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Severe Maternal Morbidity by Race and Ethnicity and Birth Mode
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 3, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study of births among individuals with a prior cesarean birth, patterns of severe maternal morbidity (SMM) by birth mode varied by race and ethnicity, with elevated rates of SMM among those from marginalized racial and ethnic groups with planned cesarean births. Future work should identify interventions to improve quality of care and promote equity for this population.
Corresponding author: To contact the corresponding author, Laura B. Attanasio, Ph.D., email lattanasio@umass.edu.
(doi: 10.1001/jamanetworkopen.2025.13578)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Three-Dimensional–Printed Models and Shared Decision-Making
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Medicare Plan Switching Among Beneficiaries With and Without a History of Cancer
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Neurologic and Psychological Outcomes 2 Years After Multisystem Inflammatory Syndrome in Children
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Outcomes for Very Preterm Infants Across Health Systems
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Social Drivers of Health and Firearm Storage Practices
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Clinical Validation of a Circulating Tumor DNA–Based Blood Test to Screen for Colorectal Cancer
JAMA
EMBARGOED FOR RELEASE: 11:15 A.M. ET, MONDAY, JUNE 2, 2025
Media advisory: The full study and editorial are linked to this news release.
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About The Study: In an average-risk colorectal cancer screening population, a blood-based test demonstrated acceptable accuracy for colorectal cancer detection, but detection of advanced precancerous lesions remains a challenge, and ongoing efforts are needed to improve test sensitivity.
Corresponding Author: To contact the corresponding author, Theodore R. Levin, MD, email theodore.levin@kp.org.
(doi:10.1001/jama.2025.7515)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Screening Colonoscopy Yields Among Adults Ages 45 to 49 After Lowering the Colon Cancer Screening Age
JAMA
EMBARGOED FOR RELEASE: 11:15 A.M. ET, MONDAY, JUNE 2, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The finding of a slightly lower prevalence of any adenoma in the younger compared with the older age group (35.4% vs 40.8%) in the current study is consistent with an evaluation of 2001 screening colonoscopies from a university-based medical center between 2019 and 2021, which reported slightly lower rates of adenoma detection in those ages 45 to 49 vs 50 to 54 (34.3% vs 38.2%) and with a large study of adenoma detection rates in those ages 45 to 49 vs 50 to 54 (28.6% vs 31.8%) who underwent a screening colonoscopy before the change in guidelines (i.e., 2014-2020).
Corresponding Author: To contact the corresponding author, Jeffrey K. Lee, MD, MPH, email jeffrey.k.lee@kp.org.
(doi:10.1001/jama.2025.7494)
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Trends in County-Level MMR Vaccination Coverage in Children in the United States
JAMA
EMBARGOED FOR RELEASE: 11:15 A.M. ET, MONDAY, JUNE 2, 2025
Media advisory: The full study is linked to this news release.
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About The Study: This county-level dataset complements the state and national-level Centers for Disease Control and Prevention data, confirming a widespread decline in measles-mumps-rubella (MMR) vaccination rates in the U.S. after the COVID-19 pandemic while revealing significant heterogeneity in vaccination patterns within and across states. This dataset can be used in spatial and statistical analyses to identify factors associated with low or declining MMR rates in U.S. counties and help inform targeted vaccination strategies to reduce the risk of measles outbreaks.
Corresponding Author: To contact the corresponding author, Lauren M. Gardner, PhD, email l.gardner@jhu.edu.
(doi:10.1001/jama.2025.8952)
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Trends in Past-Month Cannabis Use Among Older Adults
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 2, 2025
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About The Study: Between 2021 and 2023, prevalence of current cannabis use increased among adults age 65 or older nationally, with key demographic subgroups experiencing marked increases. Adults with the highest incomes initially had the lowest prevalence of cannabis use vs other income levels, but by 2023, they had the highest prevalence, which may indicate better access to medical cannabis given its costs.
Corresponding Author: To contact the corresponding author, Benjamin H. Han, MD, email b2han@health.ucsd.edu.
(doi:10.1001/jamainternmed.2025.1156)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Association of Endothelial Dysfunction With Chronic Marijuana Smoking and THC-Edible Use
JAMA Cardiology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 28, 2025
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About The Study: This cross-sectional study found that chronic cannabis smoking and tetrahydrocannabinol (THC) ingestion were associated with endothelial dysfunction similar to that observed in tobacco smokers, although apparently occurring via distinct mechanisms.
Corresponding author: To contact the corresponding author, Matthew L. Springer, Ph.D., email matt.springer@ucsf.edu.
(doi: 10.1001/jamacardio.2025.1399)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Machine Learning for Predicting Critical Events Among Hospitalized Children
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Diversity Statements and Pediatric Residency Program and Department Characteristics
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Postpandemic Cardiac Mortality Rates
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Prevalence of Artificial Sweetener Neotame in US-Marketed Disposable E-Cigarettes
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JUNE 2, 2025
Media advisory: The full study is linked to this news release.
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About The Study: This study demonstrates that the artificial sweetener neotame was a ubiquitous constituent of popular disposable e-cigarettes sold in the U.S. in 2024, including those containing no nicotine or the nicotine analogue 6-methylnicotine. Neotame is 7,000 to 13,000 times sweeter than table sugar and is 35 to 65 times sweeter than aspartame.
Corresponding Author: To contact the corresponding author, Sven E. Jordt, PhD, email sven.jordt@duke.edu.
(doi:10.1001/jama.2025.7398)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Projected Outcomes of Removing Fluoride From US Public Water Systems
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MAY 30, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This cost-effectiveness analysis found that cessation of public water fluoridation would increase tooth decay and health system costs in the U.S. Despite concerns regarding toxic effects associated with high levels of fluoride, this model demonstrates the substantial ongoing benefits of water fluoridation at safe levels currently recommended by the U.S. Environmental Protection Agency, the National Toxicity Program, and the Centers for Disease Control and Prevention.
Corresponding Author: To contact the corresponding author, Lisa Simon, MD, DMD, email lsimon@bwh.harvard.edu.
(doi:10.1001/jamahealthforum.2025.1166)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Parental Education, Own Education, and Cognitive Function in Middle-Aged and Older Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 30, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of middle-aged and older adults across 4 countries, both higher maternal and paternal education were generally associated with slower cognitive decline, and these associations were mediated by participants’ own education. These findings highlight the long-term relevance of parental education for offspring cognitive health across diverse cultural or socioeconomic contexts, and support the potential benefits of improving educational attainment to reduce intergenerational disparities in late-life cognitive health.
Corresponding Author: To contact the corresponding author, Vivian Yawei Guo, PhD, email guoyw23@mail.sysu.edu.cn.
(doi:10.1001/jamanetworkopen.2025.13036)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Sacred Moment Experiences Among Internal Medicine Physicians
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 30, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this national survey of internal medicine physicians, experiencing sacred moments —meaningful, memorable, and sometimes spiritual moments of connection— is common; discussing them with colleagues is not. These findings suggest that frequently experiencing sacred moments and discussing them with colleagues could bolster physician well-being.
Corresponding Author: To contact the corresponding author, Jessica Ameling, MPH, email jameling@med.umich.edu.
(doi:10.1001/jamanetworkopen.2025.13159)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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New Definition of Light Chain Monoclonal Gammopathy of Undetermined Significance
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Platelet Transfusion – 2025 AABB and ICTMG International Clinical Practice Guidelines
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Psychiatric Health Risks in North Korean Refugee Youths Resettled in South Korea
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Prevalence Rates, Perceptions of Risk, and Motivations for Nonmedical Cannabis Use in Pediatric Pain
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Dedicated AI Expert System vs Generative AI With Large Language Model for Clinical Diagnoses
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Vaping Cessation Methods Used by Young Adults
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Acupuncture for Nocturia in Survivors of Prostate Cancer
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 29, 2025
Media advisory: The full study is linked to this news release.
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About The Study: In this pilot trial, acupuncture produced greater reductions in nocturia (waking up 1 or more times to urinate) relative to usual care in survivors of prostate cancer. The nocturia reduction was comparable to other treatments, such as desmopressin, α-blockers, and antimuscarinic medications; however, acupuncture was associated with fewer adverse events. Nocturia affects more than half of survivors of prostate cancer.
Corresponding Author: To contact the corresponding author, Kevin T. Liou, MD, email liouk@mskcc.org.
(doi:10.1001/jamaoncol.2025.1199)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Public Awareness of the Association Between Alcohol and Cancer in the US
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 29, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The findings of this study that fewer than half of U.S. adults are aware and about one-fifth are unsure of their awareness of the association between alcohol and cancer emphasize the need to implement the recently updated Surgeon General’s recommendation to reduce the alcohol-related cancer burden in the U.S.
Corresponding Author: To contact the corresponding author, Sanjay Shete, PhD, email sshete@mdanderson.org.
(doi:10.1001/jamaoncol.2025.1146)
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Test-Negative Design for COVID-19 Vaccine Effectiveness From Randomized Trial Data
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Medical School Ranking and Neighborhood Characteristics of Initial Practice Location
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Familiarity of the Surgeon-Anesthesiologist Dyad and Major Morbidity After High-Risk Elective Surgery
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Childhood Maternal Warmth, Social Safety Schemas, and Adolescent Mental and Physical Health
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Early-Life Low Lead Levels and Academic Achievement in Childhood and Adolescence
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 28, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study assessing early life low lead level and children’s and adolescents’ academic achievement, a 1-unit increase in lead levels in the range currently considered low for further interventions was associated with worse academic performance throughout school grades comparable to that for lead levels in the range recommended for additional interventions. These findings support the need to reconsider and potentially lower current blood lead reference values for recommending further interventions.
Corresponding author: To contact the corresponding author, George L. Wehby, M.P.H., Ph.D., email george-wehby@uiowa.edu.
(doi: 10.1001/jamanetworkopen.2025.12796)
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Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension
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Risk of Parkinson Disease in Individuals With Autism Spectrum Disorder
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Trends and Disparities in Maternal Self-Reported Mental and Physical Health
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Adverse Social Exposome During the Life Course and Vascular Brain Injury
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Asian American Female Residents’ Perceptions of Facilitators and Barriers to Leadership in Medicine
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Review and Publication Times and Reporting Across Journals on Health Policy
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Characterizing Long COVID Symptoms During Early Childhood
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, MAY 27, 2025
Media advisory: The full study and Patient Page are linked to this news release.
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About The Study: This cohort study identified symptom patterns and derived research indices that were distinct between the 2 age groups (infants/toddlers [0-2 years] vs preschool-aged children [3-5 years]) and differed from those previously identified in older ages, demonstrating the need to characterize long COVID separately across age ranges.
Corresponding Author: To contact the corresponding author, Rachel S. Gross, MD, MS, email rachel.gross@nyulangone.org.
(doi:10.1001/jamapediatrics.2025.1066)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Patient-Delivered Continuous Care for Weight Loss Maintenance
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, MAY 27, 2025
Media advisory: The full study and commentary are linked to this news release.
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About The Study: In this trial, patient-delivered lifestyle intervention (mentor interventionists plus peer support) yielded significantly better weight loss maintenance and cardiovascular risk outcomes compared with standard-of-care treatment delivered by professionals. Future research may examine the effectiveness of this novel treatment approach in community and clinical settings.
Corresponding Author: To contact the corresponding author, Tricia M. Leahey, PhD, email tricia.leahey@uconn.edu.
(doi:10.1001/jamainternmed.2025.1345)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Weight Loss in Midlife, Chronic Disease Incidence, and All-Cause Mortality During Extended Follow-Up
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MAY 27, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study, conducted when surgical and pharmacological weight-loss interventions were nearly nonexistent, sustained midlife weight loss compared with persistent overweight was associated with a decreased risk of chronic diseases beyond type 2 diabetes and decreased all-cause mortality.
Corresponding Author: To contact the corresponding author, Timo E. Strandberg, MD, PhD, email timo.strandberg@helsinki.fi.
(doi:10.1001/jamanetworkopen.2025.11825)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Mediators of the Association Between Child Education and Adult Health
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Large Language Models and Text Embeddings for Detecting Depression and Suicide in Patient Narratives
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Priority Health Conditions and Global Life Expectancy Disparities
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Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage
JAMA Neurology
EMBARGOED FOR RELEASE: 4:30 A.M. (ET), FRIDAY, MAY 23, 2025
Media advisory: The full study is linked to this news release. This study is being presented at the European Stroke Organisation Conference 2025.
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About The Study: Although the global age-standardized burden rates of subarachnoid hemorrhage (SAH) more than halved over the last 3 decades, SAH remained one of the most common cardiovascular and neurological causes of death and disabilities in the world, with increasing absolute case numbers. These findings suggest evidence for the potential health benefits of proactive public health planning and resource allocation toward the prevention of SAH. Nontraumatic SAH represents the third most common stroke type after ischemic stroke and intracerebral hemorrhage, accounting for 5% to 10% of all strokes.
Corresponding Author: To contact the corresponding author, Ilari Rautalin, MD, PhD, email ilari.rautalin@aut.ac.nz.
(doi:10.1001/jamaneurol.2025.1522)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Excess US Deaths Before, During, and After the COVID-19 Pandemic
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MAY 23, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: Between 1980 and 2023, the total number of excess U.S. deaths reached an estimated 14.7 million. Although excess deaths per year peaked in 2021, there were still more than 1.5 million during 2022 to 2023. In 2023, excess death rates remained substantially higher than pre-pandemic rates. The rising trend from 1980 to 2019 appears to have continued during and after the pandemic, likely reflecting pre-pandemic causes of death, including drug overdose, firearm injury, and cardiometabolic disease. These deaths highlight the continued consequences of U.S. health system inadequacies, economic inequality, and social and political determinants of health.
Corresponding Author: To contact the corresponding author, Jacob Bor, SD, email jbor@bu.edu.
(doi:10.1001/jamahealthforum.2025.1118)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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US State Policies and Mental Health Symptoms Among Sexual and Gender Minority Adults
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Long-Term Follow-Up of Extracranial-Intracranial Bypass Surgery for Symptomatic Cerebral Artery Occlusion
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Tomosynthesis vs Digital Mammography Screening in Women with a Family History of Breast Cancer
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Breast Cancer Outcomes in Transgender and Gender-Diverse Patients in the National Cancer Database
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Neighborhood Vulnerability and Age of Natural Menopause and Menopausal Symptoms Among Midlife Women
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Medical School Faculty Diversity and the Liaison Committee on Medical Education’s Diversity Standards
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Early-Life Factors and BMI Trajectories Among Children in the ECHO Cohort
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 22, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of children in the Environmental influences on Child Health Outcomes (ECHO) cohort, analyses identified children on the path to obesity as early as age 3.5 years. Modifiable factors could be targeted for early prevention and intervention programs aimed at reducing childhood obesity.
Corresponding Author: To contact the corresponding author, Chang Liu, PhD, email c.liu@wsu.edu.
(doi:10.1001/jamanetworkopen.2025.11835)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cardiac Events in Adults Hospitalized for RSV vs COVID-19 or Influenza
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 22, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study, 1 in 10 patients hospitalized for respiratory syncytial virus (RSV) had a concurrent acute cardiovascular event. Odds of cardiac events were significantly higher in RSV vs COVID-19 hospitalizations in both vaccine-boosted and unboosted individuals. In contemporaneous hospitalizations for RSV or influenza after the pandemic (2023-2024), odds of heart failure were significantly higher in RSV hospitalizations vs vaccine-breakthrough influenza hospitalizations. These findings suggest that patients with preexisting cardiovascular risk should consider vaccination against respiratory viral infections.
Corresponding Author: To contact the corresponding author, Liang En Wee, MPH, email ian.wee.l.e@singhealth.com.sg.
(doi:10.1001/jamanetworkopen.2025.11764)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Clinical Outcomes of Laparoscopic vs Robotic-Assisted Cholecystectomy in Acute Care Surgery
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Loss of PTSD Diagnosis in Response to Evidence-Based Treatments
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Private Equity Among US Psychiatric Hospitals
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Cannabis April 20th Celebration and Related Emergency Department Visits
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Burden of Skin Cancer in Older Adults From 1990 to 2021 and Modelled Projection to 2050
JAMA Dermatology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 21, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The older population (particularly male individuals and those living in high-sociodemographic index countries) is facing a substantial growing burden of skin cancer. Despite the relative incompleteness of keratinocyte cancer data and lack of race and ethnicity data, these results highlight the urgency for more effective prevention and management strategies targeting high-risk groups.
Corresponding Author: To contact the corresponding author, Jin Chen, PhD, email chenjin7791@163.com.
(doi:10.1001/jamadermatol.2025.1276)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Nutritional Content of Ready-to-Eat Breakfast Cereals Marketed to Children
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 21, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Analysis of newly launched children’s ready-to-eat cereals from 2010 to 2023 revealed concerning nutritional shifts: notable increases in fat, sodium, and sugar alongside decreases in protein and fiber. Children’s cereals contain high levels of added sugar, with a single serving exceeding 45% of the American Heart Association’s daily recommended limit for children. These trends suggest a potential prioritization of taste over nutritional quality in product development, contributing to childhood obesity and long-term cardiovascular health risks.
Corresponding Authors: To contact the corresponding authors, email Shuoli Zhao, PhD, (szhao@uky.edu) and Qingxiao Li, PhD, (qli@agcenter.lsu.edu).
(doi:10.1001/jamanetworkopen.2025.11699)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Social Media Use and Depressive Symptoms During Early Adolescence
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 21, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of more than 11,000 children and adolescents, reporting higher than person-level mean social media use in years 1 and 2 after baseline was associated with greater depressive symptoms in the subsequent year. The findings suggest that clinicians should provide anticipatory guidance regarding social media use for young adolescents and their parents.
Corresponding Author: To contact the corresponding author, Jason M. Nagata, MD, email Jason.nagata@ucsf.edu.
(doi:10.1001/jamanetworkopen.2025.11704)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Geographic and Sociodemographic Factors and Receipt of Metabolic Disease Specialty Care
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Postdischarge Alcohol Cessation and Psychiatric Referrals in Alcoholic Liver Disease
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Exposure Therapy in Mixed Reality for Obsessive-Compulsive Disorder
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Substance Use Screening, Brief Intervention, and Referral to Treatment Among Youth-Serving Clinicians
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MAY 20, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that while most clinicians report screening youths for substance use disorders at least sometimes, a substantial proportion screened only intermittently. Efforts to improve screening rates through education and systems-based practice changes may facilitate offering anticipatory guidance and substance use disorder treatment in all youth-serving clinical settings.
Corresponding Author: To contact the corresponding author, Kathleen Ragan-Burnett, MSPH, email xwy3@cdc.gov.
(doi:10.1001/jamanetworkopen.2025.11579)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Sedentary Behavior Among US Adults
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 21, 2025
Media advisory: The full study is linked to this news release.
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About The Study: This study identified a promising trend of declining sedentary behavior among U.S. adults between 2013 and March 2020, but this decline was hampered in 2021-2023. Sedentary lifestyle was widely exacerbated during the COVID-19 pandemic, and this study highlights the enduring impact that this global pandemic may have on daily living patterns.
Corresponding Author: To contact the corresponding author, Wei Bao, MD, PhD, email wbao@ustc.edu.cn.
(doi:10.1001/jama.2025.7220)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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A Multidimensional Diagnostic Approach for COPD
JAMA
EMBARGOED FOR RELEASE: 3 P.M. ET, SUNDAY, MAY 18, 2025
Media advisory: The full study and editorial are linked to this news release. This study is being presented at the American Thoracic Society International Conference.
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About The Study: A new chronic obstructive pulmonary disease (COPD) diagnostic schema integrating respiratory symptoms, respiratory quality of life, spirometry, and structural lung abnormalities on computed tomographic imaging newly classified some individuals as having COPD. These individuals had an increased risk of all-cause and respiratory-related death, frequent exacerbations, and rapid lung function decline compared with individuals classified as not having COPD. Some individuals with airflow obstruction without respiratory symptoms or evidence of structural lung disease were no longer classified as having COPD.
Corresponding Author: To contact the corresponding author, Surya P. Bhatt, MD, MSPH, email sbhatt@uabmc.edu.
(doi:10.1001/jama.2025.7358)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Long-Acting HIV Treatment in Low- and Middle-Income Countries
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Evaluation of the Revised Criteria for Biological and Clinical Staging of Alzheimer Disease
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Chronic Kidney Disease or Hypertension After Childhood Cancer
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Long-Term Health Improvements and Economic Performance Among Individuals With Diabetes
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
Clinical Validation of At-Home Self-Collection for Cervical Cancer Screening
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Racial and Ethnic Disparities in Mother’s Milk Provision Among Mothers of Preterm Infants
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Mental Health Trajectories Among US Survivors of Adolescent and Young Adult Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 19, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, survivors of adolescence and young adulthood cancer reported significantly worse mental health trajectories into middle or older adulthood, compared with individuals who experienced cancer as adults or never had it. Cancer clinicians should recognize the mental health burden for this population into middle age and older adulthood.
Corresponding author: To contact the corresponding author, Anao Zhang, Ph.D., email zhangan@med.umich.edu.
(doi: 10.1001/jamanetworkopen.2025.11430)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Medical School Support of Students’ Professional and Personal Development by Sociodemographic Characteristics
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Antibiotic Treatment in Patients Hospitalized for Nonsevere COVID-19
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MAY 19, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this large cohort study of patients hospitalized with nonsevere COVID-19, there was no clinically meaningful difference in outcomes with early antibiotic treatment. Given the risks associated with unnecessary antibiotic treatment, these results argue against routine antibiotic use in this population.
Corresponding author: To contact the corresponding author, Michael S. Pulia, M.D., Ph.D., email mspulia@medicine.wisc.edu.
(doi: 10.1001/jamanetworkopen.2025.11499)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Race, Ethnicity, Sex, Sexual Orientation, and Discrimination in the Adolescent Brain Cognitive Development Study
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Gender Differences in Primary Care Physician Earnings and Outcomes Under Medicare Advantage Value-Based Payment
JAMA Health Forum
EMBARGOED FOR RELEASE: 5 P.M. (ET), FRIDAY, MAY 16, 2025
Media advisory: The full study is linked to this news release. This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2025.2001?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=051625
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: In this cohort study, women primary care physicians in value-based payment models had equal or better quality outcomes and higher value-based earnings compared to men in their practice groups. These results substantiate prior evidence that women physicians perform better on process and outcome measures, yet receive incommensurate patient ratings. The reversal of the gender gap under value-based payment is likely due to fewer emergency department visits and hospitalizations among women primary care physicians’ patients and may in turn reflect better alignment of value-based models to practice patterns more common in women (e.g., more face-to-face time per visit).
Corresponding Author: To contact the corresponding author, Ishani Ganguli, MD, MPH, email iganguli@bwh.harvard.edu.
(doi:10.1001/jamahealthforum.2025.2001)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Home Health Care Among Traditional Medicare Beneficiaries With or Without Dementia
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 16, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that home health use is high and has increased among people with dementia. Decreasing rates of home health use since 2020 in this high-need population suggest a need for ongoing monitoring of service use and outcomes for people with dementia.
Corresponding Author: To contact the corresponding author, Rachel M. Werner, MD, PhD, email rwerner@upenn.edu.
(doi:10.1001/jamanetworkopen.2025.10933
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Dietary Carbohydrate Intake, Carbohydrate Quality, and Healthy Aging in Women
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MAY 16, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of women, intakes of high-quality carbohydrates and dietary fiber were associated with positive health status in older adulthood, suggesting that dietary carbohydrate quality may be an important determinant of healthy aging.
Corresponding Author: To contact the corresponding author, Andres V. Ardisson Korat, ScD, email andres.ardisson_korat@tufts.edu.
(doi:10.1001/jamanetworkopen.2025.11056)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Launch Prices and Price Increases for Self-Administered Anticancer Drugs in Medicare
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Racial and Socioeconomic Disparities in California Ambulance Patient Offload Times
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Classroom-Level and Individual-Level Prosociality and Help-Seeking Behaviors Among Adolescents
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Hearing Aid Service Models, Technology, and Patient Outcomes
JAMA Otolaryngology–Head & Neck Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 15, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The results of this randomized clinical trial suggest that while over-the-counter (OTC) and OTC+ (audiologists provided limited services for OTC hearing aids) service models were effective, they did not achieve the same outcomes as the audiologists fitted prescription hearing aids following best practices service model. As high-end and low-end hearing aids yielded similar outcomes, support for the higher cost of high-end hearing aids was not identified for individuals with mild to moderate hearing loss.
Corresponding Author: To contact the corresponding author, Yu-Hsiang Wu, MD, PhD, email yu-hsiang-wu@uiowa.edu.
(doi:10.1001/jamaoto.2025.1008)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Long-Term Survival in Patients With Low-Risk Cervical Cancer After Simple, Modified, or Radical Hysterectomy
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MAY 15, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, long-term survival was similar following simple hysterectomy vs modified radical hysterectomy or radical hysterectomy, supporting the use of simple hysterectomy in select patients with low-risk early-stage cervical carcinoma.
Corresponding Authors: To contact the corresponding authors, email Kathleen M. Darcy, PhD (darcyk@whirc.org) and Christopher M. Tarney (christopher.m.tarney.mil@health.mil).
(doi:10.1001/jamanetworkopen.2025.10717)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Early Childhood Food Insecurity and Cardiovascular Health in Young Adulthood
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Psychiatric Prognosis Following Index Suicide Attempts in Early Adolescents
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Causes of Death Among US Medical Residents
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Long-Term Oncologic Outcome of Breast-Conserving Treatment in Patients With Breast Cancer With BRCA Variants
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Ransomware Attacks and Data Breaches in US Health Care Systems
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Cannabis Use Among Older Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MAY 14, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study of cannabis use in veterans ages 65 to 84, use was common, and more than one-third who used in the past 30 days had any cannabis use disorder. The prevalence of past 30-day cannabis use was close to tobacco use prevalence, and risk factors for cannabis use were similar to those observed in other populations. Frequent and inhaled cannabis use was associated with higher odds of any cannabis use disorder. Routine health screening for cannabis use in Veterans Health Administration clinical settings is necessary to identify older adults with cannabis use.
Corresponding Author: To contact the corresponding author, Vira Pravosud, PhD, MPH, MS, email vira.pravosud@va.gov.
(doi:10.1001/jamanetworkopen.2025.10173)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Glucagon-Like Peptide 1 Receptor Agonists and Mental Health
JAMA Psychiatry
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 14, 2025
Media advisory: The full study is linked to this news release.
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About The Study: In patients with overweight/obesity and/or diabetes, glucagon-like peptide 1 receptor agonist (GLP1-RA) treatment is not associated with increased risk of psychiatric adverse events or worsening depressive symptoms relative to placebo and is associated with improvements in quality of life, restrained eating, and emotional eating behavior. These findings provide reassurance regarding the psychiatric safety profile of GLP1-RAs and suggest that GLP1-RA treatment contributes to both physical and emotional well-being.
Corresponding Authors: To contact the corresponding authors, email Aureliane C. S. Pierret, MBBChir (a.pierret@nhs.net) and Toby Pillinger, PhD (toby.pillinger@kcl.ac.uk).
(10.1001/jamapsychiatry.2025.0679)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Insurer Exits After the Inflation Reduction Act Part D Redesign
JAMA
EMBARGOED FOR RELEASE: 5:30 P.M. ET, WEDNESDAY, MAY 14, 2025
Media advisory: The full study is linked to this news release. This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting.
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About The Study: In 2023 and 2024, more Part D beneficiaries were affected by their insurer exiting the marketplace than in previous years. This increase could be associated with changes to Medicare Part D from the Inflation Reduction Act (IRA), which increased Part D plan sponsor financial liability. These IRA provisions were designed to lower out-of-pocket costs for Part D beneficiaries, but increased Part D plan exits could lead to more limited coverage options and less competitive Part D marketplaces.
Corresponding Author: To contact the corresponding author, Christopher L. Cai, MD, email ccai@bwh.harvard.edu.
(doi:10.1001/jama.2025.7289)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Dental and Vision Services Among Veterans in Medicare Advantage vs Traditional Medicare
JAMA
EMBARGOED FOR RELEASE: 4:45 P.M. ET, THURSDAY, MAY 15, 2025
Media advisory: The full study is linked to this news release. This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting.
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About The Study: Although Medicare Advantage (MA) plans offer and directly market supplemental benefits for dental and vision services, veterans enrolled in MA used these services with the same frequency as veterans in traditional Medicare (TM). Moreover, MA plans spent only modestly more on dental services and vision services for veterans than TM, including for emergency dental services. After accounting for private insurance plans used by TM enrollees and out-of-pocket spending, total spending on dental services was no different for veterans in MA vs TM.
Corresponding Author: To contact the corresponding author, José F. Figueroa, MD, MPH, email jfigueroa@hsph.harvard.edu.
(doi:10.1001/jama.2025.7753)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Incomplete Team Staffing, Burnout, and Work Intentions Among US Physicians
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 5 P.M. (ET), WEDNESDAY, MAY 14, 2025
Media advisory: The full study and editorial are linked to this news release. This study is being presented at the 2025 Society of General Internal Medicine Annual Meeting.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2025.1679?guestAccessKey=cb52c805-a6cd-49e1-8f27-d519d054015e&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=051425
About The Study: In this study, physicians frequently experienced incomplete team staffing. Working with an incompletely staffed team was associated with significantly greater odds of burnout, intent to reduce clinical work hours, and intent to leave one’s current organization (ITL). Given associations between ITL and attrition, these findings emphasize the importance of adequate staffing.
Corresponding Author: To contact the corresponding author, Lisa S. Rotenstein, MD, MBA, MSc, email lisa.rotenstein@ucsf.edu.
(doi:10.1001/jamainternmed.2025.1679)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Spironolactone vs Amiloride for Resistant Hypertension
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Remote Symptom Monitoring With Electronic Patient-Reported Outcomes in Clinical Cancer Populations
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Fentanyl Test Strip Use and Overdose Risk Reduction Behaviors Among People Who Use Drugs
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School-Based Health Centers and School Attendance in Rural Areas
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