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Neurologic Medication Costs in a Direct-to-Consumer Pharmacy vs Commercial Insurance Plans
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Factors Associated With Willingness to Become a Living Organ Donor
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Healthy Food Benefit Programs, Fruit and Vegetable Consumption, and Food Security
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Threats of Weather Disasters for Drug Manufacturing Facilities in the US
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, AUGUST 20, 2025
Media advisory: The full study is linked to this news release.
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About The Study: In this nationwide assessment of the frequency with which climate-related disaster events affected counties with U.S. drug production facilities, researchers determined that nearly two-thirds of all facilities were located in counties that experienced at least one disaster declaration. These disaster events posed risks of disruptions to facilities active in all aspects of the supply chain, from active pharmaceutical ingredient manufacture to packaging, disruptions that could be further magnified by the time needed for Food and Drug Administration reinspection of damaged facilities.
Corresponding Author: To contact the corresponding author, Mahnum Shahzad, PhD, email mahnum_shahzad@g.harvard.edu.
(doi:10.1001/jama.2025.13843)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Differential Use of Depression and Anxiety Medications in Adults With a History of Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 19, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study, cancer survivors were significantly more likely to take medications for depression and anxiety compared with noncancer survivors, underscoring the importance of mental health in cancer. However, the findings suggested disparities associated with this, with non-Hispanic Black patients exhibiting decreased use.
Corresponding Author: To contact the corresponding author, Nosayaba Osazuwa-Peters, BDS, PhD, MPH, CHES, email nosa.peters@duke.edu.
(doi:10.1001/jamanetworkopen.2025.27585)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Changes in Medicare Part D Plan Designs After the Inflation Reduction Act
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Universal Pharmacare and Contraceptive Dispensations Among Youth
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Hemorrhoidal Disease – A Review
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Conflicts of Interest in Federal Vaccine Advisory Committees
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Stapokibart for Severe Uncontrolled Chronic Rhinosinusitis With Nasal Polyps
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, MONDAY, AUGUST 18, 2025
Media advisory: The full study and editorial are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.12515?guestAccessKey=3d50dfd6-5eae-4dc7-9a7c-dc565d9f5f21&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=081825
About The Study: Among patients with severe chronic rhinosinusitis with nasal polyps treated with a daily intranasal corticosteroid, stapokibart, a novel monoclonal antibody, reduced polyp size and severity of nasal symptoms at 24 weeks.
Corresponding Authors: To contact the corresponding authors, email Luo Zhang, MD, (dr.luozhang@139.com) and Chengshuo Wang, MD, (wangcs830@126.com).
(doi:10.1001/jama.2025.12515)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Prices and Affordability of Essential Medicines in 72 Low-, Middle-, and High-Income Markets
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, AUGUST 15, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: The results of this cross-sectional analysis showed significant variation in the prices and affordability of 549 essential medicines across 72 markets in 2022. Strategies to promote equitable drug prices and improve drug affordability are urgently needed.
Corresponding Author: To contact the corresponding author, Olivier J. Wouters, PhD, email olivier_wouters@brown.edu.
(doi:10.1001/jamahealthforum.2025.2043)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Suicidal Behavior in US Army Special Operations Forces
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Little Cigar and Cigarillo Graphic Health Warnings and Quitting Behaviors
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Brain Abnormalities in Children Exposed Prenatally to the Pesticide Chlorpyrifos
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Breastfeeding, Prepubertal Adiposity, and Development of Precocious Puberty
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Smartwatch Use and Physician Well-Being
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Digital Biometric Measures in Long COVID
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Symptom Burden in Adolescents and Young Adults With Cancer
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Reducing Barriers to Mental Health Care for Physicians – An Overview and Strategic Recommendations
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Over-the-Counter Oral Contraceptive Use and Initiation of Contraception
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, AUGUST 18, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.27438?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=081825
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study of U.S. individuals obtaining oral contraception, the oral contraceptive pill was accessed over-the-counter (OTC) by many who previously used no method or less-effective contraception. These findings suggest that OTC access may improve equitable access to contraception.
Corresponding Author: To contact the corresponding author, Maria I. Rodriguez, M.D., M.P.H., email rodrigma@ohsu.edu.
(doi: 10.1001/jamanetworkopen.2025.27438)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in the Proportion of US and International Medical Graduates at the County Level
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Self-Reported Hearing Aid Use and Risk of Incident Dementia
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 18, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time. https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2025.2713?guestAccessKey=a1f9c4ab-a0ae-4ca9-afa5-cb8c5e77afc3&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=081825
About The Study: Study participants with hearing loss with hearing aids showed reduced risk for dementia among those younger than age 70 at the time of hearing evaluation, when followed up for up to 20 years. This finding highlights the importance of early intervention for hearing loss for possible prevention of dementia.
Corresponding Author: To contact the corresponding author, Sudha Seshadri, M.D., email seshadri@uthscsa.edu.
(doi: 10.1001/jamaneurol.2025.2713)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Developing Competencies to Advance Health Care Access and Quality for Latino, Hispanic, and Spanish Origin Populations
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State-Level Public Awareness of HPV, HPV Vaccine, and Association With Cancer
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, AUGUST 14, 2025
Media advisory: The full study is linked to this news release.
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About The Study: In this cross-sectional study, public awareness about human papillomavirus (HPV), HPV vaccination, and the link between HPV and cancers was overwhelmingly low, particularly in Midwestern and Southern U.S. states. These findings are troubling because these regions have recently seen a marked rise in HPV-associated cancers. Notably, the lack of HPV and HPV vaccine awareness in the Midwest and South is alarming, as a majority of states in these regions have suboptimal HPV vaccination rates.
Corresponding Author: To contact the corresponding author, Kalyani Sonawane, PhD, email sonawane@musc.edu.
(doi:10.1001/jamaoncol.2025.2638)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Ocular Adverse Events With Semaglutide
JAMA Ophthalmology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, AUGUST 14, 2025
Media advisory: The full study and commentary are linked to this news release.
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About The Study: The findings of this study suggest that semaglutide was not associated with an increased risk of eye disorders or diabetic retinopathy. Despite the fact that an association between semaglutide treatment and nonarteritic anterior ischemic optic neuropathy (NAION) was found, current evidence remains insufficient to establish definitive conclusions regarding its association with NAION. Further studies with larger sample sizes and adequate evaluation of NAION are warranted to clarify this potential risk.
Corresponding Author: To contact the corresponding author, Fernando Gerchman, MD, PhD, email fgerchman@hcpa.edu.br.
(doi:10.1001/jamaophthalmol.2025.2489)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Glucagon-Like Peptide-1 Receptor Agonists in Hidradenitis Suppurativa
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Cigarette Smoking During Recovery From Substance Use Disorders
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Benzodiazepine Prescribing Patterns Following Mass Traumatic Events
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Electric Fan Use With Dehydration in Extreme Heat and Humidity
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Fatalism and Interest in Cancer Screening Among African American Individuals
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Gauging the Magnitude of Missed Opportunity for Ovarian Cancer Prevention
JAMA Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, AUGUST 13, 2025
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2025.2810?guestAccessKey=bea96908-5a9b-4f7e-a179-70b7827a29af&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=081325
About The Study: In this study, a considerable proportion of patients with high-grade serous cancer missed opportunities for risk assessment with genetic testing and for surgical prevention. Given the lack of effective screening and limited treatment options for high-grade serous cancer, eradicating it requires addressing the full spectrum of missed opportunities.
Corresponding Author: To contact the corresponding author, Rebecca L. Stone, MD, email rstone15@jhmi.edu.
(doi:10.1001/jamasurg.2025.2810)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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County-Level Cervical Cancer Screening Coverage and Differences in Incidence and Mortality
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, AUGUST 13, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.26709?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=081325
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This study found a nearly two-fold higher cervical cancer incidence, late-stage diagnosis, and mortality in counties with repeatedly low vs high cervical cancer screening coverage. Most counties with repeat low coverage were rural and lower income.
Corresponding Author: To contact the corresponding author, Trisha L. Amboree, PhD, MPH, email amboree@musc.edu.
(doi:10.1001/jamanetworkopen.2025.26709)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Dalbavancin for Treatment of Staphylococcus aureus Bacteremia
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Minimal vs Specialized Exercise Equipment for Pulmonary Rehabilitation
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Work Impairment and Financial Outcomes Among Adults With vs Without Long COVID
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 12, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this prospective cohort study of adults with SARS-CoV-2 infection, participants with current self-reported long COVID (defined as developing new, persistent symptoms lasting 3 months or longer after SARS-CoV-2 infection) reported worse work impairment, missed work, and financial distress compared with those who never had long COVID, while vaccination was associated with improved work outcomes and less financial distress even among individuals with long COVID. These data underscore the need for post-pandemic assistance programs, as well as vaccination to decrease societal harms.
Corresponding Author: To contact the corresponding author, Michael Gottlieb, MD, email MichaelGottliebMD@Gmail.com.
(doi:10.1001/jamanetworkopen.2025.26310)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Hospital Financial Health and Provision of Obstetric and Neonatal Intensive Care Unit Services
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 12, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, worse hospital financial health was associated with decreased likelihood of providing perinatal services. These hospitals were more frequently located in southern and rural areas.
Corresponding Author: To contact the corresponding author, Elizabeth G. Salazar, MD, MSHP, email salazare@chop.edu.
(doi:10.1001/jamanetworkopen.2025.26418)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Variability in Long COVID Definitions and Validation of Published Prevalence Rates
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Multidimensional Assessment of Gender Diversity in a Large National Sample of US Early Adolescents
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Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis
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Sex Differences in Mortality and Health Care Utilization After Dementia Diagnosis
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Trends and Disparities in Technology Use and Glycemic Control in Type 1 Diabetes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, AUGUST 11, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study, there was a rapid increase in the use of diabetes technology and notable improvements in glycemic control among youths and adults with type 1 diabetes during the past 15 years. Nonetheless, the prevalence of glycemic control remained low, and racial, ethnic, and socioeconomic differences grew over time.
Corresponding Author: To contact the corresponding author, Jung-Im Shin, MD, PhD, email jshin19@jh.edu.
(doi:10.1001/jamanetworkopen.2025.26353)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, AUGUST 11, 2025
Media advisory: The full study and editorial are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study of patients with type 2 diabetes who had no prior eye disorders, patients prescribed semaglutide or tirzepatide had an increased risk of nonarteritic anterior ischemic optic neuropathy and other optic nerve disorders, although the overall risk was low. These findings highlight the need for close monitoring of these conditions.
Corresponding Author: To contact the corresponding author, Rong Xu, PhD, email rxx@case.edu.
(doi:10.1001/jamanetworkopen.2025.26327)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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GLP-1 Receptor Agonists and Sight-Threatening Ophthalmic Complications in Patients With Type 2 Diabetes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, AUGUST 11, 2025
Media advisory: The full study and editorial are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of individuals with type 2 diabetes (T2D), glucagon-like peptide-1 receptor agonist (GLP-1 RA) use was associated with a modestly increased risk of incident diabetic retinopathy (DR); however, fewer patients experienced sight-threatening DR complications, including blindness, even among those with preexisting DR. These findings suggest that all patients with T2D treated with GLP-1 RAs, regardless of preexisting DR, should be regularly screened and monitored for potential complications of T2D.
Corresponding Author: To contact the corresponding author, Sarju Ganatra, MD, email sarju.ganatra@lahey.org.
(doi:10.1001/jamanetworkopen.2025.26321)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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In Utero Embolization for Fetal Vein of Galen Malformation
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Sex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium
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Rural and Urban Differences in Prostate Cancer Recurrence
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Trends in Labor After Cesarean Delivery Access in the US
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Provision of Abortion Medications Using Online Asynchronous Telemedicine Under Shield Laws in the US
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, MONDAY, AUGUST 11, 2025
Media advisory: The full study and editorial are linked to this news release.
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About The Study: This study analyzes use of online asynchronous telemedicine abortion services for the period July 2023 through September 2024 via data from a nonprofit asynchronous telemedicine service that provides abortion medications throughout the U.S.
Corresponding Author: To contact the corresponding author, Abigail R. A. Aiken, PhD, email araa2@utexas.edu.
(doi:10.1001/jama.2025.11420)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Prescription Drug Utilization and Spending by Race, Ethnicity, Payer, Health Condition, and US State
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, AUGUST 8, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: In this cross-sectional study of 143 health conditions among persons in 50 states and Washington, DC, per capita pharmaceutical use was highest among white populations and lowest among Asian or Pacific Islander and Hispanic populations. However, after standardizing for age and disease prevalence (for 52 conditions with available data), prescription fills were substantially lower for Black populations relative to the all-population mean. These patterns varied by state, highlighting the need for local- and condition-specific approaches to advancing pharmacoequity in the U.S.
Corresponding Author: To contact the corresponding author, Maitreyi Sahu, PhD, email msahu@uw.edu.
(doi:10.1001/jamahealthforum.2025.2329)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, AUGUST 8, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of adults prescribed semaglutide, initiation was associated with reductions in weight and cardiovascular risk factors but increases in health care expenditures, excluding semaglutide costs. These findings suggest potential clinical benefits in routine practice, while highlighting the need to evaluate the long-term impact of semaglutide on economic outcomes.
Corresponding Authors: To contact the corresponding authors, email Jason Abaluck, PhD, (jason.abaluck@yale.edu) and Yuan Lu, ScD, (y.lu@yale.edu).
(doi:10.1001/jamanetworkopen.2025.26013)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours
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Politicians as Clinicians – Skrmetti and Supreme Court–Sanctioned Intrusion on the Practice of Medicine
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Public Health and Ethical Risks of Rollbacks on Medicaid Coverage for Gender-Affirming Care
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Geroscience – A Review
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Donation Physician Specialists and Missed Organ Donation Opportunities
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Lymphomas of the Breast After Postmastectomy Implant-Based Breast Reconstruction
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Demographics, Lifestyle, Comorbidities, Prediabetes, and Mortality
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, AUGUST 7, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Stratified analyses in this study revealed that prediabetes was significantly associated with mortality only among younger adults (ages 20-54), highlighting the importance of age-specific interventions. Lifestyle behaviors, limited health care access, and life stage challenges may contribute to the increased mortality risk in younger adults. Early-onset health problems in this group may also reflect stronger genetic predispositions, leading to more rapid disease progression and more severe health outcomes. These findings underscore the need for tailored diabetes prevention programs targeting young adults—such as flexible, virtual, and peer-led options—to increase accessibility and engagement. Routine screening and timely referrals to age-appropriate programs are essential.
Corresponding Author: To contact the corresponding author, Leonard E. Egede, MD, MS, email legede@buffalo.edu.
(doi:10.1001/jamanetworkopen.2025.26219)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cost-Effectiveness of 2023-2024 COVID-19 Vaccination in US Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, AUGUST 7, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this modeling study, economic favorability of COVID-19 vaccination varied by age. Cost-effectiveness results for individuals in the 2 older age groups were favorable and generally robust to changes in parameter inputs, while results for the younger age group were sensitive to parameter input changes. As the evidence base for COVID-19 vaccination and burden of illness evolves, it may be important to continue to update and revise the economic evaluation of vaccination. The Advisory Committee on Immunization Practices considered these results in its decision to recommend vaccination with the 2023 to 2024 COVID-19 mRNA vaccines.
Corresponding Author: To contact the corresponding author, Lisa A. Prosser, PhD, email lisapros@umich.edu.
(doi:10.1001/jamanetworkopen.2025.23688)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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The Health Impact of Wildfires in Los Angeles County and Maui
JAMA and JAMA Network Open
EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, AUGUST 6, 2025
Media advisory: The full studies and editorial are linked to this news release.
About The Studies: JAMA and JAMA Network Open are publishing studies examining the health impact of wildfires in Los Angeles County in January 2025 and in Maui in August 2023. Among the findings:
JAMA
Excess Deaths Attributable to the Los Angeles Wildfires
While there were only 30 direct fatalities from the Los Angeles wildfires, this study estimates that 440 deaths from January 5 to February 1, 2025, were attributable to the wildfires. These additional deaths likely reflect a combination of factors, including increased exposure to poor air quality and health care delays and interruptions.
Corresponding Author: To contact the corresponding author, Andrew C. Stokes, PhD, email acstokes@bu.edu.
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JAMA
Increases in Suicides and Overdoses During the 2023 Wildfires in Maui
The results of this study show that the 2023 Maui wildfires had immediate effects on suicide and overdose deaths in Maui and across the Hawaiian Islands broadly. The latter finding suggests that direct exposure to the wildfires may have increased risk of suicide and overdose death among Maui residents who migrated to neighboring islands during or after the fires.
Corresponding Author: To contact the corresponding author, Jonathan Purtle, DrPH, email jonathan.purtle@NYU.edu.
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JAMA Network Open
Health and Social Support in the Aftermath of the Maui Wildfires
In this cohort study of adults affected by the Maui wildfires, substantial midterm cardiopulmonary and psychological health burdens were observed. Higher social support was associated with improved mental health outcomes but did not appear to buffer physiological outcomes such as reduced lung function. These findings highlight the need for disaster response models that integrate clinical surveillance, targeted mental health interventions, and culturally anchored community-based support. As climate-driven disasters intensify, proactive strategies to monitor and mitigate their long-term health effects will be essential to protect vulnerable populations and enhance resilience.
Corresponding Author: To contact the corresponding author, Ruben Juarez, PhD, email rubenj@hawaii.edu.
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Editor’s Note: Please see the articles for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.
AI–Augmented Human Instruction and Surgical Simulation Performance
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Alcohol and Cancer Risk
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Blood Pressure Measurements From Self-Service Health Kiosks in US Retail Stores
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Mental Health Outcomes in Transgender and Nonbinary People – A Review
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Guided Internet-Based Cognitive Behavior Therapy for Women With Bulimia Nervosa
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Unsolicited Patient Complaints and Industry Payments for US Physicians
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Incidence, Prevalence, and Stability of Remission in Individuals With Clinical High Risk for Psychosis
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Rapid Access to Emergency Medical Services Within Historically Redlined Areas
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 5, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study, structural disparities in rapid emergency medical services (EMS) access were associated with historically redlined areas. Strategic resource allocation and system redesign are warranted to address these inequities in prehospital emergency care.
Corresponding Author: To contact the corresponding author, Cherisse Berry, MD, email cherisse.berry@rutgers.edu.
(doi:10.1001/jamanetworkopen.2025.25681)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Racial Differences in Screening Eligibility by Breast Density After State-Level Insurance Expansion
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 5, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.25216?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=080525
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that policies for insurance coverage of supplemental screening based on breast density may have limited ability to improve early detection for Black women.
Corresponding Author: To contact the corresponding author, Anne Marie McCarthy, ScM, PhD, email annemcc@pennmedicine.upenn.edu.
(doi:10.1001/jamanetworkopen.2025.25216)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Ecolabels and the Healthfulness and Carbon Footprint of Restaurant Meal Selections
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Medicaid Payments and Racial and Ethnic Disparities in Alzheimer Disease Special Care Units
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Adolescent BMI, Weight Trajectories to Adulthood, and Osteoporosis Risk
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Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression
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Glucagon-Like Peptide-1 Receptor Agonist Eligibility Among US Adolescents and Young Adults
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 4, 2025
Media advisory: The full study and editorial are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2025.2308?guestAccessKey=f2bc51d5-0648-430b-a9be-0407aedaa88c&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=080425
About The Study: This study found that nearly 17 million adolescents and young adults were eligible for glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy. One in 5 young adults eligible for GLP-1RAs were uninsured and one-third denied having a routine place for health care—a barrier to identifying, treating, and preventing cardio-kidney-metabolic diseases.
Corresponding Author: To contact the corresponding author, Ashwin K. Chetty, BS, email ashwin.chetty@yale.edu.
(doi:10.1001/jamapediatrics.2025.2308)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Oral Semaglutide in an East Asian Population With Overweight or Obesity, With or Without Type 2 Diabetes
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 4, 2025
Media advisory: The full study and editor’s note are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2025.3599?guestAccessKey=99e30b83-caf2-456c-a6d6-e5a95aa2c22a&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=080425
About The Study: In this randomized clinical trial, among East Asian adults with overweight or obesity, with or without type 2 diabetes, oral semaglutide, 50 mg, led to a superior and clinically meaningful reduction in body weight compared with placebo, with a safety profile consistent with the glucagon-like peptide-1 receptor agonist class.
Corresponding Authors: To contact the corresponding authors, email Takashi Kadowaki, MD, PhD, (t-kadowaki@toranomon.kkr.or.jp) and Kyoung-Kon Kim, MD, PhD, (zaduplum@gilhospital.com).
(doi:10.1001/jamainternmed.2025.3599)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Influenza With and Without Oseltamivir Treatment and Neuropsychiatric Events Among Children and Adolescents
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 4, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2025.1995?guestAccessKey=11df0d27-af92-4125-9b4f-79882c523cc7&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=080425
About The Study: In this cohort study, oseltamivir treatment during influenza episodes was associated with a reduced risk of serious neuropsychiatric events among children and adolescents. These findings support oseltamivir use for prevention of these influenza-related complications.
Corresponding Author: To contact the corresponding author, James W. Antoon, MD, PhD, MPH, email james.antoon@vumc.org.
(doi:10.1001/jamaneurol.2025.1995)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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New Research on Colorectal Cancer Incidence, Screening Among Younger US Adults
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, MONDAY, AUGUST 4, 2025
Media advisory: The full studies and editorial are linked to this news release.
About The Studies: This issue of JAMA includes three studies on colorectal cancer incidence and screening among younger U.S. adults. In summary:
Colorectal Cancer Incidence in US Adults After Recommendations for Earlier Screening
After a stable 15-year trend, local-stage colorectal cancer (CRC) incidence increased steeply in adults ages 45 to 49 during 2019-2022, including a 50% relative increase between 2021 and 2022. This trend contrasts with consistent increases of distant-stage diagnoses in this age group and likely reflects diagnosis of prevalent asymptomatic cancer through first-time screening due to recommendations for adults to begin screening at age 45 instead of age 50.
Corresponding Author: To contact the corresponding author, Elizabeth J. Schafer, MPH, email elizabeth.schafer@cancer.org.
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Trends in Colorectal Cancer Screening in US Adults Ages 45 to 49
From 2019 to 2023, CRC screening increased among U.S. adults ages 45 to 49, consistent with a previous report among certain commercially insured adults ages 45 to 49 in late 2021-2022. This trend is encouraging because screening reduces CRC mortality, mostly through the detection and removal of potentially precancerous lesions.
Corresponding Author: To contact the corresponding author, Jessica Star, MA, MPH, email jessica.star@cancer.org.
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Population Health Colorectal Cancer Screening Strategies in Adults Ages 45 to 49
In a randomized clinical trial to determine the most effective population health outreach strategy to promote colorectal cancer screening in adults ages 45 to 49, the 3 strategies requiring active choice through the electronic patient portal were significantly less effective than default unsolicited mailed fecal immunochemical test (FIT) outreach. Overall screening rates were low, underscoring the need for more effective strategies to engage this age group.
Corresponding Author: To contact the corresponding author, Folasade P. May, MD, PhD, MPhil, email fmay@mednet.ucla.edu.
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Editor’s Note: Please see the articles for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.
Projected Savings From Reducing Low-Value Services in Medicare
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Difference in the Cancer Burden and Current Funding of NCI-Designated Cancer Centers
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Implementation of a Statewide Fentanyl Possession Law and Opioid-Related Overdose Deaths
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Online Reviews of Health Care Facilities
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, AUGUST 1, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional analysis, negative patient experiences frequently centered on quality of communication and administrative issues. Negative feedback centered on unmet expectations, whereas positive reviews emphasized supportive staff interactions.
Corresponding author: To contact the corresponding author, Neil K.R. Sehgal, M.E., email neilsehgal99@gmail.com.
(doi: 10.1001/jamanetworkopen.2025.24505)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Smartphone Engagement During School Hours Among US Youths
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, AUGUST 1, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cross-sectional study found that when adolescents had their phones at school, they spent nearly an hour per school day on smartphones, with most of this time on social media. The results extend prior work indicating that smartphone use during instructional hours, especially social-specific use, is not trivial. These results also highlight developmental differences, with younger adolescents using smartphones and social media less than older adolescents.
Corresponding author: To contact the corresponding author, Scott H. Kollins, Ph.D., email scott@aura.com.
(doi: 10.1001/jamanetworkopen.2025.23991)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Reporting Guideline for Chatbot Health Advice Studies
JAMA Network Open
EMBARGOED FOR RELEASE: 7 A.M. ET, FRIDAY, AUGUST 1, 2025
Media advisory: The full article is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Article: The rise in chatbot health advice studies is accompanied by heterogeneity in reporting standards, impacting their interpretability. This article provides reporting recommendations for studies evaluating the performance of generative artificial intelligence (AI)–driven chatbots when summarizing clinical evidence and providing health advice. This article is being published jointly in Artificial Intelligence in Medicine, Annals of Family Medicine, BJS, BMC Medicine, BMJ Medicine, JAMA Network Open, The Lancet, NEJM-AI, and Surgical Endoscopy.
Corresponding Author: To contact the corresponding author, Bright Huo, MD, BScPharm, email brighthuo@dal.ca.
(doi:10.1001/jamanetworkopen.2025.30220)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Nationwide Analysis of Legal Barriers to Cancer Care
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Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring
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Proportional Sedation for Persistent Agitated Delirium in Palliative Care
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GLP-1 RAs and Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Older Patients With Diabetes
JAMA Ophthalmology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JULY 31, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2025.2299?guestAccessKey=42f1da5f-87cc-4855-bc01-b68f5185be01&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=073125
About The Study: This study of Medicare enrollees age 65 or older with type 2 diabetes found an association between semaglutide use and an increased risk of nonarteritic anterior ischemic optic neuropathy. There was risk variation among the glucagon-like peptide-1 receptor agonists (GLP-1 RAs); semaglutide and liraglutide were associated with higher risks.
Corresponding Author: To contact the corresponding author, Kin Wah Fung, MD, email kfung@mail.nih.gov.
(doi:10.1001/jamaophthalmol.2025.2299)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Impact of the MISSION Act on Quality and Outcomes of Major Cardiovascular Procedures Among Veterans
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, THURSDAY, JULY 31, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The U.S. Congress enacted the Maintaining Internal Systems and Strengthening Integrated Outside Networks (MISSION) Act with the goal of improving veterans’ access to health care services. This study found that MISSION Act implementation was associated with substantial decreases in travel times among veterans who became geographically eligible for non-Veterans Affairs care. For these patients undergoing percutaneous coronary intervention or coronary artery bypass grafting, MISSION Act implementation was also associated with worsened 30-day major adverse cardiovascular events rates.
Corresponding Author: To contact the corresponding author, Peter W. Groeneveld, MD, MS, email peter.groeneveld@va.gov.
(doi:10.1001/jama.2025.11661)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Control Group Outcomes in Trials of Psilocybin, SSRIs, or Esketamine for Depression
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Transgender-Affirming Hormone Therapies, QT Prolongation, and Cardiac Repolarization
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State E-Cigarette Flavor Restrictions and Tobacco Product Use in Youths and Adults
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Preserving and Promoting Clinical Trial Representativeness
JAMA Cardiology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 30, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2025.2421?guestAccessKey=ee4fc77b-e29b-40de-a00e-bd13c6f94536&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=073025
About The Study: This review synthesizes the latest policies and initiatives concerning representation in clinical research and provides a strategic framework to ensure scientific validity of clinical trials by operationalizing broad representation at all levels. A coordinated approach among stakeholders is needed to address the scientific value of trial representation of the intended use population.
Corresponding Author: To contact the corresponding author, Roxana Mehran, MD, email roxana.mehran@mountsinai.org.
(doi:10.1001/jamacardio.2025.2421)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Mortality Among Surgeons in the United States
JAMA Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 30, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Although nonsurgeon physicians have lower mortality rates than other highly educated professionals, this mortality benefit does not extend to surgeons. Because surgeons and nonsurgeon physicians have similar levels of health care knowledge and resources, higher mortality rates among surgeons might reflect differences related to work environment, professional demands, and lifestyle. The results of this study indicate that several causes of death (e.g., motor vehicle collisions), disproportionately affect surgeons, aligning with evidence that hazardous driving events associated with extended work hours are especially pronounced among surgeons.
Corresponding Author: To contact the corresponding author, Anupam B. Jena, MD, PhD, email jena@hcp.med.harvard.edu.
(doi:10.1001/jamasurg.2025.2482)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Stroke Center Certification and Within-Hospital Racial Disparities in Treatment
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 30, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, the likelihood of receiving stroke treatments increased for white but not Black patients within the same facility after the center was stroke certified as a primary stroke center or a thrombectomy-capable or comprehensive stroke center. These within-hospital racial differences serve as sobering evidence that racial disparities in stroke care persist despite increased access to care.
Corresponding Author: To contact the corresponding author, Renee Y. Hsia, MD, MSc, email renee.hsia@ucsf.edu.
(doi:10.1001/jamanetworkopen.2025.24027)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Psychopathology and Gaming Disorder in Adolescents
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Positive Childhood Experiences and Adult Health and Opportunity Outcomes in 4 US States
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Thermal and Perceptual Responses of Older Adults With Fan Use in Heat Extremes
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Influenza-Associated Acute Necrotizing Encephalopathy in US Children
JAMA
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Media advisory: The full study and editorial are linked to this news release.
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About The Study: In this case series of children with influenza-associated acute necrotizing encephalopathy from the 2 most recent influenza seasons in the U.S., the condition was associated with high morbidity and mortality in this cohort of predominantly young and previously healthy children. The findings emphasize the need for prevention, early recognition, intensive treatment, and standardized management protocols.
Corresponding Author: To contact the corresponding author, Andrew Silverman, MD, MHS, email Aesilver@stanford.edu.
(doi:10.1001/jama.2025.11534)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
About The Editorial: Timothy M. Uyeki, MD, MPH, MPP, of the Centers for Disease Control and Prevention, wrote about the study in an Editorial.
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Demographic Data Supporting FDA Authorization of AI Devices for Alzheimer Disease and Related Dementias
JAMA
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Media advisory: The full study is linked to this news release. This study is being presented at the Alzheimer’s Association International Conference.
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About The Study: Transparency of evidence supporting Food and Drug Administration (FDA) authorization of artificial intelligence (AI)- and machine learning -based devices for Alzheimer disease and related dementias was limited, precluding effective evaluation of training and validation dataset representativeness. Disease status (i.e., dementia type and distribution), age, and sex were reported for fewer than half of devices, while race and ethnicity data were rarely disclosed, raising uncertainty about real-world generalizability and clinical accuracy in intended populations.
Corresponding Author: To contact the corresponding author, Ravi Gupta, MD, MSHP, email ravigupta@jhmi.edu.
(doi:10.1001/jama.2025.12779)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.