Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, JUNE 25, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The combination of exercise and glucagon-like peptide-1 receptor agonist (GLP-1RA) (liraglutide) was the most effective weight loss strategy while preserving bone health in this randomized clinical trial. Liraglutide treatment alone reduced bone mineral density at clinically relevant sites more than exercise alone despite similar weight loss.

Corresponding Author: To contact the corresponding author, Signe Sorensen Torekov, Ph.D., email torekov@sund.ku.dk.

 

(doi:10.1001/jamanetworkopen.2024.16775)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Physical, Sexual, and Intimate Partner Violence Among Transgender and Gender-Diverse Individuals

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, JUNE 25, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this survey study of adults in California, results showed that transgender and gender-diverse individuals, especially transgender men, are at higher risk of experiencing all forms of violence relative to cisgender women. Results highlight the need for gender-affirming violence prevention and intervention services as well as policies that protect transgender and gender-diverse individuals from discriminatory violence.

Corresponding Author: To contact the corresponding author, Sabrina C. Boyce, Ph.D., email boyce.sabrina@berkeley.edu.

 

(doi:10.1001/jamanetworkopen.2024.19137)

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Comparison of No-Test Telehealth and In-Person Medication Abortion

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JUNE 24, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This prospective, observational study found that medication abortion obtained following no-test telehealth screening and mailing of medications was associated with similar rates of complete abortion compared with in-person care with ultrasonography and met prespecified criteria for noninferiority, with a low prevalence of adverse events.

 

Quote from corresponding author Lauren J. Ralph, Ph.D., M.P.H.:

“This is a prospective, observational study comparing patients who received medication abortion care remotely and without ultrasound to those who went in person to a facility and got an ultrasound. Using data from patient surveys and their medical record, we found no differences in effectiveness of medication abortion by how they received the medications, and low prevalence of adverse events across all groups.
“No-test, telehealth medication abortion is as effective as in person care with ultrasound, and safe overall. This model of care should be offered as an option to all pregnant people seeking abortion.
“I hope that these findings are reassuring to both clinicians and patients that medication abortion using no-test, telehealth and mailing of medications is as effective as in person care with ultrasound. These models offer a safe, effective and urgently needed way to overcome logistical and geographic obstacles to accessing abortion today.
“Despite continued efforts to restrict access to medication abortion, for example by requiring in person dispensing of the medications, the research has consistently been clear that medication abortion with no-test eligibility assessment and mailing of medications is just as effective as in person care with ultrasound.”

 

Contact information for Lauren J. Ralph, Ph.D., M.P.H.: email Lauren.Ralph@ucsf.edu. 

 

(doi:10.1001/jama.2024.10680)

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Infant Deaths After Texas’ 2021 Ban on Abortion in Early Pregnancy

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 24, 2024

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About The Study: This study found that Texas’ 2021 ban on abortion in early pregnancy was associated with unexpected increases in infant and neonatal deaths in Texas between 2021 and 2022. Congenital anomalies, which are the leading cause of infant death, also increased in Texas but not the rest of the U.S. Although replication and further analyses are needed to understand the mechanisms behind these findings, the results suggest that restrictive abortion policies may have important unintended consequences in terms of trauma to families and medical cost as a result of increases in infant mortality. These findings are particularly relevant given the recent Dobbs v Jackson Women’s Health Organization U.S. Supreme Court decision and subsequent rollbacks of reproductive rights in many U.S. states.

Corresponding Author: To contact the corresponding author, Alison Gemmill, Ph.D., email agemmill@jhu.edu.

 

(doi:10.1001/jamapediatrics.2024.0885)

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Identifying and Measuring Administrative Harms Experienced by Hospitalists and Administrative Leaders

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Cardiovascular Risk Factors in Childhood and Adulthood and Cardiovascular Disease in Middle Age

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JUNE 24, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of 10,634 participants, childhood risk factors were found to be associated both directly and indirectly to adult cardiovascular disease (CVD), with the largest direct effect seen for body mass index (BMI) and low-density lipoprotein cholesterol. These findings suggest that intervention for childhood risk factors, in particular BMI, is warranted to reduce incidence of adult CVD as it cannot be fully mitigated by risk factor management in adulthood.

Corresponding Author: To contact the corresponding author, Terence Dwyer, M.D., email terence.dwyer@wrh.ox.ac.uk.

 

(doi:10.1001/jamanetworkopen.2024.18148)

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Health Status and Mental Health of Transgender and Gender-Diverse Adults

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 24, 2024

Media advisory: The full study and commentary are linked to this news release.  

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About The Study: Health status, mental health, and health inequities among transgender and gender-diverse adults in the U.S. worsened from 2014 to 2022. This population experienced over 2-fold increases in prevalence of frequent mental distress and depression, while significantly smaller changes were observed among their cisgender counterparts. 

Corresponding Author: To contact the corresponding author, Michael Liu, M.Phil., email mliu02@hms.harvard.edu.

 

(doi:10.1001/jamainternmed.2024.2544)

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Estimated Effectiveness of Pfizer-BioNTech Vaccine Against COVID-19

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 24, 2024

Media advisory: The full study and commentary are linked to this news release.  

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About The Study: The findings of this case-control study reaffirm current recommendations for broad age-based use of annually updated COVID-19 vaccines given that (1) the BNT162b2 XBB vaccine (Pfizer-BioNTech; 2023-2024 formulation) provided statistically significant additional protection against a range of COVID-19 outcomes and (2) older versions of COVID-19 vaccines offered little, if any, long-term protection, including against hospital admission, regardless of the number or type of prior doses received.  

Corresponding Author: To contact the corresponding author, Sara Y. Tartof, Ph.D., M.P.H., email sara.y.tartof@kp.org.

 

(doi:10.1001/jamainternmed.2024.1640)

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Determining Associations Between Intervention Amount and Outcomes for Young Autistic Children

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Social Media Use and Internalizing Symptoms in Clinical and Community Adolescent Samples

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Racial and Ethnic and Rural Variations in Access to Primary Care for Veterans Following the MISSION Act

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Increasing Voter Participation Through Health Care–Based Voter Registration

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

A 5:2 Intermittent Fasting Meal Replacement Diet and Glycemic Control for Adults With Diabetes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JUNE 21, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This randomized clinical trial of Chinese adults with overweight or obesity and with early type 2 diabetes found that an intermittent fasting plan consisting of two nonconsecutive fasting days and five days of habitual intake per week and meal replacement diet (5:2 MR) could improve glycemic outcomes and weight loss in the short term compared with metformin or empagliflozin, making it a promising initial intervention and early management for type 2 diabetes.

Corresponding Author: To contact the corresponding author, Lixin Guo, M.D., email glx1218@163.com.

 

(doi:10.1001/jamanetworkopen.2024.16786)

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Cannabis, Tobacco Use, and COVID-19 Outcomes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JUNE 21, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this cohort study suggest that cannabis use may be an independent risk factor for COVID-19–related complications, even after considering cigarette smoking, vaccination status, comorbidities, and other risk factors. 

Corresponding Author: To contact the corresponding author, Li-Shiun Chen, M.D., M.P.H., Sc.D., email li-shiun@wustl.edu.

 

(doi:10.1001/jamanetworkopen.2024.17977)

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Use of a Financial Incentive Code for In-Home COVID-19 Vaccination of Homebound Older Adults

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Prenatal Maternal Psychological Distress During the Pandemic and Newborn Brain Development

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JUNE 20, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that increased maternal mental health symptoms during the COVID-19 pandemic are associated with subsequent changes in regional brain growth in newborn offspring. 

Corresponding Author: To contact the corresponding author, Nickie Andescavage, M.D., email nniforat@childrensnational.org.

 

(doi:10.1001/jamanetworkopen.2024.17924)

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Healthy Lifestyle and the Likelihood of Becoming a Centenarian

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JUNE 20, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this case-control study of Chinese older adults, adhering to a healthy lifestyle appears to be important even at late ages, suggesting that constructing strategic plans to improve lifestyle behaviors among all older adults may play a key role in promoting healthy aging and longevity. 

Corresponding Authors: To contact the corresponding authors, email Xiang Gao, M.D., Ph.D. (xiang_gao@fudan.edu.cn) and Xiaoming Shi, M.D., Ph.D. (shixm@chinacdc.cn).

 

(doi:10.1001/jamanetworkopen.2024.17931)

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Variation in Postoperative Outcomes Across Federally Designated Hospital Star Ratings

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 18, 2024

Media advisory: The full study and commentary are linked to this news release.

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About The Study: Although Centers for Medicare & Medicaid Services (CMS) hospital star rating was associated with postoperative mortality, serious complications, and readmissions, there was wide variation in surgical outcomes within each star rating group. These findings highlight the limitations of the CMS hospital star rating system as a measure of surgical quality and should be a call for continued improvement of publicly reported hospital grade measures. 

Corresponding Author: To contact the corresponding author, Adrian Diaz, M.D., M.P.H., email adrian.diaz@osumc.edu.

 

(doi:10.1001/jamasurg.2024.1582)

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Multifaceted Intensive Blood Pressure Control Model in Older and Younger Individuals With Hypertension

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State Cannabis Legalization and Trends in Cannabis-Related Disorders in Older Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 18, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: Rates of cannabis-related disorder encounters increased from 2017 through 2022 among Medicare-insured older adults. This study observed the highest rates in states or territories that legalized adult and medical use of cannabis. The results also suggest higher average annual increases in states or territories that legalized medical cannabis.

Corresponding author: To contact the corresponding author, Silvia Perez-Vilar, Ph.D., Pharm.D., email silvia.perezvilar@fda.hhs.gov

 

(doi: 10.1001/jamanetworkopen.2024.17634)

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Availability of Medications for Opioid Use Disorder in Community Mental Health Facilities

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 18, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this study of 450 community outpatient mental health treatment facilities in 20 high-burden states, approximately one-third offered medications for opioid use disorder (MOUD). These results suggest that further study is needed to report MOUD uptake, either through increased prescribing at all clinics or through effective referral models

Corresponding author: To contact the corresponding author, Jonathan Cantor, Ph.D., email jcantor@rand.org.

 

(doi: 10.1001/jamanetworkopen.2024.17545)

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Interpregnancy Interval After Healthy Live Birth and Subsequent Spontaneous Abortion

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Overdose, Behavioral Health Services, and Medications for Opioid Use Disorder After a Nonfatal Overdose

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Parental History of Memory Impairment and β-Amyloid in Cognitively Unimpaired Older Adults

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Financial Incentives and Treatment Outcomes in Adolescents With Severe Obesity

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Electronic Cigarettes vs Varenicline for Smoking Cessation in Adults

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 17, 2024

Media advisory: The full study is linked to this news release.  

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About The Study: This randomized clinical trial found that varenicline and nicotine-containing electronic cigarettes were both effective in helping individuals in quitting smoking conventional cigarettes for up to 6 months. 

Corresponding Author: To contact the corresponding author, Anna Tuisku, Ph.D., email anna.tuisku@lapha.fi.

 

(doi:10.1001/jamainternmed.2024.1822)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Epidemiologic Features of Recovery From SARS-CoV-2 Infection

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JUNE 17, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: More than 1 in 5 adults did not recover within 3 months of SARS-CoV-2 infection in this cohort study. Recovery within 3 months was less likely in women and those with preexisting cardiovascular disease and more likely in those with COVID-19 vaccination or infection during the Omicron variant wave. 

Corresponding Author: To contact the corresponding author, Elizabeth C. Oelsner, M.D., M.P.H., email eco7@cumc.columbia.edu.

 

(doi:10.1001/jamanetworkopen.2024.17440)

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Trends in Private Equity Consolidation in Cardiovascular Care

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

USPSTF Recommendation Statement on Interventions for High BMI in Children and Adolescents

JAMA

EMBARGOED FOR RELEASE: 10:30 A.M. (ET), TUESDAY, JUNE 18, 2024

Media advisory: To contact the U.S. Preventive Services Task Force, email the Media Coordinator at Newsroom@USPSTF.net or call 301-951-9203. The full report and related articles are linked to this news release.

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Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends that clinicians provide or refer children and adolescents 6 years or older with a high body mass index (BMI; at or above the 95th percentile for age and sex) to comprehensive, intensive behavioral interventions. Approximately 19.7% of children and adolescents ages 2 to 19 in the U.S. have a BMI at or above the 95th percentile for age and sex, based on Centers for Disease Control and Prevention growth charts from 2000. The prevalence of high BMI increases with age and is higher among Hispanic/Latino, Native American/Alaska Native, and non-Hispanic Black children and adolescents and children from lower-income families. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this recommendation is consistent with its 2017 recommendation statement on screening for obesity in children and adolescents.

 

(doi:10.1001/jama.2024.11146)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Note: More information about the U.S. Preventive Services Task Force, its process, and its recommendations can be found on the newsroom page of its website.

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Germline CDH1 Variants and Lifetime Cancer Risk

JAMA

EMBARGOED FOR RELEASE: 4 A.M. ET, FRIDAY, JUNE 14, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the International Gastric Cancer Linkage Consortium.

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About The Study: Among families from North America with germline CDH1 P/LP variants, the cumulative risk of gastric cancer was 7% to 10%, which was lower than previously described, and the cumulative risk of breast cancer among female carriers was 37%, which was similar to prior estimates. These findings inform current management of individuals with germline CDH1 variants.

 

Quote from corresponding author Jeremy L. Davis, M.D.:

“We showed that the lifetime risk of cancer, specifically stomach cancer, in people born with CDH1 gene mutations is lower than we previously thought. This is very important to patients because for over 20 years we have recommended prophylactic stomach removal to eliminate the risk of hereditary gastric cancer. Complete stomach removal is a major operation, and life without a stomach has significant, long-lasting consequences.

“We believe these results will help many people save their stomachs. It is important to note that this research was made possible by a commitment to studying a rare disease and by sharing data across institutions.”

Contact information for Jeremy L. Davis, M.D.: email jeremy.davis@nih.gov.

 

(doi:10.1001/jama.2024.10852)

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Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction

JAMA

EMBARGOED FOR RELEASE: 4 A.M. ET, FRIDAY, JUNE 14, 2024

Media advisory: The full study and editorial are linked to this news release. This study is being presented at the Critical Care Reviews Meeting 2024.

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About The Study: The addition of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, to standard care for critically ill patients and acute organ dysfunction did not improve clinical outcomes; however, confidence intervals were wide and could not exclude relevant benefits or harms for dapagliflozin. 

Corresponding Author: To contact the corresponding author, Fernando G. Zampieri, M.D., Ph.D., email fernando.zampieri@einstein.br.

 

(doi:10.1001/jama.2024.10510)

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Cervical Cancer Screening Rates Among Rural and Urban Females

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JUNE 14, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This repeated cross-sectional study found that past-year Papanicolaou testing rates were lower in 2022 than 2019, pointing to a need to increase access to screenings to prevent an uptick in cervical cancer incidence. Rural-vs-urban differences in 2022 indicate a need to specifically target rural females. 

Corresponding Author: To contact the corresponding author, Tyrone F. Borders, Ph.D., email ty.borders@uky.edu.

 

(doi:10.1001/jamanetworkopen.2024.17094)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Pediatric RSV Hospitalizations and Respiratory Support After the Pandemic

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JUNE 13, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study identified a post-pandemic pediatric respiratory syncytial virus (RSV) surge that resulted in markedly increased hospital volumes and advanced respiratory support needs in older children with fewer comorbidities than pre-pandemic seasons. These clinical trends may inform novel vaccine allocation to reduce the overall burden during future RSV seasons.

Corresponding Author: To contact the corresponding authors, email Zachary A. Winthrop, M.D. (zachary.winthrop@childrens.harvard.edu), and Melody G. Duvall, M.D., Ph.D. (melody.duvall@childrens.harvard.edu).

 

(doi:10.1001/jamanetworkopen.2024.16852)

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Longitudinal Trends and Disparities in Diabetic Retinopathy Within an Aggregate Health Care Network

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Insurance Disparities in Quality of Care Among Patients With Head and Neck Cancer

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Association Between Cost Sharing and Naloxone Prescription Dispensing

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JUNE 13, 2024

Media advisory: The full study and editorial are linked to this news release.

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About The Study: The elimination of cost sharing might be associated with increased naloxone dispensing to commercially insured and Medicare patients.

Corresponding Author: To contact the corresponding author, Kao-Ping Chua, M.D., Ph.D., email chuak@med.umich.edu. 

 

(doi:10.1001/jama.2024.8378)

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Neighborhood Deprivation and Breast Cancer Mortality Among Black and White Women

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JUNE 12, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Neighborhood deprivation was associated with increased breast cancer mortality among non-Hispanic white women in this cohort study. Neighborhood racial composition, residential mobility, and rurality did not explain the lack of association among non-Hispanic Black women, suggesting that factors beyond those explored here may contribute to breast cancer mortality in this racial group. 

Corresponding Author: To contact the corresponding author, Lauren E. Barber, Ph.D., email lauren.barber@emory.edu.

 

(doi:10.1001/jamanetworkopen.2024.16499)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Incidence of Dementia Before Age 65 Years Among World Trade Center Attack Responders

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JUNE 12, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.16504?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=061224

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of World Trade Center responders who survived these unique exposures and participated in a longitudinal follow-up study of cognition from 2014 through 2022, when compared with responders with the lowest exposure levels or responders who used personalized protective equipment (PPE), more severe exposure to dust or debris was significantly associated with a higher risk of dementia before 65 years of age. This study suggests that the reliable use of PPE might help prevent the onset of dementia before age 65 years among individuals exposed to an uncontrolled building collapse. Future research is warranted to determine cerebral biomarkers for individuals with exposure-associated dementia.

Corresponding Author: To contact the corresponding author, Sean A. P. Clouston, Ph.D., email sean.clouston@stonybrookmedicine.edu.

 

(doi:10.1001/jamanetworkopen.2024.16504)

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Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock

JAMA

EMBARGOED FOR RELEASE: 4 A.M. ET, WEDNESDAY, JUNE 12, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the Critical Care Reviews Meeting 2024.

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About The Study: Among adults in the intensive care unit who had sepsis or septic shock, the use of prolonged β-lactam antibiotic infusions was associated with a reduced risk of 90-day mortality compared with intermittent infusions. The current evidence presents a high degree of certainty for clinicians to consider prolonged infusions as a standard of care in the management of sepsis and septic shock.

Corresponding Author: To contact the corresponding author, Jason A. Roberts, B.Pharm., Ph.D., email j.roberts@uq.edu.au. 

 

(doi:10.1001/jama.2024.9803)

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Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis

JAMA

EMBARGOED FOR RELEASE: 4 A.M. ET, WEDNESDAY, JUNE 12, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the Critical Care Reviews Meeting 2024.

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About The Study: The observed difference in 90-day mortality between continuous versus intermittent infusions of β-lactam antibiotics did not meet statistical significance in the primary analysis. However, the confidence interval around the effect estimate includes the possibility of both no important effect and a clinically important benefit in the use of continuous infusions in this group of patients.

 

Quote from corresponding author Joel M. Dulhunty, M.D., Ph.D.:

“The BLING III trial provides important evidence to guide antibiotic management and improve outcomes for patients with sepsis. This large randomized clinical trial involved over 7,000 patients with sepsis and compared continuous and short intermittent infusions for two common beta-lactam antibiotics. We found mortality at 90 days was 2% lower and clinical cure was 6% higher in patients receiving continuous infusions.

 

“While the difference in survival was not statistically significant, we conclude that these findings represent a likely clinically important benefit with the use of continuous infusions in adult patients treated for sepsis in the intensive care unit with piperacillin-tazobactam or meropenem.”

 

Contact information for Joel M. Dulhunty, M.D., Ph.D.: email Joel.Dulhunty@health.qld.gov.au.

 

(doi:10.1001/jama.2024.9779)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Global Prevalence of Overweight and Obesity in Children and Adolescents

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 10, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This study’s findings indicated 1 of 5 children or adolescents experienced excess weight and that rates of excess weight varied by regional income and Human Development Index. Excess weight among children and adolescents was associated with a mix of inherent, behavioral, environmental, and sociocultural influences that need the attention and committed intervention of primary care professionals, clinicians, health authorities, and the general public.

Corresponding Author: To contact the corresponding authors, email Kewei Li, Ph.D. (vivian5225133@outlook.com) and Zhihui Li, Ph.D. (rockoliver@vip.sina.com).

 

(doi:10.1001/jamapediatrics.2024.1576)

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Women’s Representation in RCTs Evaluating FDA-Supervised Medical Devices

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Tau Positron Emission Tomography for Predicting Dementia in Individuals With Mild Cognitive Impairment

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Cancer Incidence Trends in Successive Social Generations in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JUNE 10, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this model-based cohort analysis of incident invasive cancer in the general population, decreases in lung and cervical cancers in Generation X may be offset by gains at other sites. Generation X may be experiencing larger per-capita increases in the incidence of leading cancers than any prior generation born in 1908 through 1964. On current trajectories, cancer incidence could remain high for decades.

Corresponding Author: To contact the corresponding author, Philip S. Rosenberg, Ph.D., email rosenbep@mail.nih.gov.

 

(doi:10.1001/jamanetworkopen.2024.15731)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Severe Pediatric Neurological Manifestations With SARS-CoV-2 or MIS-C Hospitalization and New Morbidity

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JUNE 10, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study suggest that children and adolescents with acute SARS-CoV-2 or multisystem inflammatory syndrome in children (MIS-C) and severe neurological manifestations may be at high risk for long-term impairment and may benefit from screening and early intervention to assist recovery. 

Corresponding Author: To contact the corresponding author, Ericka L. Fink, M.D., M.S., email finkel@ccm.upmc.edu.

 

(doi:10.1001/jamanetworkopen.2024.14122)

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Bidirectional Associations of Depressive Symptoms and Cognitive Function Over Time

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 11, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: Greater depressive symptoms were associated with poorer memory at the study baseline and steeper memory change over time. A gradual linear change in depressive symptoms contributed to accelerated memory loss and vice versa, suggesting that psychological mood and memory performance are intrinsically associated.

Corresponding author: To contact the corresponding author, Dorina Cadar, Ph.D., email d.cadar@bsms.ac.uk.

 

(doi: 10.1001/jamanetworkopen.2024.16305)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Sedentary Behaviors, Light-Intensity Physical Activity, and Healthy Aging

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 11, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this cohort study, longer television watching time decreased odds of healthy aging, whereas light-intensity physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) increased odds of healthy aging and replacing sitting watching television with LPA or MVPA, or with sleep in those who slept 7 hours per day or less, was associated with increased odds of healthy aging, providing evidence for rearranging 24-hour behavior to promote overall health.

Corresponding author: To contact the corresponding author, Molin Wang, Ph.D., email mwang@hsph.harvard.edu.

 

(doi: 10.1001/jamanetworkopen.2024.16300)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Race and Ethnicity Representation in Phase 2/3 Oncology Clinical Trial Publications

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2024.1388?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=060724

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 3 P.M. (ET), FRIDAY, JUNE 7, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the Demystifying Long COVID North American Conference 2024. 

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2024.2007?guestAccessKey=face4b31-1b6e-498a-a147-cf6a9dee6986&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=060724

 

About The Study: The results of this randomized clinical trial showed that a 15-day course of nirmatrelvir-ritonavir in a population of patients with postacute sequelae of SARS-CoV-2 infection (PASC) was generally safe but did not demonstrate a significant benefit for improving select PASC symptoms in a mostly vaccinated cohort with protracted symptom duration. Further studies are needed to determine the role of antivirals in the treatment of PASC. 

Corresponding Author: To contact the corresponding authors, email Linda N. Geng, M.D., Ph.D. (geng@stanford.edu) and Upinder Singh, M.D. (usingh@stanford.edu).

 

(doi:10.1001/jamainternmed.2024.2007)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Bariatric Metabolic Surgery vs Glucagon-Like Peptide-1 Receptor Agonists and Mortality

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JUNE 7, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.15392?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=060724

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Bariatric metabolic surgery was associated with greater reduced mortality compared with first-generation glucagon-like peptide-1 receptor agonists (GLP-1RAs) among individuals with a diabetes duration of 10 years or less, mediated via greater weight loss in this cohort study. No differences in the risk for mortality were observed between the treatment modalities among individuals with a longer duration of diabetes, nor in the occurrence of nonfatal major adverse cardiovascular events among all patients. 

Corresponding Author: To contact the corresponding author, Orna Reges, Ph.D., email orna.reges@gmail.com.

 

(doi:10.1001/jamanetworkopen.2024.15392)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Prevalence of Iron Deficiency Using 3 Definitions Among Women in the US and Canada

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JUNE 7, 2024

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.13967?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=060724

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Three definitions of iron deficiency were associated with significantly different prevalence of iron deficiency in women, regardless of self-reported age, pregnancy, or race and ethnicity. Using higher serum ferritin thresholds to define iron deficiency could lead to diagnosis and treatment of more women with iron deficiency and greater reduction of related morbidity. 

Corresponding Author: To contact the corresponding author, James C. Barton, M.D., email bartonjames336@gmail.com.

 

(doi:10.1001/jamanetworkopen.2024.13967)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Home Blood Pressure Telemonitoring and Nurse Case Management in Black and Hispanic Patients With Stroke

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Heavy Lifetime Cannabis Use and Mortality by Sex

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JUNE 6, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.15227?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=060624

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: A positive association between cardiovascular disease mortality and heavy lifetime cannabis use was observed among females in this study. Longitudinal studies are needed in general populations to investigate the potential effects of cannabis on mortality.

Corresponding Author: To contact the corresponding author, Alexandre Vallee, M.D., Ph.D., email al.vallee@hopital-foch.com.

 

(doi:10.1001/jamanetworkopen.2024.15227)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Physical Activity, Cardiovascular Status, Mortality, and Prediabetes in Hispanic and Non-Hispanic Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JUNE 6, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.15094?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=060624

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of U.S. Hispanic or Latino and non-Hispanic adults, lower moderate to vigorous physical activity levels were associated with cardiovascular disease or mortality among participants with normoglycemia but not participants with prediabetes. Adults with prediabetes may benefit from reducing sedentary behavior and improving multiple lifestyle factors beyond improving moderate to vigorous physical activity alone. 

Corresponding Author: To contact the corresponding author, Robert C. Kaplan, Ph.D., email robert.kaplan@einsteinmed.edu.

 

(doi:10.1001/jamanetworkopen.2024.15094)

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Early Implementation of Exercise to Facilitate Recovery After Breast Cancer Surgery

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Large Language Model Capabilities in Perioperative Risk Prediction and Prognostication

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Cannabis Use Reported by Patients Receiving Primary Care in a Large Health System

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JUNE 5, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.14809?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=060524

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Cannabis use and risk of cannabis use disorder were common, and more than three-quarters of patients who reported any cannabis use reported doing so to manage a health-related symptom in this study. These findings suggest that integration of information regarding cannabis use for symptom management could help provide a crucial point-of-care opportunity for clinicians to understand their patients’ risk for cannabis use disorder. 

Corresponding Author: To contact the corresponding author, Marjan Javanbakht, M.P.H., Ph.D., email javan@ucla.edu.

 

(doi:10.1001/jamanetworkopen.2024.14809)

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The Carceral State, Social Disorganization, and Firearm Homicides in Chicago

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 5, 2024

Media advisory: The full study and commentary are linked to this news release.

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About The Study: This study found that higher rates of incarceration were associated with increased rates of firearm homicides among Black communities alone; this association was found to be mediated partially through the density of single-parent households in these areas, suggesting that social disorganization resulting from mass incarceration may perpetuate firearm homicides. Targeted policies addressing mass incarceration and the disparities therein may be a means of reducing urban firearm homicides. 

Corresponding Author: To contact the corresponding author, Michael Poulson, M.D., M.P.H., email mpoulson@bu.edu.

 

(doi:10.1001/jamasurg.2024.1596)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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