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Agent-Based Model of Combined Community- and Jail-Based Take-Home Naloxone Distribution
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Patient Gowns and Dehumanization During Hospital Admission
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Race, Ethnicity, and Sleep in US Children
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, DECEMBER 10, 2024
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.49861?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121024
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study of children’s sleep disparities, racially and ethnically minoritized children exhibited disparities in mean levels and variability of sleep compared with their white peers. These findings suggest that policies and practices should target multiple sleep dimensions among diverse racial and ethnic groups to promote equitable pediatric sleep health.
Corresponding Author: To contact the corresponding author, Yijie Wang, PhD, email yjwang@msu.edu.
(doi:10.1001/jamanetworkopen.2024.49861)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Allostatic Load, Educational Attainment, and Risk of Cancer Mortality Among US Men
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, DECEMBER 10, 2024
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.49855?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121024
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This study highlights the detrimental association of not attaining a high school degree, combined with high allostatic load as a marker of chronic stress, with cancer mortality. Efforts to promote educational attainment and address the underlying social determinants of health are imperative in reducing cancer disparities in this population.
Corresponding Author: To contact the corresponding author, Justin X. Moore, PhD, MPH, email jx.moore@uky.edu.
(doi:10.1001/jamanetworkopen.2024.49855)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Asthma Prevalence in the Disaggregated Multiracial Population of California
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Depression Treatment After a Positive Depression Screen Result
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State Parental Consent Law and Treatment Use Among Adolescents With Depression
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Stress-Related Disorders Among Young Individuals With Surgical Removal of Tonsils or Adenoids
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, DECEMBER 9, 2024
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.49807?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120924
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this cohort study suggest that early-life surgical removal of tonsils or adenoids is associated with a higher future risk of stress-related disorders and highlight a need to understand the role of adenotonsillar diseases or associated health conditions in the development of stress-related psychiatric disorders.
Corresponding Author: To contact the corresponding author, Zhe Zhang, MD, PhD, email zhangzhe@gxmu.edu.cn.
(doi:10.1001/jamanetworkopen.2024.49807)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Health and Lifestyle Factors and Dementia Risk Among Former Professional Soccer Players
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, DECEMBER 9, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cohort study found no evidence that high dementia risk among former professional soccer players was associated with potentially modifiable general health and lifestyle dementia risk factors. These data support continuation of measures directed toward reducing exposure to repetitive head impacts and traumatic brain injury in sport.
Corresponding Author: To contact the corresponding author, William Stewart, MBChB, PhD, email william.stewart@glasgow.ac.uk.
(doi:10.1001/jamanetworkopen.2024.49742)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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RSV Disease Burden and Nirsevimab Effectiveness in Young Children From 2023-2024
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 9, 2024
Media advisory: The full study is linked to this news release.
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About The Study: This analysis documented the continued high burden of medically attended respiratory syncytial virus (RSV)-associated acute respiratory illness among young children in the U.S. Nirsevimab and maternal RSV vaccine uptake was low, but nirsevimab was effective against RSV-associated hospitalization. There is a potential for substantial public health impact with increased and equitable prevention product coverage in future seasons.
Corresponding Author: To contact the corresponding author, Heidi L. Moline, MD, MPH, email ick6@cdc.gov.
(doi:10.1001/jamapediatrics.2024.5572)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Racial and Ethnic and Rural Variations in the Use of Hybrid Prenatal Care in the US
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Stakeholder Perspectives on Randomized Clinical Trials for Children With Poor-Prognosis Cancers
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Drug Overdose Deaths Among Medicaid Beneficiaries
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
Cholesterol, Triglyceride, and Glucose Levels Across Birth Cohorts in the US
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, DECEMBER 6, 2024
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.49481?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120624
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study of 52,000 participants representing 264 million U.S. adults, population-level improvements in total cholesterol and triglyceride levels decelerated and adverse trends in glucose levels accelerated in more recent birth cohorts, which was partially mediated by concurrent increases in body mass index. Public health initiatives that target antecedent health behaviors are needed to improve cardiometabolic health across generations.
Corresponding Author: To contact the corresponding author, Xiaoning Huang, PhD, email jack.huang@northwestern.edu.
(doi:10.1001/jamanetworkopen.2024.49481)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Loneliness and Social Isolation Among US Older Adults
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, DECEMBER 9, 2024
Media advisory: The full study is linked to this news release.
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About The Study: This study found that adults ages 50 to 80 commonly reported loneliness and social isolation. While the pandemic disrupted social connections, rates of loneliness and isolation were substantial both before and after the early pandemic. High rates of loneliness and social isolation occurred in several sociodemographic groups, especially those with self-reported fair or poor physical or mental health.
Corresponding Author: To contact the corresponding author, Preeti N. Malani, MD, MSJ, email pmalani@umich.edu.
(doi:10.1001/jama.2024.23213)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Diversion of Undistributed Pharmaceutical Ketamine in the US
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Discrimination Within the US Ophthalmology Workforce
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Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic
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Satellite-Based and Street-View Green Space and Adiposity in US Children
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, DECEMBER 5, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The results of this cohort study of U.S. children suggest that higher levels of satellite-based normalized difference vegetation index greenness and percentages of street-level green space components (flowers, plants, and fields) were associated with lower adiposity. The findings support the exploration of increasing residential green space levels and adding specific green space components as an urban planning and public health intervention strategy to combat the prevalence of childhood obesity in the U.S.
Corresponding Author: To contact the corresponding author, Li Yi, PhD, email li_yi@hsph.harvard.edu.
(doi:10.1001/jamanetworkopen.2024.49113)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Estimated Reduction in Health Care Spending Associated With Weight Loss in Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, DECEMBER 5, 2024
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study, projected annual savings from weight loss among U.S. adults with obesity were substantial for both Medicare and employer-based insurance.
Corresponding Author: To contact the corresponding author, Kenneth E. Thorpe, PhD, email kthorpe@emory.edu.
(doi:10.1001/jamanetworkopen.2024.49200)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Estimation of Cancer Deaths Averted From Prevention, Screening, and Treatment Efforts, 1975-2020
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, DECEMBER 5, 2024
Media advisory: The full study is linked to this news release.
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About The Study: In this model-based study using population-level cancer mortality data, an estimated 5.94 million cancer deaths were averted for breast, cervical, colorectal, lung, and prostate cancers combined from 1975 to 2020. Prevention and screening accounted for 8 of every 10 averted deaths, and the contribution varied by cancer site. Despite progress, efforts to reduce the U.S. cancer burden will require increased dissemination of effective interventions and new technologies and discoveries.
Corresponding Author: To contact the corresponding author, Katrina A. B. Goddard, PhD, email katrina.goddard@nih.gov.
(doi:10.1001/jamaoncol.2024.5381)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Obstetric Care Access at Rural and Urban Hospitals in the US
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, DECEMBER 4, 2024
Media advisory: The full study is linked to this news release.
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About The Study: Between 2010 and 2022—a time of tremendous attention to maternal health—there was a net loss of hospital-based obstetric care in both rural and urban hospitals across the U.S. In 2010, more than half of rural hospitals and two-thirds of urban hospitals offered obstetric care. Rural hospitals started with lower percentages of hospitals offering obstetrics compared with urban hospitals and experienced a larger increase in the percentage of hospitals without obstetrics.
Corresponding Author: To contact the corresponding author, Katy B. Kozhimannil, PhD, MPA, email Brad Robideau at brobidea@umn.edu.
(doi:10.1001/jama.2024.23010)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Redesigning the Hospital Environment to Improve Restfulness
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Symptom Recovery in Children Ages 5 to 12 With Sport-Related and Non–Sport-Related Concussion
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Duration of Ice Hockey Play and CTE
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Accuracy in Measurement of Infant Formula Powder and Water by Caregivers With and Without a Crying Baby Present
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Racial and Ethnic Disparities in Regulatory Air Quality Monitor Locations in the US
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, DECEMBER 4, 2024
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.49005?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120424
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest regulatory monitor data may not adequately capture air quality exposures for some marginalized race and ethnicity groups, and the consequences of incomplete or uncertain air quality estimates for these communities should be further investigated.
Corresponding Author: To contact the corresponding author, Brenna C. Kelly, MS, email brenna.kelly@utah.edu.
(doi:10.1001/jamanetworkopen.2024.49005)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Outpatient Psychotherapy Among Adults in the US
JAMA Psychiatry
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, DECEMBER 4, 2024
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2024.3903?guestAccessKey=5ab63cdd-d387-44d3-b9cf-8072c5a3efd9&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120424
About The Study: This study found that psychotherapy use increased significantly faster among several socioeconomically advantaged groups and that inequalities were evident in teletherapy access. These trends and patterns highlight a need for clinical interventions and health care policies to broaden access to psychotherapy including teletherapy.
Corresponding Author: To contact the corresponding author, Mark Olfson, MD, MPH, email mo49@cumc.columbia.edu.
(10.1001/jamapsychiatry.2024.3903)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia
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Acceptability of Guidelines to Stop Colon Cancer Screening by Estimated Life Expectancy
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Use of AI in Peer Review Among Top 100 Medical Journals
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Developing and Evaluating Large Language Model–Generated Emergency Medicine Handoff Notes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, DECEMBER 3, 2024
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of 1,600 emergency medicine patient medical records, large language model (LLM)-generated emergency medicine-to-inpatient handoff notes were determined superior compared with physician-written summaries via conventional automated evaluation methods, but marginally inferior in usefulness and safety via a novel evaluation framework. This study suggests the importance of a physician-in-loop implementation design for this model and demonstrates an effective strategy to measure pre-implementation patient safety of LLM models.
Corresponding Author: To contact the corresponding author, Vince Hartman, MS, email vince@abstractivehealth.com.
(doi:10.1001/jamanetworkopen.2024.48723)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Disease Severity Staging System for NOTCH3-Associated Small Vessel Disease, Including CADASIL
JAMA Neurology
EMBARGOED FOR RELEASE: 3 A.M. (ET), FRIDAY, NOVEMBER 29, 2024
Media advisory: The full study is linked to this news release. The study is being presented at the CADASIL meeting 2024.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2024.4487?guestAccessKey=1159cb3b-9fd9-47ed-89c3-ffc0051dcb01&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112924
About The Study: The findings of this study suggest the NOTCH3-associated small vessel disease (NOTCH3-SVD) staging system will help to better harmonize NOTCH3-SVD and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) cohort studies and registries; may improve individualized disease counseling, monitoring, and clinical management; and may facilitate patient stratification in clinical trials.
Corresponding Authors: To contact the corresponding authors, email Gido Gravesteijn, MD, PhD (g.gravesteijn@lumc.nl) and Saskia A. J. Lesnik Oberstein, MD, PhD (lesnik@lumc.nl).
(doi:10.1001/jamaneurol.2024.4487)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Drug Prices Negotiated by Medicare vs US Net Prices and Prices in Other Countries
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Advance Care Planning, End-of-Life Preferences, and Burdensome Care
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Smartphone App–Based Contingency Management and Opioid Use Disorder Treatment Outcomes
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Antiretroviral Drugs for Treatment and Prevention of HIV in Adults: 2024 Recommendations of the International Antiviral Society–USA Panel
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, SUNDAY, DECEMBER 1, 2024
Media advisory: The full article and editorial are linked to this news release.
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About The Article: This narrative review from the International Antiviral Society–USA provides updated 2024 recommendations for HIV treatment and clinical management and HIV prevention. New approaches for treating and preventing HIV offer additional tools to help end the HIV epidemic, but achieving this goal depends on addressing disparities and inequities in access to care.
Corresponding Author: To contact the corresponding author, Rajesh T. Gandhi, MD email RGANDHI@mgh.harvard.edu.
(doi:10.1001/jama.2024.24543)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Characterizing Services Advertised on Crisis Pregnancy Center Websites
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 2, 2024
Media advisory: The full study is linked to this news release.
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About The Study: The findings of this study suggest the need for greater scrutiny of crisis pregnancy center practices, particularly their service provision, provider qualifications, and how these conform with regulations or best practices. A key concern is their promotion of abortion pill reversal, which lacks FDA approval or scientific support and may cause harm.
Corresponding Author: To contact the corresponding author, John W. Ayers, PhD, MA, email ayers.john.w@gmail.com.
(doi:10.1001/jamainternmed.2024.6440)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Implementation of Electronic Triggers to Identify Diagnostic Errors in Emergency Departments
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 2, 2024
Media advisory: The full study and commentary are linked to this news release.
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About The Study: In this retrospective medical record review study, rules-based e-triggers were useful for post hoc detection of missed opportunities in diagnosis in emergency department visits. Interventions to target emergency department work system factors are urgently needed to support patient-clinician encounters and minimize harm from diagnostic errors.
Corresponding Author: To contact the corresponding author, Hardeep Singh, MD, MPH, email hardeeps@bcm.edu.
(doi:10.1001/jamainternmed.2024.6214)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Launch and Postlaunch Price Developments of New Drugs in the US, Germany, and Switzerland
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
Colorectal Cancer Incidence and Mortality After Negative Colonoscopy Screening Results
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Social Vulnerability, Intervention Utilization, and Outcomes in US Adults Hospitalized With Influenza
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Ultraprocessed Food Intake and Psoriasis
JAMA Dermatology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, NOVEMBER 27, 2024
Media advisory: The full study is linked to this news release.
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About The Study: The results of this study showed an association between high ultraprocessed food intake and active psoriasis status. After adjustments for age, body mass index (BMI), alcohol intake, and comorbidities, the results remained significant, suggesting that ultraprocessed food intake has a proinflammatory action separate from high BMI.
Corresponding Author: To contact the corresponding author, Emilie Sbidian, MD, PhD, email emilie.sbidian@aphp.fr.
(doi:10.1001/jamadermatol.2024.4832)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Race and Ethnicity, Gender, and Promotion of Physicians in Academic Medicine
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, NOVEMBER 27, 2024
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study indicate that preferential promotion of white men within academic medicine continues to persist in the new millennium, with racially and ethnically diverse women experiencing greater underpromotion. To achieve a workforce that reflects the diversity of the U.S. population, this study suggests that academic medicine needs to transform its culture and practices surrounding faculty appointments and promotions.
Corresponding Author: To contact the corresponding author, Lauren Clark, MS, email lclark5@kumc.edu.
(doi:10.1001/jamanetworkopen.2024.46018)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Testing and Masking Policies and Hospital-Onset Respiratory Viral Infections
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, NOVEMBER 27, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study, stopping universal masking and SARS-CoV-2 testing was associated with a significant increase in hospital-onset respiratory viral infections relative to community infections. Restarting the masking of health care workers was associated with a significant decrease.
Corresponding Author: To contact the corresponding author, Theodore R. Pak, MD, PhD, email tpak@mgh.harvard.edu.
(doi:10.1001/jamanetworkopen.2024.48063)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Geographic Disparities in Gynecologic Oncology Clinical Trial Availability in the US
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Virtual Home Care for Patients With Acute Illness
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Collaborative Care Model for Patients With Opioid Use Disorder and Mental Illness
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Alcohol Use and Antiobesity Medication Treatment
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, NOVEMBER 26, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cohort study among individuals participating in a weight loss program found that nearly half of those consuming alcohol at baseline decreased their alcohol use after anti-obesity medication initiation. There may be properties of anti-obesity medications that lead to reduced use. For example, naltrexone decreases cravings for alcohol and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may attenuate the rewarding effects of alcohol, similar to food.
Corresponding Author: To contact the corresponding author, Lisa R. Miller-Matero, PhD, email lmatero1@hfhs.org.
(doi:10.1001/jamanetworkopen.2024.47644)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cervical Cancer Mortality Among US Women Younger Than Age 25
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, NOVEMBER 27, 2024
Media advisory: The full study is linked to this news release.
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About The Study: This study found a steep decline in cervical cancer mortality among U.S. women younger than 25 years between 2016 and 2021. This cohort of women is the first to be widely protected against cervical cancer by human papillomavirus (HPV) vaccines. The findings from this study in the context of other published research suggest that HPV vaccination affected the sequential decline in HPV infection prevalence, cervical cancer incidence, and cervical cancer mortality.
Corresponding Author: To contact the corresponding author, Ashish A. Deshmukh, PhD, MPH, email deshmukha@musc.edu.
(doi:10.1001/jama.2024.22169)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Association of Severe Maternal Morbidity With Subsequent Birth
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, NOVEMBER 25, 2024
Media advisory: The full study is linked to this news release.
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About The Study: The findings of this study suggest that women who experience severe maternal morbidity in their first birth are less likely to have a subsequent birth. Adequate reproductive counseling and enhancing antenatal care are crucial for women with a history of severe maternal morbidity.
Corresponding Author: To contact the corresponding author, Eleni Tsamantioti, MD, MMedSc, email eleni.tsamantioti@ki.se.
(doi:10.1001/jama.2024.20957)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Modeling Health and Economic Outcomes of Eliminating Sex Disparities in Youth Physical Activity
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Antihypertensive Deprescribing and Cardiovascular Events Among Long-Term Care Residents
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Psychological Resilience and Frailty Progression in Older Adults
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Wildfire Smoke Exposure and Incident Dementia
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, NOVEMBER 25, 2024
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2024.4058?guestAccessKey=fa5fca5a-bcdf-4801-a2dc-81b6e87b95dd&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112524
About The Study: In this cohort study, after adjusting for measured confounders, long-term exposure to wildfire and non-wildfire fine particulate matter (PM2.5) over a 3-year period was associated with dementia diagnoses. As the climate changes, interventions focused on reducing wildfire PM2.5 exposure may reduce dementia diagnoses and related inequities.
Corresponding Author: To contact the corresponding author, Joan A. Casey, PhD, email jacasey@uw.edu.
(doi:10.1001/jamaneurol.2024.4058)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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COVID-19 Vaccine Reactogenicity Among Young Children
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, NOVEMBER 25, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: No unexpected reactions were identified in this analysis of reactions to COVID-19 vaccines among children. Similar to this study, data from clinical trials and V-safe found that irritability was the most common systemic reaction among children ages 6 months to younger than 2 years, followed by fever and fatigue or sleepiness. In contrast to other studies observing a higher prevalence of reactions after the second COVID-19 vaccine dose, this study observed a higher prevalence after the first dose. This difference may reflect maternal vaccination; the first COVID-19 vaccination in this cohort may be some children’s second immunological encounter with a COVID-19 vaccine.
Corresponding Author: To contact the corresponding author, Andrea J. Sharma, PhD, MPH, email aec4@cdc.gov.
(doi:10.1001/jamanetworkopen.2024.47492)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Generalizability of Clinical Trials of Novel Weight Loss Medications to the US Adult Population
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, NOVEMBER 25, 2024
Media advisory: The full study is linked to this news release.
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About The Study: This study estimates that approximately one-third of U.S. adults without diabetes who were eligible for weight loss treatment with glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GLP-1/GIP) were excluded from clinical trials supporting these medications’ safety and effectiveness. Until there is evidence from high-quality postmarketing studies, the FDA should consider updating labeling to advise caution on generalizing the safety and effectiveness of GLP-1 and GLP-1/GIP to populations excluded from pivotal trials.
Corresponding Author: To contact the corresponding author, Timothy S. Anderson, MD, MAS, email tsander@pitt.edu.
(doi:10.1001/jamainternmed.2024.6340)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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AI and Radiologist Burnout
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US Pediatric Inpatient Care Loss Before and During the COVID-19 Pandemic
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Health Care Utilization With Telemedicine and In-Person Visits in Pediatric Primary Care
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
Hearing Aid Use at the Intersection of Race, Ethnicity, and Socioeconomic Status
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
Disparities by Race and Urbanicity in Online Health Care Facility Reviews
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, NOVEMBER 22, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This serial cross-sectional study observed a significant decrease in positive reviews for health care facilities post-COVID. These findings underscore a disparity in patient experience, particularly in rural areas and areas with the highest proportions of Black and white residents.
Corresponding Author: To contact the corresponding author, Neil K. R. Sehgal, ME, email neilsehgal99@gmail.com.
(doi:10.1001/jamanetworkopen.2024.46890)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Racial and Ethnic Variation in Survival in Early-Onset Colorectal Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, NOVEMBER 22, 2024
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, racial and ethnic disparities in early-onset (before 50 years of age) colorectal cancer mortality were evident, with the highest burden among Native Hawaiian or Other Pacific Islander and non-Hispanic Black individuals. These results provide evidence of the role of social determinants of health in explaining these differences.
Corresponding Author: To contact the corresponding author, Maria Elena Martinez, PhD, email e8martinez@health.ucsd.edu.
(doi:10.1001/jamanetworkopen.2024.46820)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Characteristics of Academic Inventors on Government-Linked US Drug Patents
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A Hearing Intervention and Health-Related Quality of Life in Older Adults
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National and Regional Trends in Police Pursuit Fatalities in the US
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Physical Activity and All-Cause Mortality by Age in 4 Multinational Megacohorts
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, NOVEMBER 21, 2024
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this pooled analysis of cohort studies, the association between physical activity and mortality risk remained consistent across the adult lifespan, which contrasts with other modifiable health factors, for which associations with mortality risk diminished with age. Given these findings, the promotion of regular physical activity is essential at all stages of adult life.
Corresponding Author: To contact the corresponding author, David Martinez-Gomez, PhD, email d.martinez@uam.es.
(doi:10.1001/jamanetworkopen.2024.46802)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Prenatal Diet and Infant Growth From Birth to Age 24 Months
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, NOVEMBER 21, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, a prenatal diet that aligned with the U.S. Dietary Guidelines was associated with reduced patterns of rapid and slow infant growth, known risk factors associated with obesity. Future research should examine whether interventions to improve prenatal diet are also beneficial in improving growth trajectory in children.
Corresponding Author: To contact the corresponding author, Monique M. Hedderson, PhD, email Monique.m.Hedderson@kp.org.
(doi:10.1001/jamanetworkopen.2024.45771)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Obesity Prevention at an Early Age
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, NOVEMBER 21, 2024
Media advisory: The full editorial and related study are linked to this news release.
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About The Article: This editorial places results of the Greenlight Plus trial, recently published by JAMA, in context, including technological interventions and policies to help prevent childhood obesity.
Corresponding Author: To contact the corresponding author, Kevin G. Volpp, MD, PhD, email volpp70@wharton.upenn.edu.
(doi:10.1001/jama.2024.24026)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Alternative LDL Cholesterol–Lowering Strategy vs High-Intensity Statins in Atherosclerotic Cardiovascular Disease
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War Exposure and DNA Methylation in Syrian Refugee Children and Adolescents
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Low-Dose Oral Minoxidil Initiation for Patients With Hair Loss
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Bioengineered Human Arteries for the Repair of Vascular Injuries
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Outdoor Artificial Light at Night and Insomnia-Related Social Media Posts
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Short-Term and Long-Term Mortality Risk After Preterm Birth
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, NOVEMBER 20, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this population-based matched cohort study suggest that individuals born preterm were at an increased risk of death from birth until their third and fourth decades of life, with higher risks as gestational age decreased. Some of these associations may have been partly due to underlying health determinants that affected preterm birth and mortality. These findings suggest that preterm birth should be recognized as a risk factor for mortality and could inform preventive strategies.
Corresponding Author: To contact the corresponding author, Asma M. Ahmed, PhD, MD, MPH, email asahmed@wakehealth.edu.
(doi:10.1001/jamanetworkopen.2024.45871)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Postpartum Depression by Race, Ethnicity, and Prepregnancy BMI
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, NOVEMBER 20, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study, postpartum depression (PPD) diagnosis increased significantly across all racial and ethnic groups and body mass index (BMI) categories over the past decade. While rising PPD may reflect improved screening and diagnosis practices, the persistently high rates highlight the need to develop and implement interventions to prevent the condition while expanding efforts to mitigate the impact of PPD on maternal and child health.
Corresponding Author: To contact the corresponding author, Darios Getahun, MD, PhD, MPH, email darios.t.getahun@kp.org.
(doi:10.1001/jamanetworkopen.2024.46486)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting
JAMA Cardiology
EMBARGOED FOR RELEASE: 9:15 A.M. (ET), SUNDAY, NOVEMBER 17, 2024
Media advisory: The full study is linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
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About The Study: This randomized clinical trial found that partial cardiac denervation was an effective procedure to reduce the occurrence of postoperative atrial fibrillation (POAF) after isolated coronary artery bypass grafting (CABG) without additional postoperative complications. These results suggest that partial cardiac denervation may be a good option for cardiac surgeons to consider for preventing POAF after CABG.
Corresponding Authors: To contact the corresponding authors, email Wei Feng, MD, PhD (fengwei@fuwai.com) and Wei Zhao, MD, PhD (zhaowei_fw@163.com).
(doi:10.1001/jamacardio.2024.4639)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
JAMA Cardiology
EMBARGOED FOR RELEASE: 9:20 A.M. (ET), SUNDAY, NOVEMBER 17, 2024
Media advisory: The full study and editor’s note are linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
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About The Study: In the Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients with Heart Failure (FINEARTS-HF), finerenone reduced the risk of the primary end point similarly in women and men with heart failure with mildly reduced or preserved ejection fraction. Finerenone, a nonsteroidal mineralocorticoid receptor antagonist, had similar tolerability in women and men.
Corresponding Author: To contact the corresponding author, John J. V. McMurray, MD, email john.mcmurray@glasgow.ac.uk.
(doi:10.1001/jamacardio.2024.4613)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Finerenone, Serum Potassium, and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction
JAMA Cardiology
EMBARGOED FOR RELEASE: 9:30 A.M. (ET), SUNDAY, NOVEMBER 17, 2024
Media advisory: The full study and commentary are linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
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About The Study: In patients with heart failure with mildly reduced or preserved ejection fraction, finerenone, a nonsteroidal mineralocorticoid receptor antagonist, resulted in more frequent hyperkalemia and less frequent hypokalemia. However, with protocol-directed surveillance and dose adjustment, clinical benefit associated with finerenone relative to placebo was maintained even in those whose potassium level increased to greater than 5.5 mmol/L.
Corresponding Author: To contact the corresponding author, Scott D. Solomon, MD, email ssolomon@rics.bwh.harvard.edu.
(doi:10.1001/jamacardio.2024.4539)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Kidney Outcomes in Transthyretin Amyloid Cardiomyopathy
JAMA Cardiology
EMBARGOED FOR RELEASE: 12:50 P.M. (ET), SUNDAY, NOVEMBER 17, 2024
Media advisory: The full study is linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
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About The Study: In this retrospective cohort study, decline in kidney function was frequent in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) and was consistently associated with an increased risk of mortality, even after adjusting for established markers of worsening ATTR-CM. eGFR decline represents an independent marker of ATTR-CM disease progression that could guide treatment optimization in clinical practice.
Corresponding Author: To contact the corresponding author, Marianna Fontana, MD, PhD, email m.fontana@ucl.ac.uk.
(doi:10.1001/jamacardio.2024.4578)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Asian American Representation in Medicine by Career Stage and Residency Specialty
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Hospitalization Following Outpatient Diagnosis of RSV in Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, NOVEMBER 19, 2024
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of adults with outpatient medically attended-respiratory syncytial virus (RSV) infections from 3 large deidentified U.S. databases across 6 RSV seasons, approximately 1 in 20 adults experienced all-cause hospitalization within 28 days. The results of this study highlight the public health need for RSV prevention and treatment.
Corresponding Author: To contact the corresponding author, Joshua T. Swan, PharmD, MPH, email swan.joshua@gmail.com.
(doi:10.1001/jamanetworkopen.2024.46010)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Oral Muvalaplin for Lowering of Lipoprotein(a)
JAMA
EMBARGOED FOR RELEASE: 2:52 P.M. ET, MONDAY, NOVEMBER 18, 2024
Media advisory: The full study is linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
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About The Study: Muvalaplin, an oral small molecule lipoprotein(a) inhibitor, reduced lipoprotein(a) measured using intact lipoprotein(a) and apolipoprotein(a)-based assays and was well tolerated. The effect of muvalaplin on cardiovascular events requires further investigation.
Corresponding Author: To contact the corresponding author, Stephen J. Nicholls, MBBS, PhD, email stephen.nicholls@monash.edu.
(doi:10.1001/jama.2024.24017)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Active Surveillance or Watchful Waiting for Intermediate-Risk Prostate Cancer, 2010-2020
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, NOVEMBER 20, 2024
Media advisory: The full study is linked to this news release.
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About The Study: Amid a rising trend of conservative management for prostate cancer, this study found a significant increase in initial active surveillance and watchful waiting for intermediate–risk prostate cancer between 2010 and 2020. This corresponds with evidence of favorable longer-term outcomes and improvements in staging imaging and risk stratification.
Corresponding Author: To contact the corresponding author, Michael S. Leapman, MD, MHS, email michael.leapman@yale.edu.
(doi:10.1001/jama.2024.20580)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Pulmonary Vein Isolation With Optimized Linear Ablation vs Pulmonary Vein Isolation Alone for Persistent AF
JAMA
EMBARGOED FOR RELEASE: 10:45 A.M. ET, MONDAY, NOVEMBER 18, 2024
Media advisory: The full study and editorial are linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
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About The Study: Among patients with persistent atrial fibrillation, linear ablation combined with ethanol infusion of the vein of Marshall in addition to pulmonary vein isolation significantly improved freedom from atrial arrhythmias within 12 months compared with pulmonary vein isolation alone.
Corresponding Authors: To contact the corresponding authors, email Changsheng Ma, MD, (chshma@vip.sina.com) and Chenyang Jiang, MD, (jiangchenyangmail@163.com).
(doi:10.1001/jama.2024.24438)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Gender, Racial, and Ethnic Representation Among US Neurology Faculty
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Food Costs of a Low-Fat Vegan Diet vs a Mediterranean Diet
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Antidiabetic Medication and Asthma Attacks
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Next-Generation Multitarget Stool DNA vs Fecal Immunochemical Test in Colorectal Cancer Screening
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Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a)
JAMA
EMBARGOED FOR RELEASE: 2:40 P.M. ET, MONDAY, NOVEMBER 18, 2024
Media advisory: The full study is linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.21957?guestAccessKey=f0dc38dc-63c0-41f5-a731-77e1e406f2ab&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=111824
About The Study: Zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), was well-tolerated and reduced time-averaged lipoprotein(a) concentration by more than 80% during 36 weeks of treatment in patients with atherosclerotic cardiovascular disease.
Corresponding Author: To contact the corresponding author, Steven E. Nissen, MD, email nissens@ccf.org.
(doi:10.1001/jama.2024.21957)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.
Prevalence of Cardiovascular-Kidney-Metabolic Syndrome Stages by Social Determinants of Health
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, NOVEMBER 18, 2024
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.45309?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=111824
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The results of this study suggest a disproportionate burden of cardiovascular-kidney-metabolic syndrome by social determinants of health and sex. These findings highlight the need to address inequities in cardiovascular-kidney-metabolic syndrome through targeted interventions.
Corresponding Author: To contact the corresponding author, Jie Guo, PhD, email jie.guo@ki.se.
(doi:10.1001/jamanetworkopen.2024.45309)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.
A Nature-Based Intervention and Mental Health of Schoolchildren
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Perspectives on Telemedicine Visits Reported by Patients With Cancer
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Racial and Ethnic Differences in Prostate Cancer Epidemiology Across Disease States in the VA
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Semaglutide Eligibility Across All Current Indications for US Adults
JAMA Cardiology
EMBARGOED FOR RELEASE: 2:30 P.M. (ET), MONDAY, NOVEMBER 18, 2024
Media advisory: The full study is linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2024.4657?guestAccessKey=baa342ec-8c33-4211-98eb-b1ec08d802eb&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=111824
About The Study: A total of nearly 137 million adults, representing more than half of all U.S. adults, are eligible for semaglutide therapy. This exceeds the number of adults eligible for statins (approximately 82 million), currently the most prescribed pharmaceuticals among U.S. adults.
Corresponding Author: To contact the corresponding author, Dhruv S. Kazi, MD, MS, email dkazi@bidmc.harvard.edu.
(doi:10.1001/jamacardio.2024.4657)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Early Adoption of Sodium-Glucose Cotransporter-2 Inhibitor in Patients Hospitalized With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
JAMA Cardiology
EMBARGOED FOR RELEASE: 11:30 A.M. (ET), MONDAY, NOVEMBER 18, 2024
Media advisory: The full study is linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2024.4489?guestAccessKey=035fde61-fae7-4073-90da-14cd7c2a712d&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=111824
About The Study: In this study of discharge prescription of a sodium-glucose cotransporter-2 inhibitor (SGLT2i) among patients hospitalized for heart failure, prescription rates increased substantially within 2 years after publication of clinical trial evidence documenting benefit, although considerable variation in rates was found, highlighting the need to understand strategies used by higher prescribing centers to increase SGLT2i adoption.
Corresponding Author: To contact the corresponding author, Mohammad Abdel Jawad, MD, email abdeljawadmd@gmail.com.
(doi:10.1001/jamacardio.2024.4489)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores
JAMA
EMBARGOED FOR RELEASE: 2:30 P.M. ET, SATURDAY, NOVEMBER 16, 2024
Media advisory: The full study and editorial are linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.23784?guestAccessKey=5f0c3425-c031-4f57-8d41-a33a2be65d21&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=111624
About The Study: Coronary heart disease polygenic risk scores that performed similarly at the population level demonstrated highly variable individual-level estimates of risk. Recognizing that coronary heart disease polygenic risk scores may generate incongruent individual-level risk estimates, effective clinical implementation will require refined statistical methods to quantify uncertainty and new strategies to communicate this uncertainty to patients and clinicians.
Corresponding Author: To contact the corresponding author, Scott M. Damrauer, MD, email Scott.Damrauer@pennmedicine.upenn.edu.
(doi:10.1001/jama.2024.23784)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Heart Failure in Zero Gravity— External Constraint and Cardiac Hemodynamics
JAMA Cardiology
EMBARGOED FOR RELEASE: 3 P.M. (ET), SATURDAY, NOVEMBER 16, 2024
Media advisory: The full study is linked to this news release. This study is being presented at the American Heart Association’s Scientific Sessions 2024.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2024.4596?guestAccessKey=cc31323f-05a3-4b6b-a94e-db97024524f0&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=111624
About The Study: In this case series study, pulmonary artery systolic, diastolic, and mean pressures of 2 participants with obesity and heart failure with preserved ejection fraction were measured at zero gravity during parabolic flight to assess the effect of external constraint on left ventricular filling pressures.
Corresponding Author: To contact the corresponding author, Benjamin D. Levine, MD, email benjaminlevine@texashealth.org.
(doi:10.1001/jamacardio.2024.4596)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.