Pediatric COVID-19 Hospitalization Trends by Race and Ethnicity, 2020-2023

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JULY 15, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: This study found that among pediatric patients hospitalized with COVID-19, Black and Hispanic children were disproportionately more likely to be hospitalized for COVID-19 and experience severe disease compared with white and Asian or Pacific Islander children. A higher proportion of hospitalized Black children had underlying medical conditions. This study underlines the need for targeted interventions, particularly for children with underlying medical conditions, and the need for equitable access and use of vaccines and therapeutics for disproportionately affected populations.

Corresponding author: To contact the corresponding author, Onika Anglin, MPH, email quk3@cdc.gov.

 

(doi: 10.1001/jamanetworkopen.2025.21009)

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Clinical Decision Support System for Primary Care of Opioid Use Disorder

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Oncology “Me-Too” Drugs Compared With Original Drugs in Randomized Clinical Trials

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Behavioral Compared With Drug Therapy for Overactive Bladder Symptoms in Parkinson Disease

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Delayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JULY 14, 2025

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that delays in hypertension diagnosis were common and significantly associated with delays in treatment initiation and adverse cardiovascular outcomes, underscoring the need for earlier identification and intervention. 

Corresponding Author: To contact the corresponding author, John E. Brush Jr, MD, email jebrush@sentara.com.

 

(doi:10.1001/jamanetworkopen.2025.20498)

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Integrating Diet and Physical Activity When Prescribing GLP-1s—Lifestyle Factors Remain Crucial

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JULY 14, 2025

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About The Article: This article provides practical strategies for symptom management for patients receiving glucagon-like peptide-1 and dual receptor agonists (GLP-1 RAs) to manage weight and suggests interventions supporting muscle and nutrient preservation during GLP-1 RA treatment. 

Corresponding Author: To contact the corresponding author, JoAnn E. Manson, MD, DrPH, email jmanson@bwh.harvard.edu.

 

(doi:10.1001/jamainternmed.2025.1794)

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GLP-1 Receptor Agonists in Idiopathic Intracranial Hypertension

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JULY 14, 2025

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About The Study: Glucagon-like peptide 1 receptor agonist (GLP-1 RA) therapy in idiopathic intracranial hypertension is associated with significant reductions in medication use, symptoms/signs, and procedural interventions, suggesting its potential as a management strategy. Further prospective studies are warranted to confirm these findings.

Corresponding Author: To contact the corresponding author, Dennis J. Rivet II, MD, email dennis.rivet@vcuhealth.org.

 

(doi:10.1001/jamaneurol.2025.2020)

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Documented Firearm Access Before Suicide Among Psychiatric Emergency Service Patients

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Long-Term Obesity and Biological Aging in Young Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JULY 11, 2025

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this multiple-events case-control study, long-term obesity was associated with the expression of biochemical aging markers in adults ages 28 to 31, consistent with epigenetic alterations, telomere attrition, chronic inflammation, impaired nutrient sensing, mitochondrial stress, and compromised intercellular communication. In young adults, chronic health issues may emerge from accelerated biological aging associated with long-term obesity.

Corresponding Authors: To contact the corresponding authors, email Paulina Correa-Burrows, PhD, (paulina.correa@inta.uchile.cl) and Christian Gonzalez-Billault, PhD, (chrgonza@uchile.cl).

 

(doi:10.1001/jamanetworkopen.2025.20011)

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Use of Tobacco and Cannabis Following State-Level Cannabis Legalization

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JULY 11, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this longitudinal cohort study, recreational cannabis legalization was associated with more cannabis and electronic nicotine delivery systems use after 5 years and no significant change in cigarette use. Furthermore, cannabis use increased over time, underscoring the importance of studying commercialization policy going forward. Based on the present results, it is unlikely recreational cannabis legalization has been associated with a large increase in cigarette use, but increases in use of cannabis and vaped nicotine bear close monitoring as retail cannabis rapidly expands. 

Corresponding Author: To contact the corresponding author, Andrew S. Hyatt, MD, email ashyatt@challiance.org.

 

(doi:10.1001/jamanetworkopen.2025.20093)

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State Gun Laws and Firearm-Related Homicides and Suicides

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JULY 11, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study, stronger gun laws correlated with decreased overall firearm mortality, with the strongest correlations for decreased suicides. For firearm suicide, this analyses lend support to policies that regulate firearm sales, transfers, and permitting laws. While some gun law categories were correlated with decreased firearm homicide, sociodemographic factors, such as unemployment, poverty, and insurance status, correlated with larger changes, suggesting policies that address root causes of violence through economic mobility and access to robust social, health, and educational services may be associated with a greater reduction in homicides. 

Corresponding Author: To contact the corresponding author, Chethan Sathya, MD, MSc, email chethan.sathya@gmail.com.

 

(doi:10.1001/jamanetworkopen.2025.19955)

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Differential Obesity Trends in Asian and Native Hawaiian or Other Pacific Islander US Adults

JAMA

EMBARGOED FOR RELEASE: 11:00 A.M. ET, THURSDAY, JULY 10, 2025

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About The Study: In a large California health care system, the contemporary burden of obesity varied substantially across disaggregated Asian American, Native Hawaiian, and Pacific Islander subgroups ages 30 to 49, affecting more than half of Native Hawaiian and Other Pacific Islander adults (body mass index [BMI] 30 or greater). Rapid temporal increases in high BMI were seen among Filipino and other Southeast Asian subpopulations where nearly 50% of females and 60% of males had a BMI greater than or equal to 27.5. 

Corresponding Author: To contact the corresponding author, Joan C. Lo, MD, email Joan.C.Lo@kp.org.

 

(doi:10.1001/jama.2025.9901)

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Systemic Strategies to Prevent Nonbeneficial Treatments Near the End of Life

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Cumulative Anticholinergic Exposure and Change in Gait Speed and Grip Strength in Older Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JULY 10, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study, higher anticholinergic exposure was associated with accelerated decline in physical performance, consistent with clinically meaningful decline. These findings suggest that minimizing anticholinergic medications is important for healthy aging. 

Corresponding Author: To contact the corresponding author, Shelly L. Gray, PharmD, MS, email slgray@uw.edu.

 

(doi:10.1001/jamanetworkopen.2025.19819)

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First-Trimester Antibiotic Use for Urinary Tract Infection and Risk of Congenital Malformations

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BMI in Children Before, During, and After the COVID-19 Pandemic

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 9, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study including 426,000 children in Denmark found that body mass index (BMI) outcomes of COVID-19 pandemic–related control policies and restrictions were not exclusively observed among children with obesity, which suggests that pandemic-related mitigation policies targeting children and adolescents in all BMI categories are warranted. The findings of this study highlight differences among children of varying ages and BMI classes. 

Corresponding Author: To contact the corresponding author, Frederik Kirkemann Jensen, MPH, email kirkemannjensen@outlook.com.

 

(doi:10.1001/jamanetworkopen.2025.19528)

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Morning vs Bedtime Dosing and Nocturnal Blood Pressure Reduction in Patients With Hypertension

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 9, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this randomized clinical trial of antihypertensive chronotherapy, bedtime dosing provided better control of nocturnal blood pressure and improved the circadian rhythm, without reducing the efficacy on mean daytime or 24-hour blood pressure, or increasing the risk of nocturnal hypotension. These findings support the potential advantages of bedtime administration and offer new evidence to guide future research on antihypertensive chronotherapy. 

Corresponding Author: To contact the corresponding author, Xiaoping Chen, MD, email xiaopingchen15@126.com.

 

(doi:10.1001/jamanetworkopen.2025.19354)

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RSV Hospital Admissions During the First 2 Seasons Among Children With Chronic Medical Conditions

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Postoperative Delirium in Older Adults Undergoing Noncardiac Surgery

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Hepatitis C Screening in Emergency Departments

JAMA

EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, JULY 9, 2025

Media advisory: The full study and editor’s note are linked to this news release.

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About The Study: In this multicenter randomized clinical trial, a nontargeted screening approach was superior to targeted screening for identifying new hepatitis C virus infections among patients seen in 3 urban emergency departments. The substantial decrease in patients who went from diagnosis to sustained virologic response at 12 weeks highlights an urgent need for innovative models of hepatitis C virus treatment. 

Corresponding Author: To contact the corresponding author, Jason Haukoos, MD, MSc, email jason.haukoos@dhha.org.

 

(doi:10.1001/jama.2025.10563)

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The Failure of Life Expectancy to Fully Rebound to Pre-Pandemic Levels

JAMA

EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, JULY 9, 2025

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About The Study: This study found that California life expectancy remained lower in 2024 than in 2019, due primarily to non–COVID-19 causes. COVID-19 accounted for 12.8% of the deficit in 2024. Although a prior analysis of California data reported that the life expectancy–income gradient increased during 2020-2021, by 2024 the gap between Q1 and Q4 returned to pre-pandemic levels. Life expectancy in the Black population was much lower than in other racial and ethnic populations, and Black and Hispanic populations experienced the largest deficits. 

Corresponding Author: To contact the corresponding author, Hannes Schwandt, PhD, email schwandt@northwestern.edu.

 

(doi:10.1001/jama.2025.10439)

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Eastern Equine Encephalitis in the US

JAMA

EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, JULY 9, 2025

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About The Article: This JAMA Insights examines the epidemiology, diagnosis, and management of eastern equine encephalitis virus (EEEV) disease in the U.S. following a recent increase in reported cases. This virus is the cause of a rare mosquito-borne disease in the U.S. that causes substantial morbidity and mortality. People at highest risk of EEEV infection are those living in or visiting endemic forested areas near swamps or marshes and those whose occupations (e.g., agricultural work) or hobbies (e.g., camping, gardening) involve outdoor exposure.

Corresponding Author: To contact the corresponding author, J. Erin Staples, MD, PhD, email auv1@cdc.gov.

 

(doi:10.1001/jama.2025.9073)

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Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy

JAMA

EMBARGOED FOR RELEASE: 3 A.M. ET, SATURDAY, JULY 5, 2025

Media advisory: The full study is linked to this news release. This study is being presented at the 11th Annual Conference of the Chinese Stroke Association & Tiantan International Stroke Conference 2025.

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About The Study: In patients with acute large vessel occlusion presenting between 4.5 and 24 hours of symptom onset, intra-arterial tenecteplase after successful thrombectomy had a greater likelihood of excellent neurological outcome at 90 days without increasing the risk of symptomatic intracranial hemorrhage or mortality. However, because none of the secondary efficacy analyses supported the primary finding, further trials are needed to confirm the results. 

Corresponding Authors: To contact the corresponding authors, email Xiaochuan Huo, PhD, (huoxiaochuan@126.com) and Bernard Yan, MD, (bernard.yan@mh.org.au).

 

(doi:10.1001/jama.2025.10800)

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Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease

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Cannabidiol and Liver Enzyme Level Elevations in Healthy Adults

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JULY 7, 2025

Media advisory: The full study and editorial are linked to this news release.  

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About The Study: In this randomized double-blind clinical trial of healthy adults administered cannabidiol (CBD), 5 mg/kg/d for 28 days, 8 (5.6%) experienced liver enzyme level elevations and 7 (4.9%) met protocol defined criteria for potential drug-induced liver injury. Participants did not experience clinical symptoms related to liver function during this 28-day study and hepatic enzymes returned to normal within 1 to 2 weeks following discontinuation. The findings of this study underscore the need for further investigation on the long-term effects of CBD use, its impact on various populations, and the safety of lower doses commonly used by consumers. 

Corresponding Author: To contact the corresponding author, Jeffry Florian, PhD, email jeffry.florian@fda.hhs.gov.

 

(doi:10.1001/jamainternmed.2025.2366)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Trends in US Children’s Mortality, Chronic Conditions, Obesity, Functional Status, and Symptoms

JAMA

EMBARGOED FOR RELEASE: 11:00 A.M. ET, MONDAY, JULY 7, 2025

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About The Study: The health of U.S. children has worsened across a wide range of health indicator domains over the past 17 years. The broad scope of this deterioration highlights the need to identify and address the root causes of this fundamental decline in the nation’s health. 

Corresponding Author: To contact the corresponding author, Christopher B. Forrest, MD, PhD, email forrestc@chop.edu.

 

(doi:10.1001/jama.2025.9855)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Pathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma

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Nivolumab and Ipilimumab Combination Treatment in Advanced Ovarian and Endometrial Clear Cell Cancers

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Long-Term Cannabis Use and Risk of Postoperative Proliferative Vitreoretinopathy

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Preflight Myopia and Visual Acuity Changes in Long-Duration Astronauts

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A Harm Reduction Response to Bans on Gender-Affirming Care

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Cost-Sharing and Buprenorphine Prescription Dispensing

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Passive Smartphone Sensors for Detecting Psychopathology

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JULY 3, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings from this study suggest that major forms of psychopathology are detectable from smartphone sensors. Insights from these results, and future research that builds on them, can potentially be translated into symptom monitoring tools that fill the gaps in current practice and may eventually lead to more precise and effective treatment. 

Corresponding Author: To contact the corresponding author, Whitney R. Ringwald, PhD, email wringwal@umn.edu.

 

(doi:10.1001/jamanetworkopen.2025.19047)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Social Outcomes Among Adults With Hearing Aids and Cochlear Implants

JAMA Otolaryngology–Head & Neck Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JULY 3, 2025

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About The Study: In this systematic review and meta-analysis, hearing rehabilitative devices were associated with improved social outcomes for adults with hearing loss. Their use should be encouraged for those with hearing loss to potentially enhance social engagement and functional outcomes.

Corresponding Author: To contact the corresponding author, Janet S. Choi, MD, MPH, email janet.choi@med.usc.edu.

 

(doi:10.1001/jamaoto.2025.1777)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Mental Health Antecedents and Correlates of 2 Distinct Developmental Pathways to Suicidal Ideation

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Age-Related Deficits in Mobility Resilience With an Extreme Weather and Climate Event

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Marginalized Neighborhoods and Health Outcomes in Younger Heart Attack Survivors

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 2, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of younger acute myocardial infarction survivors with universal health care, living in marginalized neighborhoods was associated with adverse outcomes. The observed differences in health service utilization among marginalized patients warrant further investigation to better understand the underlying structural and systemic factors. 

Corresponding Author: To contact the corresponding author, Dennis T. Ko, MD, MSc, email dennis.ko@ices.on.ca.

 

(doi:10.1001/jamanetworkopen.2025.18826)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Disparities in Treatment and Referral After an Opioid Overdose Among Emergency Department Patients

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 2, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

  

About The Study: In this study, Black patients were less likely to receive outpatient referrals for opioid use disorder. These findings underscore the need for targeted interventions to address racial disparities in emergency department care for opioid use disorder, particularly in enhancing referral processes. 

Corresponding Author: To contact the corresponding author, Siri Shastry, MD, MS, email Siri.Shastry@mountsinai.org.

 

(doi:10.1001/jamanetworkopen.2025.18569)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Residential Segregation and Lung Cancer Risk in African American Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, JULY 1, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this study suggest that structural racism embedded in neighborhood conditions contributes to lung cancer development and provides evidence for policymakers and public health leaders working to reduce disparities. 

Corresponding Author: To contact the corresponding author, Loretta Erhunmwunsee, MD, email LorettaE@coh.org.

 

(doi:10.1001/jamanetworkopen.2025.18481)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Racial Inequities and Access to COVID-19 Treatment

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, JULY 1, 2025

Media advisory: The full study and editorial are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study found that racial and ethnic disparities in COVID-19 treatment are substantial and partially explainable by encounter-level factors, particularly differences in diagnostic test type, virtual care access, and site of care. These findings suggest that targeted interventions, including expanding rapid test access and virtual care, may improve equity in outpatient COVID-19 treatment. 

Corresponding Author: To contact the corresponding author, Rebecca Bromley-Dulfano, MS, email rbromleydulfano@g.harvard.edu.

 

(doi:10.1001/jamanetworkopen.2025.18459)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

FDA Authorization of Therapeutic Devices Under the Breakthrough Devices Program

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GLP-1 RA Use and Major Adverse Cardiovascular Events in Patients With Monoclonal Gammopathy of Undetermined Significance

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Intent to Test for COVID-19 in the Postpandemic Era

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JUNE 30, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Nearly one-third of U.S. adults would not or might not test for suspected COVID-19, largely because they do not see value in testing, according to the results of an online national survey. Test hesitancy may delay oral antiviral initiation and could result in missed opportunities to limit transmission. Efforts are needed to increase awareness of the value of testing. 

Corresponding Author: To contact the corresponding author, Kimberly A. Fisher, MD, email kimberly.fisher2@umassmed.edu.

 

(doi:10.1001/jamanetworkopen.2025.18250)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

COVID-19 and Cognitive Change in a Community-Based Cohort

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JUNE 30, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cohort study of older participants found accelerated decreases in cognition among individuals hospitalized for SARS-CoV-2 infection, but not nonhospitalized infection, in comparison with individuals not yet infected. These findings suggest that avoiding severe SARS-CoV-2 infection could help preserve cognitive function among older adults. 

Corresponding Authors: To contact the corresponding authors, email Ryan T. Demmer, PhD, MPH, (demmer.ryan@mayo.edu) and Elizabeth C. Oelsner, MD, DrPH, (eco7@cumc.columbia.edu).

 

(doi:10.1001/jamanetworkopen.2025.18648)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Puerto Rico’s Specialist Crisis—A Wake-Up Call for Health Equity and Action

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

The Advisory Committee on Immunization Practices— Legal Roles, Challenges, and Guardrails

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Awareness of and Beliefs About Naloxone Among Adults

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Lorundrostat in Participants With Uncontrolled Hypertension and Treatment-Resistant Hypertension

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Modeling Health and Economic Outcomes of Providing Stable Housing to Homeless Adults With Opioid Use Disorder

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Interventions to Address Potentially Inappropriate Prescribing for Older Primary Care Patients

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Multicenter Validation of a Machine Learning Model for Surgical Transfusion Risk at 45 US Hospitals

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Insurance Churn and the COVID-19 Pandemic

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 27, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: In this study, the Families First Coronavirus Response Act was associated with a significantly decreased risk of losing health insurance for individuals enrolled in the Medicaid program.

Corresponding Author: To contact the corresponding author, Sarah P. Shubeck, MD, MS, email shubeck@bsd.uchicago.edu.

 

(doi:10.1001/jamahealthforum.2025.1467)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Postpartum Medicaid Use in Birthing Parents and Access to Financed Care

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 27, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: The results of this study suggest that extending Medicaid coverage for 12 months postpartum was associated with expanded opportunities for greater access to Medicaid-financed medical and behavioral health care. Both prevention and ongoing treatment of chronic conditions may help mitigate key adverse outcomes. The findings may help policymakers and public health officials understand how extended coverage affects access to Medicaid-financed care.

Corresponding Author: To contact the corresponding author, Jonas J. Swartz, MD, MPH, email jonas.swartz@duke.edu.

 

(doi:10.1001/jamahealthforum.2025.1630)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Receipt of Buprenorphine and Naltrexone for Opioid Use Disorder by Race and Ethnicity and Insurance Type

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JUNE 26, 2025

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of opioid-related index health care events, race and ethnicity–based and insurance-based disparities in access to medications for opioid use disorder persisted despite efforts to expand treatment availability. These findings underscore the need for targeted interventions, including culturally tailored care, expanded access points, and policy reforms to address structural barriers and reduce inequities contributing to the overdose crisis. 

Corresponding Author: To contact the corresponding author, Utsha G. Khatri, MD, MSHP, email utsha.khatri@mountsinai.org.

 

(doi:10.1001/jamanetworkopen.2025.18493)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Availability of Medications for Opioid Use Disorder in Opioid Treatment Programs

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JUNE 26, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study of opioid treatment programs (OTPs), although the availability of medications for opioid use disorder (MOUD) beyond methadone increased over time, most OTPs still did not offer all 3 forms of MOUD as of 2023. Specific organizational characteristics, such as being government operated and accepting Medicare, were associated with more comprehensive MOUD offerings. Future research should evaluate why OTPs vary in their MOUD offerings. 

Corresponding Author: To contact the corresponding author, Zoe Lindenfeld, PhD, email zoe.lindenfeld@rutgers.edu.

 

(doi:10.1001/jamanetworkopen.2025.17616)

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Professional Responsibility for COVID-19 Vaccination in Pregnancy

JAMA

EMBARGOED FOR RELEASE: 11:15 A.M. ET, WEDNESDAY, JUNE 25, 2025

Media advisory: The full article is linked to this news release.

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About The Article: This Viewpoint discusses how physicians should counsel patients on vaccine safety in the wake of the U.S. Department of Health and Human Services’ decision to remove COVID-19 vaccinations as a recommended vaccine for children and pregnant women. 

Corresponding Author: To contact the corresponding author, Amos Grünebaum, MD, email agrunebaum@northwell.edu.

 

(doi:10.1001/jama.2025.11328)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Offering Psychedelic Treatments Before Assisted Dying for Psychiatric Conditions

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Estimated 2023-2024 COVID-19 Vaccine Effectiveness in Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JUNE 25, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this case-control study of vaccine effectiveness, 2023-2024 COVID-19 vaccines were estimated to provide additional effectiveness against medically attended COVID-19, with the highest and most sustained estimates against critical illness. These results highlight the importance of receiving recommended COVID-19 vaccination for adults 18 years or older. 

Corresponding Author: To contact the corresponding author, Ruth Link-Gelles, PhD, MPH, email hzt7@cdc.gov.

 

(doi:10.1001/jamanetworkopen.2025.17402)

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Increased Prescribing of ADHD Medication and Real-World Outcomes Over Time

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 25, 2025

Media advisory: The full study and editorial are linked to this news release.

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About The Study: In this study, attention-deficit/hyperactivity disorder (ADHD) medication remained associated with reduced risks of several serious real-world outcomes (self-harm, unintentional injury, traffic crashes, and crime). However, the magnitude of these associations appears to have decreased alongside rising prescription rates over time. Thus, it is important to regularly evaluate medication use in different patient populations. 

Corresponding Authors: To contact the corresponding authors, email Zheng Chang, PhD, (zheng.chang@ki.se) and Lin Li, PhD, (lin.li@ki.se).

 

(10.1001/jamapsychiatry.2025.1281)

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A Predictive Tool for Ability to Remain at Home After Cancer Surgery in Older Adults

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Climate Conditions, Weather Changes, and Air Pollutants and Atopic Dermatitis

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Care Coordination for High-Need, High-Cost Commercially Insured Patients

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Reducing Smoking Requirements for Lung Screening to Address Health Disparities in a Community Cohort

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E-Cigarette and Cannabis Social Media Posts and Adolescent Substance Use

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, JUNE 24, 2025

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.17611?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=062425

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this survey study of California adolescents, exposure to e-cigarette or cannabis posts was associated with adolescent e-cigarette, cannabis, or dual use. Improvement of social media community guidelines and greater policy attention to co-use and marketing of e-cigarettes and cannabis may help prevent youth substance use. 

Corresponding Author: To contact the corresponding author, Julia Vassey, PhD, email vassey@usc.edu.

 

(doi:10.1001/jamanetworkopen.2025.17611)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Breast Cancer Incidence Trends in Older US Women by Race, Ethnicity, Geography, and Stage

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, JUNE 24, 2025

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this population-based cross-sectional analysis of breast cancer incidence trends among older U.S. women, racial and ethnic as well as stage-specific patterns differed across age groups, highlighting the importance of disaggregating breast cancer incidence rates into age groups better aligned with screening guidelines. Future research is needed to directly examine the contribution of screening patterns to these trends and their impact on breast cancer mortality. 

Corresponding Author: To contact the corresponding author, Erica J. Lee Argov, MPH, email ejl2152@cumc.columbia.edu.

 

(doi:10.1001/jamanetworkopen.2025.16947)

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Health Economic Analysis of an All-Virtual, At-Home Acute Care Model

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Sex-Based Differences in Pediatric Mental Health Hospitalizations at US Acute Care Hospitals

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Long-Term Health Implications of the Los Angeles Wildfires and Insights From Military Burn Pit Exposures

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US Neonatal Mortality From Perinatal Causes

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 23, 2025

Media advisory: The full study is linked to this news release.

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About The Study: U.S. neonatal mortality has generally decreased, likely due to medical advancements, improved prenatal care, and neonatal intensive care interventions. However, mortality from slow fetal growth and malnutrition has increased by nearly 2% annually, possibly reflecting impaired prenatal nutrition. 

Corresponding Author: To contact the corresponding author, Muzamil Khan, MD, email muzamilkhan1411@gmail.com.

 

(doi:10.1001/jamapediatrics.2025.1710)

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Role of Sleep and White Matter in the Link Between Screen Time and Depression in Childhood and Early Adolescence

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 23, 2025

Media advisory: The full study and editorial are linked to this news release.

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About The Study: The results of this study show that more screen time in late childhood was associated with more depressive symptoms, potentially due to shorter sleep and worse white matter organization during early adolescence. These findings emphasize the importance of promoting healthy habits and balancing screen time with adequate sleep. 

Corresponding Author: To contact the corresponding author, João Paulo Lima Santos, MD, email limasantosjp2@upmc.edu.

 

(doi:10.1001/jamapediatrics.2025.1718)

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USPSTF Recommendation Statement on Screening for Intimate Partner Violence and Caregiver Abuse of Older or Vulnerable Adults

JAMA

EMBARGOED FOR RELEASE: 10:30 A.M. (ET), TUESDAY, JUNE 24, 2025

Media advisory: To contact the U.S. Preventive Services Task Force, email the Media Coordinator at Newsroom@USPSTF.net or call 301-951-9203. The full report and related articles are linked to this news release.

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Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends that clinicians screen for intimate partner violence in women of reproductive age, including those who are pregnant and postpartum. The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for caregiver abuse and neglect in older or vulnerable adults. Intimate partner violence affects millions of U.S. residents across the lifespan and is often unrecognized. Abuse of older or vulnerable adults by a caregiver or someone else they may trust is common and can result in significant injury, death, and long-term adverse health consequences. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this recommendation is consistent with its 2018 recommendation.

 

(doi:10.1001/jama.2025.9009)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Note: More information about the U.S. Preventive Services Task Force, its process, and its recommendations can be found on the newsroom page of its website.

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