Systemic Anticancer Therapy and Overall Survival in Patients With Very Advanced Solid Tumors

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Effectiveness of a Web-Based Cognitive Behavioral Self-Help Intervention for Binge Eating Disorder

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 16, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this randomized clinical trial of a web-based self-help intervention for patients with binge eating disorder, the findings confirmed its effectiveness in reducing binge eating episodes and improving various mental health outcomes, highlighting a scalable solution to bridge the treatment gap for this condition. 

Corresponding Author: To contact the corresponding author, Luise Pruessner, M.S., email luise.pruessner@psychologie.uni-heidelberg.de.

 

(doi:10.1001/jamanetworkopen.2024.11127)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Physician and AI Chatbot Responses to Cancer Questions From Social Media

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 16, 2024

Media advisory: The full study is linked to this news release.

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About The Study: The findings of this study suggest that chatbots can generate quality, empathetic, and readable responses to patient questions comparable to physician responses sourced from an online forum. Further research is required to assess the scope, process integration, and patient and physician outcomes of chatbot-facilitated interactions. 

Corresponding Author: To contact the corresponding author, Srinivas Raman, M.D., M.A.Sc., email srinivas.raman@rmp.uhn.ca.

  

(doi:10.1001/jamaoncol.2024.0836)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Pediatric Trauma Center Access, Regional Injury Burden, and Socioeconomic Disadvantage

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Dose-Dependent Association Between Body Mass Index and Mental Health and Changes Over Time

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 15, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This study revealed a U-shaped association between adolescent body mass index and mental health, which was consistent across sex and grades and became stronger over time. These insights emphasize the need for targeted interventions addressing body image and mental health, and call for further research into underlying mechanisms. 

Corresponding Author: To contact the corresponding author, Shanquan Chen, Ph.D., email Shanquan.chen@lshtm.ac.uk.

 

(10.1001/jamapsychiatry.2024.0921)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Disparities in Patient Portal Engagement Among Patients With Hypertension Treated in Primary Care

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 15, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cohort study of patients with hypertension found clear sociodemographic disparities in patient portal engagement among those treated in primary care. Without special efforts to engage patients with portals, interventions that use patient portals to target hypertension may exacerbate disparities. 

Corresponding Author: To contact the corresponding author, Rasha Khatib, Ph.D., M.H.S., email rasha.alkhatib@aah.org.

 

(doi:10.1001/jamanetworkopen.2024.11649)

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An Adaptive Behavioral Intervention for Weight Loss Management

JAMA

EMBARGOED FOR RELEASE: 6:01 P.M. ET, TUESDAY, MAY 14, 2024

Media advisory: The full study and editorial are linked to this news release. The study is being released to coincide with the European Congress on Obesity.

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About The Study: A wireless feedback system (Wi-Fi activity tracker and scale with smartphone app to provide daily feedback) was not noninferior to the same system with added coaching. Continued efforts are needed to identify strategies for weight loss management and to accurately select interventions for different individuals to achieve weight loss goals.

 

Quote from corresponding author Bonnie Spring, Ph.D.:

 

“With U.S. obesity prevalence projected to reach 49% by 2030, limited obesity treatment resources need to be spread across more of the population.  One promising approach is stepped care that begins with low cost, self-monitoring technology alone, then intensifies treatment for those who show insufficient response.

 

“It has been unknown whether first line technology treatment alone could produce clinically acceptable weight loss.  In an adaptive randomized noninferiority trial, people who initially only received technology without coach support were less likely to achieve meaningful weight loss (5% of body weight), compared to those who had a human coach at the start.

 

“Currently, a human coach remains needed from the outset of obesity treatment because digital technology alone doesn’t produce clinically acceptable weight loss for most people.”

 

Contact information for Dr. Spring: email bspring@northwestern.edu.

 

(doi:10.1001/jama.2024.0821)

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Text Messages With Financial Incentives for Men With Obesity

JAMA

EMBARGOED FOR RELEASE: 6:01 P.M. ET, TUESDAY, MAY 14, 2024

Media advisory: The full study and editorial are linked to this news release. The study is being presented at the European Congress on Obesity.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.7064?guestAccessKey=e5e4f13d-f93c-4d64-b9fb-c579e4b06a33&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=051424

 

About The Study: Among men with obesity, an intervention with text messaging with financial incentive significantly improved weight loss compared with a control group, whereas text messaging alone was not significantly better than the control condition. These findings support text messaging combined with financial incentives to attain weight loss in men with obesity.

 

Quote from corresponding author Prof. Pat Hoddinott, M.B., B.S., Ph.D.:

 

“Losing weight can make people feel better, reduce their risk of many health problems such as diabetes, and helps the health service with their aim to keep men well. However, we know men often don’t like to go to traditional weight loss groups.

 

“This was a very carefully planned study, created for men by men. We worked closely with various men’s health groups and charities, including Men’s Health Forum in the UK and Ireland, with more than 1000 men living with obesity informing the design of the incentive structure.

 

“The research showed that offering cash incentives was a popular and effective way of helping men to lose weight. This initiative would be a low-cost solution for the health service to offer to men, requiring only four short weight appointments, and with money paid out only at the end to those who lose over 5% of their starting weight.”

 

Contact information for Prof. Hoddinott:

Press officer: Sarah Manning, sarah.manning@stir.ac.uk; 01786 466436 / 07341 052 750.

 

(doi:10.1001/jama.2024.7064)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Cardiovascular Burden of the V142I Transthyretin Variant

JAMA

EMBARGOED FOR RELEASE: 3:30 A.M. ET, SUNDAY, MAY 12, 2024

Media advisory: The full study and editorials are linked to this news release. The study is being released to coincide with presentation at the European Society of Cardiology-Heart Failure Congress.

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About The Study: Among self-reported Black individuals, male and female V142I carriers faced similar and substantial risk for heart failure hospitalization, predominantly with reduced ejection fraction, and death, with steep age-dependent penetrance. Delineating the individual contributions of, and complex interplay among, the V142I variant, ancestry, the social construct of race, and biological or social determinants of health to cardiovascular disease merits further investigation. 

Corresponding Author: To contact the corresponding author, Scott D. Solomon, M.D., email ssolomon@rics.bwh.harvard.edu.

 

(doi:10.1001/jama.2024.4467)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Mortality in Patients Hospitalized for COVID-19 vs Influenza in Fall-Winter 2023-2024

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 15, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This study found that in fall-winter 2023-2024, the risk of death in patients hospitalized for COVID-19 was greater than the risk of death in patients hospitalized for seasonal influenza. 

Corresponding Author: To contact the corresponding author, Ziyad Al-Aly, M.D., email ziyad.alaly@va.gov.

 

(doi:10.1001/jama.2024.7395)

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Effect of Low-Dose Iron Supplementation on Early Development in Breastfed Infants

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Telehealth Expansion and Medicare Beneficiaries’ Care Quality and Access

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MAY 13, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of Medicare beneficiaries across all 3,436 hospital service areas (HSAs), high levels of telehealth use were associated with more clinician encounters, more ambulatory care–sensitive hospitalizations, and higher total health care costs. COVID-19 cases were still high during the period of study, which suggests that these findings partially reflect a higher capacity for providing health services in HSAs with higher telehealth intensity than other HSAs. 

Corresponding Author: To contact the corresponding author, Sara Parker-Lue, Ph.D., email sparkerlue@air.org.

 

(doi:10.1001/jamanetworkopen.2024.11006)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Mail-Order Pharmacy Dispensing of Mifepristone for Medication Abortion After In-Person Screening

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 13, 2024

Media advisory: The full study and Viewpoint are linked to this news release.

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About The Study: The findings of this cohort study indicate that mail-order pharmacy dispensing of mifepristone for medication abortion was effective, acceptable to patients, and feasible, with a low prevalence of serious adverse events. This care model should be expanded to improve access to medication abortion services. 

Corresponding Author: To contact the corresponding author, Daniel Grossman, M.D., email daniel.grossman@ucsf.edu.

 

(doi:10.1001/jamainternmed.2024.1476)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Causal Inference About the Effects of Interventions From Observational Studies in Medical Journals

JAMA

EMBARGOED FOR RELEASE: 11:30 A.M. ET, THURSDAY, MAY 9, 2024

Media advisory: The full study and editor’s note are linked to this news release.

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About The Study: Adoption of the proposed framework to identify when causal interpretation is appropriate in observational studies promises to facilitate better communication between authors, reviewers, editors, and readers. Practical implementation will require cooperation between editors, authors, and reviewers to operationalize the framework and evaluate its effect on the reporting of empirical research. 

Corresponding Author: To contact the corresponding author, Issa J. Dahabreh, M.D., Sc.D., email idahabreh@hsph.harvard.edu.

 

(doi:10.1001/jama.2024.7741)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Nurse Practitioner Care, Scope of Practice, and End-of-Life Outcomes for Nursing Home Residents With Dementia

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Social Determinants of Health and Delivery of Rehabilitation to Older Adults During ICU Hospitalization

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 10, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study highlight the need to consider social determinants of health in efforts to promote rehabilitation delivery during intensive care unit (ICU) hospitalization and to investigate factors underlying inequities in this practice. 

Corresponding Author: To contact the corresponding author, Snigdha Jain, M.D., M.H.S., email Snigdha.Jain@yale.edu.

 

(doi:10.1001/jamanetworkopen.2024.10713)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Long-Term Effect of Home Blood Pressure Self-Monitoring Plus Medication Self-Titration for Patients With Hypertension

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 10, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.10063?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=051024

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this secondary analysis of a randomized clinical trial, blood pressure (BP) self-monitoring plus self-titration of antihypertensive medication based on an individualized prearranged plan used in primary care reduced BP in the longer term with passive follow-up compared with usual care, without increasing health care use or adverse events. These results suggest that simple, inexpensive, and easy-to-implement self-management interventions have the potential to improve the long-term control of hypertension in routine clinical practice. 

Corresponding Author: To contact the corresponding author, Gabriel Sanfelix-Gimeno, Ph.D., email gabriel.sanfelix@fisabio.es.

 

(doi:10.1001/jamanetworkopen.2024.10063)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Prognostic Value of Cardiovascular Biomarkers in the Population

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MAY 13, 2024

Media advisory: The full study and editorial are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.5596?guestAccessKey=0c8356ed-b996-4dd8-a4b6-5d654d24e31b&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=051324

 

About The Study: Cardiovascular biomarkers were strongly associated with fatal and nonfatal cardiovascular events and mortality. The addition of biomarkers to established risk factors led to only a small improvement in risk prediction metrics for atherosclerotic cardiovascular disease, but was more favorable for heart failure and mortality. 

Corresponding Author: To contact the corresponding author, Johannes Tobias Neumann, M.D., Ph.D., email j.neumann@uke.de.

 

(doi:10.1001/jama.2024.5596)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Diversity, Equity, and Inclusion Content on Ophthalmology Fellowship Webpages

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Declination of Treatment, Racial and Ethnic Disparity, and Overall Survival in Patients With Breast Cancer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 9, 2024

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.9449?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=050924

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study highlights racial and ethnic disparities in treatment declination and overall survival, suggesting the need for equity-focused interventions, such as patient education on treatment benefits and improved patient-clinician communication and shared decision-making, to reduce disparities and improve patient survival. 

Corresponding Author: To contact the corresponding author, Dezheng Huo, M.D., Ph.D., email dhuo@bsd.uchicago.edu.

 

(doi:10.1001/jamanetworkopen.2024.9449)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Place-Based Measures of Inequity and Vision Difficulty and Blindness

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 9, 2024

Media advisory: The full study and commentary are linked to this news release.

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About The Study: Residential measures of inequity through segregation, income inequality, or persistent poverty were associated with a greater number of residents living with vision difficulty and blindness in this cross-sectional study. It is essential to understand and address how neighborhood characteristics can impact rates of vision difficulty and blindness. 

Corresponding Author: To contact the corresponding author, Patrice M. Hicks, Ph.D., M.P.H., email pmhicks@med.umich.edu.

 

(doi:10.1001/jamaophthalmol.2024.1207)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Burden of Mental Disorders and Suicide Attributable to Childhood Maltreatment

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Role of Inflammation in Short Sleep Duration Across Childhood and Psychosis in Young Adulthood

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Sexual Harassment, Abuse, and Discrimination in Obstetrics and Gynecology

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 8, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that there is a high prevalence of harassment in OB-GYN despite being a predominantly female field for the last decade. 

Corresponding Author: To contact the corresponding author, Ankita Gupta, M.D., M.P.H., email ankita.gupta@louisville.edu.

 

(doi:10.1001/jamanetworkopen.2024.10706)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Estimated Number of Children Who Lost a Parent to Drug Overdose in the US From 2011 to 2021

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 8, 2024

Media advisory: The full study is linked to this news release.

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About The Study: More than 320,000 children in the U.S. lost a parent to drug overdose between 2011-2021, with significant disparities evident across racial and ethnic groups. Given the potential short- and long-term negative impact of parental loss, program and policy planning should ensure that responses to the overdose crisis account for the full burden of drug overdose on families and children, including addressing the economic, social, educational, and health care needs of children who have lost parents to overdose. 

Corresponding Author: To contact the corresponding author, Christopher M. Jones, Pharm.D., Dr.P.H., M.P.H., email christopher.jones@samhsa.hhs.gov.

 

(10.1001/jamapsychiatry.2024.0810)

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Prevalence of Cardiovascular-Kidney-Metabolic Syndrome Stages in US Adults

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 8, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Almost 90% of U.S. adults met criteria for cardiovascular, kidney, and metabolic (CKM) syndrome (stage 1 or higher) and 15% met criteria for advanced stages, neither of which improved between 2011 and 2020. Substantial between-subgroup differences in advanced stages were observed, with older age, men, and Black adults at increased risk. Cardiovascular, kidney, and metabolic diseases are pathophysiologically interrelated and were the leading causes of death in 2021. In 2023, the American Heart Association introduced a novel staging construct, termed CKM syndrome, to enhance multidisciplinary approaches to prevention, risk stratification, and management of these disorders.

Corresponding Author: To contact the corresponding author, Muthiah Vaduganathan, M.D., M.P.H., email mvaduganathan@bwh.harvard.edu.

 

(doi:10.1001/jama.2024.6892)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Multilevel Characteristics of Cumulative Symptom Burden in Young Survivors of Childhood Cancer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, MAY 7, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that symptoms are prevalent years after young childhood cancer survivors’ initial cancer diagnosis, and interventions to reduce caregiver anxiety and neighborhood adversity and improve resilience may alleviate symptom burden. 

Corresponding Author: To contact the corresponding author, I-Chan Huang, Ph.D., email i-chan.huang@stjude.org.

  

(doi:10.1001/jamanetworkopen.2024.10145)

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Social Determinants of Health and the Availability of Cancer Clinical Trials in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, MAY 7, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Substantial geographic disparities in cancer clinical trials availability exist throughout the United States, with the most socially vulnerable counties being far less likely to have any trial and having only a fraction of trials available, a disparity that has worsened over time. 

Corresponding Author: To contact the corresponding author, Rishi Robert Sekar, M.D., M.S., email rsekar@med.umich.edu. 

 

(doi:10.1001/jamanetworkopen.2024.10162)

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Cytisinicline for Vaping Cessation in Adults Using Nicotine E-Cigarettes

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Behavioral Interventions to Improve Breast Cancer Screening Outreach

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 6, 2024

Media advisory: The full study is linked to this news release.

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About The Study: These findings show that text messaging women after initial breast cancer screening outreach via either electronic portal or mailings, as well as bulk ordering with or without text messaging, can increase mammogram completion rates.  

Corresponding Author: To contact the corresponding author Shivan J. Mehta, M.D., M.B.A., M.S.H.P., email shivan.mehta@pennmedicine.upenn.edu.

 

(doi:10.1001/jamainternmed.2024.0507)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Racial and Ethnic Disparities in Initiation of Direct Oral Anticoagulants Among Medicare Beneficiaries

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 6, 2024

Media advisory: The full study and editorial are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of Medicare patients with atrial fibrillation, Black and Hispanic patients were less likely to initiate direct oral anticoagulants for atrial fibrillation, although these differences diminished over time. Identifying the factors behind these early disparities is crucial for ensuring equitable access to novel therapies as they emerge for Black and Hispanic populations. 

Corresponding Authors: To contact the corresponding authors, email Kamika R. Reynolds, M.S., Ph.D. (kreynolds@ifh.rutgers.edu) and Chintan V. Dave, Pharm.D., Ph.D. (cdave@ifh.rutgers.edu). 

 

(doi:10.1001/jamanetworkopen.2024.9465)

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Racial and Ethnic Disparities in All-Cause and Cause-Specific Mortality Among US Youth

JAMA

EMBARGOED FOR RELEASE: 3:30 P.M. (ET), SATURDAY, MAY 4, 2024

Media advisory: The full study and editorial are linked to this news release. This study is being released to coincide with presentation at the Pediatric Academic Societies meeting.

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About The Study: Racial and ethnic disparities were observed for almost all leading causes of injury and disease that were associated with recent increases in youth mortality rates. Addressing the increasing disparities affecting American Indian or Alaska Native and Black youth will require efforts to prevent homicide and suicide, especially those events involving firearms. 

Authors: Elizabeth R. Wolf, M.D., M.P.H., of the Virginia Commonwealth University School of Medicine in Richmond, is the corresponding author.

 

(doi:10.1001/jama.2024.3908)

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Loss of Medicaid Coverage During the Renewal Process

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Associations of Internal Medicine Residency Milestone Ratings and Certification Examination Scores With Patient Outcomes

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Long-Term Cardiovascular Outcomes in Children and Adolescents With Hypertension

JAMA Pediatrics

EMBARGOED FOR RELEASE: 9 A.M. (ET), MONDAY, MAY 6, 2024

Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the Pediatric Academic Societies meeting.

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About The Study: Children diagnosed with hypertension had a higher associated long-term risk of major adverse cardiac events compared with controls without hypertension. Improved detection, follow-up, and control of pediatric hypertension may reduce the risk of adult cardiovascular disease. 

Authors: Rahul Chanchlani, M.B.B.S., M.D., M.Sc., of McMaster University in Hamilton, Canada, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2024.1543)

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Early Neurodevelopmental Assessments for Predicting Long-Term Outcomes in Infants at High Risk of Cerebral Palsy

JAMA Network Open

EMBARGOED FOR RELEASE: 1 P.M. (ET), MONDAY, MAY 6, 2024

Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the Pediatric Academic Societies meeting.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study support the potential to identify cerebral palsy and its severity as early as corrected age 3 to 4 months through early neurodevelopmental assessments, but the role of these tests is limited in identifying cognitive and neurodevelopmental impairments. 

Authors: Abdul Razak, M.D., of Monash University in Melbourne, Australia, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2024.9053)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Outcomes of Children Admitted to a Pediatric Observation Unit With a Psychiatric Comanagement Model

JAMA Pediatrics

EMBARGOED FOR RELEASE: 7 A.M. (ET), SUNDAY, MAY 5, 2024

Media advisory: The full study is linked to this news release. This study is being released to coincide with presentation at the Pediatric Academic Societies meeting.

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About The Study: The findings of this study show a significantly lower pediatric emergency department length of stay and inpatient psychiatric admission rate following pediatric observation unit care and potential savings in inpatient psychiatric resources without contributing to 30-day readmission rates. 

Authors: Rachel G. Kasdin, M.S., of the Icahn School of Medicine at Mount Sinai in New York, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2024.1123)

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Photokeratitis in Outdoor Event Participants Exposed to UV Radiation Display

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Longer Interval Between First Colonoscopy With Negative Findings for Colorectal Cancer and Repeat Colonoscopy

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 2, 2024

Media advisory: The full study and editorial are linked to this news release.

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About The Study: This cohort study found that for the population without a family history of colorectal cancer (CRC), the 10-year interval between colonoscopy screenings for individuals with a first colonoscopy with findings negative for CRC could potentially be extended to 15 years. A longer interval between colonoscopy screenings could be beneficial in avoiding unnecessary invasive examinations. 

Authors: Mahdi Fallah, M.D., Ph.D., of the German Cancer Research Center in Heidelberg, is the corresponding author. 

 

(doi:10.1001/jamaoncol.2024.0827)

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Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 2, 2024

Media advisory: The full study is linked to this news release.

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About The Study: For individuals who smoked but did not achieve abstinence after treatment with varenicline, increasing the dosage enhanced abstinence versus continuing, whereas for nonabstainers initially treated with combined nicotine replacement therapy, a dosage increase or switch to varenicline enhanced abstinence and may be viable rescue strategies. 

Authors: Paul M. Cinciripini, Ph.D., of the University of Texas MD Anderson Cancer Center in Houston, is the corresponding author.

 

(doi:10.1001/jama.2024.4183)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Deep Learning–Based Assessment of Built Environment From Satellite Images and Cardiometabolic Disease Prevalence

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https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2024.0749?guestAccessKey=ba082ea0-36e1-47b5-bde8-e290f10e494b&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=050124

Prospective and Retrospective Measures of Child Maltreatment and Their Association With Psychopathology

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Differences in Cardiovascular Health at the Intersection of Race, Ethnicity, and Sexual Identity

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 1, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study uses National Health and Nutrition Examination Survey data to examine differences in cardiovascular health metrics at the intersection of race, ethnicity, and sexual identity. 

Authors: Nicole Rosendale, M.D., of the University of California San Francisco, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2024.9053)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Plant-Based Diets and Disease Progression in Men With Prostate Cancer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 1, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Higher intake of plant foods after prostate cancer diagnosis was associated with lower risk of cancer progression, this study suggests. 

Authors: Stacey A. Kenfield, Sc.D., of the University of California, San Francisco, is the corresponding author. 

 

(doi:10.1001/jamanetworkopen.2024.9053)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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The Women’s Health Initiative Randomized Trials and Clinical Practice

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 1, 2024

Media advisory: The full study is linked to this news release.

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About The Study: For postmenopausal women, the Women’s Health Initiative (WHI) randomized clinical trials do not support menopausal hormone therapy to prevent cardiovascular disease or other chronic diseases. Menopausal hormone therapy is appropriate to treat bothersome vasomotor symptoms among women in early menopause, without contraindications, who are interested in taking hormone therapy. The WHI evidence does not support routine supplementation with calcium plus vitamin D for menopausal women to prevent fractures or a low-fat diet with increased fruits, vegetables, and grains to prevent breast or colorectal cancer. A potential role of a low-fat dietary pattern in reducing breast cancer mortality, a secondary outcome, warrants further study. 

Authors: JoAnn E. Manson, M.D., Dr.P.H., of Brigham and Women’s Hospital, Harvard Medical School in Boston, is the corresponding author.

 

(doi:10.1001/jama.2024.6542)

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Race and Ethnicity of Reproductive-Age Females Affected by State Abortion Bans

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 1, 2024

Media advisory: The full study is linked to this news release.

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About The Study: The proportions of American Indian or Alaska Native, Black, and white females of reproductive age in states with effective abortion bans were higher than in states without such policies, while proportions for other racial and ethnic groups were lower. Although these restrictive laws were not based on race, they were concentrated in states with higher proportions of American Indian or Alaska Native and Black individuals, resulting in a differential effect of restrictive abortion laws in these groups. American Indian or Alaska Native and Black populations are disproportionately affected by disparities in pregnancy-related deaths, reproductive health, and poverty. Policies improving access to the full spectrum of reproductive health care, including safe abortion, may reduce such disparities. 

Authors: Demetri Goutos, M.B.A., of the Boston University School of Public Health in Boston, is the corresponding author.

 

(doi:10.1001/jama.2024.6023)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

National Breast, Cervical, and Colorectal Cancer Screening Use in Federally Qualified Health Centers

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Physical Fitness and Risk of Mental Disorders in Children and Adolescents

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Identification of Human-Generated vs AI-Generated Research Abstracts by Health Care Professionals

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USPSTF Recommendation Statement on Screening for Breast Cancer

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, APRIL 30, 2024

Media advisory: To contact the U.S. Preventive Services Task Force, email the Media Coordinator at Newsroom@USPSTF.net or call 301-951-9203. The full report and related articles are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time and all USPSTF articles remain free indefinitely https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.5534?guestAccessKey=24c51c29-76d3-4743-9dd2-a7b14f990871&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=043024

 

Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends biennial screening mammography for women ages 40 to 74. The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening mammography in women 75 years or older. The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of supplemental screening for breast cancer using breast ultrasonography or magnetic resonance imaging (MRI) in women identified to have dense breasts on an otherwise negative screening mammogram. Among all U.S. women, breast cancer is the second most common cancer and the second most common cause of cancer death. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this recommendation updates the 2016 recommendation on breast cancer screening.

 

(doi:10.1001/jama.2024.5534)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Note: More information about the U.S. Preventive Services Task Force, its process, and its recommendations can be found on the newsroom page of its website.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Association of New-Onset Seizures With SARS-CoV-2 Vaccines

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, APRIL 29, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2024.0967?guestAccessKey=b4540abc-cbb6-4e8c-844d-cd259ab45960&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=042924

 

About The Study: This systematic review and meta-analysis showed that the incidence proportion of new-onset seizures after SARS-CoV-2 vaccination was not statistically different between vaccine recipients and placebo recipients or unvaccinated participants in the pooled analyses of more than 118,000 participants in randomized clinical trials.

Authors: Churl-Su Kwon, M.D., M.P.H., of Columbia University in New York, is the corresponding author.

 

(doi:10.1001/jamaneurol.2024.0967)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Global Production of Active Pharmaceutical Ingredients for US Generic Drugs Experiencing Shortages

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