Cannabis Use During Adolescence and Young Adulthood and Academic Achievement

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Portal Confidentiality Concerns and Health Information Sharing and Access

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Arm Position and Blood Pressure Readings

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 7, 2024

Media advisory: The full study is linked to this news release.  

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About The Study: This crossover randomized clinical trial showed that commonly used arm positions (lap or side) resulted in substantial overestimation of blood pressure readings and may lead to misdiagnosis and overestimation of hypertension. 

Corresponding Author: To contact the corresponding author, Tammy M. Brady, MD, PhD, email tbrady8@jh.edu

 

(doi:10.1001/jamainternmed.2024.5213)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Longitudinal Changes in Epigenetic Age Acceleration Across Childhood and Adolescence

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, OCTOBER 7, 2024

Media advisory: The full study is linked to this news release.

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About The Study: The transition from childhood to adolescence may represent a sensitive developmental period when racism can have long-term deleterious impacts on healthy human development across the life span. Future research should build on the present study and interrogate which social regularities and policies may be perpetuating discrimination against ethnically and racially minoritized adolescents.

Corresponding Author: To contact the corresponding author, Juan Del Toro, PhD, email jdeltoro@umn.edu.

 

(doi:10.1001/jamapediatrics.2024.3669)

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Decline of Mpox Antibody Responses After Modified Vaccinia Ankara–Bavarian Nordic Vaccination

JAMA

EMBARGOED FOR RELEASE: 11:30 A.M. ET, THURSDAY, OCTOBER 3, 2024

Media advisory: The full study is linked to this news release.

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About The Study: The modified vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccination generated mpox antibodies that waned by 6 to 12 months. In participants who received 2 doses of MVA-BN vaccine, mpox antibody responses at 12 months were comparable to or lower than peak antibody responses in people receiving 1 dose, which provided limited protection.

 

Quote from corresponding author Dan H. Barouch, MD, PhD:

“In this observational study, we show that mpox antibody responses decline 6-12 months following Jynneos (MVA-BN) vaccination. Our data suggest that protective immunity may be waning in individuals who were vaccinated with this vaccine in 2022.”

 

Contact information for Dan H. Barouch, MD, PhD: email dbarouch@bidmc.harvard.edu.

 

(doi:10.1001/jama.2024.20951)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Social Risk Factor Domains and Preventive Care Services in US Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, OCTOBER 4, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study of U.S. adults suggests that social risk factor domains were associated with decreased odds of receiving preventive services; this association was cumulative. There is a need to address social risk factors to optimize receipt of recommended preventive services. 

Corresponding Author: To contact the corresponding author, Leonard E. Egede, MD, MS, email legede@buffalo.edu.

 

(doi:10.1001/jamanetworkopen.2024.37492)

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Online Medication Abortion Direct-to-Patient Fulfillment Before and After the Dobbs v Jackson Decision

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, OCTOBER 4, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that online pharmacies play an increasingly critical role in direct-to-patient medication abortion provision, especially with virtual-only platforms. These findings suggest that barriers to accessing online pharmacies for abortion care should be removed. 

Corresponding Author: To contact the corresponding author, Caila Brander, MSc, email cbrander@ibisreproductivehealth.org.

 

(doi:10.1001/jamanetworkopen.2024.34675)

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Prevalence and Factors Associated With Prostate Cancer Among Transgender Women

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Fear of Cancer Recurrence in Adult Survivors of Childhood Cancer

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, OCTOBER 3, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.36144?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=100324

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Decades following treatment, one-third of childhood cancer survivors in this study reported elevated fear their cancer will recur or a subsequent malignant neoplasm will develop. Findings suggest that fear of cancer recurrence should be routinely screened, and clinically significant symptoms intervened upon as a part of survivorship care. 

Corresponding Author: To contact the corresponding author, Nicole M. Alberts, PhD, email nicole.alberts@concordia.ca.

 

(doi:10.1001/jamanetworkopen.2024.36144)

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AI Algorithm for Subclinical Breast Cancer Detection

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, OCTOBER 3, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this retrospective cohort study of women undergoing screening mammography, mean absolute artificial intelligence (AI) scores were higher for breasts developing vs not developing cancer 4 to 6 years before their eventual detection. These findings suggest that commercial AI algorithms developed for breast cancer detection may identify women at high risk of a future breast cancer, offering a pathway for personalized screening approaches that can lead to earlier cancer diagnosis. 

Corresponding Author: To contact the corresponding author, Solveig Hofvind, PhD, email sshh@kreftregisteret.no.

 

(doi:10.1001/jamanetworkopen.2024.37402)

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Bright Light Therapy for Non-Seasonal Depressive Disorders

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, OCTOBER 2, 2024

Media advisory: The full study is linked to this news release.

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About The Study: The results of this systematic review and meta-analysis reveal that bright light therapy was an effective adjunctive treatment for non-seasonal depressive disorders. Additionally, results suggest that bright light therapy may improve the response time to the initial treatment. 

Corresponding Author: To contact the corresponding author, Artur Menegaz de Almeida, MS, email arturomenegaz@gmail.com.

 

(10.1001/jamapsychiatry.2024.2871)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Mental Disorders and Suicidality in Transgender and Gender-Diverse People

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, OCTOBER 2, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This study found a higher prevalence of mental disorders and suicidal behavior in transgender and gender diverse people compared with the cisgender population. This finding aligns with other studies, which have found significantly higher rates of mental health–related health service use among transgender people compared with the general population.  

Corresponding Author: To contact the corresponding author, Ian Colman, PhD, email icolman@uottawa.ca.

 

(doi:10.1001/jamanetworkopen.2024.36883)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Trajectory of Cognitive Decline Before and After Stroke

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, OCTOBER 2, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study using pooled data from 14 cohorts, incident stroke was associated with acute and accelerated long-term cognitive decline in older stroke survivors. 

Corresponding Author: To contact the corresponding author, Jessica W. Lo, MSc, email jessica.lo@unsw.edu.au.

 

(doi:10.1001/jamanetworkopen.2024.37133)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Individual-Level Exposure to Residential Redlining in 1940 and Mortality Risk

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Food Retention at Endoscopy With Glucagon-Like Peptide-1 Receptor Agonists

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 1, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: This cross-sectional study found an association between use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and risks of retained gastric contents and inadequate bowel preparation during single endoscopic procedures.

Corresponding author: To contact the corresponding author, Ruchi Mathur, MD, email ruchi.mathur@cshs.org.

 

(doi: 10.1001/jamanetworkopen.2024.36783)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Depression and Anxiety Among US Children and Young Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, OCTOBER 1, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: This cohort study, using electronic medical record data from a large integrated health care system, found an increase in clinically diagnosed depression from 2017 to 2021, with a higher increase during the COVID-19 pandemic and higher rates in some subgroups. Equally important, this study identified high rates and an increase in clinical diagnosis of anxiety without a depression diagnosis. These results support the increased need in public health and health care effort to combat the mental health crisis in youths.

Corresponding author: To contact the corresponding author, Anny H. Xiang, Ph.D., email anny.h.xiang@kp.org.

 

(doi: 10.1001/jamanetworkopen.2024.36906)

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Pooled Analysis of Physical Activity, Sedentary Behavior, and Sleep Among Children From 33 Countries

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 30, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Most 3- and 4-year-old children in this pooled analysis did not meet the current World Health Organization guidelines for physical activity, sedentary behavior, and sleep. Priority must be given to understanding factors that influence these behaviors in this age group and to implementing contextually appropriate programs and policies proven to be effective in promoting healthy levels of movement behaviors.

Corresponding Author: To contact the corresponding author, Kar Hau Chong, PhD, email khchong@uow.edu.au.

 

(doi:10.1001/jamapediatrics.2024.3330)

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Cause-Specific Mortality Rates Among the US Black Population

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 30, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This study highlights that progress in reducing excess mortality rates among Black individuals was made primarily in reducing deaths from cancer and cardiovascular diseases among males and from cardiovascular diseases and diabetes among females. However, this progress was stalled or reversed by an increase in mortality from external causes, such as assaults and accidents, as well as a stagnation in advancements against cardiovascular diseases during periods without decrease.

 Corresponding Author: To contact the corresponding author, Harlan M. Krumholz, MD, SM, email harlan.krumholz@yale.edu.

 

(doi:10.1001/jamanetworkopen.2024.36402)

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Estimated Long-Term Benefits of Finerenone in Heart Failure

JAMA Cardiology

EMBARGOED FOR RELEASE: 6 P.M. (ET), FRIDAY, SEPTEMBER 27, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the Heart Failure Society of America Annual Scientific Meeting.

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About The Study: In this prespecified secondary analysis of the FINEARTS-HF randomized clinical trial, long-term treatment with the nonsteroidal mineralocorticoid receptor antagonist finerenone was estimated to extend event-free survival by up to 3 years among people with heart failure with mildly reduced or preserved ejection fraction. 

Corresponding Author: To contact the corresponding author, Scott D. Solomon, M.D., email ssolomon@rics.bwh.harvard.edu.

 

(doi:10.1001/jamacardio.2024.3782)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.

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Cardiac Myosin Inhibition in Heart Failure With Normal and Supranormal Ejection Fraction

JAMA Cardiology

EMBARGOED FOR RELEASE: 9:30 A.M. (ET), MONDAY, SEPTEMBER 30, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the Heart Failure Society of America Annual Scientific Meeting.

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About The Study: In an open-label trial in patients with heart failure with preserved ejection fraction with left ventricular ejection fraction of 60% or greater, mavacamten, a cardiac myosin inhibitor, was associated with improvements in biomarkers of cardiac wall stress and injury, with no sustained reductions in left ventricular ejection fraction observed. 

Corresponding Authors: To contact the corresponding authors, email Sanjiv J. Shah, MD, (sanjiv.shah@northwestern.edu) and Scott D. Solomon, MD, (ssolomon@bwh.harvard.edu).

 

(doi:10.1001/jamacardio.2024.3810)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.

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Redlining and Time to Viral Suppression Among Persons With HIV

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 30, 2024

Media advisory: The full study, commentary and related article are linked to this news release.  

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About The Study: The findings of this study suggest the enduring effects of systemic racism on present-day health outcomes among persons with HIV. Regardless of their neighborhood’s contemporary level of gentrification, individuals diagnosed with HIV while living in historically redlined neighborhoods may experience a significantly longer time to viral suppression. 

Corresponding Author: To contact the corresponding author, John R. Bassler, MS, email jbassle1@uab.edu.

 

(doi:10.1001/jamainternmed.2024.5003)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Inequities in Self-Reported Social Risk Factors by Sexual Orientation and Gender Identity

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Voter Support for Policies Associated With Child Health as National Campaign Priorities

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Menopausal Hormone Therapy Use Among Postmenopausal Women

JAMA Health Forum

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, SEPTEMBER 27, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

 

About The Study: The results of this cross-sectional study show that over the past 2 decades, menopausal hormone therapy use declined among U.S. postmenopausal women of all age and racial and ethnic groups. Women of racial and ethnic minority groups had lower prevalence of menopausal hormone therapy use compared to non-Hispanic white women. 

Corresponding Authors: To contact the corresponding authors, email Lin Yang, PhD, (lin.yang@ahs.ca) and Adetunji T. Toriola, MD, PhD, MPH, (a.toriola@wustl.edu).

 

(doi:10.1001/jamahealthforum.2024.3128)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Trends in Female Physicians Entering High-Compensation Specialties

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 30, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This study found that female physicians were underrepresented among residents entering high-compensation specialties compared with non–high-compensation specialties. However, while high-compensation surgical specialties experienced a steady increase in the proportion of female applicants and matriculants over time, high-compensation nonsurgical specialties experienced an overall decrease in the proportion of female applicants and no significant changes in the proportion of female matriculants.

Corresponding Author: To contact the corresponding author, Karina Pereira-Lima, PhD, MSc, email pereiral@med.umich.edu.

 

(doi:10.1001/jama.2024.17516)

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Rates of Sudden Unexpected Infant Death Before and During the Pandemic

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, SEPTEMBER 26, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study found increased rates of both sudden unexpected infant death (SUID) and sudden infant death syndrome (SIDS) during the COVID-19 pandemic, with a significant shift in epidemiology from the pre-pandemic period noted in June to December 2021. These findings support the hypothesis that off-season resurgences in endemic infectious pathogens may be associated with SUID rates, with respiratory syncytial virus (RSV) rates in the U.S. closely approximating this shift. Further investigation into the role of infection in SUID and SIDS is needed. 

Corresponding Author: To contact the corresponding author, Emma G. Guare, BA, email egguare@gmail.com.

 

(doi:10.1001/jamanetworkopen.2024.35722)

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Estimation of Tax Benefit of Nonprofit Hospitals

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, SEPTEMBER 26, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This study highlights the wide variation of nonprofit hospitals’ tax benefit across states, its high concentration among a small number of hospitals, and the primary role played by state and local taxes. Policy efforts to strengthen nonprofit hospitals’ taxpayer accountability are likely to be more effective when pursued at the local level.

Corresponding Author: To contact the corresponding author, Ge Bai, PhD, CPA, email gbai@jhu.edu.

 

(doi:10.1001/jama.2024.13413)

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Suicidal Ideation and Suicide Attempts After Direct or Indirect Psychotherapy

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Predicting Suicides Among US Army Soldiers After Leaving Active Service

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Home- vs Office-Based Narrowband UV-B Phototherapy for Patients With Psoriasis

JAMA Dermatology

EMBARGOED FOR RELEASE: 4:55 A.M. (ET), WEDNESDAY, SEPTEMBER 25, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Academy of Dermatology and Venereology Congress 2024.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/jamadermatol.2024.3897?guestAccessKey=e2392f94-a984-44d6-a838-ab3bea7b69e0&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=092524

 

About The Study: In this randomized clinical trial, home-based phototherapy was as effective as office-based phototherapy for plaque or guttate psoriasis in everyday clinical practice and had less burden to patients.

Corresponding Author: To contact the corresponding author, Joel M. Gelfand, MD, email joel.gelfand@pennmedicine.upenn.edu.

 

(doi:10.1001/jamadermatol.2024.3897)

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Emerging SARS-CoV-2 Resistance After Antiviral Treatment

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 25, 2024

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.35431?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092524

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Treatment-emergent nirmatrelvir resistance mutations were commonly detected, especially in individuals who were immunosuppressed in this cohort study of 156 participants. However, these mutations were generally present at low frequencies and were transient in nature, suggesting a low risk for the spread of nirmatrelvir resistance in the community with the current variants and drug usage patterns.

Corresponding Author: To contact the corresponding author, Jonathan Z. Li, MD, MMsc, email jli@bwh.harvard.edu.

 

(doi:10.1001/jamanetworkopen.2024.35431)

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Semaglutide and Opioid Overdose Risk in Patients With Type 2 Diabetes and Opioid Use Disorder

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 25, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.35247?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092524

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study, semaglutide was associated with reduced opioid overdose risk in patients with comorbid type 2 diabetes and opioid use disorder, suggesting its potential therapeutic value for preventing overdoses. The results need validation from other data resources and study populations. Further research is warranted to investigate the underlying mechanisms and randomized clinical trials are necessary to corroborate the clinical effects on opioid use disorder. 

Corresponding Authors: To contact the corresponding authors, email Rong Xu, PhD, (rxx@case.edu) and Nora D. Volkow, MD, (nvolkow@nida.nih.gov).

 

(doi:10.1001/jamanetworkopen.2024.35247)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Positive Autism Screening Rates in Toddlers Born During the COVID-19 Pandemic

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of 2 groups of children with prenatal pandemic exposure and/or exposure to maternal SARS-CoV-2 infection, neither exposure was associated with greater Modified Checklist for Autism in Toddlers, Revised positivity. 

Corresponding Author: To contact the corresponding author, Dani Dumitriu, MD, PhD, email dani.dumitriu@columbia.edu.

 

(doi:10.1001/jamanetworkopen.2024.35005)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Deprescribing of Antihypertensive Medications and Cognitive Function in Nursing Home Residents

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Direct-to-Consumer Educational Brochures to Promote Gabapentinoid Deprescribing in Older Adults

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Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation

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Perceived CTE and Suicidality in Former Professional Football Players

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study and editorial are linked to this news release.

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About The Study: This study found that approximately one-third of living former professional football players reported perceived chronic traumatic encephalopathy (CTE). Men with perceived CTE had an increased prevalence of suicidality and were more likely to have health problems associated with cognitive impairment compared with men without perceived CTE. Perceived CTE represents a novel risk factor for suicidality and, if present, should motivate the diagnostic assessment and treatment of medical and behavioral conditions that may be misattributed to CTE neuropathological change.

Corresponding Authors: To contact the corresponding authors, email Rachel Grashow, PhD, MS, (rgrashow@hsph.harvard.edu) and Aaron L. Baggish, MD, (aaron.baggish@chuv.ch).

 

(doi:10.1001/jamaneurol.2024.3083)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Efficacy of Gamified Digital Mental Health Interventions for Pediatric Mental Health Conditions

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study is linked to this news release.

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About The Study: The findings of this study suggest a benefit of gamified digital mental health interventions for youth with attention-deficit/hyperactivity disorder (ADHD) or depressive disorder. Pediatricians and other health care professionals have new information about novel, accessible, and efficacious options for pediatric mental health care.

Corresponding Author: To contact the corresponding author, Joseph F. McGuire, PhD, email jfmcguire@jhmi.edu.

 

(doi:10.1001/jamapediatrics.2024.3139)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Influenza Infection During Pregnancy and Risk of Seizures in Offspring

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this cohort study suggest that maternal influenza infection during pregnancy was associated with an increased risk of childhood seizures, especially febrile seizures, but not epilepsy. Further studies are needed to elucidate the mechanisms underlying childhood neurological development. 

Corresponding Author: To contact the corresponding author, Ming-Chih Lin, MD, PhD, email mingclin@gmail.com.

 

(doi:10.1001/jamanetworkopen.2024.34935)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Historical Redlining, Contemporary Gentrification, and Severe Maternal Morbidity in California

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings from this cross-sectional study demonstrate that the legacies of redlining, intertwined with current dynamics of displacement and gentrification, affect severe maternal morbidity. Place-based sociopolitical mechanisms that inequitably distribute resources may be important intervention points to address structural drivers of adverse pregnancy outcomes and their racial inequities. 

Corresponding Author: To contact the corresponding author, Mahasin S. Mujahid, PhD, email mujahid@berkeley.edu.

 

(doi:10.1001/jamanetworkopen.2024.29428)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Voice-Activated Cognitive Behavioral Therapy for Insomnia

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 24, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: This randomized clinical trial of an in-home, voice-activated cognitive behavioral therapy for insomnia program among breast cancer survivors found that the intervention improved insomnia symptoms. Future studies may explore how this program can be taken to scale and integrated into ambulatory care.

Corresponding author: To contact the corresponding author, Hannah Arem, Ph.D., email Hannah.Arem@medstar.net.

 

(doi: 10.1001/jamanetworkopen.2024.35011)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Absolute and Functional Iron Deficiency in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 24, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.33126?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092424

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: The findings of this study suggest that absolute and functional iron deficiency affect a large proportion of American adults even in the absence of anemia, heart failure, or chronic kidney disease. Further research on the role of functional iron deficiency in adverse health outcomes and on iron deficiency screening strategies is needed.

Corresponding author: To contact the corresponding author, Leo F. Buckley, Pharm.D., M.P.H., email lfbuckley@bwh.harvard.edu.

 

(doi: 10.1001/jamanetworkopen.2024.33126)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Rural-Urban Disparities in Hospital Services and Outcomes for Children With Medical Complexity

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 24, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: Rural-residing children with medical complexity were significantly more likely to present to hospitals without dedicated pediatric services in this cohort study. These findings suggest that efforts are justified to ensure that all hospital types are prepared to care for children with medical complexity.

Corresponding author: To contact the corresponding author, JoAnna K. Leyenaar, M.D., Ph.D., M.P.H., email joanna.k.leyenaar@hitchcock.org.

 

(doi: 10.1001/jamanetworkopen.2024.35187)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Understanding Variation in Negotiated Rates Using Novel Health Plan Price Transparency Data

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Wearable Device–Based Intervention for Promoting Patient Physical Activity After Lung Cancer Surgery

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 20, 2024

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.34180?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092024

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this nonrandomized clinical trial, integration of perioperative exercise interventions using wearable devices improved physical activity (especially moderate-to-vigorous physical activity) and dyspnea at 6 months after lung cancer surgery compared with usual care. This finding suggests a promising role for wearable devices in personalizing perioperative rehabilitation strategies.

Corresponding Authors: To contact the corresponding authors, email Danbee Kang, PhD, (dbee.kang@gmail.com) and Hye Yun Park, MD, (hyeyunpark@skku.edu).

 

(doi:10.1001/jamanetworkopen.2024.34180)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Projections of Extreme Temperature–Related Deaths in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 20, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.34942?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092024

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study found that extreme temperature–related deaths in the contiguous U.S. were projected to increase substantially by mid–21st century, with certain populations, such as non-Hispanic Black and Hispanic adults, projected to disproportionately experience this increase. The results point to the need to mitigate the adverse outcome of extreme temperatures for population health. 

Corresponding Author: To contact the corresponding author, Sameed Ahmed M. Khatana, MD, MPH, email sameed.khatana@pennmedicine.upenn.edu.

 

(doi:10.1001/jamanetworkopen.2024.34942)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Comorbidity and Disease Activity in Multiple Sclerosis

JAMA Neurology

EMBARGOED FOR RELEASE: 6 A.M. (ET), WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Committee for Treatment and Research in Multiple Sclerosis 2024 Annual Congress.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2024.2920?guestAccessKey=197708bb-2594-4190-9cc1-fcd859428206&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091824

 

About The Study: In this study, a higher burden of comorbidity was associated with worse clinical outcomes in people with multiple sclerosis (MS), although comorbidity could potentially be a partial mediator of other negative prognostic factors. The findings suggest a substantial adverse association of the comorbidities investigated with MS disease activity and that prevention and management of comorbidities should be a pressing concern in clinical practice. 

Corresponding Author: To contact the corresponding author, Amber Salter, PhD, email amber.salter@utsouthwestern.edu.

 

(doi:10.1001/jamaneurol.2024.2920)

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Safety of the Seasonal Influenza Vaccine in 2 Successive Pregnancies

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, SEPTEMBER 19, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.34857?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091924

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this large cohort study of successive pregnancies, influenza vaccination was not associated with increased risk of adverse perinatal outcomes, irrespective of interpregnancy interval and vaccine type. Findings support recommendations to vaccinate pregnant people or those who might be pregnant during the influenza season.  

Corresponding Author: To contact the corresponding author, Darios Getahun, MD, PhD, MPH, email darios.t.getahun@kp.org.

 

(doi:10.1001/jamanetworkopen.2024.34857)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Preconception and Early-Pregnancy BMI in Women and Men, Time to Pregnancy, and Risk of Miscarriage

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, SEPTEMBER 19, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.36157?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091924

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that optimizing body mass index (BMI) in women and men from the preconception period onward might be an important strategy to improve fertility and reduce the risk of miscarriage.

Corresponding Author: To contact the corresponding author, Vincent W. V. Jaddoe, MD, PhD, email v.jaddoe@erasmusmc.nl.

 

(doi:10.1001/jamanetworkopen.2024.36157)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

An Update on the Survival of the First 50 Face Transplants Worldwide

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2024.3748?guestAccessKey=6d63c824-4da2-4d41-8166-6a626581bc52&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091824

 

About The Study: In this study, the overall survival of the face transplants is encouraging. These data suggest that the acceptable long-term survival of face transplants makes them a reconstructive option for extensive facial defects.

 

Quote from corresponding author Pauliina Homsy, MD, PhD:

“A total of 50 face transplants have been performed since 2005. Activity has been concentrated with only 18 centers in 11 countries giving this treatment. Our study demonstrates an overall 5- and 10-year survival of face transplants at 85% and 74%, respectively.

“The majority of patients with severe facial defects can be treated with conventional methods but there are those whose defect is too complex for it. The encouraging face transplant survival rate suggests that face transplantation can be a long-term reconstructive option for these patients.”

 

Contact information for Pauliina Homsy, MD, PhD: email pauliina.homsy@hus.fi.

 

(doi:10.1001/jamasurg.2024.3748)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Suicidality Calls to a National Helpline After a Terror Attack and War

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2024.2034?guestAccessKey=d0f1d5da-d04f-4bbb-89cc-f9eb1137b9ec&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091824

Patient Self-Guided Interventions to Reduce Sedative Use and Improve Sleep

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2024.2731?guestAccessKey=764174f0-d782-498a-a696-8b4f3c953d86&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091824

 

About The Study: The results of this randomized clinical trial showed that transitioning insomnia care for older adults away from long-term sedative use and toward cognitive behavioral therapy for insomnia can be achieved using a mailed, direct-to-patient approach. 

Corresponding Author: To contact the corresponding author, David M. Gardner, PharmD, MSc CH&E, email david.gardner@dal.ca.

 

(10.1001/jamapsychiatry.2024.2731)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Social Determinants of Health and Insurance Claim Denials for Preventive Care

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.33316?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091824

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of 1.5 million patients seeking preventive care, denials of insurance claims for preventive care were disproportionately more common among at-risk patient populations. This administrative burden potentially perpetuates inequitable access to high-value health care. 

Corresponding Author: To contact the corresponding author, Alex Hoagland, PhD, email alexander.hoagland@utoronto.ca.

 

(doi:10.1001/jamanetworkopen.2024.33316)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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