamaophthalmol.2025.2822)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Debt, Bankruptcy, and Credit Scores After Cancer Diagnosis

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, AUGUST 28, 2025

Media advisory: The full study is linked to this news release.

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About The Study: In this retrospective cohort study, modest amounts of medical debt in collections persisted for years after cancer diagnosis. Total debt in collections was present at higher amounts for certain cancer subpopulations. The persistence of adverse financial outcomes after cancer diagnosis, despite high rates of insurance coverage in Massachusetts, warrants further research and consideration of broader systemic reforms.

Corresponding Author: To contact the corresponding author, Benjamin C. James, MD, MS, email bjames1@bidmc.harvard.edu.

 

(doi:10.1001/jamaoncol.2025.3302)

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First-Line β-Blocker Use for Hypertension in the Veterans Health Administration

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Loss of Independence and Mortality in Geriatric Emergency General Surgery by Procedural Risk Level

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Use of Glucagon-Like Peptide-1 Agonists Among Individuals Undergoing Bariatric Surgery in the US

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, AUGUST 27, 2025

Media advisory: The full study and commentary are linked to this news release.

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About The Study: In this retrospective cohort study using a nationwide database, among a cohort of U.S. adults undergoing bariatric surgery, approximately 1 in 10 initiated a glucagon-like peptide-1 receptor agonist. Initiation was greater among women, those undergoing sleeve gastrectomy, and individuals with larger body mass index regain than among their counterparts. 

Corresponding Author: To contact the corresponding author, Hemalkumar B. Mehta, MS, PhD, email hbmehta@jhu.edu.

 

(doi:10.1001/jamasurg.2025.3089)

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Global Inequities in Diabetes Technology and Insulin Access and Glycemic Outcomes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, AUGUST 27, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study found that HbA1c levels were associated with the accessibility of modern diabetes technologies and insulin. Efforts to ensure universal accessibility are required to reduce global inequities and glycemic outcomes for children with type 1 diabetes.

Corresponding Author: To contact the corresponding author, Zdenek Sumnik, MD, PhD, email zdenek.sumnik@lfmotol.cuni.cz.

 

(doi:10.1001/jamanetworkopen.2025.28933)

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Body Composition, Fitness, and Mental Health in Preadolescent Children

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, AUGUST 26, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this cross-sectional study of preadolescent children, greater lean mass and higher fitness were associated with fewer anxiety and depression symptoms, while higher visceral adipose tissue was associated with increased symptoms of both. Body fat percentage was only associated with greater anxiety. These findings highlight the roles of body composition in mental health and underscore the value of early identification of physical health markers to support children’s well-being and development.

Corresponding author: To contact the corresponding author, Lauren B. Raine, M.P.H., Ph.D., email l.raine@northeastern.edu.

 

(doi: 10.1001/jamanetworkopen.2025.28868)

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Medical School Admissions After the Supreme Court’s 2023 Affirmative Action Ruling

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, AUGUST 26, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this study, underrepresented in medicine (URiM) student matriculation into U.S. medical schools declined after the 2023 Supreme Court of the United States (SCOTUS) ruling, with an emergent disparity in acceptance rates of URiM applicants relative to Asian and white students. The decline in URiM student matriculation was concentrated in states without a preexisting state-level affirmative action ban, suggesting that there may be an association between the SCOTUS ruling and demographic changes in matriculation.

Corresponding author: To contact the corresponding author, Mytien Nguyen, M.S., email mytien.nguyen@yale.edu.

 

(doi: 10.1001/jamanetworkopen.2025.27008)

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Partial Heart Transplant for Congenital Heart Disease

JAMA

EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, AUGUST 27, 2025

Media advisory: The full study and editorial are linked to this news release.

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About The Study: In this case series, 19 patients underwent partial heart transplant, which appears to be a safe and feasible procedure that enables valve growth, representing a promising solution to overcome the limitations of current nongrowing valve replacement options. Careful follow-up and monitoring are crucial to support the continued expansion of this novel technique.

Corresponding Author: To contact the corresponding author, Joseph W. Turek, MD, PhD, MBA, email joseph.turek@duke.edu,

 

(doi:10.1001/jama.2025.13580)

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Trends in Industry Marketing of Stimulants to Physicians and Advanced Practice Clinicians

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Posttraumatic Growth in ICU Health Care Professionals After COVID-19

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Testing Bidirectional Associations Between Maternal and Child Depression During Emerging Adolescence

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 25, 2025

Media advisory: The full study is linked to this news release.

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About The Study: Contrary to prevailing assumptions, the findings of this study suggest that children’s depression over time may have contributed to worsening maternal depression, rather than the other way around. While these results should be replicated in non-pandemic contexts to confirm their generalizability, they highlight the need for family-centered approaches to mental health care. 

Corresponding Author: To contact the corresponding author, Sheri Madigan, PhD, email sheri.madigan@ucalgary.ca.

 

(doi:10.1001/jamapediatrics.2025.2822)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Proportion of Obesity-Related Conditions Attributable to Obesity and Overweight in US Youth

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 25, 2025

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About The Study: Large portions of obesity-related conditions in U.S. adolescents and young adults may be attributable to obesity and, to a lesser extent, overweight. Obesity-related conditions during youth increase the risk of more severe disease in the future, and treating and preventing obesity may reduce obesity-related conditions and associated costs. 

Corresponding Author: To contact the corresponding author, Ashwin K. Chetty, BS, email ashwin.chetty@yale.edu.

 

(doi:10.1001/jamapediatrics.2025.2716)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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A Fall Prevention Program Integrated in Primary Health Care for Older People in Rural China

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Clinician Perspectives on AI-Generated Drafts of Patient Test Result Explanations

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Estimating Costs of Market Exclusivity Extensions For 4 Top-Selling Prescription Drugs in the US

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Cardiovascular Health at the Intersection of Race and Gender in Medicare Fee for Service

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, AUGUST 22, 2025

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: This cross-sectional study found that Asian and Pacific Islander, Black, and Hispanic transgender and gender diverse beneficiaries had a high prevalence of cardiovascular-related conditions and had an elevated prevalence of several conditions, attributable to the intersection of gender, race, and ethnicity. Medicare should use the tools at its disposal to support the health of transgender and gender diverse beneficiaries.

Corresponding Author: To contact the corresponding author, Gray Babbs, MPH, email gray_babbs@brown.edu.

 

(doi:10.1001/jamahealthforum.2025.3014)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Depression and Anxiety Symptoms in Adults Displaced by Natural Disasters

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, AUGUST 22, 2025

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This study found that, in U.S. adults, disaster-induced displacement from home was associated with increased odds of depression and anxiety symptoms, with the highest odds among those who never returned home. There is an urgent need to address mental health care for populations displaced by natural disasters, particularly socially vulnerable populations.

Corresponding Author: To contact the corresponding author, Ther W. Aung, PhD, email twa21@case.edu.

 

(doi:10.1001/jamanetworkopen.2025.28546)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Ambient Documentation Technology in Clinician Experience of Documentation Burden and Burnout

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GLP-1 Receptor Agonists and Cancer Risk in Adults With Obesity

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, AUGUST 21, 2025

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About The Study: This retrospective cohort study found that taking glucagon-like peptide-1 receptor agonists (GLP-1RAs) was associated with a reduced overall risk of cancer, including lower risks of endometrial, ovarian, and meningioma cancers, among patients with obesity or overweight. However, taking GLP-1RAs may be associated with an increased risk of kidney cancer, highlighting the need for longer-term follow-up to clarify the underlying mechanisms and clinical implications of these findings.

Corresponding Author: To contact the corresponding author, Jiang Bian, PhD, email bianji@iu.edu.

 

(doi:10.1001/jamaoncol.2025.2681)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Impact of a Weight Loss Intervention on 1-Year Weight Change in Women With Stage II/III Breast Cancer

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, AUGUST 21, 2025

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About The Study: In this secondary analysis of a randomized clinical trial, a telephone-based weight loss intervention induced significant weight loss in patients with breast cancer with overweight and obesity across demographic and treatment factors. Further follow-up of the Breast Cancer Weight Loss trial will evaluate whether the weight loss intervention improves disease outcomes.

Corresponding Author: To contact the corresponding author, Jennifer A. Ligibel, MD, email jennifer_ligibel@dfci.harvard.edu.

 

(doi:10.1001/jamaoncol.2025.2738)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Toripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma

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Statin Eligibility According to Atherosclerotic Cardiovascular Disease Risk in the US

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Psychiatric and Substance Use Disorders After Nonfatal Firearm Injury

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Family Socioeconomic Position and Eating Disorder Symptoms Across Adolescence

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, AUGUST 20, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cohort study using Avon Longitudinal Study of Parents and Children data found that eating disorder symptoms were more common in individuals experiencing socioeconomic deprivation. Potential socioeconomic inequalities in eating disorder presentation and diagnosis in clinical settings require further investigation. Reducing population-level socioeconomic inequalities could also aid eating disorder prevention.

Corresponding Author: To contact the corresponding author, Jane S. Hahn, MSc, email Sungmin.hahn.19@ucl.ac.uk.

 

(doi:10.1001/jamanetworkopen.2025.27934)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Drought, Extreme Heat, and Intimate Partner Violence in Low- and Middle-Income Countries

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, AUGUST 20, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study of 42 low- and middle-income countries, drought conditions with various durations were associated with increased intimate partner violence risk. Given the increasing extreme events under climate change, there is a pressing need for enhanced initiatives to prevent domestic violence.

Corresponding Author: To contact the corresponding author, Pin Wang, PhD, email pinwang@umd.edu.

 

(doi:10.1001/jamanetworkopen.2025.27818)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Neurologic Medication Costs in a Direct-to-Consumer Pharmacy vs Commercial Insurance Plans

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Factors Associated With Willingness to Become a Living Organ Donor

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Healthy Food Benefit Programs, Fruit and Vegetable Consumption, and Food Security

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Threats of Weather Disasters for Drug Manufacturing Facilities in the US

JAMA

EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, AUGUST 20, 2025

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About The Study: In this nationwide assessment of the frequency with which climate-related disaster events affected counties with U.S. drug production facilities, researchers determined that nearly two-thirds of all facilities were located in counties that experienced at least one disaster declaration. These disaster events posed risks of disruptions to facilities active in all aspects of the supply chain, from active pharmaceutical ingredient manufacture to packaging, disruptions that could be further magnified by the time needed for Food and Drug Administration reinspection of damaged facilities.

Corresponding Author: To contact the corresponding author, Mahnum Shahzad, PhD, email mahnum_shahzad@g.harvard.edu.

 

(doi:10.1001/jama.2025.13843)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Differential Use of Depression and Anxiety Medications in Adults With a History of Cancer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 19, 2025

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study, cancer survivors were significantly more likely to take medications for depression and anxiety compared with noncancer survivors, underscoring the importance of mental health in cancer. However, the findings suggested disparities associated with this, with non-Hispanic Black patients exhibiting decreased use.

Corresponding Author: To contact the corresponding author, Nosayaba Osazuwa-Peters, BDS, PhD, MPH, CHES, email nosa.peters@duke.edu.

 

(doi:10.1001/jamanetworkopen.2025.27585)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Changes in Medicare Part D Plan Designs After the Inflation Reduction Act

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Stapokibart for Severe Uncontrolled Chronic Rhinosinusitis With Nasal Polyps

JAMA

EMBARGOED FOR RELEASE: 11:00 A.M. ET, MONDAY, AUGUST 18, 2025

Media advisory: The full study and editorial are linked to this news release.

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About The Study: Among patients with severe chronic rhinosinusitis with nasal polyps treated with a daily intranasal corticosteroid, stapokibart, a novel monoclonal antibody, reduced polyp size and severity of nasal symptoms at 24 weeks.

Corresponding Authors: To contact the corresponding authors, email Luo Zhang, MD, (dr.luozhang@139.com) and Chengshuo Wang, MD, (wangcs830@126.com).

 

(doi:10.1001/jama.2025.12515)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Prices and Affordability of Essential Medicines in 72 Low-, Middle-, and High-Income Markets

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, AUGUST 15, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: The results of this cross-sectional analysis showed significant variation in the prices and affordability of 549 essential medicines across 72 markets in 2022. Strategies to promote equitable drug prices and improve drug affordability are urgently needed.

Corresponding Author: To contact the corresponding author, Olivier J. Wouters, PhD, email olivier_wouters@brown.edu.

 

(doi:10.1001/jamahealthforum.2025.2043)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Reducing Barriers to Mental Health Care for Physicians – An Overview and Strategic Recommendations

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Over-the-Counter Oral Contraceptive Use and Initiation of Contraception

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, AUGUST 18, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this cross-sectional study of U.S. individuals obtaining oral contraception, the oral contraceptive pill was accessed over-the-counter (OTC) by many who previously used no method or less-effective contraception. These findings suggest that OTC access may improve equitable access to contraception.

Corresponding Author: To contact the corresponding author, Maria I. Rodriguez, M.D., M.P.H., email rodrigma@ohsu.edu.

 

(doi: 10.1001/jamanetworkopen.2025.27438)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Self-Reported Hearing Aid Use and Risk of Incident Dementia

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 18, 2025

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Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time. https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2025.2713?guestAccessKey=a1f9c4ab-a0ae-4ca9-afa5-cb8c5e77afc3&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=081825 

 

About The Study: Study participants with hearing loss with hearing aids showed reduced risk for dementia among those younger than age 70 at the time of hearing evaluation, when followed up for up to 20 years. This finding highlights the importance of early intervention for hearing loss for possible prevention of dementia.

Corresponding Author: To contact the corresponding author, Sudha Seshadri, M.D., email seshadri@uthscsa.edu.

 

(doi: 10.1001/jamaneurol.2025.2713)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

State-Level Public Awareness of HPV, HPV Vaccine, and Association With Cancer

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, AUGUST 14, 2025

Media advisory: The full study is linked to this news release.

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About The Study: In this cross-sectional study, public awareness about human papillomavirus (HPV), HPV vaccination, and the link between HPV and cancers was overwhelmingly low, particularly in Midwestern and Southern U.S. states. These findings are troubling because these regions have recently seen a marked rise in HPV-associated cancers. Notably, the lack of HPV and HPV vaccine awareness in the Midwest and South is alarming, as a majority of states in these regions have suboptimal HPV vaccination rates.

Corresponding Author: To contact the corresponding author, Kalyani Sonawane, PhD, email sonawane@musc.edu.

 

(doi:10.1001/jamaoncol.2025.2638)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Ocular Adverse Events With Semaglutide

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, AUGUST 14, 2025

Media advisory: The full study and commentary are linked to this news release.

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About The Study: The findings of this study suggest that semaglutide was not associated with an increased risk of eye disorders or diabetic retinopathy. Despite the fact that an association between semaglutide treatment and nonarteritic anterior ischemic optic neuropathy (NAION) was found, current evidence remains insufficient to establish definitive conclusions regarding its association with NAION. Further studies with larger sample sizes and adequate evaluation of NAION are warranted to clarify this potential risk. 

Corresponding Author: To contact the corresponding author, Fernando Gerchman, MD, PhD, email fgerchman@hcpa.edu.br.

 

(doi:10.1001/jamaophthalmol.2025.2489)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Glucagon-Like Peptide-1 Receptor Agonists in Hidradenitis Suppurativa

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Fatalism and Interest in Cancer Screening Among African American Individuals

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Gauging the Magnitude of Missed Opportunity for Ovarian Cancer Prevention

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, AUGUST 13, 2025

Media advisory: The full study and commentary are linked to this news release.

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About The Study: In this study, a considerable proportion of patients with high-grade serous cancer missed opportunities for risk assessment with genetic testing and for surgical prevention. Given the lack of effective screening and limited treatment options for high-grade serous cancer, eradicating it requires addressing the full spectrum of missed opportunities. 

Corresponding Author: To contact the corresponding author, Rebecca L. Stone, MD, email rstone15@jhmi.edu.

 

(doi:10.1001/jamasurg.2025.2810)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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County-Level Cervical Cancer Screening Coverage and Differences in Incidence and Mortality

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, AUGUST 13, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This study found a nearly two-fold higher cervical cancer incidence, late-stage diagnosis, and mortality in counties with repeatedly low vs high cervical cancer screening coverage. Most counties with repeat low coverage were rural and lower income.

Corresponding Author: To contact the corresponding author, Trisha L. Amboree, PhD, MPH, email amboree@musc.edu.

 

(doi:10.1001/jamanetworkopen.2025.26709)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Minimal vs Specialized Exercise Equipment for Pulmonary Rehabilitation

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Work Impairment and Financial Outcomes Among Adults With vs Without Long COVID

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 12, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this prospective cohort study of adults with SARS-CoV-2 infection, participants with current self-reported long COVID (defined as developing new, persistent symptoms lasting 3 months or longer after SARS-CoV-2 infection) reported worse work impairment, missed work, and financial distress compared with those who never had long COVID, while vaccination was associated with improved work outcomes and less financial distress even among individuals with long COVID. These data underscore the need for post-pandemic assistance programs, as well as vaccination to decrease societal harms.

Corresponding Author: To contact the corresponding author, Michael Gottlieb, MD, email MichaelGottliebMD@Gmail.com.

 

(doi:10.1001/jamanetworkopen.2025.26310)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Hospital Financial Health and Provision of Obstetric and Neonatal Intensive Care Unit Services

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 12, 2025

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.26418?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=081225

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study, worse hospital financial health was associated with decreased likelihood of providing perinatal services. These hospitals were more frequently located in southern and rural areas.

Corresponding Author: To contact the corresponding author, Elizabeth G. Salazar, MD, MSHP, email salazare@chop.edu.

 

(doi:10.1001/jamanetworkopen.2025.26418)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Multidimensional Assessment of Gender Diversity in a Large National Sample of US Early Adolescents

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Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2025.3832?guestAccessKey=bcce4a8c-35c1-4ae1-b815-2d264500eb91&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=081125

Sex Differences in Mortality and Health Care Utilization After Dementia Diagnosis

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Trends and Disparities in Technology Use and Glycemic Control in Type 1 Diabetes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, AUGUST 11, 2025

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.26353?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=081125

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study, there was a rapid increase in the use of diabetes technology and notable improvements in glycemic control among youths and adults with type 1 diabetes during the past 15 years. Nonetheless, the prevalence of glycemic control remained low, and racial, ethnic, and socioeconomic differences grew over time.

Corresponding Author: To contact the corresponding author, Jung-Im Shin, MD, PhD, email jshin19@jh.edu.

 

(doi:10.1001/jamanetworkopen.2025.26353)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, AUGUST 11, 2025

Media advisory: The full study and editorial are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of patients with type 2 diabetes who had no prior eye disorders, patients prescribed semaglutide or tirzepatide had an increased risk of nonarteritic anterior ischemic optic neuropathy and other optic nerve disorders, although the overall risk was low. These findings highlight the need for close monitoring of these conditions.

Corresponding Author: To contact the corresponding author, Rong Xu, PhD, email rxx@case.edu.

 

(doi:10.1001/jamanetworkopen.2025.26327)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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GLP-1 Receptor Agonists and Sight-Threatening Ophthalmic Complications in Patients With Type 2 Diabetes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, AUGUST 11, 2025

Media advisory: The full study and editorial are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.26321?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=081125

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of individuals with type 2 diabetes (T2D), glucagon-like peptide-1 receptor agonist (GLP-1 RA) use was associated with a modestly increased risk of incident diabetic retinopathy (DR); however, fewer patients experienced sight-threatening DR complications, including blindness, even among those with preexisting DR. These findings suggest that all patients with T2D treated with GLP-1 RAs, regardless of preexisting DR, should be regularly screened and monitored for potential complications of T2D.

Corresponding Author: To contact the corresponding author, Sarju Ganatra, MD, email sarju.ganatra@lahey.org.

 

(doi:10.1001/jamanetworkopen.2025.26321)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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