Long-Term Survival in Patients With Low-Risk Cervical Cancer After Simple, Modified, or Radical Hysterectomy

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 15, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study, long-term survival was similar following simple hysterectomy vs modified radical hysterectomy or radical hysterectomy, supporting the use of simple hysterectomy in select patients with low-risk early-stage cervical carcinoma.

Corresponding Authors: To contact the corresponding authors, email Kathleen M. Darcy, PhD (darcyk@whirc.org) and Christopher M. Tarney (christopher.m.tarney.mil@health.mil).

 

(doi:10.1001/jamanetworkopen.2025.10717)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Early Childhood Food Insecurity and Cardiovascular Health in Young Adulthood

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Psychiatric Prognosis Following Index Suicide Attempts in Early Adolescents

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Long-Term Oncologic Outcome of Breast-Conserving Treatment in Patients With Breast Cancer With BRCA Variants

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Cannabis Use Among Older Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 14, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study of cannabis use in veterans ages 65 to 84, use was common, and more than one-third who used in the past 30 days had any cannabis use disorder. The prevalence of past 30-day cannabis use was close to tobacco use prevalence, and risk factors for cannabis use were similar to those observed in other populations. Frequent and inhaled cannabis use was associated with higher odds of any cannabis use disorder. Routine health screening for cannabis use in Veterans Health Administration clinical settings is necessary to identify older adults with cannabis use.

Corresponding Author: To contact the corresponding author, Vira Pravosud, PhD, MPH, MS, email vira.pravosud@va.gov.

 

(doi:10.1001/jamanetworkopen.2025.10173)

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Glucagon-Like Peptide 1 Receptor Agonists and Mental Health

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 14, 2025

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About The Study: In patients with overweight/obesity and/or diabetes, glucagon-like peptide 1 receptor agonist (GLP1-RA) treatment is not associated with increased risk of psychiatric adverse events or worsening depressive symptoms relative to placebo and is associated with improvements in quality of life, restrained eating, and emotional eating behavior. These findings provide reassurance regarding the psychiatric safety profile of GLP1-RAs and suggest that GLP1-RA treatment contributes to both physical and emotional well-being.

Corresponding Authors: To contact the corresponding authors, email Aureliane C. S. Pierret, MBBChir (a.pierret@nhs.net) and Toby Pillinger, PhD (toby.pillinger@kcl.ac.uk).

 

(10.1001/jamapsychiatry.2025.0679)

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Insurer Exits After the Inflation Reduction Act Part D Redesign

JAMA

EMBARGOED FOR RELEASE: 5:30 P.M. ET, WEDNESDAY, MAY 14, 2025

Media advisory: The full study is linked to this news release. This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting.

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About The Study: In 2023 and 2024, more Part D beneficiaries were affected by their insurer exiting the marketplace than in previous years. This increase could be associated with changes to Medicare Part D from the Inflation Reduction Act (IRA), which increased Part D plan sponsor financial liability. These IRA provisions were designed to lower out-of-pocket costs for Part D beneficiaries, but increased Part D plan exits could lead to more limited coverage options and less competitive Part D marketplaces. 

Corresponding Author: To contact the corresponding author, Christopher L. Cai, MD, email ccai@bwh.harvard.edu.

 

(doi:10.1001/jama.2025.7289)

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Dental and Vision Services Among Veterans in Medicare Advantage vs Traditional Medicare

JAMA

EMBARGOED FOR RELEASE: 4:45 P.M. ET, THURSDAY, MAY 15, 2025

Media advisory: The full study is linked to this news release. This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting.

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About The Study: Although Medicare Advantage (MA) plans offer and directly market supplemental benefits for dental and vision services, veterans enrolled in MA used these services with the same frequency as veterans in traditional Medicare (TM). Moreover, MA plans spent only modestly more on dental services and vision services for veterans than TM, including for emergency dental services. After accounting for private insurance plans used by TM enrollees and out-of-pocket spending, total spending on dental services was no different for veterans in MA vs TM. 

Corresponding Author: To contact the corresponding author, José F. Figueroa, MD, MPH, email jfigueroa@hsph.harvard.edu.

 

(doi:10.1001/jama.2025.7753)

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Incomplete Team Staffing, Burnout, and Work Intentions Among US Physicians

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 5 P.M. (ET), WEDNESDAY, MAY 14, 2025

Media advisory: The full study and editorial are linked to this news release.  This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting. 

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About The Study: In this study, physicians frequently experienced incomplete team staffing. Working with an incompletely staffed team was associated with significantly greater odds of burnout, intent to reduce clinical work hours, and intent to leave one’s current organization (ITL). Given associations between ITL and attrition, these findings emphasize the importance of adequate staffing.  

Corresponding Author: To contact the corresponding author, Lisa S. Rotenstein, MD, MBA, MSc, email lisa.rotenstein@ucsf.edu.

 

(doi:10.1001/jamainternmed.2025.1679)

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Remote Symptom Monitoring With Electronic Patient-Reported Outcomes in Clinical Cancer Populations

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Fentanyl Test Strip Use and Overdose Risk Reduction Behaviors Among People Who Use Drugs

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Stigmatizing and Positive Language in Birth Clinical Notes Associated With Race and Ethnicity

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MAY 13, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study examining clinical notes of more than 18,000 patients admitted for labor and birth, there were notable disparities in how stigmatizing and positive language was documented across racial and ethnic groups. This underscores the necessity for improving documentation and communication practices to reduce the use of stigmatizing language.

Corresponding Author: To contact the corresponding author, Veronica Barcelona, PhD, RN, email vb2534@cumc.columbia.edu.

 

(doi:10.1001/jamanetworkopen.2025.9599)

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African Genetic Ancestry, Structural and Social Determinants of Health, and Mortality in Black Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MAY 13, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study, associations of structural and social determinants of health with mortality persisted with adjustment for percentage African genetic ancestry. The findings support the hypothesis that structural and social determinants of health should be the primary factors to consider for eliminating health disparities.

Corresponding Author: To contact the corresponding author, Hari S. Iyer, ScD, MPH, email hi97@cinj.rutgers.edu.

 

(doi:10.1001/jamanetworkopen.2025.10016)

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Mental Distress Among Females Following 2021 Abortion Restrictions in Texas

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MAY 12, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that Texas’s abortion restrictions were associated with increases in mental distress among females of reproductive age, especially among younger individuals who may have less ability to overcome barriers to abortion care.

Corresponding Author: To contact the corresponding author, Jusung Lee, PhD, email jusung.lee@utsa.edu.

 

(doi:10.1001/jamanetworkopen.2025.9576)

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Landscape of Emergency Medicaid and Health Care Coverage for Undocumented Immigrants in the US

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Sexual Health of US Transgender Boys, Nonbinary Youth, and Cisgender Girls

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Nicotine Pouch Use in Youths and Adults Who Use Cigarettes, E-Cigarettes, and Smokeless Tobacco

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Changes in Physical and Mental Health After the End of SNAP Emergency Allotments

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MAY 12, 2025

Media advisory: The full study is linked to this news release.

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About The Study: After the end of emergency allotments nationwide by March 2023, there were significant increases in food insecurity and poor physical health days among Supplemental Nutrition Assistance Program (SNAP) participants. No changes in poor mental health days or poor or fair health status were observed. 

Corresponding Author: To contact the corresponding author, Rishi K. Wadhera, MD, MPP, MPhil, email rwadhera@bidmc.harvard.edu.

 

(doi:10.1001/jama.2025.6010)

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US Children Living With a Parent With Substance Use Disorder

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 12, 2025

Media advisory: The full study is linked to this news release.

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About The Study: Nearly 19 million children were estimated to be living in a household with at least 1 parent with substance use disorder, accounting for one-quarter of all U.S. children in 2023. Children in such households are more likely to develop adverse health outcomes than their peers without exposure to parental substance use disorder. 

Corresponding Author: To contact the corresponding author, Sean Esteban McCabe, PhD, email plius@umich.edu.

 

(doi:10.1001/jamapediatrics.2025.0828)

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First-Generation and Low-Income Students in the National Medical Student Body

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MAY 12, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study of U.S. medical student matriculants found a decrease in the number of matriculants who were first-generation. These students were at significant risk of attrition from medical school, particularly when considering the intersectionality with low-income and underrepresented in medicine identities. These results suggest a need to recruit and retain these students, so that the physician workforce better reflects the backgrounds and experiences of the communities served.

Corresponding Author: To contact the corresponding author, Sophia C. Kamran, MD, email skamran@mgh.harvard.edu.

 

(doi:10.1001/jamanetworkopen.2025.9769)

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Estimates of Illicit Opioid Use in the US

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MAY 9, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: In this national survey of 1,515 adults conducted in June 2024, 166 respondents (11%) reported illicit opioid use and 114 (7.5%) reported illicitly manufactured fentanyl use within the past 12 months. These rates are much higher than previously reported estimates. The findings highlight the need for more timely and accurate data to inform policy and intervention strategies. Enhanced data collection efforts are essential for understanding and mitigating the opioid crisis.

Corresponding Author: To contact the corresponding author, David Powell, PhD, email dpowell@rand.org.

 

(doi:10.1001/jamahealthforum.2025.0809)

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Behavioral Health Flag Use by Race and Ethnicity in a Pediatric Emergency Department

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Effectiveness and Safety of RSV Vaccine for US Adults Age 60 or Older

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 9, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Vaccine effectiveness (VE) for the respiratory syncytial virus (RSV) protein subunit vaccine in this case-control study was similar to the VE in clinical trials. The VE for immunocompromised patients was mildly (overall) to moderately (for stem cell transplant recipients) diminished. Risk of immune thrombocytopenic purpura after vaccination was not elevated, but the risk of Guilain-Barré syndrome was statistically significantly elevated in patients who received the RSVPreF vaccine but not in those who received RSVPreF+AS01 vaccine, although the risk was small. These observations should inform clinicians’ choices and patient instructions.

Corresponding Author: To contact the corresponding author, Pamela B. Davis, MD, PhD, email pbd@case.edu.

 

(doi:10.1001/jamanetworkopen.2025.8322)

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USPSTF Recommendation on Screening for Syphilis Infection During Pregnancy

JAMA

EMBARGOED FOR RELEASE: 10:30 A.M. (ET), TUESDAY, MAY 13, 2025

Media advisory: To contact the U.S. Preventive Services Task Force, email the Media Coordinator at Newsroom@USPSTF.net or call 301-951-9203. The full report and related articles are linked to this news release.

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Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends early, universal screening for syphilis infection during pregnancy; if an individual is not screened early in pregnancy, the USPSTF recommends screening at the first available opportunity. Untreated syphilis infection during pregnancy can be passed to the fetus, causing congenital syphilis. Congenital syphilis is associated with premature birth, low birth weight, stillbirth, neonatal death, and significant abnormalities in the infant such as deformed bones, anemia, enlarged liver and spleen, jaundice, brain and nerve problems (e.g., permanent vision or hearing loss), and meningitis. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this recommendation is consistent with the 2018 recommendation.

 

(doi:10.1001/jama.2025.5009)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Note: More information about the U.S. Preventive Services Task Force, its process, and its recommendations can be found on the newsroom page of its website.

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Characterization of Research Grant Terminations at the National Institutes of Health

JAMA

EMBARGOED FOR RELEASE: 11:15 A.M. ET, THURSDAY, MAY 8, 2025

Media advisory: The full study is linked to this news release.

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About The Study: Between February 28, 2025, and April 8, 2025, 694 National Institutes of Health (NIH) grants were terminated across 24 of the 26 institutes and centers (including the Office of the Director) that administered active NIH grants. Targeted grant terminations have affected more than $1.8 billion in NIH funding. Terminations were spread across nearly all NIH institutes and centers, although cuts disproportionately impacted the National Institute on Minority Health and Health Disparities (30% of all funding).

Corresponding Author: To contact the corresponding author, Harlan M. Krumholz, MD, SM, email harlan.krumholz@yale.edu.

 

(doi:10.1001/jama.2025.7707)

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Intersystem Medical Error Discovery in Otolaryngology– Head and Neck Surgery

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Depression and Heart Failure in US Veterans

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 8, 2025

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study, depression among veterans was associated with an increased hazard of incident heart failure after controlling for demographic and cardiovascular risk factors. Higher incident heart failure rates in patients with depression remained consistent in an otherwise low-risk cohort.

Corresponding Author: To contact the corresponding author, Evan L. Brittain, MD, MSc, email evan.brittain@vumc.org.

 

(doi:10.1001/jamanetworkopen.2025.9246)

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Experiences of Care and Gaslighting in Patients With Vulvovaginal Disorders

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 8, 2025

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study, a patient-centered measure of adverse experiences in vulvovaginal care was developed. Participants reported common past experiences with gaslighting (a patient’s concerns are dismissed without proper evaluation) and substantial distress; they frequently considered ceasing care. There is an urgent need for education supporting a biopsychosocial, trauma-informed approach to vulvovaginal pain and continued development of validated instruments to quantify patient experiences.

Corresponding Author: To contact the corresponding author, Chailee F. Moss, MD, email chaileem@gmail.com.

 

(doi:10.1001/jamanetworkopen.2025.9486)

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Maternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Ages 2 to 18

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 8, 2025

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of 12,480 mother-offspring pairs, researchers found that pre-pregnancy obesity, gestational diabetes, and hypertensive disorders of pregnancy, alone or in various combinations, were prospectively associated with higher offspring blood pressure at an early age and with an increased rate of blood pressure change from age 2 to 18 years, with the most profound associations with diastolic blood pressure among female offspring and with systolic blood pressure among Black offspring. These findings suggest that protecting pregnant individuals from cardiometabolic risk factors may promote healthier blood pressure in the next generation.

Corresponding Author: To contact the corresponding author, Shohreh F. Farzan, PhD, email sffarzan@usc.edu.

 

(doi:10.1001/jamanetworkopen.2025.9205)

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Clinical and Neuropathological Evaluations of the New Brunswick Neurological Syndrome of Unknown Cause

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 7, 2025

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About The Study: There was no evidence supporting a diagnosis of neurological syndrome of unknown cause (NSUC) in this cohort. The data inclusive of independent examinations and neuropathology strongly supported the presence of several neurodegenerative and non-neurodegenerative conditions. Unfounded concerns that a potentially fatal mystery disease, possibly induced by an environmental toxin, is causing the patients’ neurological symptoms has been amplified in traditional and social media. Second, independent clinical evaluations are needed for any patient given a diagnosis of NSUC.

Corresponding Author: To contact the corresponding author, Anthony E. Lang, MD, email anthony.lang@uhn.ca.

 

(doi:10.1001/jamaneurol.2025.1718)

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Real-Time AI-Assisted Insulin Titration System for Glucose Control in Patients With Type 2 Diabetes

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APOE4, Blood Neurodegenerative Biomarkers, and Cognitive Decline in Community-Dwelling Older Adults

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Reporting and Representation of Race and Ethnicity in Clinical Trials of Pharmacotherapy for Mental Disorders

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 7, 2025

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About The Study: The findings of this meta-analysis suggest that differences in reporting race and ethnicity across geographic locations and underrepresentation of certain racial and ethnic groups in U.S.-based randomized clinical trials highlight the need for international guidelines to ensure equitable recruitment and reporting in clinical trials. 

Corresponding Author: To contact the corresponding author, Alessio Bellato, PhD, email a.bellato@soton.ac.uk.

 

(10.1001/jamapsychiatry.2025.0666)

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Vehicle Age and Driver Assistance Technologies in Fatal Crashes Involving Teen and Middle-Aged Drivers

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 7, 2025

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that older vehicles and those with fewer driver assistance technologies are associated with increased risk of driver death in fatal crashes; thus, teens should drive the safest vehicles available, not older family cars. The findings underscore the urgent need to ensure teens drive safer vehicles to protect their lives.

Corresponding Author: To contact the corresponding author, Jingzhen Yang, PhD, MPH, email ginger.yang@nationwidechildrens.org.

 

(doi:10.1001/jamanetworkopen.2025.8942)

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Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults Age 50 and Older

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 7, 2025

Media advisory: The full study is linked to this news release.

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About The Study: In this phase 3 study, mRNA-1083, an investigational, multicomponent vaccine against seasonal influenza and SARS-CoV-2, met noninferiority criteria and induced higher immune responses than recommended standard care influenza (standard and high dose) and COVID-19 vaccines against all 4 influenza strains (among those ages 50-64), the 3 clinically relevant influenza strains (among those age 65 and older), and SARS-CoV-2 (all ages), with an acceptable tolerability and safety profile.

Corresponding Author: To contact the corresponding author, Amanda K. Rudman Spergel, MD, email Amanda.RudmanSpergel@modernatx.com.

 

(doi:10.1001/jama.2025.5646)

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Physician-and Large Language Model–Generated Hospital Discharge Summaries

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Parenting Training Plus Behavioral Treatment for Children With Obesity

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Conversion Therapy Exposure and Elevated Cardiovascular Disease Risk

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, MAY 6, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this cohort study of sexual and gender minority (SGM) young adults assigned male at birth, exposure to sexual orientation and gender identity change efforts (SOGICE) was associated with adverse cardiovascular health indicators, including elevated diastolic blood pressure and systolic blood pressure, increased systemic inflammation, and higher odds of self-reported hypertension or high blood pressure. These findings underscore the need for public health and policy interventions to enforce and strengthen bans on SOGICE practices. Recognizing the cardiovascular health consequences of SOGICE contributes to addressing SGM health disparities and emphasizes the importance of affirmative care approaches that prioritize the well-being of SGM individuals.

Corresponding author: To contact the corresponding author, Brian Mustanski, Ph.D., R.N., email brian@northwestern.edu.

 

(doi: 10.1001/jamanetworkopen.2025.8745)

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Depressive Symptoms Among US Adults

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 5, 2025

Media advisory: The full study is linked to this news release.  

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About The Study: In this study, the prevalence of depressive symptoms increased substantially among U.S. adults during the COVID-19 pandemic. Worsening mental health trends were concentrated among younger adults. 

Corresponding Author: To contact the corresponding author, Rishi K. Wadhera, MD, MPP, MPhil, email rwadhera@bidmc.harvard.edu.

 

(doi:10.1001/jamainternmed.2025.0993)

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Differences in Abortion Use by Sexual Orientation in 3 National Cohorts

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, MAY 6, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this study using data from retrospectively reported pregnancies from 3 longitudinal cohorts, all sexual minority groups had increased abortion use compared with completely heterosexual participants, and abortion use was heterogeneous; given the higher use of abortion among sexual minority populations, they are more likely to be disproportionately impacted by the narrowing of abortion access in the U.S. after the Supreme Court Dobbs decision. Future research is needed to understand the pathways that contribute to the unique abortion care needs of sexual minority individuals, in order to provide adequate support for abortion seekers.

Corresponding author: To contact the corresponding author, Payal Chakraborty, Ph.D., email pchakraborty@hsph.harvard.edu.

 

(doi: 10.1001/jamanetworkopen.2025.8644)

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Parental Technology Use in a Child’s Presence and Health and Development in the Early Years

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 5, 2025

Media advisory: The full study and editorial are linked to this news release.

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About The Study: Parents’ use of technology in their child’s presence was negatively associated with cognitive and psychosocial outcomes and screen time among young children, although the effect sizes were small. Further research focusing on potential impacts on physical activity, sleep, and motor skills is needed. Understanding these associations is crucial for informing research and guidelines aimed at minimizing the potential negative effects of this phenomenon on early childhood development. 

Corresponding Author: To contact the corresponding author, Marcelo Toledo-Vargas, BPhysio (Hons), email mstv798@uowmail.edu.au.

 

(doi:10.1001/jamapediatrics.2025.0682)

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Prenatal Cannabis Use and Neonatal Outcomes

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 5, 2025

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About The Study: Cannabis use in pregnancy was associated with greater odds of preterm birth, small for gestational age, and low birth weight even after adjusting for co-use of tobacco products, and confidence in these findings increased from low in the prior review to moderate in the current meta-analysis. The findings of this study may help inform patient counseling and future public health policies. 

Corresponding Author: To contact the corresponding author, Jamie O. Lo, MD, email loj@ohsu.edu.

 

(doi:10.1001/jamapediatrics.2025.0689)

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Racial, Ethnic, and Sex Differences in Need and Receipt of Support for Social Needs Among Veterans

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Cost-Effectiveness of Universal Routine Depression Screening for Adolescents in Primary Care

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

State-Level Tax Policy, Cancer Screening, and Mortality Rates in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 2, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study, tax policy was associated with increased state-level cancer screening rates, as well as decreased cancer mortality rates, which mostly benefited white populations, suggesting that state-level policies may contribute to bridging ongoing cancer care gaps.

Corresponding Author: To contact the corresponding author, Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA, email tim.pawlik@osumc.edu.

 

(doi:10.1001/jamanetworkopen.2025.8455)

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Postpartum Care Differences in LGBTQ+ and Non-LGBTQ+ Individuals

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MAY 2, 2025

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: Despite similar access to health insurance, lesbian, gay, bisexual, transgender, queer, and other sexual and gender minority (LGBTQ+) people had large inequities in unmet health care needs and cost-related medication nonadherence in the postpartum year. Results suggested LGBTQ+ people receive lower-quality care in the postpartum period. Although use of pregnancy-related care was comparable, LGBTQ+ individuals used more primary and specialist care and were nearly twice as likely to use the emergency department compared with non-LGBTQ+ people.

Corresponding Author: To contact the corresponding author, Kevin H. Nguyen, PhD, email nguyen@bu.edu.

 

(doi:10.1001/jamahealthforum.2025.0672)

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Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 1, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest a narrowing of racial and ethnic disparities in receipt of ERBB2 (formerly HER2 or HER2/neu)-targeted therapies over time among older Medicare beneficiaries with ERBB2-positive breast cancer. Future research is needed to understand the practices that contributed to the narrowing of racial and ethnic disparities and to develop implementation strategies to effectively improve the quality and equity of breast cancer care.

Corresponding Author: To contact the corresponding author, Utibe R. Essien, MD, MPH, email uessien@mednet.ucla.edu.

 

(doi:10.1001/jamanetworkopen.2025.8086)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Sex- and Race-Specific Prevalence of Hearing Loss Across the Adult Lifespan and Associated Factors

JAMA Otolaryngology–Head & Neck Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 1, 2025

Media advisory: The full study and commentary are linked to this news release.

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About The Study: The prevalence and degree of hearing loss were highest among white male individuals and lowest among Black female individuals in this cohort study of 1,787 adults. Some factors associated with hearing loss, including noise exposure, differed across sex-specific and race-specific groups. Hearing loss is an important public health concern that could be addressed through tailored interventions to reduce its risk across populations.

Corresponding Author: To contact the corresponding author, Lauren K. Dillard, PhD, AuD, email dillalau@musc.edu.

 

(doi:10.1001/jamaoto.2025.0534)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Noninfectious Intraocular Inflammation After Intravitreal Aflibercept

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Gender Differences in Case Volume Among Ophthalmology Resident Graduates

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Positive Emotion Dysregulation in Opioid Use Disorder and Normalization by Mindfulness-Oriented Recovery Enhancement

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Timing of Complementary Feeding in Preterm Infants and Prevalence of Overweight and Obesity

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Tiered Clinician Vaccine Communication Strategy to Improve Childhood Vaccine Uptake

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Generalizability of FDA-Approved AI-Enabled Medical Devices for Clinical Use

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Nicotine Pouch and E-Cigarette Use and Co-Use Among US Youths

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 30, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study, commercial nontobacco nicotine use in U.S. 10th and 12th graders shifted from 2023 to 2024, marked by a doubling in nicotine pouch past-30-day use, an increase in pouch plus e-cigarette dual use, and a decrease in exclusive e-cigarette use. Prioritizing surveillance, regulation, and prevention addressing pediatric nicotine pouch use warrants consideration.

Corresponding Author: To contact the corresponding author, Adam M. Leventhal, PhD, email adam.leventhal@usc.edu.

 

(doi:10.1001/jamanetworkopen.2025.6739)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Wildfire Smoke Exposure and Cause-Specific Hospitalization in Older Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 30, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Exposure to high levels of smoke pollution was associated with an increase in hospitalizations for respiratory diseases in this cohort study. These findings underscore the need for interventions to mitigate the health impacts of wildfire smoke exposure.

Corresponding Author: To contact the corresponding author, Rachel C. Nethery, PhD, email rnethery@hsph.harvard.edu.

 

(doi:10.1001/jamanetworkopen.2025.7956)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

AI-Enabled Screening for Retinopathy of Prematurity in Low-Resource Settings

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Consensus on Adolescent and Young Adult HIV Research Consent in Low- and Middle-Income Countries

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Long-Term Efficacy and Cost-Effectiveness of Laser Tonsillotomy vs Tonsillectomy

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Prenatal and Perinatal Factors of Life’s Essential 8 Cardiovascular Health Trajectories

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, APRIL 29, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Pre-pregnancy overweight or obesity, smoking during pregnancy, and formula-feeding in the first 6 months of life were each associated with adverse cardiovascular health trajectories early in life in this cohort study. Future work should examine whether interventions that address these factors would be effective in optimizing cardiovascular health in children.

Corresponding Author: To contact the corresponding author, Izzuddin M. Aris, PhD, email izzuddin_aris@hphci.harvard.edu.

 

(doi:10.1001/jamanetworkopen.2025.7774)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Maternal Hypertension and Adverse Neurodevelopment in a Cohort of Preterm Infants

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, APRIL 29, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this preterm cohort study, maternal hypertensive disorders of pregnancy were independently associated with adverse cognitive and language development, with accentuated associations observed in preeclampsia-exposed preterm infants, emphasizing the clinical importance of recognizing hypertensive disorders of pregnancy as a risk, enabling targeted risk management strategies for closer monitoring and aggressive early intervention in affected populations.

Corresponding Author: To contact the corresponding author, Nehal A. Parikh, DO, MS, email nehal.parikh@cchmc.org.

 

(doi:10.1001/jamanetworkopen.2025.7788)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Menstrual Cycle Length Changes Following Vaccination Against Influenza Alone or With COVID-19

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, APRIL 29, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of individuals with regular menstrual cycles, influenza vaccine given alone or in combination with a COVID-19 vaccine was associated with a small but temporary change in menstrual cycle length. These findings may help clinicians confirm the utility of vaccination for patients with concerns about menstrual adverse effects of vaccination.

Corresponding Author: To contact the corresponding author, Alison Edelman, MD, MPH, email edelmana@ohsu.edu.

 

(doi:10.1001/jamanetworkopen.2025.7871)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Temporal Trends in the Childhood Opportunity Index at Children’s Hospitals

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Changes in Inhaled Steroid Dispensing to Children After Withdrawal of Brand-Name Fluticasone Propionate

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Toward Defining Problematic Media Usage Patterns in Adolescents

JAMA

EMBARGOED FOR RELEASE: 3:15 P.M. ET, MONDAY, APRIL 28, 2025

Media advisory: The full article is linked to this news release.

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About The Article: This Viewpoint proposes an analogous taxonomy for digital media use that identifies patterns of use, irrespective of content, that could be problematic but, at a minimum, should be flagged as warranting further evaluation and potential remediation.

Corresponding Author: To contact the corresponding author, Dimitri A. Christakis, MD, MPH, email dimitri.christakis@seattlechildrens.org.

 

(doi:10.1001/jama.2025.6113)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Trends in Maternal, Fetal, and Infant Mortality in the US, 2000-2023

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, APRIL 28, 2025

Media advisory: The full study is linked to this news release.

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About The Study: The results of this study suggest that maternal health was difficult to track due to changes in reporting practices, but public health emergencies such as the COVID-19 pandemic can have large negative impacts.

Corresponding Author: To contact the corresponding author, Seth Flaxman, PhD, email seth.flaxman@cs.ox.ac.uk.

 

(doi:10.1001/jamapediatrics.2025.0440)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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All-Cause Mortality and Life Expectancy by Birth Cohort Across US States

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, APRIL 28, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Cohort-specific patterns across states reveal wide disparities in mortality. Some states have experienced little or no improvements in life expectancy from the 1900 to 2000 birth cohorts. Understanding how mortality patterns vary by birth cohort within each state can inform decision-making around resource allocation and public health interventions.

Corresponding Author: To contact the corresponding author, Theodore R. Holford, PhD, email theodore.holford@yale.edu.

 

(doi:10.1001/jamanetworkopen.2025.7695)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, APRIL 29, 2025

Media advisory: The full study is linked to this news release.

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About The Study: Semaglutide and tirzepatide prescriptions within Epic-affiliated health care systems increased slightly between 2021 and 2024, but their uptake remained limited, with only 3% of eligible patients having ever received a prescription during that period. Furthermore, there were disparities in prescribing of varying magnitude based on race and ethnicity, social vulnerability, and urbanicity, although the absolute differences were small compared with the overall underutilization.

Corresponding Author: To contact the corresponding author, Yuan Lu, ScD, email y.lu@yale.edu.

 

(doi:10.1001/jama.2025.4735)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Buprenorphine Treatment in Pregnancy and Maternal-Infant Outcomes

JAMA Health Forum

EMBARGOED FOR RELEASE: 4:45 P.M. (ET), SUNDAY, APRIL 27, 2025

Media advisory: The full study is linked to this news release. This study is being presented at the Pediatric Academic Societies 2025 meeting.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: In this cohort study of pregnant individuals with opioid use disorder, buprenorphine treatment was associated with improved outcomes for the mother and infant, underscoring the need to improve access to treatment nationwide.

Corresponding Author: To contact the corresponding author, Stephen W. Patrick, MD, MPH, MS, email stephen.patrick@emory.edu.

 

(doi:10.1001/jamahealthforum.2025.1814)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Alcohol Use Disorder Diagnoses Among Individuals Who Take HIV Preexposure Prophylaxis

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