Characteristics and Trends of Prehospital Encounters for Opioid Overdoses Among US Youth, 2018-2022

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 18, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Prehospital encounters for youth opioid overdoses were increasing prior to the pandemic, increased with the onset, and then stabilized, remaining higher than pre-pandemic levels. Although overall patterns were largely driven by those ages 18 through 24, adolescents ages 12 through 17 were the only subgroup with an increasing number of encounters both before and during the pandemic.

Corresponding Author: To contact the corresponding author, Jamie Lim, MD, email jlim@luriechildrens.org.

 

(doi:10.1001/jama.2024.17341)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Excess Body Weight and the Risk of Second Primary Cancers Among Cancer Survivors

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 17, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: In this cohort study of older survivors of nonmetastatic cancer, those who had overweight or obesity at the time of their first cancer diagnosis were at higher risk of developing a second cancer, especially an obesity-related second cancer. Given the high prevalence of overweight and obesity among cancer survivors, it is important to promote survivorship care guidelines recommending weight management and increase awareness of second cancers among physicians and cancer survivors.

Corresponding author: To contact the corresponding author, Clara Bodelon, Ph.D., M.S., email clara.bodelon@cancer.org

 

(doi: 10.1001/jamanetworkopen.2024.33132)

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Outcomes by Race and Ethnicity Following a Medicare Bundled Payment Program for Joint Replacement

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 17, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

About The Study: This cohort study shows that the Comprehensive Care for Joint Replacement program outcomes differed by race and ethnicity for patients covered outside traditional Medicare, with home discharge rates increasing more for Hispanic compared with non-Hispanic white patients. These findings suggest the importance of considering differential outcomes of Medicare payment policies for racial and ethnic minority patient populations beyond the initially targeted groups.

Corresponding author: To contact the corresponding author, Narae Kim, Ph.D., email naraekim@usc.edu.

 

(doi: 10.1001/jamanetworkopen.2024.33962)

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Malaria Rapid Tests, Febrile Illness Management, and Child Mortality Across Sub-Saharan African Countries

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GLP-1 Receptor Agonists and Risk for Cirrhosis and Related Complications in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease

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Cannabinoids Used for Medical Purposes in Children and Adolescents

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Neighborhood Food Access in Early Life and Trajectories of Child BMI and Obesity

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 16, 2024

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About The Study: Residence in low-income, low–food access neighborhoods in early life was associated with higher subsequent child body mass index and higher risk of obesity and severe obesity. Future studies should examine the effectiveness of investments in neighborhood resources to improve food access in preventing child obesity.

Corresponding Author: To contact the corresponding author, Izzuddin M. Aris, PhD, email izzuddin_aris@hphci.harvard.edu.

 

(doi:10.1001/jamapediatrics.2024.3459)

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Air Pollution and Parkinson Disease in a Population-Based Study

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 16, 2024

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that a reduction in air pollution may help reduce Parkinson disease risk, modifying the Parkinson disease phenotype and the risk of dyskinesia in patients with Parkinson disease. 

Corresponding Authors: To contact the corresponding authors, email Brittany Krzyzanowski, PhD, (brittany.krzyzanowski@barrowneuro.org) and Rodolfo Savica, MD, PhD, (savica.rodolfo@mayo.edu).

 

(doi:10.1001/jamanetworkopen.2024.33602)

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Real-Time Exposure to Negative News Media and Suicidal Ideation Intensity Among LGBTQ+ Young Adults

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 16, 2024

Media advisory: The full study and editorial are linked to this news release.

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About The Study: This intensive longitudinal cohort study found that suicidal ideation intensity modestly increased in the hours immediately following exposure to lesbian, gay, bisexual, transgender, or queer (LGBTQ+) negative news or media among LGBTQ+ young adults. These findings have timely implications for research and intervention, particularly within sociopolitical and geographic contexts where news or media coverage about LGBTQ+ topics is intensified.

Corresponding Author: To contact the corresponding author, Kirsty A. Clark, MPH, PhD, email kirsty.clark@vanderbilt.edu.

 

(doi:10.1001/jamapediatrics.2024.3133)

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Efficacy and Safety of Erenumab for Nonopioid Medication Overuse Headache in Chronic Migraine

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 16, 2024

Media advisory: The full study is linked to this news release.

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About The Study: In this study, monthly, 140 mg erenumab injections safely and effectively achieved medication overuse headaches remission in patients with nonopioid chronic migraine and medication overuse headaches within 6 months.

 

Quote from corresponding author Stewart J. Tepper, MD:

“Those patients with medication overuse headache (MOH) have higher disability and a significant unmet clinical need. Erenumab proved effective versus placebo in significantly higher rates of MOH remission and marked reduction in days in which acute migraine treatment was taken in a randomized controlled trial, with these benefits sustained through a one- year open label treatment period.

“The change for clinical care will be that practitioners can start patients with MOH on erenumab and expect a likelihood of MOH remission for most without other interventions, such as planned wean, inpatient detoxification, or behavioral therapies. This will simplify and improve care of MOH patients.”

 

Contact information for Stewart J. Tepper, MD: email sjtepper@gmail.com.

 

(doi:10.1001/jamaneurol.2024.3043)

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Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of COPD

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A Machine Learning Method for Allocating Scarce COVID-19 Monoclonal Antibodies

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Evaluating Policy Changes for Adjusting Payment to Address Health Disparities

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Stimulant, Antidepressant, and Opioid Telehealth Prescription Trends Between 2019 and 2022

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 13, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: From 2019 to 2022, overall prescription volumes for stimulant and antidepressant medications increased, while prescription volume for opioids decreased. Concurrently, the proportion of telehealth prescriptions climbed across medications, increasing by a factor of 188 in opioids and more than 20 for antidepressants. These findings align with existing research highlighting the shift toward telehealth and the rise in stimulant and opioid telehealth prescribing during the pandemic. While in-person prescribing remains the most common, increasing telehealth utilization across medications suggests a growing acceptance, need, or preference for remote services.

Corresponding Author: To contact the corresponding author, Ashwini Nagappan, MBE, email ashwininagappan@ucla.edu.

 

(doi:10.1001/jamanetworkopen.2024.33334)

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Adolescents and Young Adults’ Sources of Contraceptive Information

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 13, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This study’s results suggest discrepancies between preferred and actual sources of contraceptive information for assigned female at birth adolescents and young adults in the U.S. Findings underscore the role of clinicians in supporting informed contraceptive decision-making among adolescents and young adults. Clinicians were the most commonly preferred source, and receiving information from them was associated with having sufficient information to choose a contraceptive method; however, clinicians were the source with the largest discrepancy between preferred and actual use. 

Corresponding Author: To contact the corresponding author, Elizabeth Pleasants, DrPH, MPH, email b_pleasants@berkeley.edu.

 

(doi:10.1001/jamanetworkopen.2024.33310)

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One-Year Weight Reduction With Semaglutide or Liraglutide in Clinical Practice

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 13, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this retrospective cohort study of 3,389 patients with obesity, weight reduction at 1 year was associated with the medication’s active agent, its dosage, treatment indication, persistent medication coverage, and patient sex. Future research should focus on identifying the reasons for discontinuation of medication use and interventions aimed at improving long-term persistent coverage. 

Corresponding Author: To contact the corresponding author, Hamlet Gasoyan, PhD, email gasoyah@ccf.org.

 

(doi:10.1001/jamanetworkopen.2024.33326)

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Health Warnings on Instagram Advertisements for Synthetic Nicotine E-Cigarettes and Engagement

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 13, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study of synthetic nicotine brand Instagram accounts, 87% of sampled posts did not adhere to FDA health warning requirements in tobacco promotions. Enforcement of FDA compliant health warnings on social media may reduce youth engagement with tobacco marketing. 

Corresponding Author: To contact the corresponding author, Traci Hong, PhD, email tjhong@bu.edu.

 

(doi:10.1001/jamanetworkopen.2024.34434)

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Molecular, Socioeconomic, and Clinical Factors Affecting Racial and Ethnic Disparities in Colorectal Cancer Survival

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 12, 2024

Media advisory: The full study and commentary are linked to this news release.

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About The Study: This single-center cohort study identified substantial overall survival disparity and differing frequencies of driver gene variations by race and ethnicity. Socioeconomic status had the largest contribution but accounted for less than one-third of the disparity, with substantial contribution from tumor molecular features. Further study of the associations of genetic ancestry and the molecular pathogenesis of colorectal cancer with chemotherapy response is needed. 

Corresponding Author: To contact the corresponding author, John Paul Shen, MD, email jshen8@mdanderson.org.

 

(doi:10.1001/jamaoncol.2024.3666)

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Retinopathy Associated With Hair Dye

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 12, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This case report describes a woman who presented with bilateral blurry vision a few days after dyeing her hair with hair dye containing aromatic amines. 

Corresponding Author: To contact the corresponding author, Nicolas Chirpaz, MD, email nicolas.chirpaz@chu-lyon.fr.

 

(doi:10.1001/jamaophthalmol.2024.3453)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Race, Social Determinants of Health, and the Quality of Diabetic Eye Care

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 12, 2024

Media advisory: The full study and commentary are linked to this news release.

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About The Study: This study found that certain social determinants of health affected monitoring for diabetic retinopathy similarly for Black and white patients with diabetes while others affected them differently. Patients living in rural communities, Black patients with preexisting diabetic retinopathy, and Hispanic white patients were not receiving eye care in accordance with clinical practice guidelines, which may contribute to worse outcomes. 

Corresponding Author: To contact the corresponding author, Dustin D. French, PhD, email dustin.french@northwestern.edu.

 

(doi:10.1001/jamaophthalmol.2024.3528)

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Teaching Bleeding Control and Building Trust With a Community Affected by Firearm Injuries

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Neighborhood Child Opportunity and Preterm Birth Rates by Race and Ethnicity

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 11, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study of neighborhood opportunity and preterm birth, elevated risk associated with exposure to a very low opportunity neighborhood, coupled with the disproportionate exposure by race and ethnicity, points to a modifiable factor that may contribute to racial and ethnic inequities in preterm birth. Future research should investigate interventions that seek to address neighborhood opportunity. 

Corresponding Author: To contact the corresponding author, Candice Belanoff, ScD, MPH, email cbelanof@bu.edu.

 

(doi:10.1001/jamanetworkopen.2024.32766)

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Examining the Hypertension Control Cascade in Adults With Uncontrolled Hypertension in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 11, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this cross-sectional study, more than 50% of adults with uncontrolled hypertension in the U.S. were unaware of their hypertension and were untreated, and 70.8% of those who were treated had hypertension that remained uncontrolled. These findings have serious implications for the nation’s overall health given the association of hypertension with increased risk for cardiovascular disease. 

Corresponding Author: To contact the corresponding author, LaTonia C. Richardson, PhD, email lcrichardson@cdc.gov.

 

(doi:10.1001/jamanetworkopen.2024.31997)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Pharmacy Benefit Manager Market Concentration for Prescriptions Filled at US Retail Pharmacies

JAMA

EMBARGOED FOR RELEASE: 1 P.M. ET, TUESDAY, SEPTEMBER 10, 2024

Media advisory: The full study is linked to this news release.

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About The Study: In 2023, all 3 payer markets (commercial insurance, Medicare Part D, and Medicaid managed care) for pharmacy benefit manager (PBM) services were highly concentrated, but concentration varied and was highest in Medicare Part D. While CVS Caremark held the dominant share in all 3 payer markets, each of the PBMs appeared focused on a different payer: Express Script’s largest share was in the commercial market, while Optum Rx’s and CVS Caremark’s were in Medicare Part D and Medicaid managed care, respectively. These findings underscore the importance of considering payer-specific concentration when evaluating PBMs’ anticompetitive practices, as the 3 top PBMs may be pursuing different market strategies.

Corresponding Author: To contact the corresponding author, Dima M. Qato, PharmD, MPH, PhD, email qato@usc.edu.

 

(doi:10.1001/jama.2024.17332)

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Estimated Health and Economic Outcomes of Racial and Ethnic Tuberculosis Disparities in US-Born Persons

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, SEPTEMBER 10, 2024

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: In this modeling study of racial and ethnic disparities of tuberculosis (TB), these disparities were associated with substantial future health and economic outcomes of TB among U.S.-born persons without interventions beyond current efforts. Actions to eliminate disparities may reduce the excess TB burden among these persons and may contribute to accelerating TB elimination within the U.S.

Corresponding Author: To contact the corresponding author, Nicole A. Swartwood, MSPH, email nswartwood@hsph.harvard.edu.

 

(doi:10.1001/jamanetworkopen.2024.31988)

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Tubal Sterilization Rates by State Abortion Laws After the Dobbs Decision

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 11, 2024

Media advisory: The full study is linked to this news release.

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About The Study: This study found an increase in use of tubal sterilization in all included states after the Dobbs decision, followed by a further monthly increase in banned states and a similar but not significant tendency in limited states (but not in protected states). The study extends prior research by differentiating restrictiveness of state abortion laws.

Corresponding Author: To contact the corresponding author, Xiao Xu, PhD, email xx2451@cumc.columbia.edu.

 

(doi:10.1001/jama.2024.16862)

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Telehealth vs In-Person Early Palliative Care for Patients With Advanced Lung Cancer

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 11, 2024

Media advisory: The full study, editorial and Viewpoint are linked to this news release.

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About The Study: The delivery of early palliative care virtually vs in person demonstrated equivalent effects on quality of life in patients with advanced non–small cell lung cancer, underscoring the considerable potential for improving access to this evidence-based care model through telehealth delivery.

Corresponding Author: To contact the corresponding author, Joseph A. Greer, PhD, email jgreer2@mgh.harvard.edu.

 

(doi:10.1001/jama.2024.13964)

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Machine Learning to Enhance Electronic Detection of Diagnostic Errors

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Uptake of Cancer Genetic Services for Chatbot vs Standard-of-Care Delivery Models

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Nurse-Supported Self-Directed Cognitive Behavioral Therapy for Insomnia

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Early Newborn Metabolic Patterning and Sudden Infant Death Syndrome

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 9, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Results from this case-control study showed an association between aberrant metabolic analytes at birth and sudden infant death syndrome (SIDS). These findings suggest that we may be able to identify infants at increased risk for SIDS soon after birth, which could inform further mechanistic research and clinical efforts focused on monitoring and prevention.

Corresponding Author: To contact the corresponding author, Scott P. Oltman, MS, email scott.oltman@ucsf.edu.

 

(doi:10.1001/jamapediatrics.2024.3033)

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Parental Engagement With Children Around Firearms and Unsecure Storage

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, SEPTEMBER 9, 2024

Media advisory: The full study is linked to this news release.

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About The Study: In this study, parents who demonstrated and practiced proper firearm handling with their children and taught them how to shoot their firearms were more likely to store at least 1 firearm unlocked and loaded. Consistent with qualitative research results, these findings suggest that some parents may believe that modeling responsible firearm use negates the need for secure storage. However, it is unknown whether parents’ modeling responsible behavior is associated with a decreased risk of firearm injury.

Corresponding Author: To contact the corresponding author, Jennifer Paruk, PhD, email jp2328@sph.rutgers.edu.

 

(doi:10.1001/jamapediatrics.2024.3055)

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Melanoma Incidence and Mortality Trends in Sweden

JAMA Dermatology

EMBARGOED FOR RELEASE: 6:05 P.M. (ET), SUNDAY, SEPTEMBER 8, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Society for Medical Oncology Congress 2024.

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About The Study: The findings of this cohort study showed a significant recent downward trend in both melanoma incidence and melanoma mortality in the age group 30 to 49 years in Sweden. The reasons for these declines are unclear but may include UV protection, public health campaigns, changing population demographics, and the introduction of effective melanoma treatment. None of these possibilities were evaluated; further study is needed.

Corresponding Author: To contact the corresponding author, Hildur Helgadottir, MD, PhD, email hildur.helgadottir@sll.se.

 

(doi:10.1001/jamadermatol.2024.3514)

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Combined Whole Eye and Face Transplant

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, SEPTEMBER 9, 2024

Media advisory: The full study and editorials are linked to this news release.

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About The Study: This is the first report of whole eye transplant combined with facial transplant, demonstrating allograft survival including rejection-free graft survival and electroretinographic measurements indicating retinal response to light stimuli. These data highlight the potential for clinical allotransplantation for globe loss. The successful revascularization of the transplanted eye achieved in this study may serve as a step towards the goal of globe transplant for restoration of vision.

 

Quote from corresponding author Eduardo D. Rodriguez, MD, DDS:

“The study reveals clinical outcomes from the past year following the world’s first whole-eye and partial-face transplant, highlighting promising initial results, and establishing a foundation for future advancements.

“While the recipient has not regained vision, the transplanted eye has maintained normal pressure, good blood flow, and some remaining structure and functions in the retina. Many experts did not think we would even be here, but we’ve successfully transplanted and maintained an eye without immune rejection.

“Now, the next challenge is understanding how to restore sight. I look forward to continuing this research in collaboration across academia to accelerate these discoveries with unique tools and the best therapies.”

Contact information for Eduardo D. Rodriguez, MD, DDS: email Katie Ullman at kathryn.ullman@nyulangone.org.

 

(doi:10.1001/jama.2024.12601)

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Disparities in Medication Use for Criminal Justice System –Referred Opioid Use Disorder Treatment

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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

COVID-19 and Rates of Cancer Diagnosis in the US

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, SEPTEMBER 6, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This population-based cross-sectional study of U.S. cancer incidence trends found that rates of diagnosis improved in 2021 but continued to be lower than expected, adding to the existing deficit of diagnosed cases from 2020. Particular attention should be directed at strategies to immediately increase cancer screenings to make up lost ground. 

Corresponding Author: To contact the corresponding author, Krystle A. Lang Kuhs, PhD, MPH, email krystle.kuhs@uky.edu.

 

(doi:10.1001/jamanetworkopen.2024.32288)

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Cannabis Laws and Utilization of Medications for the Treatment of Mental Health Disorders

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, SEPTEMBER 5, 2024

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cross-sectional study of commercially insured patients suggests that there may have been meaningful heterogeneous associations between cannabis policy and state and between cannabis policy and drug class (e.g., decreases in dispensing of benzodiazepines but increases in dispensing of antidepressants and antipsychotics). This finding suggests additional clinical research is needed to understand the association between cannabis use and mental health. The results have implications for patient substance use and mental health–related outcomes. 

Corresponding Author: To contact the corresponding author, Ashley C. Bradford, PhD, email bradford@gatech.edu.

 

(doi:10.1001/jamanetworkopen.2024.32021)

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Vision Impairment and the Population Attributable Fraction of Dementia in Older Adults

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, SEPTEMBER 5, 2024

Media advisory: The full study and commentary are linked to this news release.

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About The Study: The population attributable fraction of dementia from vision impairments ranged from 4.9%-19.0%. While not proving a cause-and-effect relationship, these findings support inclusion of multiple objective measures of vision impairments, including contrast sensitivity and visual acuity, to capture the total potential impact of addressing vision impairment on dementia. 

Corresponding Author: To contact the corresponding author, Jason R. Smith, ScM, email jsmit491@jhu.edu.

 

(doi:10.1001/jamaophthalmol.2024.3131)

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Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, SEPTEMBER 5, 2024

Media advisory: The full study and editorial are linked to this news release.

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About The Study: In patients with symptomatic intracranial atherosclerotic stenosis, balloon angioplasty plus aggressive medical management, compared with aggressive medical management alone, statistically significantly lowered the risk of a composite outcome of any stroke or death within 30 days or an ischemic stroke or revascularization of the qualifying artery after 30 days through 12 months. The findings suggest that balloon angioplasty plus aggressive medical management may be an effective treatment for symptomatic intracranial atherosclerotic stenosis, although the risk of stroke or death within 30 days of balloon angioplasty should be considered in clinical practice.

Corresponding Authors: To contact the corresponding authors, email Zhongrong Miao, MD, PhD (zhongrongm@163.com) and Yilong Wang, MD, PhD (yilong528@aliyun.com).

 

(doi:10.1001/jama.2024.12829)

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Risk of Suicide Across Medical Conditions and the Role of Prior Mental Disorder

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Lesion-Level Effects of LDL-C–Lowering Therapy in Patients With Acute Myocardial Infarction

JAMA Cardiology

EMBARGOED FOR RELEASE: 4:40 A.M. (ET), MONDAY, SEPTEMBER 2, 2024

Media advisory: The full study and commentary are linked to this news release. This study is being presented at the European Society of Cardiology Congress 2024.

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About The Study: At the lesion level, very intensive lipid-lowering therapy induced substantially greater percent atheroma volume regression than described in previous vessel-level analyses. Compared with statin therapy alone, alirocumab treatment was associated with greater enlargement of the lesion minimum lumen area and more frequent transition of presumably high-risk plaque phenotypes into more stable, less lipid-rich plaque phenotypes. 

Corresponding Author: To contact the corresponding author, Lorenz Raber, MD, PhD, email lorenz.raeber@insel.ch.

 

(doi:10.1001/jamacardio.2024.3200)

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RSV Vaccine Effectiveness Against Hospitalization Among US Adults 60 Years and Older

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, SEPTEMBER 4, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Among adults age 60 years and older in 19 U.S. states, respiratory syncytial virus (RSV) vaccination was associated with a reduced likelihood of hospitalization with RSV compared with no vaccination. These findings expand upon prelicensure trial results in 2 ways. First, they provide evidence of vaccine protection against RSV-associated hospitalization, of which an estimated 60,000 to 160,000 occur annually among U.S. adults age 65 years and older. Second, they demonstrate protection in a population that more closely represents those at high risk of severe RSV disease, including adults age 75 years and older and those with immunocompromising conditions.

Corresponding Author: To contact the corresponding author, Diya Surie, MD, email dsurie@cdc.gov.

 

(doi:10.1001/jama.2024.15775)

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Sex and Size Disparities in Access to Liver Transplant for Patients With Hepatocellular Carcinoma

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, SEPTEMBER 4, 2024

Media advisory: The full study and commentary are linked to this news release.

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About The Study: In this study, women with hepatocellular carcinoma were less likely to receive a deceased-donor liver transplant and more likely to die while wait-listed than men with hepatocellular carcinoma; these differences were largely (but not entirely) explained by sex-based differences in candidate size. For candidates listed with exception scores, additional changes to allocation policy are needed to resolve the sex disparity, including solutions to improve access to size-matched donor livers for smaller candidates. 

Corresponding Author: To contact the corresponding author, Heidi Yeh, MD, email hyeh@mgh.harvard.edu.

 

(doi:10.1001/jamasurg.2024.3498)

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State-to-State Variation in Rates and Causes of Child and Adolescent Mortality in the US

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Pulmonary Vein Isolation vs Sham Intervention in Symptomatic Atrial Fibrillation

JAMA

EMBARGOED FOR RELEASE: 6:00 A.M. ET, MONDAY, SEPTEMBER 2, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Society of Cardiology Congress 2024.

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About The Study: Pulmonary vein isolation resulted in a statistically significant and clinically important decrease in atrial fibrillation burden at 6 months, with substantial improvements in symptoms and quality of life, compared with a sham procedure.

Corresponding Authors: To contact the corresponding authors, email Rick A. Veasey, MD, (rick.veasey@nhs.net) and Rajdip Dulai, MBBS, (rajdip.dulai.21@ucl.ac.uk)

 

(doi:10.1001/jama.2024.17921)

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Low-Dose Triple-Pill vs Standard-Care Protocols for Hypertension Treatment in Nigeria

JAMA

EMBARGOED FOR RELEASE: 4:20 A.M. ET, SATURDAY, AUGUST 31, 2024

Media advisory: The full study and editorial are linked to this news release. This study is being presented at the European Society of Cardiology Congress 2024.

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About The Study: Among Black African adults with uncontrolled hypertension, a low-dose triple-pill protocol achieved better blood pressure lowering and control with good tolerability compared with the standard-care protocol.

Corresponding Author: To contact the corresponding author, Anthony Rodgers, PhD, email arodgers@georgeinstitute.org.

 

(doi:10.1001/jama.2024.18080)

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Psychiatric Safety of Semaglutide for Weight Management in People Without Known Major Psychopathology

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 3, 2024

Media advisory: The full study and editor’s note are linked to this news release.  

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About The Study: The results of this post hoc analysis suggest that treatment with semaglutide, 2.4 mg, did not increase the risk of developing symptoms of depression or suicidal ideation/behavior vs placebo and was associated with a small but statistically significant reduction in depressive symptoms (not considered clinically meaningful). People with obesity should be monitored for mental health concerns so they can receive appropriate support and care. 

Corresponding Author: To contact the corresponding author, Thomas A. Wadden, PhD, email wadden@pennmedicine.upenn.edu.

 

(doi:10.1001/jamainternmed.2024.4346)

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GLP-1 Receptor Agonist Use and Risk of Suicide Death

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 3, 2024

Media advisory: The full study and editor’s note are linked to this news release.  

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About The Study: This cohort study, including mostly patients with type 2 diabetes, does not show an association between use of glucagon-like peptide-1 (GLP-1) receptor agonists and an increased risk of suicide death, self-harm, or incident depression and anxiety-related disorders.

Corresponding Author: To contact the corresponding author, Peter Ueda, MD, PhD, email peter.ueda@ki.se.

 

(doi:10.1001/jamainternmed.2024.4369)

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Effects of Sacubitril/Valsartan on All-Cause Hospitalizations in Heart Failure

JAMA Cardiology

EMBARGOED FOR RELEASE: 3 A.M. (ET), FRIDAY, AUGUST 30, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Society of Cardiology Congress 2024.

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About The Study: In this post hoc pooled analysis of 13,194 patients with chronic heart failure (HF) in the PARADIGM-HF and PARAGON-HF randomized clinical trials, sacubitril/valsartan significantly reduced hospitalization for any reason, with benefits most apparent in patients with a left ventricular ejection fraction below normal. This reduction appeared to be principally driven by lower rates of cardiac and pulmonary hospitalizations.

Corresponding Author: To contact the corresponding author, Muthiah Vaduganathan, MD, MPH, email mvaduganathan@bwh.harvard.edu.

 

(doi:10.1001/jamacardio.2024.2566)

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Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial Infarction

JAMA Cardiology

EMBARGOED FOR RELEASE: 4 A.M. (ET), FRIDAY, AUGUST 30, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Society of Cardiology Congress 2024.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2024.2298?guestAccessKey=a0145eff-4cd6-44be-ae67-9c736ee0ef94&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=083024

 

About The Study: In patients with ST-segment elevation myocardial infarction, treatment with prehospital pulse-dose glucocorticoid did not reduce final infarct size after 3 months. However, the trial was likely underpowered as the final infarct size was smaller than anticipated. The glucocorticoid group had improved acute parameters compared with placebo.

Corresponding Author: To contact the corresponding author, Jasmine Melissa Madsen, MD, email jasmine.melissa.madsen.01@regionh.dk.

 

(doi:10.1001/jamacardio.2024.2298)

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Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery

JAMA

EMBARGOED FOR RELEASE: 12 P.M. ET, SATURDAY, AUGUST 31, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Society of Cardiology Congress 2024.

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About The Study: For atrial fibrillation after cardiac surgery prophylaxis, supplementation only when serum potassium concentration fell below 3.6 mEq/L was noninferior to the current widespread practice of supplementing potassium to maintain a serum potassium concentration greater than or equal to 4.5 mEq/L. The lower threshold of supplementation was not associated with any increase in dysrhythmias or adverse clinical outcomes.

Corresponding Author: To contact the corresponding author, Benjamin O’Brien, MD, PhD, email Ben.OBrien@dhzc-charite.de.

 

(doi:10.1001/jama.2024.17888)

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Autoimmune Sequelae After Delta or Omicron Variant SARS-CoV-2 Infection in a Highly Vaccinated Cohort

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, AUGUST 30, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.30983?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=083024

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cohort study observed no significantly elevated long-term risk of autoimmune sequelae after SARS-CoV-2 Delta and Omicron BA.1 or BA.2 variant infection, except for a modestly increased risk of inflammatory bowel disease and bullous skin disorders in the hospitalized subgroup during the predominance of the Omicron variant. Booster vaccination appeared to mitigate the risk of long-term autoimmune sequelae. 

Corresponding Author: To contact the corresponding author, Liang En Wee, MPH, email ian.wee.l.e@singhealth.com.sg.

 

(doi:10.1001/jamanetworkopen.2024.30983)

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Disparate Patient Advocacy When Facing Unaffordable and Problematic Medical Bills

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2024.2744?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=083024

About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.

Racial Disparities in Cancer Stage at Diagnosis and Survival for Adolescents and Young Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, AUGUST 30, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.30975?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=083024

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study suggest that racial disparities in cancer stage at diagnosis and survival exist among adolescent and young adult patients when disaggregated according to federal guidelines, which has health policy and funding implications. These results support the need for tailored interventions and informed public policy to achieve cancer care equity for all races. 

Corresponding Author: To contact the corresponding author, Kekoa Taparra, MD, PhD, email ktaparra@stanford.edu.

 

(doi:10.1001/jamanetworkopen.2024.30975)

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Structural Equality and Support Index in Early Childhood Education

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, AUGUST 30, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.32050?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=083024

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: This cohort study found that early childhood programming is associated with social determinants of health in adulthood. These findings reinforce the importance of early childhood education in addressing health disparities and contributing to healthier, more equitable communities and suggest that educational attainment is a key mechanism for health promotion.

Corresponding Author: To contact the corresponding author, Arthur J. Reynolds, PhD, email ajr@umn.edu.

 

(doi:10.1001/jamanetworkopen.2024.32050)

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Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery

JAMA

EMBARGOED FOR RELEASE: 6:45 A.M. ET, FRIDAY, AUGUST 30, 2024

Media advisory: The full study is linked to this news release. This study is being presented at the European Society of Cardiology Congress 2024.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.17123?guestAccessKey=a9f8f5ad-deed-423b-b4a8-e20edbe38c37&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=083024

 

About The Study: Among patients who underwent major noncardiac surgery, a continuation strategy of renin-angiotensin system inhibitors before surgery was not associated with a higher rate of postoperative complications than a discontinuation strategy.

Corresponding Authors: To contact the corresponding authors, email Matthieu Legrand, MD, PhD (matthieu.legrand@ucsf.edu) and Etienne Gayat, MD, PhD (etienne.gayat@aphp.fr).

 

(doi:10.1001/jama.2024.17123)

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Greenhouse Gas Emissions and Costs of Inhaler Devices in the US

JAMA

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, AUGUST 29, 2024

Media advisory: The full study is linked to this news release.

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About The Study: Inhaler prescriptions filled by Centers for Medicare & Medicaid Services beneficiaries in 2022 resulted in an estimated 1.15 million metric tons of carbon dioxide equivalent emissions, equivalent to 226,960 homes’ yearly electricity use. Metered-dose inhalers were responsible for nearly all inhaler-related emissions, with the largest contribution arising from short-acting β-agonist medications. Although dry-powder and soft-mist inhalers had substantially lower emissions, they accounted for a disproportionate amount of spending, representing nearly two-thirds of inhaler costs but only one-third of claims.

Corresponding Author: To contact the corresponding author, Jyothi Tirumalasetty, MD, email jtsetty@stanford.edu.

 

(doi:10.1001/jama.2024.15331)

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Persistent Neighborhood Poverty and Breast Cancer Outcomes

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, AUGUST 29, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.27755?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=082924

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: The findings of this study of women ages 18 or older diagnosed with stage I to III breast cancer between 2010 and 2018 suggest that residing in persistently impoverished neighborhoods is associated with poor tumor characteristics and increased mortality. 

Corresponding Author: To contact the corresponding author, Samilia Obeng-Gyasi, MD, MPH, email samilia.obeng-gyasi@osumc.edu.

 

(doi:10.1001/jamanetworkopen.2024.27755)

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Hormone Therapy and Biological Aging in Postmenopausal Women

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, AUGUST 29, 2024

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.30839?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=082924

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

 

About The Study: Postmenopausal women with historical hormone therapy (HT) use were biologically younger than those not receiving HT, with a more evident association observed in those with low socioeconomic status. The biological aging discrepancy mediated the association between HT and decreased mortality. Promoting HT in postmenopausal women could be important for healthy aging.

Corresponding Author: To contact the corresponding author, Chenglong Li, PhD, email chenglongli@bjmu.edu.cn.

 

(doi:10.1001/jamanetworkopen.2024.30839)

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Prenatal Fish Oil Supplementation, Maternal COX1 Genotype, and Childhood Atopic Dermatitis

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