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Cancer Risk and Estimated Lithium Exposure in Drinking Groundwater in the US
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Inequities in the Application of Behavioral Flags for Hospitalized Pediatric Patients
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, FEBRUARY 20, 2025
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.61079?guestAccessKey=c0957767-f5eb-4d6d-88a4-15c747418b57&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=022025
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cohort study found significant inequities in incidence of behavioral flags in the electronic health record among racially and socioeconomically marginalized pediatric patients. This finding was most pronounced for Black or African American patients younger than 8 years, suggesting that this phenomenon may be a response to Black families rather than specific patient behavior.
Corresponding Author: To contact the corresponding author, April Edwell, MD, MAEd, email April.edwell@ucsf.edu.
(doi:10.1001/jamanetworkopen.2024.61079)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy
JAMA Ophthalmology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, FEBRUARY 20, 2025
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2024.6555?guestAccessKey=9cc7cefb-e963-490d-bbd1-8ad419a0b542&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=022025
About The Study: The results of this study suggest a modest increase in the risk of nonarteritic anterior ischemic optic neuropathy among individuals with type 2 diabetes associated with semaglutide use, smaller than that previously reported, and warranting further investigation into the clinical implications of this association.
Corresponding Author: To contact the corresponding author, Cindy X. Cai, MD, MS, email ccai6@jhmi.edu.
(doi:10.1001/jamaophthalmol.2024.6555)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Maternal RSVpreF and Infant Nirsevimab Immunizations Uptake During RSV Season
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RSV Vaccine and Nirsevimab Uptake Among Pregnant People and Their Neonates
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Clinician Experiences With Ambient Scribe Technology to Assist With Documentation Burden and Efficiency
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Health Care Staffing Shortages and Potential National Hospital Bed Shortage
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, FEBRUARY 19, 2025
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.60645?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=021925
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The U.S. has achieved a new post-pandemic hospital occupancy steady state 11 percentage points higher than it was pre-pandemic. This persistently elevated occupancy appears to be driven by a 16% reduction in the number of staffed U.S. hospital beds rather than by a change in the number of hospitalizations. Experts in developed countries have posited that a national hospital occupancy of 85% constitutes a hospital bed shortage (a conservative estimate). The findings of the current study show that the U.S. could reach this dangerous threshold as soon as 2032, with some states at much higher risk than others.
Corresponding Author: To contact the corresponding author, Richard K. Leuchter, MD, email rleuchter@mednet.ucla.edu.
(doi:10.1001/jamanetworkopen.2024.60645)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Predicting Diagnostic Progression to Schizophrenia or Bipolar Disorder via Machine Learning
JAMA Psychiatry
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, FEBRUARY 19, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The findings of this study suggest that it is possible to predict diagnostic transition to schizophrenia and bipolar disorder from routine clinical data extracted from
electronic health records, with schizophrenia being notably easier to predict than bipolar disorder.
Corresponding Author: To contact the corresponding author, Lasse Hansen, MSc, PhD, email lasse.hansen@clin.au.dk.
(10.1001/jamapsychiatry.2024.4702)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Long-Term Outcomes of Laparoscopic Roux-en-Y Gastric Bypass vs Laparoscopic Sleeve Gastrectomy for Obesity
JAMA Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, FEBRUARY 19, 2025
Media advisory: The full study is linked to this news release.
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About The Study: After more than 10 years of follow-up in the Swiss Multicenter Bypass or Sleeve Study randomized clinical trial, Roux-en-Y gastric bypass demonstrated superiority over sleeve gastrectomy for patient excess body mass index loss.
Corresponding Author: To contact the corresponding author, Ralph Peterli, MD, email ralph.peterli@clarunis.ch.
(doi:10.1001/jamasurg.2024.7052)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Digital Physiotherapeutic Scoliosis-Specific Exercises for Adolescent Idiopathic Scoliosis
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Tobacco and E-Product Use by US Adults With Disabilities
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, FEBRUARY 18, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.60471?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=021825
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this survey study, disparities in tobacco use existed across cumulative disabilities. Despite declines in tobacco use over time, differences in use across cumulative disabilities persisted or worsened, especially among those with 3 or more disabilities. Targeted prevention, screening, and cessation efforts inclusive of multiple products are needed.
Corresponding author: To contact the corresponding author, Michael J. Parks, Ph.D., email Michael.parks@nih.gov.
(doi: 10.1001/jamanetworkopen.2024.60471)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Abortion Changes Among Residents of an Abortion Rights Protective State
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, FEBRUARY 18, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cross-sectional study found a statistically significant increase in abortions for Colorado residents in association with the implementation of Texas SB8. This aligns with reports from area clinicians who experienced dramatic increases in patient demand after SB8, also reported by the media, resulting in delayed appointments for everyone.
Corresponding author: To contact the corresponding author, Kelly A. DeBie, J.D., email kelly.debie@colostate.edu.
(doi: 10.1001/jamanetworkopen.2024.60460)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Neural Response to Food Cues in Avoidant/Restrictive Food Intake Disorder
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Illicit Substance Use and Treatment Access Among Adults Experiencing Homelessness
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, FEBRUARY 19, 2025
Media advisory: The full study is linked to this news release.
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About The Study: In a representative study of adults experiencing homelessness in California, there was a high proportion of current drug use, history of overdose, and unmet need for treatment. Improving access to treatment tailored to the needs of people experiencing homelessness could improve outcomes.
Corresponding Author: To contact the corresponding author, Ryan D. Assaf, PhD, MPH, email ryan.assaf@ucsf.edu.
(doi:10.1001/jama.2024.27922)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Emergency Clinician Buprenorphine Initiation, Subsequent Prescriptions, and Continuous Prescriptions
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Percentage of Opioid Tests Available in US Injury Death Investigations
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Efficacy and Safety of Zilucoplan in ALS
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CNM-Au8 in ALS
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Pridopidine in ALS
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Verdiperstat in ALS
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Platform Trials in ALS
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, FEBRUARY 17, 2025
Media advisory: The full editorial and related articles are linked to this news release.
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About The Editorial: The JAMA Network is publishing the results of four trials undertaken within the HEALEY amyotrophic lateral sclerosis (ALS) platform. The results are notable not because of therapeutic success—indeed, none of the interventions reached key end points—but because they represent the first platform trial results in ALS. Platform trials represent a departure from the familiar randomized clinical trial: different interventions targeting the same disease, in this case ALS, are studied concurrently within a common administrative and operational infrastructure (i.e., platform).
Corresponding Author: To contact the corresponding author, John Turnbull, M.D., Ph.D., email turnbull@mcmaster.ca.
(doi:10.1001/jama.2025.0100)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Calcium Intake and Risk of Colorectal Cancer in the NIH-AARP Diet and Health Study
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Growing Health Concern Regarding Gambling Addiction in the Age of Sportsbooks
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Heterogeneity of Primary Outcomes in Large Atherosclerotic Cardiovascular Disease Trials Published in Prominent Medical Journals
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How Does Health Care Spending Vary Across the US—and Why?
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, FEBRUARY 14, 2025
Media advisory: The full article is linked to this news release.
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About The Article: This article discusses the regional variations in health care spending and the factors driving these differences.
(doi:10.1001/jama.2025.0072)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Tracking US Health Care Spending by Health Condition and County
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, FEBRUARY 14, 2025
Media advisory: The full study and editorial are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.26790?guestAccessKey=783582d7-4e27-4a8c-8b5a-ecebb4c21894&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=021425
About The Study: Broad variation in health care spending was observed across U.S. counties. Understanding this variation by health condition, sex, age, type of care, and payer is valuable for identifying outliers, highlighting inequalities, and assessing health care gaps.
Corresponding Author: To contact the corresponding author, Joseph L. Dieleman, PhD, email dieleman@uw.edu.
(doi:10.1001/jama.2024.26790)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Physician Voting Rates in the 2020 and 2022 US Elections
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
Prostate Cancer Mortality in Men Age 70 Who Recently Underwent Prostate-Specific Antigen Screening
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Automated Insulin Delivery in Adults With Type 2 Diabetes
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Physician Gender and Patient Perceptions of Interpersonal and Technical Skills in Online Reviews
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Patients’ Trust in Health Systems to Use AI
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Multilevel Stressors and Systemic and Tumor Immunity in Black and White Women With Breast Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, FEBRUARY 14, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this cross-sectional study of Black and white women with breast cancer suggest that perceived stress, perceived inadequate social support, perceived racial and ethnic discrimination, and neighborhood deprivation were associated with deleterious alterations to the systemic and tumor immune environment, particularly for Black women. Understanding biology as a possible mediator of cancer health disparities may inform prevention and public health interventions.
Corresponding Author: To contact the corresponding author, Stefan Ambs, PhD, MPH, email ambss@mail.nih.gov.
(doi:10.1001/jamanetworkopen.2024.59754)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Childhood Lifestyle Behaviors and Mental Health Symptoms in Adolescence
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, FEBRUARY 14, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cohort study of Finnish children and adolescents found that higher physical activity and lower screen time from childhood were associated with perceived stress and depressive symptoms in adolescence. These findings emphasize reducing screen time and increasing physical activity to promote mental health in youth.
Corresponding Author: To contact the corresponding author, Eero A. Haapala, PhD, email eero.a.haapala@jyu.fi.
(doi:10.1001/jamanetworkopen.2024.60012)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Drivers of Variation in Health Care Spending Across US Counties
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, FEBRUARY 14, 2025
Media advisory: The full study and editorial are linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: In this cross-sectional study, variation in health care spending among U.S. counties was largely related to variation in service utilization. Understanding the drivers of spending variation in the U.S. may help policymakers assess the allocation of health care resources.
Corresponding Author: To contact the corresponding author, Joseph L. Dieleman, PhD, email dieleman@uw.edu.
(doi:10.1001/jamahealthforum.2024.5220)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Generative AI Guidelines of Ophthalmology Journals
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Workplace Injury and Mental Health Outcomes
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Mapping Neuroimaging Findings of Creativity and Brain Disease Onto a Common Brain Circuit
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Tumor-Infiltrating Lymphocytes and Survival Outcomes in Early ERBB2-Positive Breast Cancer
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Perceived Taste Loss From Early Adulthood to Mid to Late Adulthood and Mortality
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US Abortion Bans and Infant Mortality
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, FEBRUARY 13, 2025
Media advisory: The full study, editorial and Viewpoints are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.28517?guestAccessKey=b72029ae-86e1-4152-b21b-996a42715af0&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=021325
About The Study: U.S. states that adopted abortion bans had higher than expected infant mortality after the bans took effect. The estimated relative increases in infant mortality were larger for deaths with congenital causes and among groups that had higher than average infant mortality rates at baseline, including Black infants and those in southern states.
Corresponding Author: To contact the corresponding author, Alison Gemmill, PhD, email agemmill@jhu.edu.
(doi:10.1001/jama.2024.28517)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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US Abortion Bans and Fertility
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, FEBRUARY 13, 2025
Media advisory: The full study, editorial and Viewpoints are linked to this news release.
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About The Study: The findings of this study provide evidence that fertility rates in states with abortion bans were higher than would have been expected in the absence of these policies, with the largest estimated differences among subpopulations experiencing the greatest structural disadvantages and in states with among the worst maternal and child health and well-being outcomes.
Corresponding Author: To contact the corresponding author, Suzanne O. Bell, PhD, email suzannebell@jhu.edu.
(doi:10.1001/jama.2024.28527)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Obesity-Related Measures Among US Children, Adolescents, and Adults
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, FEBRUARY 13, 2025
Media advisory: The full study is linked to this news release.
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About The Study: From 2013-2014 to August 2021-August 2023, there were small increases in the percentage of children and adolescents with obesity, as well as in adults with severe obesity (but not obesity). There were no other significant changes in obesity-related measures, including waist circumference. This period included the COVID-19 pandemic; a study using electronic health records found a small increase in mean weight among adults during the pandemic.
Corresponding Author: To contact the corresponding author, Samuel D. Emmerich, DVM, email semmerich@cdc.gov.
(doi:10.1001/jama.2024.27676)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Postoperative Sexual Function After Vaginal Surgery and Clitoral Size, Position, and Shape
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Mapping Lesions That Cause Psychosis to a Human Brain Circuit and Proposed Stimulation Target
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ADHD in Medicaid-Enrolled Autistic Adults
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Dust Storms and Emergency Department Visits in 3 Southwestern States Using NWS Storm Reports
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Disparities in Substance Use Disorder Telehealth Services
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, FEBRUARY 12, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.59606?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=021225
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Medicare Advantage-enrolled and commercially insured individuals were disproportionately more likely to use telehealth, with overall substance use disorder treatment (SUDT) increasing over time. Medicaid-covered individuals were underrepresented within telehealth SUDT utilization, with overall SUDT declining. This finding raises equity concerns for Medicaid populations. For rural individuals, telehealth may be reducing disparities, with overall SUDT increasing throughout the public health emergency to a greater extent than for urban individuals.
Corresponding Author: To contact the corresponding author, Lauryn Saxe Walker, PhD, MPH, email lauryn@vahealthinnovation.org.
(doi:10.1001/jamanetworkopen.2024.59606)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Once-Weekly Semaglutide in Adults With Alcohol Use Disorder
JAMA Psychiatry
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, FEBRUARY 12, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The findings of this study provide initial prospective evidence that low-dose semaglutide can reduce craving and some drinking outcomes, justifying larger clinical trials to evaluate glucagon-like peptide 1 receptor agonists (GLP-1RAs) for alcohol use disorder.
Corresponding Author: To contact the corresponding author, Christian S. Hendershot, PhD, email christian.hendershot@usc.edu.
(10.1001/jamapsychiatry.2024.4789)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Moving Toward Implementation of Responsible AI in Health Care
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Pregnancy-Associated Mortality Due to Homicide, Suicide, and Drug Overdose
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Lithium for Bipolar Disorder and Risk of Thyroid Dysfunction and Chronic Kidney Disease
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Accelerated Intermittent Theta-Burst Stimulation for Treatment-Resistant Bipolar Depression
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Prepandemic Prevalence of Dietary Supplement Use for Immune Benefits
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, FEBRUARY 11, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This study has 3 findings in a prepandemic context. First, approximately 1 in 9 U.S. residents used a dietary supplement for perceived immune benefits (supplements to prevent colds or boost the immune system), and such usage varied by several sociodemographic and health characteristics. Second, label claims related to immune benefits consistently appeared on over half of dietary supplements taken for perceived immune benefits. Lastly, the prevalence of dietary supplement use for perceived immune benefits due to a doctor recommendation and dietary supplement use exclusively for perceived immune benefits were both generally low, but both increased among older adults and individuals in poorer health.
Corresponding Author: To contact the corresponding author, Jaime J. Gahche, PhD, MPH, email jaime.gahche@nih.gov.
(doi:10.1001/jamanetworkopen.2024.59291)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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ADHD Symptoms and Later E-Cigarette and Tobacco Use in Youths
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, FEBRUARY 11, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of U.S. youths, attention-deficit/hyperactivity disorder (ADHD) symptoms were associated with the onset of nicotine and tobacco use. The findings highlight the importance of early diagnosis and effective treatment of ADHD to alleviate symptoms and reduce the risk of later nicotine and tobacco use.
Corresponding Author: To contact the corresponding author, Sean Esteban McCabe, PhD, email plius@umich.edu.
(doi:10.1001/jamanetworkopen.2024.58834)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Travel Time to Obtain Surgical Care for Rural Patients
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, FEBRUARY 12, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The percentage of rural patients traveling more than 60 minutes to obtain surgical care significantly increased between 2010 and 2020 for both low- and high-risk operations. Additionally, increases in median travel time for rural patients outpaced changes for nonrural patients. These findings suggest a persistent and growing disparity in travel for rural patients undergoing surgical procedures. Contributing factors likely include ongoing rural hospital closures, workforce shortages, and rural patients bypassing local facilities to obtain care elsewhere.
Corresponding Author: To contact the corresponding author, Cody Lendon Mullens, MD, MPH, email codymu@med.umich.edu.
(doi:10.1001/jama.2025.0447)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Low to Moderate Prenatal Alcohol Exposure and Facial Shape of Children at Ages 6 to 8
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, FEBRUARY 10, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Low to moderate prenatal alcohol exposure was associated with characteristic changes in the faces of children, which persisted until at least 6 to 8 years of age. A linear association between alcohol exposure levels and facial shape was not supported.
Corresponding Author: To contact the corresponding author, Evelyne Muggli, MPH, email evi.muggli@mcri.edu.au.
(doi:10.1001/jamapediatrics.2024.6151)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Injury Rates Among Children With Autism Spectrum Disorder With or Without ADHD
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Lung Cancer Screening and USPSTF Recommendations
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Medicare Opioid Policy and Opioid Use in Beneficiaries With Disabilities
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Detection of Alzheimer Neuropathology in Alzheimer and Non-Alzheimer Clinical Syndromes With Blood-Based Biomarkers
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Victim-Shooter Relationships in Mass Shootings Involving Child Victims
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, FEBRUARY 10, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The findings of this study indicate that from 2009 through 2020, a child was most likely to be killed in a mass shooting by a parent or family member, rather than a stranger or a peer. While school shootings dominate media coverage, this study suggests that domestic violence plays a larger role in child mass shootings.
Corresponding Author: To contact the corresponding author, Stephanie Chao, MD, email sdchao1@stanford.edu.
(doi:10.1001/jamapediatrics.2024.6609)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Glucose-Lowering Medications and Risk of COPD Exacerbations in Patients With Type 2 Diabetes
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, FEBRUARY 10, 2025
Media advisory: The full study and editor’s note are linked to this news release.
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About The Study: The results of this comparative effectiveness research study suggest that sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RAs) were associated with a reduced risk of moderate or severe chronic obstructive pulmonary disease (COPD) exacerbations compared with dipeptidyl peptidase 4 inhibitors in adults with type 2 diabetes and active COPD. This may inform prescribing of glucose-lowering medications among patients with type 2 diabetes and active COPD.
Corresponding Author: To contact the corresponding author, Elisabetta Patorno, MD, DrPH, email epatorno@bwh.harvard.edu.
(doi:10.1001/jamainternmed.2024.7811)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Contemporary Hormonal Contraception and Risk of Venous Thromboembolism
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, FEBRUARY 10, 2025
Media advisory: The full study is linked to this news release.
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About The Study: This study showed venous thromboembolism (VTE) risk variation across hormonal contraceptives with highest rates for combined pills, especially those containing third-generation progestins, and no significant difference in risk for intrauterine devices (IUDs) relative to no use. For patches and implants, the increased VTE risk was uncertain due to limited data. Variation in VTE risk across products underscores the importance of personalized contraceptive counseling.
Corresponding Author: To contact the corresponding author, Harman Gailan Hassan Yonis, MD, email harman@live.dk.
(doi:10.1001/jama.2024.28778)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Financial Incentives for COVID-19 Vaccination
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Pediatric Gastrointestinal Tract Outcomes During the Postacute Phase of COVID-19
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Industry Payments and Sentiments Toward Robotic Surgery Among US Physicians
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Cardiometabolic Trajectories Preceding Dementia in Community-Dwelling Older Individuals
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, FEBRUARY 7, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.58591?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=020725
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study of older individuals, decline in body mass index, waist circumference, and high-density lipoprotein (HDL) occurred up to a decade before dementia diagnosis. These findings provide insights into cardiometabolic changes preceding dementia and the potential for early monitoring and intervention.
Corresponding Author: To contact the corresponding author, Zimu Wu, PhD, email zimu.wu1@monash.edu.
(doi:10.1001/jamanetworkopen.2024.58591)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Changes in US Primary Care Access and Capabilities During the COVID-19 Pandemic
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, FEBRUARY 7, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: In this cohort study, over the time period including the COVID-19 pandemic, primary care practices reported a decline in access to care, while average practice capabilities improved. Integrated practice ownership and accountable care organization participation were both associated with better access and capability scores, suggesting that value-based payment and integrated care delivery support the development of higher-quality primary care. Variations across practices point to large opportunities for improvement overall and underscore the importance of incentives and structures as levers to improve primary care delivery.
Corresponding Author: To contact the corresponding author, Matthew Mackwood, MD, MPH, email matthew.b.mackwood@dartmouth.edu.
(doi:10.1001/jamahealthforum.2024.5237)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Reflections on the Successes of Pediatric Vaccines
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Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity
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Public Understanding of Risk and Benefit of Mifepristone
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Changes in Young Adult Handgun Carrying in the US
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COVID-19 Pandemic and Rates of Common Ophthalmic Procedures Among Medicare Beneficiaries
JAMA Ophthalmology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, FEBRUARY 6, 2025
Media advisory: The full study and commentary are linked to this news release.
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About The Study: The results of this study show that the COVID-19 pandemic caused a notable drop in the number of common ophthalmic procedures among Medicare beneficiaries, especially in laser peripheral iridotomy, while eye drug injections saw minimal changes. The Northeast experienced the largest reductions, highlighting the pandemic’s association with changes in eye care and indicating a need for focused recovery efforts in the hardest hit areas.
Corresponding Author: To contact the corresponding author, Jessica D. Randolph, MD, email jessica.randolph@vcuhealth.org.
(doi:10.1001/jamaophthalmol.2024.6065)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cannabis Use Disorder Emergency Department Visits and Hospitalizations and 5-Year Mortality
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, FEBRUARY 6, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of all residents of Ontario, Canada, individuals with incident hospital-based cannabis use disorder care were at markedly increased risk of death compared with the general population. These findings suggest important clinical and policy implications, given global trends toward cannabis legalization and market commercialization accompanied by increasing cannabis use and cannabis use disorders.
Corresponding Author: To contact the corresponding author, Daniel T. Myran, MD, MPH, email dmyran@ohri.ca.
(doi:10.1001/jamanetworkopen.2024.57852)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cardiovascular Hospitalizations Among Older Adults in the US and Denmark
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Effective Treatment for Mental and Substance Use Disorders in 21 Countries
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Return on Investment of Enhanced Behavioral Health Services
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Socioeconomic and Geographic Differences in Mammography Trends Following the 2009 USPSTF Policy Update
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Salt Substitution and Recurrent Stroke and Death
JAMA Cardiology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, FEBRUARY 5, 2025
Media advisory: The full study and editorial are linked to this news release.
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About The Study: The results of this cluster trial demonstrate that salt substitution was safe, along with reduced risks of stroke recurrence and death, which underscores large health gains from scaling up this low-cost intervention among patients with stroke.
Corresponding Authors: To contact the corresponding authors, email Lijing L. Yan, MPH, PhD, (lijing.yan@duke.edu) and Maoyi Tian, PhD, (maoyi.tian@hrbmu.edu.cn)
(doi:10.1001/jamacardio.2024.5417)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Firearm Type and Number of People Killed in Publicly Targeted Fatal Mass Shooting Events
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, FEBRUARY 5, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This study found that most publicly targeted fatal mass shootings involved multiple types of firearms and handguns were the most common type of firearm present. Assault weapons being present during a publicly targeted mass shooting was associated with a slight increase in the number of injuries and deaths occurring during that incident.
Corresponding Author: To contact the corresponding author, Leslie M. Barnard, MPH, DrPH, email leslie.barnard@ucdenver.edu.
(doi:10.1001/jamanetworkopen.2024.58085)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Recent Drug Overdose Mortality Decline Compared With Pre–COVID-19 Trend
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, FEBRUARY 5, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Drug overdose deaths have increased exponentially since 1979. This rate of increase accelerated during the COVID-19 pandemic but has since waned. When comparing recent drug-related mortality rates with their pre-2020 trajectory, the vast majority of states remained higher than expected. In the 4 years between 2020 and 2023, nearly all states had higher drug-related mortality rates than their 2019 rates.
Corresponding Author: To contact the corresponding author, Keith Humphreys, PhD, email knh@stanford.edu.
(doi:10.1001/jamanetworkopen.2024.58090)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Large Language Models for Chatbot Health Advice Studies
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Rest-Activity Rhythms, Their Modulators, and Brain-Clinical Correlates in Opioid Use Disorder
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Changes in Incident Schizophrenia Diagnoses Associated With Cannabis Use Disorder After Cannabis Legalization
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, FEBRUARY 4, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of individuals ages 14 to 65 in Ontario, Canada, the proportion of incident cases of schizophrenia associated with cannabis use disorder almost tripled during a period of substantial liberalization of cannabis policy. Ongoing research is indicated to understand the long-term associations of cannabis policy with the prevalence of psychotic disorders.
Corresponding author: To contact the corresponding author, Daniel T. Myran M.D., M.P.H., email dmyran@ohri.ca.
(doi: 10.1001/jamanetworkopen.2024.57868)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Exercise Interventions for Depression, Anxiety, and Quality of Life in Older Adults With Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, FEBRUARY 4, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this systematic review and meta-analysis of 27 randomized clinical trials, exercise interventions were found to be associated with significantly reduced levels of depression and anxiety and significantly improved health-related quality-of-life in older adults with cancer. These findings suggest that health care professionals and policymakers should focus more on implementing exercise interventions to improve mental health outcomes in this vulnerable population.
Corresponding author: To contact the corresponding author, Matthew Zhixuan Chen, MBBS, email zhixuan_matthew_chen@nuhs.edu.sg.
(doi: 10.1001/jamanetworkopen.2024.57859)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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UV Stabilizer BTMPS in the Illicit Fentanyl Supply in 9 US Locations
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Extreme Heat and Hospitalization Among Older Persons With Alzheimer Disease and Related Dementias
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Comparison of Clinical Evidence Submitted to the FDA and EMA for Cell and Gene Therapies
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Prophylactic Aspirin Dose and Preeclampsia
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Over-the-Counter Naloxone and Nonprescription Syringe Availability in Community Pharmacies
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Risk of Attempted and Completed Suicide in Persons Diagnosed With Headache
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, FEBRUARY 3, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2024.4974?guestAccessKey=cae45619-36a0-4a63-9487-f5c657639a93&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=020325
About The Study: The results of this cohort study revealing the robust and persistent association of headache diagnoses with attempted and completed suicide suggest that behavioral health evaluation and treatment may be important for these patients.
Corresponding Author: To contact the corresponding author, Holly Elser, MD, PhD, email holly.elser@pennmedicine.upenn.edu.
(doi:10.1001/jamaneurol.2024.4974)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Long COVID Prevalence and Associated Activity Limitation in US Children
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, FEBRUARY 3, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2024.6206?guestAccessKey=ec8a3208-1552-4258-9fac-da27cf7173c5&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=020325
About The Study: In 2023, post–COVID condition (PCC) continued to affect U.S. children at similar levels as 2022 and to have similar sociodemographic patterns. The large proportion of children experiencing PCC with any activity limitation highlights the need to examine the severity of activity limitation, functional outcomes, and days lost from school.
Corresponding Author: To contact the corresponding author, Nicole D. Ford, PhD, MPH, email yex9@cdc.gov.
(doi:10.1001/jamapediatrics.2024.6206)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Adolescent Smartphone Use During School Hours
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, FEBRUARY 3, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Using passive sensing on a sample of U.S. adolescents, this study found half of adolescents use their smartphones during school for at least 66 minutes daily, primarily using messaging and social media. These findings extend a prior study limited to Android devices that found adolescents spent a median of 43 minutes on their phones during school.
Corresponding Author: To contact the corresponding author, Lauren Hale, PhD, email Lauren.Hale@stonybrookmedicine.edu.
(doi:10.1001/jamapediatrics.2024.6627)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Intersection of Race and Rurality With Health Care–Associated Infections and Subsequent Outcomes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, FEBRUARY 3, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cohort study of hospitalized adults identified inequities related to race and rurality in health care–associated infections (HAIs) and adverse outcomes from HAIs. These findings suggest that factors such as structural racism and disinvestment in rural communities may be associated with individual HAI risk and post-HAI outcomes. Future work to further understand the reasons underpinning these disparities and methods to address structural factors through policy and process changes are critical to eliminate health inequities.
Corresponding Author: To contact the corresponding author, Jennie H. Kwon, DO, MSCI, email j.kwon@wustl.edu.
(doi:10.1001/jamanetworkopen.2024.53993)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Ultraprocessed Food Consumption and Obesity Development in Canadian Children
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JANUARY 31, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: High ultraprocessed food consumption during early childhood was associated with obesity development, primarily in males in this cohort study of Canadian children. These findings can inform targeted public health initiatives for early childhood centers and caregiver education programs to reduce ultraprocessed food intake and prevent obesity.
Corresponding Author: To contact the corresponding author, Kozeta Miliku, MD, PhD, email kozeta.miliku@utoronto.ca.
(doi:10.1001/jamanetworkopen.2024.57341)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Use of Machine Learning to Assess the Management of Uncomplicated Urinary Tract Infection
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The Digital Health Competencies in Medical Education Framework
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Assessing the Gun Violence Archive and Public Police Data as Comprehensive Sources for Gun Violence
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