Social Media Use and Depressive Symptoms During Early Adolescence

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 21, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of more than 11,000 children and adolescents, reporting higher than person-level mean social media use in years 1 and 2 after baseline was associated with greater depressive symptoms in the subsequent year. The findings suggest that clinicians should provide anticipatory guidance regarding social media use for young adolescents and their parents.

Corresponding Author: To contact the corresponding author, Jason M. Nagata, MD, email Jason.nagata@ucsf.edu.

 

(doi:10.1001/jamanetworkopen.2025.11704)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Substance Use Screening, Brief Intervention, and Referral to Treatment Among Youth-Serving Clinicians

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MAY 20, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that while most clinicians report screening youths for substance use disorders at least sometimes, a substantial proportion screened only intermittently. Efforts to improve screening rates through education and systems-based practice changes may facilitate offering anticipatory guidance and substance use disorder treatment in all youth-serving clinical settings.

Corresponding Author: To contact the corresponding author, Kathleen Ragan-Burnett, MSPH, email xwy3@cdc.gov.

 

(doi:10.1001/jamanetworkopen.2025.11579)

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Trends in Sedentary Behavior Among US Adults

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 21, 2025

Media advisory: The full study is linked to this news release.

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About The Study: This study identified a promising trend of declining sedentary behavior among U.S. adults between 2013 and March 2020, but this decline was hampered in 2021-2023. Sedentary lifestyle was widely exacerbated during the COVID-19 pandemic, and this study highlights the enduring impact that this global pandemic may have on daily living patterns. 

Corresponding Author: To contact the corresponding author, Wei Bao, MD, PhD, email wbao@ustc.edu.cn.

 

(doi:10.1001/jama.2025.7220)

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A Multidimensional Diagnostic Approach for COPD

JAMA

EMBARGOED FOR RELEASE: 3 P.M. ET, SUNDAY, MAY 18, 2025

Media advisory: The full study and editorial are linked to this news release. This study is being presented at the American Thoracic Society International Conference.

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About The Study: A new chronic obstructive pulmonary disease (COPD) diagnostic schema integrating respiratory symptoms, respiratory quality of life, spirometry, and structural lung abnormalities on computed tomographic imaging newly classified some individuals as having COPD. These individuals had an increased risk of all-cause and respiratory-related death, frequent exacerbations, and rapid lung function decline compared with individuals classified as not having COPD. Some individuals with airflow obstruction without respiratory symptoms or evidence of structural lung disease were no longer classified as having COPD. 

Corresponding Author: To contact the corresponding author, Surya P. Bhatt, MD, MSPH, email sbhatt@uabmc.edu.

 

(doi:10.1001/jama.2025.7358)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Long-Term Health Improvements and Economic Performance Among Individuals With Diabetes

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2025.0756?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=051625

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Mental Health Trajectories Among US Survivors of Adolescent and Young Adult Cancer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 19, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this cohort study, survivors of adolescence and young adulthood cancer reported significantly worse mental health trajectories into middle or older adulthood, compared with individuals who experienced cancer as adults or never had it. Cancer clinicians should recognize the mental health burden for this population into middle age and older adulthood.

Corresponding author: To contact the corresponding author, Anao Zhang, Ph.D., email zhangan@med.umich.edu.

 

(doi: 10.1001/jamanetworkopen.2025.11430)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Antibiotic Treatment in Patients Hospitalized for Nonsevere COVID-19

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 19, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this large cohort study of patients hospitalized with nonsevere COVID-19, there was no clinically meaningful difference in outcomes with early antibiotic treatment. Given the risks associated with unnecessary antibiotic treatment, these results argue against routine antibiotic use in this population.

Corresponding author: To contact the corresponding author, Michael S. Pulia, M.D., Ph.D., email mspulia@medicine.wisc.edu.

 

(doi: 10.1001/jamanetworkopen.2025.11499)

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Gender Differences in Primary Care Physician Earnings and Outcomes Under Medicare Advantage Value-Based Payment

JAMA Health Forum

EMBARGOED FOR RELEASE: 5 P.M. (ET), FRIDAY, MAY 16, 2025

Media advisory: The full study is linked to this news release. This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2025.2001?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=051625

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: In this cohort study, women primary care physicians in value-based payment models had equal or better quality outcomes and higher value-based earnings compared to men in their practice groups. These results substantiate prior evidence that women physicians perform better on process and outcome measures, yet receive incommensurate patient ratings. The reversal of the gender gap under value-based payment is likely due to fewer emergency department visits and hospitalizations among women primary care physicians’ patients and may in turn reflect better alignment of value-based models to practice patterns more common in women (e.g., more face-to-face time per visit).

Corresponding Author: To contact the corresponding author, Ishani Ganguli, MD, MPH, email iganguli@bwh.harvard.edu.

 

(doi:10.1001/jamahealthforum.2025.2001)

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Trends in Home Health Care Among Traditional Medicare Beneficiaries With or Without Dementia

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 16, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that home health use is high and has increased among people with dementia. Decreasing rates of home health use since 2020 in this high-need population suggest a need for ongoing monitoring of service use and outcomes for people with dementia.

Corresponding Author: To contact the corresponding author, Rachel M. Werner, MD, PhD, email rwerner@upenn.edu.

 

(doi:10.1001/jamanetworkopen.2025.10933

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Dietary Carbohydrate Intake, Carbohydrate Quality, and Healthy Aging in Women

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 16, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of women, intakes of high-quality carbohydrates and dietary fiber were associated with positive health status in older adulthood, suggesting that dietary carbohydrate quality may be an important determinant of healthy aging.

Corresponding Author: To contact the corresponding author, Andres V. Ardisson Korat, ScD, email andres.ardisson_korat@tufts.edu.

 

(doi:10.1001/jamanetworkopen.2025.11056)

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Trends in Launch Prices and Price Increases for Self-Administered Anticancer Drugs in Medicare

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Racial and Socioeconomic Disparities in California Ambulance Patient Offload Times

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Classroom-Level and Individual-Level Prosociality and Help-Seeking Behaviors Among Adolescents

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Hearing Aid Service Models, Technology, and Patient Outcomes

JAMA Otolaryngology–Head & Neck Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 15, 2025

Media advisory: The full study is linked to this news release.

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About The Study: The results of this randomized clinical trial suggest that while over-the-counter (OTC) and OTC+ (audiologists provided limited services for OTC hearing aids) service models were effective, they did not achieve the same outcomes as the audiologists fitted prescription hearing aids following best practices service model. As high-end and low-end hearing aids yielded similar outcomes, support for the higher cost of high-end hearing aids was not identified for individuals with mild to moderate hearing loss.

Corresponding Author: To contact the corresponding author, Yu-Hsiang Wu, MD, PhD, email yu-hsiang-wu@uiowa.edu.

 

(doi:10.1001/jamaoto.2025.1008)

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Long-Term Survival in Patients With Low-Risk Cervical Cancer After Simple, Modified, or Radical Hysterectomy

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 15, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study, long-term survival was similar following simple hysterectomy vs modified radical hysterectomy or radical hysterectomy, supporting the use of simple hysterectomy in select patients with low-risk early-stage cervical carcinoma.

Corresponding Authors: To contact the corresponding authors, email Kathleen M. Darcy, PhD (darcyk@whirc.org) and Christopher M. Tarney (christopher.m.tarney.mil@health.mil).

 

(doi:10.1001/jamanetworkopen.2025.10717)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Early Childhood Food Insecurity and Cardiovascular Health in Young Adulthood

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Psychiatric Prognosis Following Index Suicide Attempts in Early Adolescents

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Long-Term Oncologic Outcome of Breast-Conserving Treatment in Patients With Breast Cancer With BRCA Variants

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Cannabis Use Among Older Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 14, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study of cannabis use in veterans ages 65 to 84, use was common, and more than one-third who used in the past 30 days had any cannabis use disorder. The prevalence of past 30-day cannabis use was close to tobacco use prevalence, and risk factors for cannabis use were similar to those observed in other populations. Frequent and inhaled cannabis use was associated with higher odds of any cannabis use disorder. Routine health screening for cannabis use in Veterans Health Administration clinical settings is necessary to identify older adults with cannabis use.

Corresponding Author: To contact the corresponding author, Vira Pravosud, PhD, MPH, MS, email vira.pravosud@va.gov.

 

(doi:10.1001/jamanetworkopen.2025.10173)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Glucagon-Like Peptide 1 Receptor Agonists and Mental Health

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 14, 2025

Media advisory: The full study is linked to this news release.

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About The Study: In patients with overweight/obesity and/or diabetes, glucagon-like peptide 1 receptor agonist (GLP1-RA) treatment is not associated with increased risk of psychiatric adverse events or worsening depressive symptoms relative to placebo and is associated with improvements in quality of life, restrained eating, and emotional eating behavior. These findings provide reassurance regarding the psychiatric safety profile of GLP1-RAs and suggest that GLP1-RA treatment contributes to both physical and emotional well-being.

Corresponding Authors: To contact the corresponding authors, email Aureliane C. S. Pierret, MBBChir (a.pierret@nhs.net) and Toby Pillinger, PhD (toby.pillinger@kcl.ac.uk).

 

(10.1001/jamapsychiatry.2025.0679)

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Insurer Exits After the Inflation Reduction Act Part D Redesign

JAMA

EMBARGOED FOR RELEASE: 5:30 P.M. ET, WEDNESDAY, MAY 14, 2025

Media advisory: The full study is linked to this news release. This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting.

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About The Study: In 2023 and 2024, more Part D beneficiaries were affected by their insurer exiting the marketplace than in previous years. This increase could be associated with changes to Medicare Part D from the Inflation Reduction Act (IRA), which increased Part D plan sponsor financial liability. These IRA provisions were designed to lower out-of-pocket costs for Part D beneficiaries, but increased Part D plan exits could lead to more limited coverage options and less competitive Part D marketplaces. 

Corresponding Author: To contact the corresponding author, Christopher L. Cai, MD, email ccai@bwh.harvard.edu.

 

(doi:10.1001/jama.2025.7289)

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Dental and Vision Services Among Veterans in Medicare Advantage vs Traditional Medicare

JAMA

EMBARGOED FOR RELEASE: 4:45 P.M. ET, THURSDAY, MAY 15, 2025

Media advisory: The full study is linked to this news release. This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting.

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About The Study: Although Medicare Advantage (MA) plans offer and directly market supplemental benefits for dental and vision services, veterans enrolled in MA used these services with the same frequency as veterans in traditional Medicare (TM). Moreover, MA plans spent only modestly more on dental services and vision services for veterans than TM, including for emergency dental services. After accounting for private insurance plans used by TM enrollees and out-of-pocket spending, total spending on dental services was no different for veterans in MA vs TM. 

Corresponding Author: To contact the corresponding author, José F. Figueroa, MD, MPH, email jfigueroa@hsph.harvard.edu.

 

(doi:10.1001/jama.2025.7753)

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Incomplete Team Staffing, Burnout, and Work Intentions Among US Physicians

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 5 P.M. (ET), WEDNESDAY, MAY 14, 2025

Media advisory: The full study and editorial are linked to this news release.  This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting. 

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About The Study: In this study, physicians frequently experienced incomplete team staffing. Working with an incompletely staffed team was associated with significantly greater odds of burnout, intent to reduce clinical work hours, and intent to leave one’s current organization (ITL). Given associations between ITL and attrition, these findings emphasize the importance of adequate staffing.  

Corresponding Author: To contact the corresponding author, Lisa S. Rotenstein, MD, MBA, MSc, email lisa.rotenstein@ucsf.edu.

 

(doi:10.1001/jamainternmed.2025.1679)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Remote Symptom Monitoring With Electronic Patient-Reported Outcomes in Clinical Cancer Populations

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Fentanyl Test Strip Use and Overdose Risk Reduction Behaviors Among People Who Use Drugs

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Stigmatizing and Positive Language in Birth Clinical Notes Associated With Race and Ethnicity

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MAY 13, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study examining clinical notes of more than 18,000 patients admitted for labor and birth, there were notable disparities in how stigmatizing and positive language was documented across racial and ethnic groups. This underscores the necessity for improving documentation and communication practices to reduce the use of stigmatizing language.

Corresponding Author: To contact the corresponding author, Veronica Barcelona, PhD, RN, email vb2534@cumc.columbia.edu.

 

(doi:10.1001/jamanetworkopen.2025.9599)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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African Genetic Ancestry, Structural and Social Determinants of Health, and Mortality in Black Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MAY 13, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study, associations of structural and social determinants of health with mortality persisted with adjustment for percentage African genetic ancestry. The findings support the hypothesis that structural and social determinants of health should be the primary factors to consider for eliminating health disparities.

Corresponding Author: To contact the corresponding author, Hari S. Iyer, ScD, MPH, email hi97@cinj.rutgers.edu.

 

(doi:10.1001/jamanetworkopen.2025.10016)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Mental Distress Among Females Following 2021 Abortion Restrictions in Texas

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MAY 12, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that Texas’s abortion restrictions were associated with increases in mental distress among females of reproductive age, especially among younger individuals who may have less ability to overcome barriers to abortion care.

Corresponding Author: To contact the corresponding author, Jusung Lee, PhD, email jusung.lee@utsa.edu.

 

(doi:10.1001/jamanetworkopen.2025.9576)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Landscape of Emergency Medicaid and Health Care Coverage for Undocumented Immigrants in the US

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Sexual Health of US Transgender Boys, Nonbinary Youth, and Cisgender Girls

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Nicotine Pouch Use in Youths and Adults Who Use Cigarettes, E-Cigarettes, and Smokeless Tobacco

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Changes in Physical and Mental Health After the End of SNAP Emergency Allotments

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MAY 12, 2025

Media advisory: The full study is linked to this news release.

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About The Study: After the end of emergency allotments nationwide by March 2023, there were significant increases in food insecurity and poor physical health days among Supplemental Nutrition Assistance Program (SNAP) participants. No changes in poor mental health days or poor or fair health status were observed. 

Corresponding Author: To contact the corresponding author, Rishi K. Wadhera, MD, MPP, MPhil, email rwadhera@bidmc.harvard.edu.

 

(doi:10.1001/jama.2025.6010)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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US Children Living With a Parent With Substance Use Disorder

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 12, 2025

Media advisory: The full study is linked to this news release.

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About The Study: Nearly 19 million children were estimated to be living in a household with at least 1 parent with substance use disorder, accounting for one-quarter of all U.S. children in 2023. Children in such households are more likely to develop adverse health outcomes than their peers without exposure to parental substance use disorder. 

Corresponding Author: To contact the corresponding author, Sean Esteban McCabe, PhD, email plius@umich.edu.

 

(doi:10.1001/jamapediatrics.2025.0828)

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First-Generation and Low-Income Students in the National Medical Student Body

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MAY 12, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study of U.S. medical student matriculants found a decrease in the number of matriculants who were first-generation. These students were at significant risk of attrition from medical school, particularly when considering the intersectionality with low-income and underrepresented in medicine identities. These results suggest a need to recruit and retain these students, so that the physician workforce better reflects the backgrounds and experiences of the communities served.

Corresponding Author: To contact the corresponding author, Sophia C. Kamran, MD, email skamran@mgh.harvard.edu.

 

(doi:10.1001/jamanetworkopen.2025.9769)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Estimates of Illicit Opioid Use in the US

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MAY 9, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: In this national survey of 1,515 adults conducted in June 2024, 166 respondents (11%) reported illicit opioid use and 114 (7.5%) reported illicitly manufactured fentanyl use within the past 12 months. These rates are much higher than previously reported estimates. The findings highlight the need for more timely and accurate data to inform policy and intervention strategies. Enhanced data collection efforts are essential for understanding and mitigating the opioid crisis.

Corresponding Author: To contact the corresponding author, David Powell, PhD, email dpowell@rand.org.

 

(doi:10.1001/jamahealthforum.2025.0809)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Behavioral Health Flag Use by Race and Ethnicity in a Pediatric Emergency Department

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Effectiveness and Safety of RSV Vaccine for US Adults Age 60 or Older

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 9, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Vaccine effectiveness (VE) for the respiratory syncytial virus (RSV) protein subunit vaccine in this case-control study was similar to the VE in clinical trials. The VE for immunocompromised patients was mildly (overall) to moderately (for stem cell transplant recipients) diminished. Risk of immune thrombocytopenic purpura after vaccination was not elevated, but the risk of Guilain-Barré syndrome was statistically significantly elevated in patients who received the RSVPreF vaccine but not in those who received RSVPreF+AS01 vaccine, although the risk was small. These observations should inform clinicians’ choices and patient instructions.

Corresponding Author: To contact the corresponding author, Pamela B. Davis, MD, PhD, email pbd@case.edu.

 

(doi:10.1001/jamanetworkopen.2025.8322)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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USPSTF Recommendation on Screening for Syphilis Infection During Pregnancy

JAMA

EMBARGOED FOR RELEASE: 10:30 A.M. (ET), TUESDAY, MAY 13, 2025

Media advisory: To contact the U.S. Preventive Services Task Force, email the Media Coordinator at Newsroom@USPSTF.net or call 301-951-9203. The full report and related articles are linked to this news release.

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Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends early, universal screening for syphilis infection during pregnancy; if an individual is not screened early in pregnancy, the USPSTF recommends screening at the first available opportunity. Untreated syphilis infection during pregnancy can be passed to the fetus, causing congenital syphilis. Congenital syphilis is associated with premature birth, low birth weight, stillbirth, neonatal death, and significant abnormalities in the infant such as deformed bones, anemia, enlarged liver and spleen, jaundice, brain and nerve problems (e.g., permanent vision or hearing loss), and meningitis. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this recommendation is consistent with the 2018 recommendation.

 

(doi:10.1001/jama.2025.5009)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Note: More information about the U.S. Preventive Services Task Force, its process, and its recommendations can be found on the newsroom page of its website.

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Characterization of Research Grant Terminations at the National Institutes of Health

JAMA

EMBARGOED FOR RELEASE: 11:15 A.M. ET, THURSDAY, MAY 8, 2025

Media advisory: The full study is linked to this news release.

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About The Study: Between February 28, 2025, and April 8, 2025, 694 National Institutes of Health (NIH) grants were terminated across 24 of the 26 institutes and centers (including the Office of the Director) that administered active NIH grants. Targeted grant terminations have affected more than $1.8 billion in NIH funding. Terminations were spread across nearly all NIH institutes and centers, although cuts disproportionately impacted the National Institute on Minority Health and Health Disparities (30% of all funding).

Corresponding Author: To contact the corresponding author, Harlan M. Krumholz, MD, SM, email harlan.krumholz@yale.edu.

 

(doi:10.1001/jama.2025.7707)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Intersystem Medical Error Discovery in Otolaryngology– Head and Neck Surgery

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Depression and Heart Failure in US Veterans

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 8, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study, depression among veterans was associated with an increased hazard of incident heart failure after controlling for demographic and cardiovascular risk factors. Higher incident heart failure rates in patients with depression remained consistent in an otherwise low-risk cohort.

Corresponding Author: To contact the corresponding author, Evan L. Brittain, MD, MSc, email evan.brittain@vumc.org.

 

(doi:10.1001/jamanetworkopen.2025.9246)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Experiences of Care and Gaslighting in Patients With Vulvovaginal Disorders

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 8, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study, a patient-centered measure of adverse experiences in vulvovaginal care was developed. Participants reported common past experiences with gaslighting (a patient’s concerns are dismissed without proper evaluation) and substantial distress; they frequently considered ceasing care. There is an urgent need for education supporting a biopsychosocial, trauma-informed approach to vulvovaginal pain and continued development of validated instruments to quantify patient experiences.

Corresponding Author: To contact the corresponding author, Chailee F. Moss, MD, email chaileem@gmail.com.

 

(doi:10.1001/jamanetworkopen.2025.9486)

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Maternal Cardiometabolic Risk Factors in Pregnancy and Offspring Blood Pressure at Ages 2 to 18

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 8, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of 12,480 mother-offspring pairs, researchers found that pre-pregnancy obesity, gestational diabetes, and hypertensive disorders of pregnancy, alone or in various combinations, were prospectively associated with higher offspring blood pressure at an early age and with an increased rate of blood pressure change from age 2 to 18 years, with the most profound associations with diastolic blood pressure among female offspring and with systolic blood pressure among Black offspring. These findings suggest that protecting pregnant individuals from cardiometabolic risk factors may promote healthier blood pressure in the next generation.

Corresponding Author: To contact the corresponding author, Shohreh F. Farzan, PhD, email sffarzan@usc.edu.

 

(doi:10.1001/jamanetworkopen.2025.9205)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Clinical and Neuropathological Evaluations of the New Brunswick Neurological Syndrome of Unknown Cause

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 7, 2025

Media advisory: The full study is linked to this news release.

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About The Study: There was no evidence supporting a diagnosis of neurological syndrome of unknown cause (NSUC) in this cohort. The data inclusive of independent examinations and neuropathology strongly supported the presence of several neurodegenerative and non-neurodegenerative conditions. Unfounded concerns that a potentially fatal mystery disease, possibly induced by an environmental toxin, is causing the patients’ neurological symptoms has been amplified in traditional and social media. Second, independent clinical evaluations are needed for any patient given a diagnosis of NSUC.

Corresponding Author: To contact the corresponding author, Anthony E. Lang, MD, email anthony.lang@uhn.ca.

 

(doi:10.1001/jamaneurol.2025.1718)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Real-Time AI-Assisted Insulin Titration System for Glucose Control in Patients With Type 2 Diabetes

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APOE4, Blood Neurodegenerative Biomarkers, and Cognitive Decline in Community-Dwelling Older Adults

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Reporting and Representation of Race and Ethnicity in Clinical Trials of Pharmacotherapy for Mental Disorders

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 7, 2025

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2025.0666?guestAccessKey=6a7e637c-9712-4ad0-8e5e-8d7804f08e15&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=050725

 

About The Study: The findings of this meta-analysis suggest that differences in reporting race and ethnicity across geographic locations and underrepresentation of certain racial and ethnic groups in U.S.-based randomized clinical trials highlight the need for international guidelines to ensure equitable recruitment and reporting in clinical trials. 

Corresponding Author: To contact the corresponding author, Alessio Bellato, PhD, email a.bellato@soton.ac.uk.

 

(10.1001/jamapsychiatry.2025.0666)

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Vehicle Age and Driver Assistance Technologies in Fatal Crashes Involving Teen and Middle-Aged Drivers

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 7, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that older vehicles and those with fewer driver assistance technologies are associated with increased risk of driver death in fatal crashes; thus, teens should drive the safest vehicles available, not older family cars. The findings underscore the urgent need to ensure teens drive safer vehicles to protect their lives.

Corresponding Author: To contact the corresponding author, Jingzhen Yang, PhD, MPH, email ginger.yang@nationwidechildrens.org.

 

(doi:10.1001/jamanetworkopen.2025.8942)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults Age 50 and Older

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 7, 2025

Media advisory: The full study is linked to this news release.

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About The Study: In this phase 3 study, mRNA-1083, an investigational, multicomponent vaccine against seasonal influenza and SARS-CoV-2, met noninferiority criteria and induced higher immune responses than recommended standard care influenza (standard and high dose) and COVID-19 vaccines against all 4 influenza strains (among those ages 50-64), the 3 clinically relevant influenza strains (among those age 65 and older), and SARS-CoV-2 (all ages), with an acceptable tolerability and safety profile.

Corresponding Author: To contact the corresponding author, Amanda K. Rudman Spergel, MD, email Amanda.RudmanSpergel@modernatx.com.

 

(doi:10.1001/jama.2025.5646)

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Physician-and Large Language Model–Generated Hospital Discharge Summaries

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Parenting Training Plus Behavioral Treatment for Children With Obesity

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Conversion Therapy Exposure and Elevated Cardiovascular Disease Risk

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, MAY 6, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this cohort study of sexual and gender minority (SGM) young adults assigned male at birth, exposure to sexual orientation and gender identity change efforts (SOGICE) was associated with adverse cardiovascular health indicators, including elevated diastolic blood pressure and systolic blood pressure, increased systemic inflammation, and higher odds of self-reported hypertension or high blood pressure. These findings underscore the need for public health and policy interventions to enforce and strengthen bans on SOGICE practices. Recognizing the cardiovascular health consequences of SOGICE contributes to addressing SGM health disparities and emphasizes the importance of affirmative care approaches that prioritize the well-being of SGM individuals.

Corresponding author: To contact the corresponding author, Brian Mustanski, Ph.D., R.N., email brian@northwestern.edu.

 

(doi: 10.1001/jamanetworkopen.2025.8745)

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Depressive Symptoms Among US Adults

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 5, 2025

Media advisory: The full study is linked to this news release.  

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About The Study: In this study, the prevalence of depressive symptoms increased substantially among U.S. adults during the COVID-19 pandemic. Worsening mental health trends were concentrated among younger adults. 

Corresponding Author: To contact the corresponding author, Rishi K. Wadhera, MD, MPP, MPhil, email rwadhera@bidmc.harvard.edu.

 

(doi:10.1001/jamainternmed.2025.0993)

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Differences in Abortion Use by Sexual Orientation in 3 National Cohorts

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, MAY 6, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this study using data from retrospectively reported pregnancies from 3 longitudinal cohorts, all sexual minority groups had increased abortion use compared with completely heterosexual participants, and abortion use was heterogeneous; given the higher use of abortion among sexual minority populations, they are more likely to be disproportionately impacted by the narrowing of abortion access in the U.S. after the Supreme Court Dobbs decision. Future research is needed to understand the pathways that contribute to the unique abortion care needs of sexual minority individuals, in order to provide adequate support for abortion seekers.

Corresponding author: To contact the corresponding author, Payal Chakraborty, Ph.D., email pchakraborty@hsph.harvard.edu.

 

(doi: 10.1001/jamanetworkopen.2025.8644)

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Parental Technology Use in a Child’s Presence and Health and Development in the Early Years

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 5, 2025

Media advisory: The full study and editorial are linked to this news release.

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About The Study: Parents’ use of technology in their child’s presence was negatively associated with cognitive and psychosocial outcomes and screen time among young children, although the effect sizes were small. Further research focusing on potential impacts on physical activity, sleep, and motor skills is needed. Understanding these associations is crucial for informing research and guidelines aimed at minimizing the potential negative effects of this phenomenon on early childhood development. 

Corresponding Author: To contact the corresponding author, Marcelo Toledo-Vargas, BPhysio (Hons), email mstv798@uowmail.edu.au.

 

(doi:10.1001/jamapediatrics.2025.0682)

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Prenatal Cannabis Use and Neonatal Outcomes

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 5, 2025

Media advisory: The full study is linked to this news release.

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About The Study: Cannabis use in pregnancy was associated with greater odds of preterm birth, small for gestational age, and low birth weight even after adjusting for co-use of tobacco products, and confidence in these findings increased from low in the prior review to moderate in the current meta-analysis. The findings of this study may help inform patient counseling and future public health policies. 

Corresponding Author: To contact the corresponding author, Jamie O. Lo, MD, email loj@ohsu.edu.

 

(doi:10.1001/jamapediatrics.2025.0689)

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Racial, Ethnic, and Sex Differences in Need and Receipt of Support for Social Needs Among Veterans

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Cost-Effectiveness of Universal Routine Depression Screening for Adolescents in Primary Care

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

State-Level Tax Policy, Cancer Screening, and Mortality Rates in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 2, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study, tax policy was associated with increased state-level cancer screening rates, as well as decreased cancer mortality rates, which mostly benefited white populations, suggesting that state-level policies may contribute to bridging ongoing cancer care gaps.

Corresponding Author: To contact the corresponding author, Timothy M. Pawlik, MD, PhD, MPH, MTS, MBA, email tim.pawlik@osumc.edu.

 

(doi:10.1001/jamanetworkopen.2025.8455)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Postpartum Care Differences in LGBTQ+ and Non-LGBTQ+ Individuals

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MAY 2, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: Despite similar access to health insurance, lesbian, gay, bisexual, transgender, queer, and other sexual and gender minority (LGBTQ+) people had large inequities in unmet health care needs and cost-related medication nonadherence in the postpartum year. Results suggested LGBTQ+ people receive lower-quality care in the postpartum period. Although use of pregnancy-related care was comparable, LGBTQ+ individuals used more primary and specialist care and were nearly twice as likely to use the emergency department compared with non-LGBTQ+ people.

Corresponding Author: To contact the corresponding author, Kevin H. Nguyen, PhD, email nguyen@bu.edu.

 

(doi:10.1001/jamahealthforum.2025.0672)

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Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 1, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest a narrowing of racial and ethnic disparities in receipt of ERBB2 (formerly HER2 or HER2/neu)-targeted therapies over time among older Medicare beneficiaries with ERBB2-positive breast cancer. Future research is needed to understand the practices that contributed to the narrowing of racial and ethnic disparities and to develop implementation strategies to effectively improve the quality and equity of breast cancer care.

Corresponding Author: To contact the corresponding author, Utibe R. Essien, MD, MPH, email uessien@mednet.ucla.edu.

 

(doi:10.1001/jamanetworkopen.2025.8086)

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Sex- and Race-Specific Prevalence of Hearing Loss Across the Adult Lifespan and Associated Factors

JAMA Otolaryngology–Head & Neck Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 1, 2025

Media advisory: The full study and commentary are linked to this news release.

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About The Study: The prevalence and degree of hearing loss were highest among white male individuals and lowest among Black female individuals in this cohort study of 1,787 adults. Some factors associated with hearing loss, including noise exposure, differed across sex-specific and race-specific groups. Hearing loss is an important public health concern that could be addressed through tailored interventions to reduce its risk across populations.

Corresponding Author: To contact the corresponding author, Lauren K. Dillard, PhD, AuD, email dillalau@musc.edu.

 

(doi:10.1001/jamaoto.2025.0534)

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Noninfectious Intraocular Inflammation After Intravitreal Aflibercept

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