EMBARGOED FOR RELEASE: 9 A.M. (ET), SUNDAY, APRIL 7, 2024
Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the American College of Cardiology’s Annual Scientific Session.
About The Study: This randomized clinical trial demonstrates the potential clinical utility of plozasiran, an investigational APOC3-targeted small interfering–RNA drug, to reduce triglyceride level in patients with severe hypertriglyceridemia. Additional studies will be required to determine whether plozasiran favorably modulates the risk of severe hypertriglyceridemia-associated complications.
Authors: Daniel Gaudet, M.D., Ph.D., of the Université de Montréal, is the corresponding author.
(doi:10.1001/jamacardio.2024.0959)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
EMBARGOED FOR RELEASE: 9 A.M. (ET), SUNDAY, APRIL 7, 2024
Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the American College of Cardiology’s Annual Scientific Session.
About The Study: High-dose influenza vaccine elicited a more robust humoral response in patients with heart failure or prior myocardial infarction enrolled in the INVESTED randomized clinical trial, with no association between seroconversion status and the risk for cardiopulmonary hospitalizations or all-cause mortality. Vaccination to prevent influenza remains critical in high-risk populations.
Authors: Scott D. Solomon, M.D., of Brigham and Women’s Hospital and Harvard Medical School in Boston, and Orly Vardeny, Pharm.D., M.S., of the University of Minnesota in Minneapolis, are the corresponding authors.
(doi:10.1001/jamacardio.2024.0468)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About The Study: Acetaminophen use during pregnancy was not associated with children’s risk of autism, attention-deficit/hyperactivity disorder (ADHD), or intellectual disability in sibling control analysis. This suggests that associations observed in other models may have been attributable to familial confounding.
Authors: Brian K. Lee, Ph.D., of Drexel University in Philadelphia, is the corresponding author.
(doi:10.1001/jama.2024.3172)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
EMBARGOED FOR RELEASE: 5 P.M. (ET), SUNDAY, APRIL 7, 2024
Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the American College of Cardiology’s Annual Scientific Session.
About The Study: In this randomized clinical trial including 103 American Indian patients, a telephone-based strategy of remote initiation and titration for outpatients with heart failure with reduced ejection fraction led to improved rates of guideline-directed medical therapy at 30 days compared with usual care. This low-cost strategy could be expanded to other rural settings where access to care is limited.
Authors: Lauren A. Eberly, M.D., M.P.H., of the Indian Health Service in Gallup, New Mexico, is the corresponding author.
(doi:10.1001/jamainternmed.2024.1523)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
EMBARGOED FOR RELEASE: 6:30 P.M. (ET), SUNDAY, APRIL 7, 2024
Media advisory: The full study and editorial are linked to this news release. This study is being released to coincide with presentation at the American Association for Cancer Research Annual Meeting 2024.
About The Study: In this systematic review and meta-analysis that included 41 randomized clinical trials of cancer screening, incidence of late-stage cancer may be a suitable alternative end point to cancer-specific mortality for some cancer types, but is not suitable for others. These results have implications for clinical trials of multicancer screening tests.
Authors: Hilary A. Robbins, Ph.D., M.H.S., M.S.P.H., of the International Agency for Research on Cancer in Lyon, France, is the corresponding author.
(doi:10.1001/jama.2024.5814)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
EMBARGOED FOR RELEASE: 2 P.M. (ET), SUNDAY, APRIL 7, 2024
Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the American Association for Cancer Research Annual Meeting 2024.
About The Study: Most cancer drugs granted accelerated approval did not demonstrate benefit in overall survival or quality of life within five years of accelerated approval.
Patients should be clearly informed about the cancer drugs that use the accelerated approval pathway and do not end up showing benefits in patient-centered clinical outcomes.
Authors: Aaron S. Kesselheim, M.D., J.D., M.P.H., of Brigham and Women’s Hospital and Harvard Medical School in Boston, is the corresponding author.
(doi:10.1001/jama.2024.2396)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Supply chain issues associated with drug shortages increased at the beginning of the COVID-19 pandemic according to the results of this national cross-sectional study. Ongoing policy work is needed to protect U.S. drug supplies from future shocks and to prioritize clinically valuable drugs at greatest shortage risk.
Authors: Katie J. Suda, Pharm.D., M.S., of the University of Pittsburgh School of Medicine, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.4246)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
EMBARGOED FOR RELEASE: 2 A.M. (ET), FRIDAY, APRIL 5, 2024
Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the 39th Annual European Association of Urology Congress.
About The Study: The results of this systematic review and meta-analysis suggest that integrating magnetic resonance imaging (MRI) in prostate cancer screening pathways is associated with a reduced number of unnecessary biopsies and overdiagnosis of insignificant prostate cancer while maintaining clinically significant prostate cancer detection as compared with prostate-specific antigen (PSA)-only screening.
Authors: Shahrokh F. Shariat, M.D., D.Dr.(hc), of Medical University Vienna in Vienna, is the corresponding author.
(doi:10.1001/jamaoncol.2024.0734)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
EMBARGOED FOR RELEASE: 4:15 A.M. (ET), SATURDAY, APRIL 6, 2024
Media advisory: The full study and editorial are linked to this news release. This study is being released to coincide with presentation at the 39th Annual European Association of Urology Congress.
About The Study: In this preliminary descriptive report from an ongoing randomized clinical trial, one additional high-grade cancer per 196 men and one low-grade cancer per 909 men were detected among those randomized to be invited to undergo a single prostate cancer screening intervention compared with those not invited to undergo screening. These preliminary findings from a single round of screening should be interpreted cautiously, pending results of the study’s primary mortality outcome.
Authors: Anssi Auvinen, M.D., Ph.D., of Tampere University in Tampere, Finland, is the corresponding author.
(doi:10.1001/jama.2024.3841)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
EMBARGOED FOR RELEASE: 2:30 A.M. (ET), SATURDAY, APRIL 6, 2024
Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the 39th Annual European Association of Urology Congress.
About The Study: A single invitation for prostate-specific antigen (PSA) screening compared with standard practice without routine screening reduced prostate cancer deaths at a median follow-up of 15 years in this secondary analysis of a randomized clinical trial. However, the absolute reduction in deaths was small.
Authors: Richard M. Martin, B.M., B.S., Ph.D., of the University of Bristol in Bristol, United Kingdom, is the corresponding author.
(doi:10.1001/jama.2024.4011)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this randomized crossover clinical trial with 62 participants, non-hospitalized patients with post-COVID condition (PCC) generally tolerated exercise with preserved cardiovascular function but showed lower aerobic capacity and less muscle strength than the control group. They also showed signs of postural orthostatic tachycardia and myopathy. The findings suggest cautious exercise adoption could be recommended to prevent further skeletal muscle deconditioning and health impairment in patients with PCC.
Authors: Andrea Tryfonos, Ph.D., of the Karolinska Institutet in Stockholm, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.4386)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Among 7,998 adults hospitalized during the 16 months before the first respiratory syncytial virus (RSV) vaccine recommendations, RSV disease was less common but similar in severity compared with COVID-19 or influenza disease among unvaccinated patients and more severe than COVID-19 or influenza disease among vaccinated patients for the most serious outcomes of invasive mechanical ventilation or death.
Authors: Diya Surie, M.D., of the Centers for Disease Control and Prevention in Atlanta, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.4954)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About The Study: In a survey study of residents of all accredited general surgery programs, one-third of trainees reported lack of meaningful mentorship, particularly non-white or Hispanic trainees. Although education and wellness are multifactorial issues, mentorship was associated with improvement; thus, efforts to facilitate mentorship are needed, especially for minoritized residents.
Authors: Yue-Yung Hu, M.D., M.P.H., of Northwestern University in Chicago, is the corresponding author.
(doi:10.1001/jamasurg.2024.0533)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that the consequences of structural racism extend beyond inequities in health care to drive disparities in breast cancer outcome. Additional research is needed with more comprehensive social and environmental measures to better understand the influence of social determinants on aggressive estrogen receptor-positive tumor biology among racial and ethnic minoritized women from disadvantaged and historically marginalized communities.
Authors: Gregory S. Calip, Pharm.D., M.P.H., Ph.D., of the University of Southern California in Los Angeles, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.4862)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: High levels of glucose and triglycerides and low levels of high-density lipoprotein were associated with future risk of depression, anxiety, and stress-related disorders in this study of more than 200,000 participants. These findings may support closer follow-up of individuals with metabolic dysregulations for the prevention and diagnosis of psychiatric disorders.
Authors: Charilaos Chourpiliadis, M.D., of the Karolinska Institutet in Stockholm, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.4525)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study of 9,740 surveillance colonoscopies among 9,601 adults ages 70 to 85 with prior colorectal adenoma, colorectal cancer detection was rare regardless of prior adenoma finding, whereas the advanced neoplasia yield was 12% overall. Yields were higher among those with a prior advanced adenoma than among those with prior nonadvanced adenoma and did not increase significantly with age. These findings can help inform whether to continue surveillance colonoscopy in older adults.
Authors: Jeffrey K. Lee, M.D., M.P.H., of Kaiser Permanente Northern California in Oakland, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.4611)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this nationally representative cohort study, polybrominated diphenyl ether (PBDE) exposure was significantly associated with an increased risk of cancer mortality. Since the 1970s, PBDEs have been used as flame retardants in a wide array of consumer products, such as building materials, furnishings, and electronics. Further studies are needed to replicate the findings and determine the underlying mechanisms.
Authors: Wei Bao, M.D., Ph.D., and Buyun Liu, M.D., Ph.D., of the University of Science and Technology of China in Hefei, Anhui, China, are the corresponding authors.
(doi:10.1001/jamanetworkopen.2024.3127)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this survey study, binge drinking in both men and women was reported at greater frequency among sports wagering individuals compared with nongamblers and non–sports gamblers.
Authors: Joshua B. Grubbs, Ph.D., of the University of New Mexico in Albuquerque, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.5473)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that smartphones could offer a feasible, reliable, valid, and scalable solution for remote evaluations of frontotemporal lobar degeneration, a neurodegenerative pathology causing early-onset dementia syndromes, and may improve early detection. Smartphone assessments should be considered as a complementary approach to traditional in-person trial designs. Future research should validate these results in diverse populations and evaluate the utility of these tests for longitudinal monitoring.
Authors: Adam M. Staffaroni, Ph.D., of the University of California, San Francisco, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.4266)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: The findings of this study suggest that biosimilar competition was not consistently associated with lower out-of-pocket costs for commercially insured outpatients, highlighting the need for targeted policy interventions to ensure that the savings generated from biosimilar competition translate into increased affordability for patients who need biologics.
Authors: Benjamin N. Rome, M.D., M.P.H., of Brigham and Women’s Hospital in Boston, is the corresponding author.
(doi:10.1001/jamahealthforum.2024.5429)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This study found that the more states were inclined to vote Republican, the more likely their vaccine recipients or their clinicians reported COVID-19 vaccine adverse events. These results suggest that either the perception of vaccine adverse events or the motivation to report them was associated with political inclination.
Authors: David A. Asch, M.D., M.B.A., of the University of Pennsylvania in Philadelphia, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.4177)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About The Study: In this quality improvement study of 35 health care facilities in Orange County, California, using quasi-experimental design, chlorhexidine bathing and nasal decolonization were associated with significantly lower multidrug-resistant organism prevalence and incident clinical cultures. Infection-related hospitalizations, associated costs, and deaths among nursing home residents also decreased.
Authors: Susan S. Huang, M.D., M.P.H., of the University of California Irvine School of Medicine in Irvine, is the corresponding author.
(doi:10.1001/jama.2024.2759)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this survey study of 204 oncologists, few reported that patients needed to understand artificial intelligence (AI) models, but most agreed that patients should consent to their use, and many tasked patients with choosing between physician- and AI-recommended treatment regimens. These findings suggest that the implementation of AI in oncology must include rigorous assessments of its effect on care decisions as well as decisional responsibility when problems related to AI use arise.
Authors: Gregory A. Abel, M.D., M.P.H., of the Dana-Farber Cancer Institute in Boston, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.4077)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About The Study: From 2013 to 2022, U.S. physicians received $12.1 billion from industry. More than half of physicians received at least one payment. Payments varied widely between specialties and between physicians within the same specialty. A small number of physicians received the largest amounts, often exceeding $1 million, while the median physician received much less, typically less than a hundred dollars.
Authors: Andrew J. Foy, M.D., of the Penn State Milton S. Hershey Medical Center in Hershey, Pennsylvania, is the corresponding author.
(doi:10.1001/jama.2024.1989)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: High prices limit access to newer diabetes medicines in many countries. The findings of this study suggest that robust generic and biosimilar competition could reduce prices to more affordable levels and enable expansion of diabetes treatment globally.
Authors: Melissa J. Barber, Ph.D., of the Yale Collaboration for Regulatory Rigor, Integrity, and Transparency in New Haven, Connecticut, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.3474)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Individuals at high genetic risk of obesity needed higher daily step counts to reduce the risk of obesity than those at moderate or low genetic risk in this study of 3,124 adults. Population-based recommendations may underestimate physical activity needed to prevent obesity among those at high genetic risk.
Authors: Evan L. Brittain, M.D., M.Sc., and Douglas M. Ruderfer, Ph.D., of the Vanderbilt University Medical Center in Nashville, are the corresponding authors.
(doi:10.1001/jamanetworkopen.2024.3821)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About The Study: Inappropriate diagnosis of community-acquired pneumonia was common, particularly among older adults, those with dementia, and those presenting with altered mental status in this study of 17,000 hospitalized adults treated for pneumonia in 48 Michigan hospitals. Full-course antibiotic treatment of those inappropriately diagnosed with community-acquired pneumonia may be harmful.
Authors: Ashwin B. Gupta, M.D., of the VA Ann Arbor Healthcare System in Ann Arbor, Michigan, is the corresponding author.
(doi:10.1001/jamainternmed.2024.0077)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this observational study of 20,000 adults suggest that a measure of follow-up colonoscopy within defined periods after an abnormal result of a stool-based screening test for colorectal cancer is warranted based on low current performance rates and would be feasible to collect by health systems and produce valid, reliable results.
Authors: Elizabeth L. Ciemins, Ph.D., M.P.H., M.A., of the American Medical Group Association in Alexandria, Virginia, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.2693)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study of 18,000 adults who were employed, greater job flexibility was significantly associated with reduced odds of experiencing serious psychological distress and experiencing anxiety. Greater job security was significantly associated with reduced odds of experiencing serious psychological distress and experiencing anxiety.
Authors: Monica L. Wang, Sc.D., M.S., of the Boston University School of Public Health, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.3439)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About The Study: Provision of medications for self-managed abortions increased in the six months following the Dobbs v Jackson Women’s Health Organization decision. Results suggest that a substantial number of abortion seekers accessed services despite the implementation of state-level bans and restrictions.
Authors: Abigail R. A. Aiken, Ph.D., of the University of Texas at Austin, is the corresponding author.
(doi:10.1001/jama.2024.4266)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: The cumulative incidence of heart offer acceptance by a transplant center team was consistently lower for Black candidates than for white candidates of the same gender and higher for women than for men in this study. These disparities persisted after adjusting for candidate-, donor-, and offer-level variables, possibly suggesting racial and gender bias in the decision-making process. Further investigation of site-level decision-making may reveal strategies for equitable donor heart acceptance.
Authors: Khadijah Breathett, M.D., M.S., of Indiana University in Indianapolis, is the corresponding author.
(doi:10.1001/jama.2024.0065)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: The results of this study of Medicare enrollees suggest that although nationally, Black and Hispanic individuals and individuals of other racial groups received more telemedicine visits during the pandemic and disproportionately lived in geographic regions with higher telemedicine use, after controlling for geographic region, Black and Hispanic individuals and individuals of other racial groups received fewer telemedicine visits than white individuals.
Authors: Felippe O. Marcondes, M.D., M.P.H., of Massachusetts General Hospital in Boston, is the corresponding author.
(doi:10.1001/jamahealthforum.2024.0131)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study of 5,437 U.S. adults with health care visits in 2022, many patients, including those with the greatest care needs, chose telemedicine even after in-person visits were available. These findings support continuing this care delivery approach as an option valued by patients. Differences were not observed by most common measures of socioeconomic status. Continued monitoring of telemedicine use is needed to ensure equitable access to health care innovations.
Authors: Eva Chang, Ph.D., M.P.H., of Advocate Health in Milwaukee, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.3354)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study including 309,000 Danish children, longer duration of exclusive breastfeeding was associated with reduced risk of childhood B-cell precursor-acute lymphoblastic leukemia, corroborating results of previous case-control investigations in this field. To inform future preemptive interventions, continued research should focus on the potential biologic mechanisms underlying the observed association.
Authors: Signe Holst Søegaard, Ph.D., of the Danish Cancer Society in Copenhagen, is the corresponding author.
(doi: 10.1001/jamanetworkopen.2024.3115)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of 64,000 low-income Americans, nearly 80% of study participants consumed sodium exceeding the current recommended daily amount, which was associated with 10% to 30% of cardiovascular disease mortality. Public health programs targeted to reduce sodium intake among this underserved population may be beneficial.
Authors: Xiao-Ou Shu, M.D., Ph.D., of the Vanderbilt University School of Medicine in Nashville, is the corresponding author.
(doi: 10.1001/jamanetworkopen.2024.3802)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This analysis including 157,000 individuals from two large study cohorts found that among U.S. veterans, higher body mass index (BMI) variability was a significant risk marker associated with adverse cardiovascular events independent of mean BMI across major racial and ethnic groups. Results were consistent in the UK Biobank for the cardiovascular death end point. Further studies should investigate the phenotype of high BMI variability.
Authors: Yan V. Sun, Ph.D., M.S., of Emory University in Atlanta, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.3062)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this early childhood study including 303 children, concussion was associated with more postconcussive symptoms than orthopedic injuries or typical development up to three months after injury. Given the limited verbal and cognitive abilities typical of early childhood, using developmentally appropriate manifestations and behaviors is a valuable way of tracking postconcussive symptoms and could aid in concussion diagnosis in young children.
Authors: Miriam Beauchamp, Ph.D., of the Universite de Montreal, is the corresponding author.
(doi:10.1001/jamanetworkopen.2024.3182)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or emailmedia relations.
