Fracture Risk Among Living Kidney Donors 25 Years After Donation

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JANUARY 24, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This survey study found a reduced rate of overall fractures but an excess of vertebral fractures among living kidney donors compared with controls after a mean follow-up of 25 years. Treatment of excess vertebral fractures with dietary supplements such as vitamin D3 may reduce the numbers of vertebral fractures and patient morbidity.

Authors: Rajiv Kumar, M.B.B.S., of the Mayo Clinic in Rochester, Minnesota, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.53005)

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Rape-Related Pregnancies in the 14 States With Total Abortion Bans

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Maternal Autistic Traits and Adverse Birth Outcomes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 23, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of 87,000 women, higher level of maternal autistic traits was associated with increased risk of adverse birth outcomes, particularly very preterm birth. Acknowledging the risks and providing tailored and timely antenatal care support to women with a high level of autistic traits in the general population, particularly women with autistic traits within the clinical range, regardless of formal diagnosis, is warranted.

Authors: Mariko Hosozawa, M.D., Ph.D., of the National Center for Global Health and Medicine in Tokyo, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.52809)

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Patient Self-Assessment of Walking Ability and Fracture Risk in Older Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 23, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Self-reported walking limitations were associated with increased risk of fracture in this study of 238,000 participants age 45 and older. These findings suggest that walking ability should be sought by clinicians to identify high-risk candidates for further assessment.

Authors: Dana Bliuc, Ph.D., of the Garvan Institute of Medical Research in Sydney, New South Wales, Australia, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.52675)

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International Consensus Criteria for Pediatric Sepsis and Septic Shock

JAMA

EMBARGOED FOR RELEASE: 12:30 P.M. (ET), SUNDAY, JANUARY 21, 2024

Media advisory: The full study and editorials are linked to this news release. This study is being released to coincide with presentation at the Society of Critical Care Medicine’s Critical Care Congress.  

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About The Study: The Phoenix sepsis criteria for sepsis and septic shock in children were derived and validated by the international Society of Critical Care Medicine Pediatric Sepsis Definition Task Force using a large international database and survey, systematic review and meta-analysis, and modified Delphi consensus approach. A Phoenix Sepsis Score of at least 2 identified potentially life-threatening organ dysfunction in children younger than 18 years with infection, and its use has the potential to improve clinical care, epidemiological assessment, and research in pediatric sepsis and septic shock around the world. 

Authors: R. Scott Watson, M.D., M.P.H., of the University of Washington in Seattle, is the corresponding author.

 

(doi:10.1001/jama.2024.0179)

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Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock

JAMA

EMBARGOED FOR RELEASE: 12:30 P.M. (ET), SUNDAY, JANUARY 21, 2024

Media advisory: The full study and editorials are linked to this news release. This study is being released to coincide with presentation at the Society of Critical Care Medicine’s Critical Care Congress.  

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About The Study: In this international, multicenter, retrospective cohort study including more than 3.6 million pediatric encounters, a novel score, the Phoenix Sepsis Score, was derived and validated to predict mortality in children with suspected or confirmed infection. The new criteria for pediatric sepsis and septic shock based on the score performed better than existing organ dysfunction scores and the International Pediatric Sepsis Consensus Conference criteria. 

Authors: Tellen D. Bennett, M.D., M.S., of the University of Colorado School of Medicine and Children’s Hospital Colorado in Aurora, is the corresponding author.

 

(doi:10.1001/jama.2024.0196)

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First Trimester Use of Buprenorphine or Methadone and the Risk of Congenital Malformations

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Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology

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Evaluation of a Large Language Model to Identify Confidential Content in Adolescent Encounter Notes

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Improvement of Social Isolation and Loneliness and Excess Mortality Risk in People With Obesity

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JANUARY 22, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study of 398,000 UK Biobank participants support the improvement of social isolation and loneliness in people with obesity to decrease obesity-related excess risk of mortality.

Authors: Lu Qi, M.D., Ph.D., of the Tulane University School of Public Health and Tropical Medicine in New Orleans, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.52824)

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Anxiety and Depression Symptoms After the Dobbs Abortion Decision

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 23, 2024

Media advisory: The full study and editorial are linked to this news release.

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About The Study: In this analysis of survey data from 718,000 participants from December 2021 to January 2023, residence in states with abortion trigger laws (anticipatory bans that would go into effect should Roe v Wade be overturned) compared with residence in states without such laws was associated with a small but significantly greater increase in anxiety and depression symptoms after the Dobbs v Jackson decision in June 2022. 

Authors: Benjamin Thornburg, B.S., of Johns Hopkins University in Baltimore, is the corresponding author.

 

(doi:10.1001/jama.2023.25599)

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Cancer Diagnoses After Recent Weight Loss

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 23, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Health professionals with weight loss within the prior two years had a significantly higher risk of cancer during the subsequent 12 months compared with those without recent weight loss in this study that included 157,000 participants. Cancer of the upper gastrointestinal tract was particularly common among participants with recent weight loss compared with those without recent weight loss. 

Authors: Brian M. Wolpin, M.D., M.P.H., of the Dana-Farber Cancer Institute and Harvard Medical School in Boston, is the corresponding author.

 

(doi:10.1001/jama.2023.25869)

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In Utero Exposure to Maternal COVID-19 Vaccination and Offspring Neurodevelopment at 12 and 18 Months

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JANUARY 22, 2024

Media advisory: The full study is linked to this news release.

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About The Study: The results of this study including 2,261 and 1,940 infants ages 12 and 18 months, respectively, suggest that COVID-19 vaccination was safe during pregnancy from the perspective of infant neurodevelopment to 18 months of age. Additional longer-term research should be conducted to corroborate these findings and buttress clinical guidance with a strong evidence base. 

Authors: Eleni G. Jaswa, M.D., M.Sc., of the University of California, San Francisco, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2023.5743)

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USPSTF Statement on Screening for Speech and Language Delay and Disorders in Children

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 23, 2024

Media advisory: To contact the U.S. Preventive Services Task Force, email the Media Coordinator at Newsroom@USPSTF.net or call 301-951-9203. The full report and related articles are linked to this news release.

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Bottom Line: The U.S. Preventive Services Task Force (USPSTF) concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for speech and language delay and disorders in children 5 years or younger without signs or symptoms. Speech and language delays and disorders can pose significant problems for children and their families. Evidence suggests that school-aged children with speech or language delays may be at increased risk of learning and literacy disabilities, including difficulties with reading and writing. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this updated recommendation is consistent with its 2015 recommendation on screening for speech and language delay and disorders in children 5 years or younger.

 

(doi:10.1001/jama.2023.26952)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Note: More information about the U.S. Preventive Services Task Force, its process, and its recommendations can be found on the newsroom page of its website.

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Recreational and Medical Cannabis Legalization and Opioid Prescriptions and Mortality

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Survey Protocols, Response Rates, and Representation of Underserved Patients

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Opioid Prescribing Patterns After Imposition of Setting-Specific Limits on Prescription Duration

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Timing of Maternal COVID-19 Vaccine and Antibody Concentrations in Infants Born Preterm

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JANUARY 19, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this prospective cohort study of 220 pregnant individuals with preterm and full-term deliveries, receipt of three or more compared with two doses of COVID-19 vaccine before delivery resulted in 10-fold higher cord anti-Spike antibody levels. Maternal antibody concentration appeared more important than delivery gestational age in determining cord anti-Spike antibody levels. The number of doses and timing considerations for COVID-19 vaccine in pregnancy should include individuals at risk for preterm delivery.

Authors: Alisa Kachikis, M.D., M.S., of the University of Washington in Seattle, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.52387)

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Occupational Sitting Time, Leisure Physical Activity, and All-Cause and Cardiovascular Disease Mortality

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JANUARY 19, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study involving 481,000 individuals over a mean follow-up period of nearly 13 years, individuals who predominantly engaged in sitting at work exhibited a higher risk of mortality from all causes and cardiovascular disease compared with those who predominantly did not sit. Individuals who predominantly sit at work would need to engage in an additional 15 to 30 minutes of physical activity per day to mitigate this increased risk and reach the same level of risk as individuals who predominantly do not sit at work.

Authors: Chi-Pang Wen, M.D., Ph.D., of the National Health Research Institutes in Miaoli County, Taiwan, and Min-Kuang Tsai, Ph.D., of Taipei Medical University in New Taipei City, Taiwan, are the corresponding authors. 

 

(doi:10.1001/jamanetworkopen.2023.50680)

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Out-of-Pocket Costs and Outpatient Visits Among Patients With Cancer in High-Deductible Health Plans

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Physical Function Trajectories and Mortality in Older Adults With Multisensory Impairment

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Neurostimulation for Advanced Parkinson Disease and Quality of Life at 5 Years

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JANUARY 18, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This nonrandomized controlled trial of 108 patients with advanced Parkinson disease found that at 5-year follow-up quality of life remained stable in the deep brain stimulation of the subthalamic nucleus (STN-DBS) group and worsened in the standard-of-care medication group, mainly driven by the favorable effect of STN-DBS on mobility. These findings may provide helpful information when counseling patients on the efficacy of STN-DBS for Parkinson disease and monitoring patients postoperatively in long-term follow-up.

Authors: Stefanie T. Jost, Ph.D., and Haidar S. Dafsari, M.D., of the University of Cologne, Germany, are the corresponding authors. 

 

(doi:10.1001/jamanetworkopen.2023.52177)

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Cannabis and Driving in Older Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JANUARY 18, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study that included 31 participants ages 65 to 79 suggest that older drivers, even if they regularly use cannabis, show evidence of impaired driving performance after smoking cannabis. Weaving was increased and speed was decreased at 30 minutes after smoking, which was not correlated with blood tetrahydrocannabinol (THC) concentrations; subjective experience and self-reports of impaired driving persisted for three hours.

Authors: Patricia Di Ciano, Ph.D., of the Centre for Addiction and Mental Health in Toronto, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.52233)

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Components and Delivery Formats of Cognitive Behavioral Therapy for Chronic Insomnia in Adults

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Incidence Trajectories of Psychiatric Disorders After Assault, Injury, and Bereavement

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Comparative Effectiveness of Psychotherapy vs Antidepressants for Depression in Heart Failure

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JANUARY 17, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this comparative effectiveness trial of behavioral activation psychotherapy (BA) and antidepressant medication management (MEDS) in 416 patients with heart failure experiencing depression, both treatments significantly reduced depressive symptoms by nearly 50% with no statistically significant differences between treatments. BA recipients experienced better physical health-related quality of life, fewer emergency department visits, and fewer days hospitalized. The study findings suggest that patients with heart failure could be given the choice between BA or MEDS to ameliorate depression.

Authors: Waguih William IsHak, M.D., of Cedars-Sinai Medical Center in Los Angeles, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.52094)

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Prenatal Opioid Exposure and Immune-Related Conditions in Children

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JANUARY 17, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Prenatal opioid exposure was associated with an increased risk of infection, eczema and dermatitis, and asthma, but not allergies and anaphylaxis or autoimmune conditions in this study of 401,000 neonates. These findings highlight the importance of further study of opioid-induced immune changes during pregnancy, the potential impact on long-term health in exposed children, and the mechanisms of opioid-induced immune dysregulation. 

Authors: Erin Kelty, Ph.D., of the University of Western Australia in Crawley, Western Australia, Australia, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.51933)

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Long-Term Microvascular Changes in Multisystem Inflammatory Syndrome in Children

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Experiences of Interpersonal Violence in Sport and Perceived Coaching Style Among College Athletes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 16, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this survey study involving 4,119 currently competing U.S. college athletes suggest that interpersonal violence is associated with marked changes in the psychosocial health and emotional well-being of college athletes, particularly those who identify as female and with non-heterosexual sexual orientations. Variations in coaching style have the potential to alter these associations. Ongoing efforts are needed to leverage the unique position that coaches hold to help reduce interpersonal violence and create safe places where all college athletes can thrive. 

Authors: Yetsa A. Tuakli-Wosornu, M.D., M.P.H., of the Yale School of Public Health in New Haven, Connecticut, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.50248)

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Employer-Sponsored Health Insurance Premium Cost Growth and Its Association With Earnings Inequality Among Families

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 16, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study of U.S. families receiving employer-sponsored health insurance suggest that three decades of increasing health care premiums were likely associated with reduced annual earnings and increased earnings inequality by race and ethnicity and wage level and were meaningfully associated with wage stagnation. 

Authors: Kurt Hager, Ph.D., M.S., of the UMass Chan Medical School in Worcester, Massachusetts, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.51644)

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Consumption of 100% Fruit Juice and Body Weight in Children and Adults

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 16, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This systematic review and meta-analysis of 42 eligible studies, including 17 among children (n = 45,851) and 25 among adults (n = 268,095), found a positive association between intake of 100% fruit juice and weight gain in children. Analysis of cohort studies in adults found a significant positive association among studies unadjusted for total energy, suggesting potential mediation by calories; an analysis of trials in adults found no significant association between 100% fruit juice consumption and body weight. The findings support guidance to limit consumption of fruit juice to prevent the intake of excess calories and weight gain.

Authors: Vasanti S. Malik, M.Sc., Sc.D., of the University of Toronto, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2023.6124)

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Analysis of Breast Cancer Mortality in the US

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 16, 2024

Media advisory: The full study and editorial are linked to this news release.

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About The Study: Based on four simulation models, breast cancer screening, treatment of stage I to III breast cancer, and treatment of metastatic breast cancer were each associated with reduced breast cancer mortality between 1975 and 2019 in the U.S. 

Authors: Sylvia K. Plevritis, Ph.D., of the Stanford University School of Medicine in Stanford, California, is the corresponding author.

 

(doi:10.1001/jama.2023.25881)

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Medicaid Expansion Under the Affordable Care Act and Early Mortality Following Lung Cancer Surgery

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JANUARY 12, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of nearly 15,000 adults with non–small cell lung cancer, Medicaid expansion was associated with declines in 30- and 90-day postoperative mortality following hospital discharge. These findings suggest that Medicaid expansion may be an effective strategy for improving access to care and cancer outcomes in this population. 

Authors: Leticia M. Nogueira, Ph.D., M.P.H., of the American Cancer Society in Atlanta, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.51529)

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Trends in Cancer Mortality Disparities Between Black and White Individuals in the US

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JANUARY 12, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: Although U.S. age-adjusted cancer mortality rates declined significantly between 2000 and 2020, substantial racial and ethnic disparities persisted for many common and preventable cancers, including female breast and male colorectal cancer. Cancer disparities arise from a confluence of factors, including structural racism, medical mistrust, health care access inequities, poor socioenvironmental conditions, aggressive tumor biology, and genetic ancestry.

Authors: Tomi Akinyemiju, Ph.D., M.S., of the Duke University School of Medicine in Durham, North Carolina, is the corresponding author.

 

(doi:10.1001/jamahealthforum.2023.4617)

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Head and Neck Cancer Incidence Before and During the Pandemic

JAMA Otolaryngology–Head & Neck Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JANUARY 11, 2024

Media advisory: The full study is linked to this news release.

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About The Study: In this study of patients diagnosed with head and neck cancer from 2017 to 2020 in the U.S., the incidence of localized head and neck cancer declined during the first year of the pandemic. A subsequent increase in advanced-stage diagnoses may be observed in later years. 

Authors: Nosayaba (Nosa) Osazuwa-Peters, B.D.S., Ph.D., M.P.H., C.H.E.S., of the Duke University School of Medicine in Durham, North Carolina, is the corresponding author. 

 

(doi:10.1001/jamaoto.2023.4322)

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Substance Use Disorders Among Adult Cancer Survivors

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JANUARY 11, 2024

Media advisory: The full study is linked to this news release.

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About The Study: The findings of this study of 6,101 adult cancer survivors suggest that substance use disorder (SUD) prevalence is higher among survivors of certain types of cancer; this information could be used to identify cancer survivors who may benefit from integrated cancer and SUD care. Future efforts to understand and address the needs of adult cancer survivors with comorbid SUD should prioritize cancer populations in which SUD prevalence is high. 

Authors: Devon K. Check, Ph.D., of the Duke University School of Medicine in Durham, North Carolina, is the corresponding author. 

 

(doi:10.1001/jamaoncol.2023.5785)

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A Systematic Evaluation of Machine Learning–Based Biomarkers for Major Depressive Disorder

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Global Prevalence of Adolescent Use of Nonprescription Weight-Loss Products

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JANUARY 10, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This meta-analysis that included 90 studies with 604,000 participants found that use of weight-loss products occurs at high levels in adolescents, especially girls. These findings suggest that, given the ineffectiveness of these products for weight loss coupled with their harmful long-term health consequences, interventions are required to reduce use of weight-loss products in this group. 

Authors: Natasha Yvonne Hall, Pharm.B., M.H.E., of Deakin University in Melbourne, Australia, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.50940)

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Early Prediction of Autistic Spectrum Disorder Using Developmental Surveillance Data

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JANUARY 10, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of nearly 1.2 million children, prediction models achieved high performance in predicting the likelihood of autistic spectrum disorder, using information from routine developmental assessments. This tool may be seamlessly integrated in the clinical workflow to improve early identification of children who may benefit from timely interventions. 

Authors: Guy Amit, Ph.D., of the KI Research Institute in Kfar Malal, Israel, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.51052)

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Racial and Ethnic Disparities in Receipt of General Anesthesia for Cesarean Delivery

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 9, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Racial disparities in rates of general anesthesia continue to exist; however, the findings of this study including 35,000 patients who underwent cesarean delivery suggest that, for laboring patients who had labor epidural catheters in situ, no disparity by race or ethnicity existed. Future studies should address whether disparities in care that occur prior to neuraxial catheter placement are associated with higher rates of general anesthesia among patients from ethnic and racial minority groups. 

Authors: Caroline Leigh Thomas, M.D., of the University of Chicago Medical Center, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2023.50825)

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Perinatal Depression and Risk of Suicidal Behavior

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 9, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of 952,000 participants, women with perinatal depression were at an increased risk of suicidal behavior, particularly within the first year after diagnosis with persistent risk elevations throughout the 18 years of follow-up, highlighting the need for vigilant clinical monitoring of this vulnerable group. 

Authors: Hang Yu, M.Sc., and Donghao Lu, M.D., Ph.D., of the Karolinska Institutet in Stockholm, are the corresponding authors. 

 

(doi:10.1001/jamanetworkopen.2023.50897)

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Social Risk and Dialysis Facility Performance in the First Year of the ESRD Treatment Choices Model

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Early Tecovirimat Treatment for Mpox Disease Among People With HIV

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Primary Care Patients’ Perspectives on Health Care Screening for Firearms in a Diverse, Urban Area

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Long-Acting Reversible Contraception Initiation Among Adolescents After an American Academy of Pediatrics Policy Statement

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Diagnostic Errors in Hospitalized Adults Who Died Or Were Transferred to Intensive Care

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JANUARY 8, 2024

Media advisory: The full study, editor’s note and Viewpoint are linked to this news release.

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About The Study: Diagnostic errors in hospitalized adults who died or were transferred to the intensive care unit were common and associated with patient harm in this analysis of 2,428 patient records at 29 hospitals. Problems with choosing and interpreting tests and the processes involved with clinician assessment are high-priority areas for improvement efforts. 

Authors: Andrew D. Auerbach, M.D., M.P.H., of the University of California, San Francisco, is the corresponding author.

 

(doi:10.1001/jamainternmed.2023.7347)

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Early-Life Digital Media Experiences and Development of Atypical Sensory Processing

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JANUARY 8, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Early-life digital media exposure was associated with atypical sensory processing outcomes in multiple domains in this study that included 1,471 children. These findings suggest that digital media exposure might be a potential risk factor for the development of atypical sensory profiles. Further research is needed to understand the relationship between screen time and specific sensory-related developmental and behavioral outcomes, and whether minimizing early-life exposure can improve subsequent sensory-related outcomes. 

Authors: Karen F. Heffler, M.D., of the Drexel University College of Medicine in Philadelphia, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2023.5923)

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Sibling Death in Childhood and Early Adulthood and Risk of Early-Onset Cardiovascular Disease

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JANUARY 8, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.50814?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=010824

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study of more than 2 million individuals born in Denmark, sibling death in childhood and early adulthood was associated with increased risks of overall and most type-specific early-onset cardiovascular diseases, with the strength of associations varying by cause of death and age difference between sibling pairs. The findings highlight the need for extra attention and support to the bereaved siblings to reduce cardiovascular disease risk later in life. 

Authors: Guoyou Qin, Ph.D., and Yongfu Yu, Ph.D., of Fudan University in Shanghai, China, are the corresponding authors. 

 

(doi:10.1001/jamanetworkopen.2023.50814)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Trends in High-Acuity Cardiovascular Events During the Pandemic

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2023.4572?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=010524

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Maternal Diabetes and Overweight and Congenital Heart Defects in Offspring

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JANUARY 5, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.50579?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=010524

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This study of 620,000 children found that maternal type 1 diabetes was associated with increased risk for most types of congenital heart defects in offspring, while obesity and overweight were associated with increased risk for complex defects and outflow tract obstruction and decreased risk for ventricular septal defects. These different risk profiles of type 1 diabetes and overweight and obesity may suggest distinct underlying teratogenic mechanisms. 

Authors: Riitta Turunen, M.D., Ph.D., and Emmi Helle, M.D., Ph.D., of the University of Helsinki, are the corresponding authors. 

 

(doi:10.1001/jamanetworkopen.2023.50579)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Evaluation of Changes in Prices and Purchases Following Implementation of Sugar-Sweetened Beverage Taxes Across the US

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JANUARY 5, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2023.4737?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=010524

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: Sugar-sweetened beverage (SSB) taxes in Boulder, Colorado; Philadelphia, Oakland, San Francisco, and Seattle led to substantial, consistent declines in SSB purchases following price increases associated with those taxes. Scaling SSB taxes nationally could yield substantial public health benefits. 

Authors: Scott Kaplan, Ph.D., of the U.S. Naval Academy in Annapolis, Maryland, is the corresponding author.

 

(doi:10.1001/jamahealthforum.2023.4737)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

#  #  #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.