Estimation of Tax Benefit of Nonprofit Hospitals

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, SEPTEMBER 26, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This study highlights the wide variation of nonprofit hospitals’ tax benefit across states, its high concentration among a small number of hospitals, and the primary role played by state and local taxes. Policy efforts to strengthen nonprofit hospitals’ taxpayer accountability are likely to be more effective when pursued at the local level.

Corresponding Author: To contact the corresponding author, Ge Bai, PhD, CPA, email gbai@jhu.edu.

 

(doi:10.1001/jama.2024.13413)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Suicidal Ideation and Suicide Attempts After Direct or Indirect Psychotherapy

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Predicting Suicides Among US Army Soldiers After Leaving Active Service

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Home- vs Office-Based Narrowband UV-B Phototherapy for Patients With Psoriasis

JAMA Dermatology

EMBARGOED FOR RELEASE: 4:55 A.M. (ET), WEDNESDAY, SEPTEMBER 25, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Academy of Dermatology and Venereology Congress 2024.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/jamadermatol.2024.3897?guestAccessKey=e2392f94-a984-44d6-a838-ab3bea7b69e0&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=092524

 

About The Study: In this randomized clinical trial, home-based phototherapy was as effective as office-based phototherapy for plaque or guttate psoriasis in everyday clinical practice and had less burden to patients.

Corresponding Author: To contact the corresponding author, Joel M. Gelfand, MD, email joel.gelfand@pennmedicine.upenn.edu.

 

(doi:10.1001/jamadermatol.2024.3897)

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Emerging SARS-CoV-2 Resistance After Antiviral Treatment

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 25, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Treatment-emergent nirmatrelvir resistance mutations were commonly detected, especially in individuals who were immunosuppressed in this cohort study of 156 participants. However, these mutations were generally present at low frequencies and were transient in nature, suggesting a low risk for the spread of nirmatrelvir resistance in the community with the current variants and drug usage patterns.

Corresponding Author: To contact the corresponding author, Jonathan Z. Li, MD, MMsc, email jli@bwh.harvard.edu.

 

(doi:10.1001/jamanetworkopen.2024.35431)

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Semaglutide and Opioid Overdose Risk in Patients With Type 2 Diabetes and Opioid Use Disorder

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 25, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this study, semaglutide was associated with reduced opioid overdose risk in patients with comorbid type 2 diabetes and opioid use disorder, suggesting its potential therapeutic value for preventing overdoses. The results need validation from other data resources and study populations. Further research is warranted to investigate the underlying mechanisms and randomized clinical trials are necessary to corroborate the clinical effects on opioid use disorder. 

Corresponding Authors: To contact the corresponding authors, email Rong Xu, PhD, (rxx@case.edu) and Nora D. Volkow, MD, (nvolkow@nida.nih.gov).

 

(doi:10.1001/jamanetworkopen.2024.35247)

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Positive Autism Screening Rates in Toddlers Born During the COVID-19 Pandemic

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of 2 groups of children with prenatal pandemic exposure and/or exposure to maternal SARS-CoV-2 infection, neither exposure was associated with greater Modified Checklist for Autism in Toddlers, Revised positivity. 

Corresponding Author: To contact the corresponding author, Dani Dumitriu, MD, PhD, email dani.dumitriu@columbia.edu.

 

(doi:10.1001/jamanetworkopen.2024.35005)

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Deprescribing of Antihypertensive Medications and Cognitive Function in Nursing Home Residents

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Direct-to-Consumer Educational Brochures to Promote Gabapentinoid Deprescribing in Older Adults

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Left Atrial Appendage Occlusion vs Standard of Care After Ischemic Stroke Despite Anticoagulation

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Perceived CTE and Suicidality in Former Professional Football Players

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study and editorial are linked to this news release.

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About The Study: This study found that approximately one-third of living former professional football players reported perceived chronic traumatic encephalopathy (CTE). Men with perceived CTE had an increased prevalence of suicidality and were more likely to have health problems associated with cognitive impairment compared with men without perceived CTE. Perceived CTE represents a novel risk factor for suicidality and, if present, should motivate the diagnostic assessment and treatment of medical and behavioral conditions that may be misattributed to CTE neuropathological change.

Corresponding Authors: To contact the corresponding authors, email Rachel Grashow, PhD, MS, (rgrashow@hsph.harvard.edu) and Aaron L. Baggish, MD, (aaron.baggish@chuv.ch).

 

(doi:10.1001/jamaneurol.2024.3083)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Efficacy of Gamified Digital Mental Health Interventions for Pediatric Mental Health Conditions

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study is linked to this news release.

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About The Study: The findings of this study suggest a benefit of gamified digital mental health interventions for youth with attention-deficit/hyperactivity disorder (ADHD) or depressive disorder. Pediatricians and other health care professionals have new information about novel, accessible, and efficacious options for pediatric mental health care.

Corresponding Author: To contact the corresponding author, Joseph F. McGuire, PhD, email jfmcguire@jhmi.edu.

 

(doi:10.1001/jamapediatrics.2024.3139)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Influenza Infection During Pregnancy and Risk of Seizures in Offspring

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The results of this cohort study suggest that maternal influenza infection during pregnancy was associated with an increased risk of childhood seizures, especially febrile seizures, but not epilepsy. Further studies are needed to elucidate the mechanisms underlying childhood neurological development. 

Corresponding Author: To contact the corresponding author, Ming-Chih Lin, MD, PhD, email mingclin@gmail.com.

 

(doi:10.1001/jamanetworkopen.2024.34935)

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Historical Redlining, Contemporary Gentrification, and Severe Maternal Morbidity in California

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 23, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings from this cross-sectional study demonstrate that the legacies of redlining, intertwined with current dynamics of displacement and gentrification, affect severe maternal morbidity. Place-based sociopolitical mechanisms that inequitably distribute resources may be important intervention points to address structural drivers of adverse pregnancy outcomes and their racial inequities. 

Corresponding Author: To contact the corresponding author, Mahasin S. Mujahid, PhD, email mujahid@berkeley.edu.

 

(doi:10.1001/jamanetworkopen.2024.29428)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Voice-Activated Cognitive Behavioral Therapy for Insomnia

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 24, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: This randomized clinical trial of an in-home, voice-activated cognitive behavioral therapy for insomnia program among breast cancer survivors found that the intervention improved insomnia symptoms. Future studies may explore how this program can be taken to scale and integrated into ambulatory care.

Corresponding author: To contact the corresponding author, Hannah Arem, Ph.D., email Hannah.Arem@medstar.net.

 

(doi: 10.1001/jamanetworkopen.2024.35011)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Absolute and Functional Iron Deficiency in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 24, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: The findings of this study suggest that absolute and functional iron deficiency affect a large proportion of American adults even in the absence of anemia, heart failure, or chronic kidney disease. Further research on the role of functional iron deficiency in adverse health outcomes and on iron deficiency screening strategies is needed.

Corresponding author: To contact the corresponding author, Leo F. Buckley, Pharm.D., M.P.H., email lfbuckley@bwh.harvard.edu.

 

(doi: 10.1001/jamanetworkopen.2024.33126)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Rural-Urban Disparities in Hospital Services and Outcomes for Children With Medical Complexity

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 24, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: Rural-residing children with medical complexity were significantly more likely to present to hospitals without dedicated pediatric services in this cohort study. These findings suggest that efforts are justified to ensure that all hospital types are prepared to care for children with medical complexity.

Corresponding author: To contact the corresponding author, JoAnna K. Leyenaar, M.D., Ph.D., M.P.H., email joanna.k.leyenaar@hitchcock.org.

 

(doi: 10.1001/jamanetworkopen.2024.35187)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Understanding Variation in Negotiated Rates Using Novel Health Plan Price Transparency Data

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Wearable Device–Based Intervention for Promoting Patient Physical Activity After Lung Cancer Surgery

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 20, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this nonrandomized clinical trial, integration of perioperative exercise interventions using wearable devices improved physical activity (especially moderate-to-vigorous physical activity) and dyspnea at 6 months after lung cancer surgery compared with usual care. This finding suggests a promising role for wearable devices in personalizing perioperative rehabilitation strategies.

Corresponding Authors: To contact the corresponding authors, email Danbee Kang, PhD, (dbee.kang@gmail.com) and Hye Yun Park, MD, (hyeyunpark@skku.edu).

 

(doi:10.1001/jamanetworkopen.2024.34180)

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Projections of Extreme Temperature–Related Deaths in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 20, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study found that extreme temperature–related deaths in the contiguous U.S. were projected to increase substantially by mid–21st century, with certain populations, such as non-Hispanic Black and Hispanic adults, projected to disproportionately experience this increase. The results point to the need to mitigate the adverse outcome of extreme temperatures for population health. 

Corresponding Author: To contact the corresponding author, Sameed Ahmed M. Khatana, MD, MPH, email sameed.khatana@pennmedicine.upenn.edu.

 

(doi:10.1001/jamanetworkopen.2024.34942)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Comorbidity and Disease Activity in Multiple Sclerosis

JAMA Neurology

EMBARGOED FOR RELEASE: 6 A.M. (ET), WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Committee for Treatment and Research in Multiple Sclerosis 2024 Annual Congress.

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About The Study: In this study, a higher burden of comorbidity was associated with worse clinical outcomes in people with multiple sclerosis (MS), although comorbidity could potentially be a partial mediator of other negative prognostic factors. The findings suggest a substantial adverse association of the comorbidities investigated with MS disease activity and that prevention and management of comorbidities should be a pressing concern in clinical practice. 

Corresponding Author: To contact the corresponding author, Amber Salter, PhD, email amber.salter@utsouthwestern.edu.

 

(doi:10.1001/jamaneurol.2024.2920)

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Safety of the Seasonal Influenza Vaccine in 2 Successive Pregnancies

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, SEPTEMBER 19, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.34857?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091924

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this large cohort study of successive pregnancies, influenza vaccination was not associated with increased risk of adverse perinatal outcomes, irrespective of interpregnancy interval and vaccine type. Findings support recommendations to vaccinate pregnant people or those who might be pregnant during the influenza season.  

Corresponding Author: To contact the corresponding author, Darios Getahun, MD, PhD, MPH, email darios.t.getahun@kp.org.

 

(doi:10.1001/jamanetworkopen.2024.34857)

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Preconception and Early-Pregnancy BMI in Women and Men, Time to Pregnancy, and Risk of Miscarriage

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, SEPTEMBER 19, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that optimizing body mass index (BMI) in women and men from the preconception period onward might be an important strategy to improve fertility and reduce the risk of miscarriage.

Corresponding Author: To contact the corresponding author, Vincent W. V. Jaddoe, MD, PhD, email v.jaddoe@erasmusmc.nl.

 

(doi:10.1001/jamanetworkopen.2024.36157)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

An Update on the Survival of the First 50 Face Transplants Worldwide

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2024.3748?guestAccessKey=6d63c824-4da2-4d41-8166-6a626581bc52&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091824

 

About The Study: In this study, the overall survival of the face transplants is encouraging. These data suggest that the acceptable long-term survival of face transplants makes them a reconstructive option for extensive facial defects.

 

Quote from corresponding author Pauliina Homsy, MD, PhD:

“A total of 50 face transplants have been performed since 2005. Activity has been concentrated with only 18 centers in 11 countries giving this treatment. Our study demonstrates an overall 5- and 10-year survival of face transplants at 85% and 74%, respectively.

“The majority of patients with severe facial defects can be treated with conventional methods but there are those whose defect is too complex for it. The encouraging face transplant survival rate suggests that face transplantation can be a long-term reconstructive option for these patients.”

 

Contact information for Pauliina Homsy, MD, PhD: email pauliina.homsy@hus.fi.

 

(doi:10.1001/jamasurg.2024.3748)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Suicidality Calls to a National Helpline After a Terror Attack and War

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2024.2034?guestAccessKey=d0f1d5da-d04f-4bbb-89cc-f9eb1137b9ec&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091824

Patient Self-Guided Interventions to Reduce Sedative Use and Improve Sleep

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2024.2731?guestAccessKey=764174f0-d782-498a-a696-8b4f3c953d86&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091824

 

About The Study: The results of this randomized clinical trial showed that transitioning insomnia care for older adults away from long-term sedative use and toward cognitive behavioral therapy for insomnia can be achieved using a mailed, direct-to-patient approach. 

Corresponding Author: To contact the corresponding author, David M. Gardner, PharmD, MSc CH&E, email david.gardner@dal.ca.

 

(10.1001/jamapsychiatry.2024.2731)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Social Determinants of Health and Insurance Claim Denials for Preventive Care

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.33316?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091824

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cohort study of 1.5 million patients seeking preventive care, denials of insurance claims for preventive care were disproportionately more common among at-risk patient populations. This administrative burden potentially perpetuates inequitable access to high-value health care. 

Corresponding Author: To contact the corresponding author, Alex Hoagland, PhD, email alexander.hoagland@utoronto.ca.

 

(doi:10.1001/jamanetworkopen.2024.33316)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Characteristics and Trends of Prehospital Encounters for Opioid Overdoses Among US Youth, 2018-2022

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Prehospital encounters for youth opioid overdoses were increasing prior to the pandemic, increased with the onset, and then stabilized, remaining higher than pre-pandemic levels. Although overall patterns were largely driven by those ages 18 through 24, adolescents ages 12 through 17 were the only subgroup with an increasing number of encounters both before and during the pandemic.

Corresponding Author: To contact the corresponding author, Jamie Lim, MD, email jlim@luriechildrens.org.

 

(doi:10.1001/jama.2024.17341)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Excess Body Weight and the Risk of Second Primary Cancers Among Cancer Survivors

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 17, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.33132?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091724

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this cohort study of older survivors of nonmetastatic cancer, those who had overweight or obesity at the time of their first cancer diagnosis were at higher risk of developing a second cancer, especially an obesity-related second cancer. Given the high prevalence of overweight and obesity among cancer survivors, it is important to promote survivorship care guidelines recommending weight management and increase awareness of second cancers among physicians and cancer survivors.

Corresponding author: To contact the corresponding author, Clara Bodelon, Ph.D., M.S., email clara.bodelon@cancer.org

 

(doi: 10.1001/jamanetworkopen.2024.33132)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Outcomes by Race and Ethnicity Following a Medicare Bundled Payment Program for Joint Replacement

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 17, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: This cohort study shows that the Comprehensive Care for Joint Replacement program outcomes differed by race and ethnicity for patients covered outside traditional Medicare, with home discharge rates increasing more for Hispanic compared with non-Hispanic white patients. These findings suggest the importance of considering differential outcomes of Medicare payment policies for racial and ethnic minority patient populations beyond the initially targeted groups.

Corresponding author: To contact the corresponding author, Narae Kim, Ph.D., email naraekim@usc.edu.

 

(doi: 10.1001/jamanetworkopen.2024.33962)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Malaria Rapid Tests, Febrile Illness Management, and Child Mortality Across Sub-Saharan African Countries

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GLP-1 Receptor Agonists and Risk for Cirrhosis and Related Complications in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease

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Cannabinoids Used for Medical Purposes in Children and Adolescents

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2024.3045?guestAccessKey=18370056-5092-42ac-8ed3-b9d13f5388ee&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091624

Neighborhood Food Access in Early Life and Trajectories of Child BMI and Obesity

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 16, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Residence in low-income, low–food access neighborhoods in early life was associated with higher subsequent child body mass index and higher risk of obesity and severe obesity. Future studies should examine the effectiveness of investments in neighborhood resources to improve food access in preventing child obesity.

Corresponding Author: To contact the corresponding author, Izzuddin M. Aris, PhD, email izzuddin_aris@hphci.harvard.edu.

 

(doi:10.1001/jamapediatrics.2024.3459)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Air Pollution and Parkinson Disease in a Population-Based Study

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 16, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that a reduction in air pollution may help reduce Parkinson disease risk, modifying the Parkinson disease phenotype and the risk of dyskinesia in patients with Parkinson disease. 

Corresponding Authors: To contact the corresponding authors, email Brittany Krzyzanowski, PhD, (brittany.krzyzanowski@barrowneuro.org) and Rodolfo Savica, MD, PhD, (savica.rodolfo@mayo.edu).

 

(doi:10.1001/jamanetworkopen.2024.33602)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Real-Time Exposure to Negative News Media and Suicidal Ideation Intensity Among LGBTQ+ Young Adults

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 16, 2024

Media advisory: The full study and editorial are linked to this news release.

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About The Study: This intensive longitudinal cohort study found that suicidal ideation intensity modestly increased in the hours immediately following exposure to lesbian, gay, bisexual, transgender, or queer (LGBTQ+) negative news or media among LGBTQ+ young adults. These findings have timely implications for research and intervention, particularly within sociopolitical and geographic contexts where news or media coverage about LGBTQ+ topics is intensified.

Corresponding Author: To contact the corresponding author, Kirsty A. Clark, MPH, PhD, email kirsty.clark@vanderbilt.edu.

 

(doi:10.1001/jamapediatrics.2024.3133)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Efficacy and Safety of Erenumab for Nonopioid Medication Overuse Headache in Chronic Migraine

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 16, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2024.3043?guestAccessKey=eaf63723-49d8-4ab9-b76b-b3c2d525b92d&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091624

 

About The Study: In this study, monthly, 140 mg erenumab injections safely and effectively achieved medication overuse headaches remission in patients with nonopioid chronic migraine and medication overuse headaches within 6 months.

 

Quote from corresponding author Stewart J. Tepper, MD:

“Those patients with medication overuse headache (MOH) have higher disability and a significant unmet clinical need. Erenumab proved effective versus placebo in significantly higher rates of MOH remission and marked reduction in days in which acute migraine treatment was taken in a randomized controlled trial, with these benefits sustained through a one- year open label treatment period.

“The change for clinical care will be that practitioners can start patients with MOH on erenumab and expect a likelihood of MOH remission for most without other interventions, such as planned wean, inpatient detoxification, or behavioral therapies. This will simplify and improve care of MOH patients.”

 

Contact information for Stewart J. Tepper, MD: email sjtepper@gmail.com.

 

(doi:10.1001/jamaneurol.2024.3043)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of COPD

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A Machine Learning Method for Allocating Scarce COVID-19 Monoclonal Antibodies

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2024.2884?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091324

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Evaluating Policy Changes for Adjusting Payment to Address Health Disparities

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2024.2905?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091324

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Stimulant, Antidepressant, and Opioid Telehealth Prescription Trends Between 2019 and 2022

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 13, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.33334?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091324

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: From 2019 to 2022, overall prescription volumes for stimulant and antidepressant medications increased, while prescription volume for opioids decreased. Concurrently, the proportion of telehealth prescriptions climbed across medications, increasing by a factor of 188 in opioids and more than 20 for antidepressants. These findings align with existing research highlighting the shift toward telehealth and the rise in stimulant and opioid telehealth prescribing during the pandemic. While in-person prescribing remains the most common, increasing telehealth utilization across medications suggests a growing acceptance, need, or preference for remote services.

Corresponding Author: To contact the corresponding author, Ashwini Nagappan, MBE, email ashwininagappan@ucla.edu.

 

(doi:10.1001/jamanetworkopen.2024.33334)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Adolescents and Young Adults’ Sources of Contraceptive Information

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 13, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.33310?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091324

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This study’s results suggest discrepancies between preferred and actual sources of contraceptive information for assigned female at birth adolescents and young adults in the U.S. Findings underscore the role of clinicians in supporting informed contraceptive decision-making among adolescents and young adults. Clinicians were the most commonly preferred source, and receiving information from them was associated with having sufficient information to choose a contraceptive method; however, clinicians were the source with the largest discrepancy between preferred and actual use. 

Corresponding Author: To contact the corresponding author, Elizabeth Pleasants, DrPH, MPH, email b_pleasants@berkeley.edu.

 

(doi:10.1001/jamanetworkopen.2024.33310)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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One-Year Weight Reduction With Semaglutide or Liraglutide in Clinical Practice

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 13, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.33326?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091324

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this retrospective cohort study of 3,389 patients with obesity, weight reduction at 1 year was associated with the medication’s active agent, its dosage, treatment indication, persistent medication coverage, and patient sex. Future research should focus on identifying the reasons for discontinuation of medication use and interventions aimed at improving long-term persistent coverage. 

Corresponding Author: To contact the corresponding author, Hamlet Gasoyan, PhD, email gasoyah@ccf.org.

 

(doi:10.1001/jamanetworkopen.2024.33326)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Health Warnings on Instagram Advertisements for Synthetic Nicotine E-Cigarettes and Engagement

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 13, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.34434?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=091324

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study of synthetic nicotine brand Instagram accounts, 87% of sampled posts did not adhere to FDA health warning requirements in tobacco promotions. Enforcement of FDA compliant health warnings on social media may reduce youth engagement with tobacco marketing. 

Corresponding Author: To contact the corresponding author, Traci Hong, PhD, email tjhong@bu.edu.

 

(doi:10.1001/jamanetworkopen.2024.34434)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Molecular, Socioeconomic, and Clinical Factors Affecting Racial and Ethnic Disparities in Colorectal Cancer Survival

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 12, 2024

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2024.3666?guestAccessKey=68345ab4-be63-495f-92c1-465f42ac77fb&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=091224

 

About The Study: This single-center cohort study identified substantial overall survival disparity and differing frequencies of driver gene variations by race and ethnicity. Socioeconomic status had the largest contribution but accounted for less than one-third of the disparity, with substantial contribution from tumor molecular features. Further study of the associations of genetic ancestry and the molecular pathogenesis of colorectal cancer with chemotherapy response is needed. 

Corresponding Author: To contact the corresponding author, John Paul Shen, MD, email jshen8@mdanderson.org.

 

(doi:10.1001/jamaoncol.2024.3666)

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Retinopathy Associated With Hair Dye

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 12, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This case report describes a woman who presented with bilateral blurry vision a few days after dyeing her hair with hair dye containing aromatic amines. 

Corresponding Author: To contact the corresponding author, Nicolas Chirpaz, MD, email nicolas.chirpaz@chu-lyon.fr.

 

(doi:10.1001/jamaophthalmol.2024.3453)

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Race, Social Determinants of Health, and the Quality of Diabetic Eye Care

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 12, 2024

Media advisory: The full study and commentary are linked to this news release.

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About The Study: This study found that certain social determinants of health affected monitoring for diabetic retinopathy similarly for Black and white patients with diabetes while others affected them differently. Patients living in rural communities, Black patients with preexisting diabetic retinopathy, and Hispanic white patients were not receiving eye care in accordance with clinical practice guidelines, which may contribute to worse outcomes. 

Corresponding Author: To contact the corresponding author, Dustin D. French, PhD, email dustin.french@northwestern.edu.

 

(doi:10.1001/jamaophthalmol.2024.3528)

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Teaching Bleeding Control and Building Trust With a Community Affected by Firearm Injuries

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Neighborhood Child Opportunity and Preterm Birth Rates by Race and Ethnicity

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 11, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study of neighborhood opportunity and preterm birth, elevated risk associated with exposure to a very low opportunity neighborhood, coupled with the disproportionate exposure by race and ethnicity, points to a modifiable factor that may contribute to racial and ethnic inequities in preterm birth. Future research should investigate interventions that seek to address neighborhood opportunity. 

Corresponding Author: To contact the corresponding author, Candice Belanoff, ScD, MPH, email cbelanof@bu.edu.

 

(doi:10.1001/jamanetworkopen.2024.32766)

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Examining the Hypertension Control Cascade in Adults With Uncontrolled Hypertension in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 11, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study, more than 50% of adults with uncontrolled hypertension in the U.S. were unaware of their hypertension and were untreated, and 70.8% of those who were treated had hypertension that remained uncontrolled. These findings have serious implications for the nation’s overall health given the association of hypertension with increased risk for cardiovascular disease. 

Corresponding Author: To contact the corresponding author, LaTonia C. Richardson, PhD, email lcrichardson@cdc.gov.

 

(doi:10.1001/jamanetworkopen.2024.31997)

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Pharmacy Benefit Manager Market Concentration for Prescriptions Filled at US Retail Pharmacies

JAMA

EMBARGOED FOR RELEASE: 1 P.M. ET, TUESDAY, SEPTEMBER 10, 2024

Media advisory: The full study is linked to this news release.

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About The Study: In 2023, all 3 payer markets (commercial insurance, Medicare Part D, and Medicaid managed care) for pharmacy benefit manager (PBM) services were highly concentrated, but concentration varied and was highest in Medicare Part D. While CVS Caremark held the dominant share in all 3 payer markets, each of the PBMs appeared focused on a different payer: Express Script’s largest share was in the commercial market, while Optum Rx’s and CVS Caremark’s were in Medicare Part D and Medicaid managed care, respectively. These findings underscore the importance of considering payer-specific concentration when evaluating PBMs’ anticompetitive practices, as the 3 top PBMs may be pursuing different market strategies.

Corresponding Author: To contact the corresponding author, Dima M. Qato, PharmD, MPH, PhD, email qato@usc.edu.

 

(doi:10.1001/jama.2024.17332)

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Estimated Health and Economic Outcomes of Racial and Ethnic Tuberculosis Disparities in US-Born Persons

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, SEPTEMBER 10, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this modeling study of racial and ethnic disparities of tuberculosis (TB), these disparities were associated with substantial future health and economic outcomes of TB among U.S.-born persons without interventions beyond current efforts. Actions to eliminate disparities may reduce the excess TB burden among these persons and may contribute to accelerating TB elimination within the U.S.

Corresponding Author: To contact the corresponding author, Nicole A. Swartwood, MSPH, email nswartwood@hsph.harvard.edu.

 

(doi:10.1001/jamanetworkopen.2024.31988)

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Tubal Sterilization Rates by State Abortion Laws After the Dobbs Decision

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 11, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This study found an increase in use of tubal sterilization in all included states after the Dobbs decision, followed by a further monthly increase in banned states and a similar but not significant tendency in limited states (but not in protected states). The study extends prior research by differentiating restrictiveness of state abortion laws.

Corresponding Author: To contact the corresponding author, Xiao Xu, PhD, email xx2451@cumc.columbia.edu.

 

(doi:10.1001/jama.2024.16862)

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Telehealth vs In-Person Early Palliative Care for Patients With Advanced Lung Cancer

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 11, 2024

Media advisory: The full study, editorial and Viewpoint are linked to this news release.

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About The Study: The delivery of early palliative care virtually vs in person demonstrated equivalent effects on quality of life in patients with advanced non–small cell lung cancer, underscoring the considerable potential for improving access to this evidence-based care model through telehealth delivery.

Corresponding Author: To contact the corresponding author, Joseph A. Greer, PhD, email jgreer2@mgh.harvard.edu.

 

(doi:10.1001/jama.2024.13964)

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Machine Learning to Enhance Electronic Detection of Diagnostic Errors

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Uptake of Cancer Genetic Services for Chatbot vs Standard-of-Care Delivery Models

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Nurse-Supported Self-Directed Cognitive Behavioral Therapy for Insomnia

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Early Newborn Metabolic Patterning and Sudden Infant Death Syndrome

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 9, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Results from this case-control study showed an association between aberrant metabolic analytes at birth and sudden infant death syndrome (SIDS). These findings suggest that we may be able to identify infants at increased risk for SIDS soon after birth, which could inform further mechanistic research and clinical efforts focused on monitoring and prevention.

Corresponding Author: To contact the corresponding author, Scott P. Oltman, MS, email scott.oltman@ucsf.edu.

 

(doi:10.1001/jamapediatrics.2024.3033)

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Parental Engagement With Children Around Firearms and Unsecure Storage

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 9, 2024

Media advisory: The full study is linked to this news release.

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About The Study: In this study, parents who demonstrated and practiced proper firearm handling with their children and taught them how to shoot their firearms were more likely to store at least 1 firearm unlocked and loaded. Consistent with qualitative research results, these findings suggest that some parents may believe that modeling responsible firearm use negates the need for secure storage. However, it is unknown whether parents’ modeling responsible behavior is associated with a decreased risk of firearm injury.

Corresponding Author: To contact the corresponding author, Jennifer Paruk, PhD, email jp2328@sph.rutgers.edu.

 

(doi:10.1001/jamapediatrics.2024.3055)

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Melanoma Incidence and Mortality Trends in Sweden

JAMA Dermatology

EMBARGOED FOR RELEASE: 6:05 P.M. (ET), SUNDAY, SEPTEMBER 8, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Society for Medical Oncology Congress 2024.

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About The Study: The findings of this cohort study showed a significant recent downward trend in both melanoma incidence and melanoma mortality in the age group 30 to 49 years in Sweden. The reasons for these declines are unclear but may include UV protection, public health campaigns, changing population demographics, and the introduction of effective melanoma treatment. None of these possibilities were evaluated; further study is needed.

Corresponding Author: To contact the corresponding author, Hildur Helgadottir, MD, PhD, email hildur.helgadottir@sll.se.

 

(doi:10.1001/jamadermatol.2024.3514)

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Combined Whole Eye and Face Transplant

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 9, 2024

Media advisory: The full study and editorials are linked to this news release.

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About The Study: This is the first report of whole eye transplant combined with facial transplant, demonstrating allograft survival including rejection-free graft survival and electroretinographic measurements indicating retinal response to light stimuli. These data highlight the potential for clinical allotransplantation for globe loss. The successful revascularization of the transplanted eye achieved in this study may serve as a step towards the goal of globe transplant for restoration of vision.

 

Quote from corresponding author Eduardo D. Rodriguez, MD, DDS:

“The study reveals clinical outcomes from the past year following the world’s first whole-eye and partial-face transplant, highlighting promising initial results, and establishing a foundation for future advancements.

“While the recipient has not regained vision, the transplanted eye has maintained normal pressure, good blood flow, and some remaining structure and functions in the retina. Many experts did not think we would even be here, but we’ve successfully transplanted and maintained an eye without immune rejection.

“Now, the next challenge is understanding how to restore sight. I look forward to continuing this research in collaboration across academia to accelerate these discoveries with unique tools and the best therapies.”

Contact information for Eduardo D. Rodriguez, MD, DDS: email Katie Ullman at kathryn.ullman@nyulangone.org.

 

(doi:10.1001/jama.2024.12601)

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