Examining Changes to FDA Approval, Regulation of Pharmaceuticals Over 4 Decades

Posted January 9, 2020 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 14, 2020

Media advisory: To contact corresponding author Jonathan J. Darrow, S.J.D., J.D., M.B.A., email Elaine St. Peter at estpeter@bwh.harvard.edu. The full study and editorial are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.20288?guestAccessKey=6c172781-0a0e-4e36-8c5c-a51962ecc2f7&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=011420

Bottom Line: Publicly available and Food and Drug Administration (FDA) data were used in this observational study to describe the number and types of prescription drugs approved from 1983 to 2018 and how the approval process and regulation of drugs changed during this period. Approvals of new generic drugs and biologics increased over this time, as the median annual number of generic drugs approved was 284 from 1985 to 2012 and 588 from 2013 to 2018. The authors report that the average annual number of new drug approvals, including biologics, was 34 from 1990-1999, decreasing to 25 from 2000-2009, and increasing to 41 from 2010-2018. There has been an expansion in the number of expedited development and approval programs since 1983, while the amount of evidence used for approvals has decreased. The proportion of new approvals supported by at least two pivotal trials declined from 81% in 1995-1997 to 53% in 2015-2017. The amount of industry-paid user fees collected, funds used to accelerate review times, have increased to an annual average of $820 million in 2013-2017. FDA drug review times declined from more than three years in 1983 to less than one year in 2017. A limitation of the study is the difficulty in comparing the size of the clinical benefit of drugs across different indications and populations.

Authors: Jonathan J. Darrow, S.J.D., J.D., M.B.A., of Brigham and Women’s Hospital, Harvard Medical School, Boston, and coauthors.

(doi:10.1001/jama.2019.20288)

Editor’s Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted January 7, 2020 by Jim Michalski

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.19066?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=011020

Here’s a link to provide your readers free access to the full-text article

Posted January 7, 2020 by Jim Michalski

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.18911?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=011020

Here’s a link to provide your readers free access to the full-text article

Posted January 7, 2020 by Jim Michalski

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2019.5540?guestAccessKey=7d6b7488-1696-4700-875e-5d17bd74cf2b&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010920

Here’s a link to provide your readers free access to the full-text article

Posted January 6, 2020 by Jim Michalski

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2019.4379?guestAccessKey=fdc8dba0-558d-47eb-a446-bb84a8a28481&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010820

Here’s a link to provide your readers free access to the full-text article

Posted January 6, 2020 by Jim Michalski

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2019.4845?guestAccessKey=2d417ed8-8556-482e-bec9-d8db5f06141e&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010820

Views of Rural US Adults on Serious Health, Economic Issues in Their Communities

Posted January 6, 2020 by Jim Michalski

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JANUARY 8, 2020

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.18745?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=010820

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

What The Study Did: Nationally representative surveys from 2018 and 2019 were used to examine the views of adults in the rural U.S. on the serious health and economic problems facing their communities, including the cost and access to health care and addiction to opioids.

Author: Mary G. Findling, Ph.D., Sc.M., of the Harvard T.H. Chan School of Public Health in Boston, is the corresponding author.

(10.1001/jamanetworkopen.2019.18745)

Editor’s Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted January 7, 2020 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2019.5672?guestAccessKey=e19ac1dc-fd08-4dbf-8f5c-27cd30f396ab&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010920

Public Opinion on Proposals in California to Prevent Firearm Violence

Posted January 6, 2020 by Jim Michalski

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JANUARY 8, 2020

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.18786?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=010820

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

What The Study Did: This survey study assessed public opinion in California (overall and by firearm ownership status) on two proposals to prevent firearm injuries: an amnesty program that would allow individuals to turn in ammunition magazines that hold more than 10 bullets, no questions asked; and a law that prevents someone from buying a gun for five years if they have had two or more driving under the influence of alcohol or drugs convictions in five years. It is illegal in California to buy or sell ammunition magazines that hold more than 10 bullets; it may soon be illegal to have them.

Author: Rocco Pallin, M.P.H., of the University of California, Davis, is the corresponding author.

(10.1001/jamanetworkopen.2019.18786)

Editor’s Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Are There Shared Genetic Factors Between Weight and Major Psychiatric Disorders?

Posted January 6, 2020 by Jim Michalski

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JANUAURY 8, 2020

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2019.4188?guestAccessKey=ab3c0b15-e953-4f31-9e03-bd259554df90&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010820

What The Study Did: Data from 1.3 million people were used to investigate genetic overlap between body mass index and major psychiatric disorders such as schizophrenia, bipolar disorder and major depression. Obesity is a risk factor for cardiovascular disease and a shorter life expectancy among people with major psychiatric disorders is mainly due to coexisting cardiovascular diseases.

Authors: Shahram Bahrami, Ph.D., and Ole A. Andreassen, M.D., Ph.D., of the University of Oslo in Norway, are the corresponding authors.

(10.1001/jamapsychiatry.2019.4188)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted January 6, 2020 by Jim Michalski

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2019.5220?guestAccessKey=d6507015-c203-4c28-b648-efbac2bd60b1&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010820

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted January 2, 2020 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.19003?guestAccessKey=391616d7-b6ad-4648-a08d-4381e92868a8&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010720

Electric Scooter Injuries, Hospital Admissions in US

Posted January 6, 2020 by Jim Michalski

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JANUAURY 8, 2020

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2019.5423?guestAccessKey=cd562764-e2da-4c2e-b3af-80654ee5ab06&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010820

What The Study Did: Electric scooters are increasingly used as fast and convenient transportation in the United States. This observational study reports on injuries and hospital admissions related to electric scooters from 2014 to 2018 using national data.

Authors: Benjamin N. Breyer, M.D., M.A.S., of the University of California, San Francisco, is the corresponding author.

(doi:10.1001/jamasurg.2019.5423)

Editor’s Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted January 2, 2020 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2019.5727?guestAccessKey=2795f089-768d-4603-9277-dfaf20df31bd&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010620

Here’s a link to provide your readers free access to the full-text article

Posted January 2, 2020 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2019.4509?guestAccessKey=db86122a-620e-43b6-90e0-6e5c3818791b&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010620

Here’s a link to provide your readers free access to the full-text article

Posted January 2, 2020 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2019.4552?guestAccessKey=a0202303-6309-4964-a637-e4033870a98e&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010620

Here’s a link to provide your readers free access to the full-text article

Posted January 2, 2020 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2019.4501?guestAccessKey=42dfd5b4-48de-43d2-bd90-65f4eaa6d59d&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010620

Here’s a link to provide your readers free access to the full-text article

Posted January 2, 2020 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2019.5183?guestAccessKey=cd11367a-ae9c-47ea-955b-c6c557732796&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010620

Pooled Data Used to Examine Powder Use by Women in Genital Area, Ovarian Cancer Risk

Posted January 2, 2020 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 7, 2020

Media advisory: The full study and editorial are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.20079?guestAccessKey=e8a84e15-2f81-4957-be2b-e14e08d5f9b3&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010720

What The Study Did: Researchers pooled data from four large study groups with 250,000 women to estimate the association between using body powder in the genital area and risk of ovarian cancer.

Authors: Katie M. O’Brien, of the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina, is the corresponding author.

(doi:10.1001/jama.2019.20079)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted January 2, 2020 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2019.5204?guestAccessKey=41091360-7457-457d-ba4a-211e3c8a647c&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010620

Trial Examines Effect of Folic Acid, Zinc Supplementation in Male Partners of Couples Seeking Infertility Treatment

Posted January 2, 2020 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 7, 2020

Media advisory: The full study is linked to this news release. A visual abstract is below.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.18714?guestAccessKey=47179784-451b-4342-aadd-5f74ea3f79b1&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010720

What The Study Did: This randomized clinical trial examined the effects of daily folic acid and zinc supplementation in men on semen quality and live births among 2,300 couples planning infertility treatment.

Authors: Enrique F. Schisterman, Ph.D., of the Eunice Kennedy Shriver National Institute of Child Health and Human Development in Bethesda, Maryland, is the corresponding author.

Visual Abstract

(doi:10.1001/jama.2019.18714)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Cesarean Delivery Rates in China

Posted January 2, 2020 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JANUARY 7, 2020

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.17595?guestAccessKey=5c1a443c-dc74-48fe-a213-9b384d7febb4&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010720

What The Study Did: This study assessed changes between 2008 and 2018 in the rate of cesarean deliveries in China.

Authors: Jian-meng Liu, Ph.D., of the Peking University Health Science Center in Beijing, is the corresponding author.

(doi:10.1001/jama.2019.17595)

Editor’s Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 27, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2019.5582?guestAccessKey=96a37efe-c6d2-46cf-8b51-d8e2d01fde69&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010220

How Plant Closures Are Associated With Opioid Overdose Deaths

Posted December 26, 2019 by Deanna Bellandi

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 30, 2019

Media Advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2019.5686?guestAccessKey=7f42af1b-e097-44de-96f0-e2885753f572&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=123019

What The Study Did: Prior studies have reported mixed findings about an association between economic factors, such as unemployment and income, and opioid overdose deaths. This study estimated how automotive assembly plant closures were associated with opioid overdose mortality rates among adults of working age from 1999 through 2016.

Authors: Atheendar S. Venkataramani, M.D., Ph.D., of the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, is the corresponding author.

(doi:10.1001/jamainternmed.2019.5686)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Operating Room Reproductive Hazards for Female Surgeons

Posted December 27, 2019 by Jim Michalski

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JANUARY 2, 2020

Media Advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2019.5420?guestAccessKey=7db8d23b-51b3-4faa-a04b-084c46fac677&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010220

What The Study Did: Researchers in this review article discuss occupational reproductive hazards for female surgeons in the operating room, including radiation exposure, surgical smoke, working conditions and physical demands, sharps injuries, anesthetic gases and the use of toxic agents.

Authors: Matilda Anderson, M.B.B.S., M.P.H., of the Western Health Surgical Department, in Victoria, Australia, and Rose H. Goldman, M.D., M.P.H., of Harvard Medical School in Boston, are the authors.

(doi:10.1001/jamasurg.2019.5420)

Editor’s Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Study Examines Insecticide Exposure With Risk of Death

Posted December 26, 2019 by Jim Michalski

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 30, 2019

Media Advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2019.6019?guestAccessKey=4d9f43f5-46db-430b-bd39-83ddc0129475&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=123019

What The Study Did: Pyrethroid insecticides are a commonly-used class of insecticides used in agriculture, residential pest control and numerous consumer products. In this observational study, data from a nationally representative sample of about 2,100 adults were used to examine associations of pyrethroid exposure, as measured by a biomarker in urine samples, with risk of death over about 14 years.

Authors: Wei Bao, M.D., Ph.D., of the University of Iowa in Iowa City, is the corresponding author.

(doi:10.1001/jamainternmed.2019.6019)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Examining Antiepileptic Drug Exposure in Infants Breastfed by Mothers With Epilepsy

Posted December 26, 2019 by Jim Michalski

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 30, 2019

Media Advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2019.4443?guestAccessKey=1b78ea8b-b91e-4db1-b8f9-5a4094d9e17f&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=123019

What The Study Did: This observational study examined blood concentrations of antiepileptic drugs to report the extent of drug exposure from breastfeeding in infants whose mothers had epilepsy.

Authors: Angela K. Birnbaum, Ph.D., of the University of Minnesota in Minneapolis, is the corresponding author.

(doi:10.1001/jamaneurol.2019.4443)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 19, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2019.4874?guestAccessKey=2e82c383-5f10-487f-b102-f488bde04cc1&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=122619

Patient Views on Religious Affiliations of Health Care Facilities

Posted December 20, 2019 by Deanna Bellandi

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, DECEMBER 27, 2019

Media advisory: To contact corresponding author Maryam Guiahi, M.D., M.Sc., email David Kelly at david.kelly@cuanschutz.edu. The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17008?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=122719

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

Bottom Line: A survey of U.S. adults suggests most don’t consider an institution’s religious affiliation when selecting a health care facility. The survey, delivered on the phone or via the internet, was completed by 1,446 participants, most of whom were white and the most common religion was Protestant. Only 6.4% of adults reported that they considered religious affiliation when selecting a health care facility. However, most participants (71.4%), especially women, agreed their personal health decisions should take priority over an institution’s religious values in the provision of services. Federal protections allow health facilities to limit options to patients on the basis of religious values. Limitations of the study include a low response rate and a large proportion of individuals who were white and who had higher education and higher income.

Authors: Maryam Guiahi, M.D., M.Sc., University of Colorado School of Medicine in Aurora, and and coauthors

(doi:10.1001/jamanetworkopen.2019.17008)

Editor’s Note: The article contains conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Imaging to Examine Brain Architecture Association With Mood, Attentional Symptoms

Posted December 19, 2019 by Jim Michalski

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, DECEMBER 26, 2019

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2019.4208?guestAccessKey=cfe9c9c0-ab1e-4860-8f85-e75109f701e4&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=122619

What The Study Did: Researchers looked at whether certain patterns of connectivity between specific regions of the brain in children at age 7 (measured by magnetic resonance imaging) were associated with later development of symptoms related to attention-deficit/hyperactivity disorder and major depressive disorder.

Authors: Susan Whitfield-Gabrieli, Ph.D., of the University of California at Berkeley, is the corresponding author.

(doi:10.1001/jamapsychiatry.2019.4208)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted January 13, 2020 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.18436?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=011520

State Opioid Prescribing Limits

Posted December 20, 2019 by Deanna Bellandi

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, DECEMBER 27, 2019

Media advisory: To contact corresponding author Sunil Agarwal, M.D., email Nicole Rouech at MichiganOPEN@umich.edu. The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.18361?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=122719

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

Bottom Line: Many states have passed laws restricting the duration of opioid prescriptions for acute pain. This analysis focused on Massachusetts and Connecticut, the first states to implement limits after the Centers for Disease Control and Prevention published opioid prescribing guidelines in March 2016, to examine the association of opioid prescribing duration limits and postoperative opioid prescribing in those two states. The states implemented limits of seven days on initial opioid prescriptions in 2016 with exceptions for some patients and leeway for clinicians to override the limits based on their medical judgment. After analyzing data for 16,281 adults not using opioids but who filled an initial prescription within 3 days of surgery between mid 2014 and late 2017, investigators report opioid duration prescribing limits were associated in Massachusetts with decreases in average prescription size filed, the duration supplied and prescribing more than a seven-day supply, although the changes were small. Prescribing limits weren’t associated with changes in Connecticut. Limitations of the study include that it captured only opioid prescriptions reimbursed through employer-based health insurance and it didn’t include all surgical procedures performed in Massachusetts and Connecticut.

Authors: Sunil Agarwal, M.D., of the Michigan Opioid Prescribing Engagement Network, Ann Arbor, Michigan, and coauthors

(doi:10.1001/jamanetworkopen.2019.18361)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Imaging of Mummified Remains of Ancient Inuit People Suggests Vascular Calcifications

Posted December 20, 2019 by Deanna Bellandi

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, DECEMBER 27, 2019

Media advisory: To contact corresponding author L. Samuel Wann, M.D., and senior author Gregory Thomas, M.D., email Nick Ragone at Nick.Ragone@ascension.org and Rhoda Weiss at reweiss@memorialcare.org. The full study is linked to this news release. An image of the mummified remains is below.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.18270?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=122719

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

Bottom Line: Computed tomography (CT) imaging of mummified remains of three young Inuit people living 500 years ago in Greenland shows calcifications in remnants of their arteries that resemble atherosclerosis (a hardening and narrowing of the arteries) seen in living humans and other mummies. In an effort to better understand the early human history of atherosclerosis, researchers examined the remains of the mummies from the Peabody Museum of Archaeology and Ethnology in Cambridge, Massachusetts, because the ancient Inuit were hunter-gatherer people who ate a marine-based diet, which is rich in omega-3 fatty acids. While this case series presents evidence of calcified plaques in the mummified remains, an incomplete visualization of the arteries means the authors can’t determine the severity of the vascular calcifications or evaluate clinical disease.

Authors: L. Samuel Wann, M.D., of Ascension Healthcare, in Milwaukee, and coauthors

(doi:10.1001/jamanetworkopen.2019.18270)

Editor’s Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Eye Changes From Spaceflight Compared to Simulated Weightlessness

Posted December 19, 2019 by Jim Michalski

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, DECEMBER 26, 2019

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2019.5261?guestAccessKey=5dbe0b08-4206-40ca-acb0-b80f45b7f4c7&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=122619

What The Study Did: Some astronauts who fly long missions to the International Space Station experience eye changes. This study investigated whether the eye changes from the traditional spaceflight analog (an experience on earth meant to mimic spaceflight) of simulated weightlessness from 30 days of bed rest with head tilted down were similar to those experienced by astronauts during spaceflight.

Authors: Steven S. Laurie, Ph.D., of KBR in Houston, is the corresponding author.

(doi:10.1001/jamaophthalmol.2019.5261)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 18, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2019.5001?guestAccessKey=2f5a42f2-fb97-4c9d-812d-d79c3d20f1d8&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=122019

Here’s a link to provide your readers free access to the full-text article

Posted December 18, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2019.4794?guestAccessKey=9bc5a4eb-d937-413d-ac60-e81bc3b1051b&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=122019

Thyroid Cancer Rates in US

Posted December 18, 2019 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, DECEMBER 20, 2019

Media advisory: To contact corresponding author Jennifer L. Marti, M.D., email Grace Naugle at gen4001@med.cornell.edu. The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.18528?guestAccessKey=4b72acb9-f3b6-4eee-acf6-9437d49f61b3&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=122019

Bottom Line: An analysis suggests rates of thyroid cancer in the U.S. appear to have plateaued in recent years after decades on the rise. That increase was mostly attributed to more screening and imaging over the last three decades that detected many small thyroid cancers. Researchers in this observational study used cancer surveillance registry data to examine changes in rates of new cases of thyroid cancer in the U.S. from 1992 to 2016. Authors report the rate increased from 5.7 to 13.8 per 100,000 between 1992 and 2009, with the greatest annual percentage change (6.6%) from 1998 to 2009. The rate of increase slowed from 2009 to 2014 (13.8 to 14.7 per 100,000) and the rate has been stable since 2014 (from 14.7 to 14.1 per 100,000). The rate changes possibly may be due to a decline in the occurrence of thyroid cancer but the changes happened when there was a greater understanding about overdiagnosis of thyroid cancer and practice guidelines changed so a less intensive workup of thyroid nodules is a more likely explanation. Limitations of the study include that observational analyses like these cannot determine causality and the results may not be generalizable to other areas of the U.S. beyond the regions included in the registry data.

Authors: Jennifer L. Marti, M.D., Weill Cornell Medicine, New York, and coauthors.

(doi:10.1001/jama.2019.18528)

Editor’s Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

How Common is Diabetes Among Racial/Ethnic Groups?

Posted December 18, 2019 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, DECEMBER 20, 2019

Media advisory: To contact corresponding author Yiling J. Cheng, M.D., Ph.D., email Alaina Robertson at ifs2@cdc.gov. The full study and editorial are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.19365?guestAccessKey=357114c9-93bb-459d-b78c-01867571ad41&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=122019

Bottom Line: Estimating how common diabetes (both diagnosed and undiagnosed) was among U.S. adults by racial and ethnic groups was the objective of this observational study. A group of 7,575 adults 20 and older who participated in the National Health and Nutrition Examination Surveys between 2011-2016 were included. Among them, 2,266 people had diagnosed diabetes, and 377 had undiagnosed diabetes. The age-sex-adjusted proportion of adults with diabetes (diagnosed and undiagnosed) was 12.1% non-Hispanic white, 20.4% non-Hispanic black, 22.1% Hispanic, and 19.1% non-Hispanic Asian. The results also show that among selected Hispanic and non-Hispanic Asian subpopulations, there were noteworthy differences in how common diabetes was. The age-sex-adjusted proportion of adults with undiagnosed diabetes was 3.9% non-Hispanic white, 5.2% non-Hispanic black, 7.5% Hispanic, and 7.5% non-Hispanic Asian. Limitations of the study include diagnosed diabetes was self-reported, and there was a small sample of adults in some subgroups used for estimates.

Authors: Yiling J. Cheng, M.D., Ph.D., Centers for Disease Control and Prevention, Atlanta, and coauthors.

(doi:10.1001/jama.2019.19365)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 17, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.18058?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=122019

Here’s a link to provide your readers free access to the full-text article

Posted December 17, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17995?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=122019

Evaluating Clinical Evidence of Acupuncture, Acupressure for Improving Cancer Pain?

Posted December 17, 2019 by Jim Michalski

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, DECEMBER 19, 2019

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2019.5233?guestAccessKey=ab31a5b6-b9e7-45f4-bfbb-816e975b76a4&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121919

What The Study Did: This study (called a systematic review and meta-analysis) combined results from 14 randomized clinical trials to evaluate evidence of an association between acupuncture and acupressure for reducing pain in patients with cancer. Previous studies have had inconsistent findings.

Authors: Haibo Zhang, M.D., of Guangdong Provincial Academy of Chinese Medical Sciences in Guangzhou, China, and Charlie Changli Xue, Ph.D., of RMIT University in Melbourne, Australia, were the corresponding authors.

(doi:10.1001/jamaoncol.2019.5233)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 17, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17789?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=122019

Here’s a link to provide your readers free access to the full-text article

Posted December 16, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17669?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121819

Here’s a link to provide your readers free access to the full-text article

Posted December 16, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17885?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121819

How Common Are Concussions Not Related to Sports Among College Undergrads?

Posted December 16, 2019 by Jim Michalski

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, DECEMBER 18, 2019

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17626?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121819

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

What The Study Did: Researchers in this observational study looked at the number of concussions(both sports-related and not related to sports) experienced by undergraduate students at a large U.S. public university over three academic years.

Authors: John Breck, D.O., of Medical Services at University of Colorado in Boulder, is the corresponding author.

(doi:10.1001/jamanetworkopen.2019.17626)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Heart Transplants From Donors Positive for Hepatitis C

Posted December 13, 2019 by Jim Michalski

JAMA Cardiology

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, DECEMBER 18, 2019

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2019.4748?guestAccessKey=cd0a2ef8-c10a-47d3-94d4-8c2c7d0aaa3b&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121819

What The Study Did: Researchers at Vanderbilt University Medical Center in Nashville, Tennessee, report in this case series on 80 patients who had heart transplants using hearts from donors positive for hepatitis C.

Authors: Kelly H. Schlendorf, M.D., of Vanderbilt University Medical Center, is the corresponding author.

(doi:10.1001/jamacardio.2019.4748)

Editor’s Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Association of Household With Risk of 1st Psychiatric Hospitalization in Finland

Posted December 16, 2019 by Jim Michalski

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, DECEMBER 18, 2019

Media advisory: The full study and editorial are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2019.3647?guestAccessKey=d18ee18a-4dd3-4384-8064-69faec1a9776&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121819

What The Study Did: National registry data for 6.2 million people in Finland from 1996 to 2014 were used to examine how household income was associated with risk for a first admission to a psychiatric hospital for treatment of a mental disorder.

Authors: Sami Pirkola, M.D., of the University of Tampere in Tampere, Finland, is the corresponding author.

(doi:10.1001/jamapsychiatry.2019.3647)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Association of Greenness Surrounding Schools, Likelihood of ADHD Symptoms in Kids in China

Posted December 16, 2019 by Deanna Bellandi

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, DECEMBER 18, 2019

Media advisory: To contact corresponding authors Guang-Hui Dong, M.D., Ph.D., and Yunjiang Yu, Ph.D., email donggh5@mail.sysu.edu.cn and yuyunjiang@scies.org. The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17862?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121819

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

Bottom Line: Attending schools in greener areas appears to be associated with a lower likelihood of having symptoms of attention-deficit/hyperactivity disorder (ADHD) in this observational study of children in China. There were 59,754 children (ages 2 to 17) included, of whom 2,566 (4.3%) had ADHD symptoms. Attending schools in greener areas (as measured by satellite image-derived vegetation indexes) was associated with lower odds of ADHD symptoms, which was defined as six or more symptoms. Limitations of the study include other potential factors that could explain the results; a causal link cannot be made between greener areas surrounding schools or kindergartens and ADHD symptoms; and ADHD symptoms were measured using questionnaires completed by parents and guardians with no clinical verification. While further studies are needed, researchers suggest their findings could be helpful for developing strategies to plan more green spaces around schools.

Authors: Guang-Hui Dong, M.D., Ph.D., of Sun Yat-sen University, and Yunjiang Yu, Ph.D., of the South China Institute of Environmental Sciences, in Guangzhou, China, and coauthors

(doi:10.1001/jamanetworkopen.2019.17862)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Marijuana Use in e-Cigarettes Increases Among US Students 2017-2018

Posted December 16, 2019 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 12 A.M. (ET), WEDNESDAY, DECEMBER 18, 2019

Media advisory: To contact corresponding author Hongying Dai, Ph.D., email Vicky Cerino at vcerino@unmc.edu. The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.19571?guestAccessKey=e55d0af9-7eb5-436f-9de4-4ea80835522e&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121719

Bottom Line: Marijuana use in electronic cigarettes increased among U.S. middle and high school students from 2017 to 2018. This observational study analyzed responses from 38,000 students in the sixth to 12th grades on the National Youth Tobacco Survey. Researchers report that among all students, the proportion who reported ever using marijuana in an e-cigarette increased from 11.1% in 2017 to 14.7% in 2018, with the increases seen among some demographic groups, including male and female students, adolescents 13 to 17, high-schoolers, and non-Hispanic white and Hispanic students. In 2018, 42.7% of students who ever used e-cigarettes, 53.5% of current e-cigarette users, and 71.6% of multiple tobacco product users reported ever using marijuana in e-cigarettes. A limitation of the study is that the information was self-reported. Studies about the short- and long-term health effects of using marijuana in e-cigarettes are needed.

Author: Hongying Dai, Ph.D., University of Nebraska Medical Center, Omaha

(doi:10.1001/jama.2019.19571)

Editor’s Note: The article includes funding/support disclosures. Please see the article for additional information, including author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Exploring Associations Between Ultraprocessed Food Consumption, Type 2 Diabetes

Posted December 12, 2019 by Deanna Bellandi

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 16, 2019

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article: This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2019.5942?guestAccessKey=0dd02341-f701-48a5-8d97-18b1173f7d9d&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121619

What The Study Did: Associations between consumption of ultraprocessed foods and risk of type 2 diabetes were explored among a large group of participants in a web-based study cohort in France. Ultraprocessed foods generally contain food additives and have longer shelf-lives because of preservatives. This observational study didn’t focus on a particular food category or additive.

Authors: Bernard Srour, Pharm.D., M.P.H., Ph.D., of the Epidemiology and Statistics Research Center-University of Paris, is the corresponding author.

(doi:10.1001/jamainternmed.2019.5942)

Editor’s Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Marijuana Vaping Increases Among US Teens 2018-2019

Posted December 16, 2019 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 12 A.M. (ET), WEDNESDAY, DECEMBER 18, 2019

Media advisory: To contact corresponding author Richard A. Miech, Ph.D., email Nick Prieur at nprieur@umich.edu. The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.20185?guestAccessKey=ed8256f1-6c66-41d8-b834-055ab7bb1ce1&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121719

Bottom Line: Marijuana vaping reported by U.S. adolescents increased from 2018 to 2019. This observational study used annual Monitoring the Future surveys from a nationally representative group of eighth, 10th and 12th graders to examine changes in marijuana vaping among adolescents. In 2019, past 30-day marijuana vaping was reported by 14% of 12th graders, an absolute increase of 6.5% from 2018. Additionally, 3.9% of 8th graders reported past 30-day use, an absolute increase of 1.3% from 2018 to 2019, and 12.6% of 10th graders reported such use in 2019, an absolute increase of 5.6% over 2018. One-year increases from 2018 to 2019 were larger than the increases from 2017 to 2018 for 10th and 12th graders for past 30-day use. Limitations of the study include potential errors in self-reported use and an absence of high-school dropouts. The growth in marijuana vaping suggests new prevention and intervention efforts aimed specifically at adolescents are needed.

Authors: Richard A. Miech, Ph.D., University of Michigan, Ann Arbor, and coauthors.

(doi:10.1001/jama.2019.20185)

Editor’s Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 16, 2019 by Jim Michalski

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2019.4063?guestAccessKey=962d4ff1-e50b-484c-ab81-fee4bf89959e&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121819

Here’s a link to provide your readers free access to the full-text article

Posted December 10, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17571?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121319

Here’s a link to provide your readers free access to the full-text article

Posted December 10, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17550?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121319

Here’s a link to provide your readers free access to the full-text article

Posted December 10, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17371?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121319

Here’s a link to provide your readers free access to the full-text article

Posted December 10, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2019.4097?guestAccessKey=ceb47962-5fdd-42cc-97d7-0fd4d068593f&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121219

Here’s a link to provide your readers free access to the full-text article

Posted December 10, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2019.4636?guestAccessKey=a94b4384-3492-45a4-a2a9-14b990657c04&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121219

Historical Look at US Army Suicides

Posted December 10, 2019 by Deanna Bellandi

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, DECEMBER 13, 2019

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17448?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121319

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

What The Study Did: Nearly 200 years of military records from 1819 to 2017 were used to examine suicide rates among active-duty personnel in the U.S. Army in this observational study.

Authors: Jeffrey Allen Smith, Ph.D.,of the University of Hawaii in Hilo, is the corresponding author.

(doi:10.1001/jamanetworkopen.2019.17448)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Changes in Opioid-Related Drug Overdose Deaths in US

Posted December 12, 2019 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, DECEMBER 17, 2019

Media advisory: To contact corresponding author Mark Olfson, M.D., M.P.H., email Gregory Flynn at Gregory.Flynn@nyspi.columbia.edu. The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.16566?guestAccessKey=2760f6ab-79d4-4419-a1b5-4c896967e7e0&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121719

Bottom Line: Researchers analyzed changes in the proportion of drug overdose deaths involving opioids that were certified as suicide, unintentional or of undetermined intent in this observational study. Using 2000-2017 mortality data, researchers report 47,506 total opioid deaths (excluding homicides) in 2017: 90.6% were unintentional deaths, 4% were suicides and 5.4% were of undetermined intent. Between 2000 and 2017, the percentage of opioid-related deaths that were suicides declined from 9% to 4%; unintentional opioid-related deaths increased from 73.8% to 90.6%; and deaths of undetermined intent decreased from 17.2% to 5.4%. There were significant increases in opioid-related suicide rates for males and females, all racial/ethnic groups, and all age groups except those between the ages of 35 and 44. Between 2000 and 2017, the rate of opioid-related deaths increased from 2.2 to 13.2 per 100,000 people for unintentional deaths and from 0.27 to 0.58 per 100,000 for suicides with no significant change in the rate for deaths of undetermined intent. Limitations of the study include fewer drug overdose deaths that didn’t have information on the specific drug because of increased toxicological screening and that may have contributed to the increase in opioid-related deaths over time, as well as uncertainty about determinations made by coroners or medical examiners about the manner of death.

Authors: Mark Olfson, M.D., M.P.H., Columbia University Vagelos College of Physicians and Surgeons, New York, and coauthors.

(doi:10.1001/jama.2019.16566)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

New Estimates of Neonatal Abstinence Syndrome, Associated Costs

Posted December 12, 2019 by Jim Michalski

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 16, 2019

Media Advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2019.4791?guestAccessKey=8ae2e5a2-278a-4d10-9b13-525dab36b526&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121619

What The Study Did: Neonatal abstinence syndrome is withdrawal that happens in infants who were exposed to opioids in utero during pregnancy. This study gives new national estimates of neonatal abstinence syndrome and associated health care costs.

Authors: Andrea E. Strahan, Ph.D., of the Centers for Disease Control and Prevention in Atlanta, is the corresponding author.

(doi:10.1001/jamapediatrics.2019.4791)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 9, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2019.3655?guestAccessKey=6e07f748-b1ef-470c-8352-22ce8f3bdcb4&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121119

Here’s a link to provide your readers free access to the full-text article

Posted December 9, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2019.3993?guestAccessKey=0fa33aac-476f-4dba-bd04-623774ae2ecf&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121119

Here’s a link to provide your readers free access to the full-text article

Posted December 9, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17134?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=121119

Examining Opioid Prescribing After New Florida Law

Posted December 9, 2019 by Deanna Bellandi

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, DECEMBER 11, 2019

Media advisory: The full study is are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2019.4913?guestAccessKey=301774f5-cdbe-4fba-bd14-e8987bf5a945&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121119

What The Study Did: Researchers compared opioid prescribing at discharge from the Mayo Clinic in Jacksonville, Florida, across 25 procedures before and after a Florida law that mandated changes to opioid prescribing went into effect in 2018.

Authors: Steven B. Porter, M.D., of the Mayo Clinic in Jacksonville, Florida, is the corresponding author.

(doi:10.1001/jamasurg.2019.4913)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Opioid Prescribing Patterns, Overdose Risk in Teens, Young Adults

Posted December 12, 2019 by Jim Michalski

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 16, 2019

Media Advisory: The full study and editorial are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2019.4878?guestAccessKey=7a366bfc-9e19-4c80-ab27-32624f2a6cb3&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121619

What The Study Did: Researchers used a private insurance claims database in the U.S. to examine opioid prescribing patterns and how they were associated with overdose risk among 2.7 million adolescents and young adults without cancer.

Authors: Kao-Ping Chua, M.D., Ph.D., of the University of Michigan Medical School in Ann Arbor, is the corresponding author.

(doi:10.1001/jamapediatrics.2019.4878)

Editor’s Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 12, 2019 by Jim Michalski

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2019.4200?guestAccessKey=b9fd1299-e59e-4124-8537-b788fd14a892&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121619

Here’s a link to provide your readers free access to the full-text article

Posted December 5, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.18037?guestAccessKey=d0ac6271-6e75-4fe0-babd-c035de1c4a4e&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121019

Review of Studies on Cigarette Smoking, Multiple Sclerosis

Posted December 12, 2019 by Jim Michalski

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 16, 2019

Media Advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2019.4271?guestAccessKey=27b33aa4-2559-43e1-aebb-afc23a004eca&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121619

What The Study Did: Researchers conducted a literature review of studies to summarize outcomes in patients with multiple sclerosis who smoke cigarettes and who are exposed to smoke.

Authors: Tanuja Chitnis, M.D., and Mattia Rosso, M.D., of Harvard Medical School in Boston, are the authors.

(doi:10.1001/jamaneurol.2019.4271)

Editor’s Note: The article includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Examining Association Between Breastfeeding, Postpartum MS Relapses

Posted December 5, 2019 by Deanna Bellandi

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 9, 2019

Media Advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2019.4173?guestAccessKey=75c51ca7-5882-4ac7-941c-ae527bf9d86d&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120919

What The Study Did: Therapies to reduce relapses of multiple sclerosis (MS) aren’t recommended in pregnancy or breastfeeding so women often decide to skip breastfeeding to resume their MS treatment. This systematic review and meta-analysis included 24 studies and combined some of their results in an updated examination of the association between breastfeeding and postpartum relapses in women with MS.

Authors: Kristen M. Krysko, M.D., M.A.S., of the University of California, San Francisco, is the corresponding author.

(doi:10.1001/jamaneurol.2019.4173)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 5, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2019.4192?guestAccessKey=9ab41cff-d3db-43e2-bf15-e3ec89cdfb63&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120919

Long-Term Ozone Exposure in Smokers

Posted December 5, 2019 by Deanna Bellandi

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, DECEMBER 9, 2019

Media Advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2019.5498?guestAccessKey=91abaffe-6e95-4826-a521-d3aa9188c69f&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120919

What The Study Did: Data for nearly 1,900 current and former smokers with or without chronic obstructive pulmonary disease (COPD) were analyzed to investigate the association between long-term ozone exposure and the respiratory health of adults with a history of heavy smoking.

Authors: Laura M. Paulin, M.D., M.H.S., of the Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire, and Nadia N. Hansel, M.D., M.P.H., of the Johns Hopkins School of Medicine in Baltimore, are the corresponding authors.

(doi:10.1001/jamainternmed.2019.5498)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 3, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.16910?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120619

Here’s a link to provide your readers free access to the full-text article

Posted December 3, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17043?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120619

USPSTF Updates Recommendations for Abdominal Aortic Aneurysm Screening

Posted December 5, 2019 by Jim Michalski

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, DECEMBER 10, 2019

Media advisory: To contact the U.S. Preventive Services Task Force, email the Media Coordinator at Newsroom@USPSTF.net or call 202-572-2044. The full report, related articles and a podcast are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time and all USPSTF articles remain free indefinitely https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.18928?guestAccessKey=835ef7fd-26e2-4fc5-a700-ab6129adc5b5&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=121019

Bottom Line: The U.S. Preventive Services Task Force (USPSTF) has updated its recommendations on screening for an abdominal aortic aneurysm and the recommendations vary depending on factors such as patient age, sex and if they ever smoked. An abdominal aortic aneurysm is an enlarged area of the main blood vessel that supplies blood to the body and it can be life-threatening if it bursts. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this statement updates its 2014 recommendations.

(doi:10.1001/jama.2019.18928)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Note: More information about the U.S. Preventive Services Task Force, its process, and its recommendations can be found on the newsroom page of its website.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 3, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.17001?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120619

Here’s a link to provide your readers free access to the full-text article

Posted December 2, 2019 by Deanna Bellandi

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.16641?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120419

Here’s a link to provide your readers free access to the full-text article

Posted December 2, 2019 by Deanna Bellandi

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.16722?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120419

Here’s a link to provide your readers free access to the full-text article

Posted December 2, 2019 by Deanna Bellandi

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.16729?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120419

Here’s a link to provide your readers free access to the full-text article

Posted December 2, 2019 by Deanna Bellandi

Media advisory: The full study and editorial are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.16800?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=120419

Cell Phone Injuries

Posted December 3, 2019 by Jim Michalski

JAMA Otolaryngology-Head & Neck Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, DECEMBER 5, 2019

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2019.3678?guestAccessKey=7365d177-20a7-4233-aa3f-75181d35d038&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120519

What The Study Did: Cell phones are mainstays of daily life. This observational study analyzed 20 years of data on people who went to emergency departments with head and neck injuries from cell phone use to estimate the number of injuries, learn what types of injuries there were, and understand how the injuries occurred, such as from distracted driving or walking.

Authors: Boris Paskhover, M.D., of Rutgers New Jersey Medical School in Newark, New Jersey, is the corresponding author.

(doi:10.1001/jamaoto.2019.3678)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted December 2, 2019 by Jim Michalski

Media advisory: The full study and editorial are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2019.3900?guestAccessKey=9e852b88-786c-41fe-b78b-38366e408320&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120419

Here’s a link to provide your readers free access to the full-text article

Posted December 2, 2019 by Jim Michalski

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2019.5047?guestAccessKey=562b0c2d-c019-4ef2-96b6-f3bdb6d39d87&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120419

How Race is Associated With Differences Among Patients With Hypertrophic Cardiomyopathy

Posted December 2, 2019 by Jim Michalski

JAMA Cardiology

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, DECEMBER 4, 2019

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2019.4638?guestAccessKey=ce302e44-673e-405b-9f99-ccbdcaedfd3e&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120419

What The Study Did: Researchers in this observational study looked at how race was associated with difference in symptoms, access to care, genetic testing and clinical outcomes among 2,467 patients (8.3% black and 91.7% white) with hypertrophic cardiomyopathy, a condition where the heart muscle becomes abnormally thick, which can make it harder to pump blood.

Authors: Neal K. Lakdawala, M.D., of Brigham and Women’s Hospital in Boston, is the corresponding author.

(doi:10.1001/jamacardio.2019.4638)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Cancer Treatment for Patients With HIV

Posted December 3, 2019 by Jim Michalski

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, DECEMBER 5, 2019

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2019.4648?guestAccessKey=1d1ad1cf-e523-403e-9d94-49f95d782cc8&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120519

What The Study Did: For patients with HIV, CD4 counts reflect the health of their immune system and HIV RNA levels indicate their viral load. This observational study focused on how cancer treatments were associated with those two important clinical measures and risk of death in nearly 200 patients with HIV and cancer.

Authors: Keri L. Calkins, Ph.D., of the Johns Hopkins Bloomberg School of Public Health in Baltimore, is the corresponding author.

(doi:10.1001/jamaoncol.2019.4648)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Here’s a link to provide your readers free access to the full-text article

Posted November 26, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2019.17432?guestAccessKey=13c69944-7287-4d8f-b1f1-ed786bc028cd&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120319

Here’s a link to provide your readers free access to the full-text article

Posted November 26, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2019.5280?guestAccessKey=0e823d91-90d3-4a37-83fe-779d0850d010&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120219

Here’s a link to provide your readers free access to the full-text article

Posted November 26, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2019.4113?guestAccessKey=cbc9cdbc-74e4-4b28-9d27-c9d5984d36b7&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120219

Here’s a link to provide your readers free access to the full-text article

Posted November 26, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2019.4532?guestAccessKey=aca1dba9-e113-4f19-a36f-c7342cb9d67e&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120219

Here’s a link to provide your readers free access to the full-text article

Posted November 26, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2019.4498?guestAccessKey=15dea2df-ed3c-4765-80ba-867bfb6810f5&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120219

Here’s a link to provide your readers free access to the full-text article

Posted November 26, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2019.4368?guestAccessKey=854117da-7fdb-4c22-a092-1a904ae8c006&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=120219

Podcast: Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease

Posted November 22, 2019 by Deanna Bellandi

Physician Depressive Symptoms Associated With Medical Errors

Posted November 25, 2019 by Deanna Bellandi

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, NOVEMBER 27, 2019

Media advisory: To contact corresponding author Karina Pereira-Lima, Ph.D., email Kara Gavin at kegavin@med.umich.edu. The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.16097?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=112719

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

Bottom Line: Physician depressive symptoms were associated with increased risk of perceived medical errors, and medical errors were associated with subsequent depressive symptoms in physicians in this analysis that combined data from multiple studies. Data were pulled from 11 studies and all but one study used self-reported measures of medical errors. Medical errors harm patients and previous research suggests depression is common among physicians. More studies are needed to determine whether interventions for reducing depressive symptoms in physicians could help to reduce medical errors and improve patient safety.

Authors: Karina Pereira-Lima, Ph.D., of the University of Michigan Medical School, Ann Arbor, and coauthors

(doi:10.1001/jamanetworkopen.2019.16097)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Heartburn Medication and Intestinal Viral Infection Risk

Posted November 25, 2019 by Deanna Bellandi

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, NOVEMBER 22, 2019

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.16205?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=112719

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

What The Study Did: Proton pump inhibitors (PPIs) are a widely prescribed class of drugs for reducing stomach acid levels and this observational study examined the association between continuous use of PPIs and risk of at least one intestinal viral infection during winter months when circulation of enteric viruses is highest. The study compared 233,596 patients receiving continuous PPI therapy with 626,887 patients not receiving PPI therapy by using a drug dispensing database from a panel of community pharmacies in France.

Authors: Ana-Maria Vilcu, M.Sc., Sorbonne Universite, Paris, and coauthors

(doi:10.1001/jamanetworkopen.2019.16205)

Editor’s Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

How Patients Feel About Providers’ Cultural Competence

Posted November 25, 2019 by Deanna Bellandi

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, NOVEMBER 27, 2019

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.16105?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=112719

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

What The Study Did: Nonwhite, low-income and uninsured patients were less likely to report being treated with respect and more likely to feel the cultural competence of health care professionals was important in this survey study that used data from five new cultural competency questions that were part of a national survey.

Authors: Lynn Blewett, Ph.D., M.A., of the University of Minnesota School of Public Health in Minneapolis, is the corresponding author.

(doi:10.1001/jamanetworkopen.2019.16105)

Editor’s Note: The articles includes conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Understanding Association of Marijuana Use, Risk of Developing Cancer

Posted November 25, 2019 by Deanna Bellandi

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, NOVEMBER 27, 2019

Media advisory: To contact corresponding author Deborah Korenstein, M.D., email Nicole McNamara at mcnamarn@mskcc.org. The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2019.16318?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=112719

About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. Every Wednesday and Friday, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

Bottom Line: The association between marijuana use and the risk of developing different kinds of cancer remained largely unclear in this analysis of 25 studies. The available studies were limited by small numbers of participants with high levels of marijuana use, poor quantification of marijuana use, and the presence of other factors such as cigarette smoking, which could influence results. Long-term studies are needed to improve understanding of marijuana’s association with the risk of developing cancer.

Authors: Deborah Korenstein, M.D., Memorial Sloan Kettering Cancer Center, New York, and coauthors

(doi:10.1001/jamanetworkopen.2019.16318)

Editor’s Note: The article contains conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email mediarelations@jamanetwork.org.

Here’s a link to provide your readers free access to the full-text article

Posted November 25, 2019 by Deanna Bellandi

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2019.3639?guestAccessKey=6f966d42-66a9-420f-a142-60439f910d33&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112719

The Eyes of Rembrandt, Leonardo da Vinci

Posted November 25, 2019 by Jim Michalski

JAMA Ophthalmology

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, NOVEMBER 27, 2019

Media advisory: The full study is linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2019.4603?guestAccessKey=64793dcb-77ac-4f8e-a6f6-523ebcc26568&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112719

What The Study Did: In self-portraits, Rembrandt and Leonardo da Vinci drew their own eyes with one eye turned outward, a condition known as exotropia. Researchers in this report used photographs, diagrams and a trigonometric equation to explore the notion that rather than exotropia, which apparently was never documented in these artists, Rembrandt and da Vinci probably had one strongly dominant eye, which could affect how they perceived their eyes appeared when looking in a mirror to paint or sketch a self-portrait.

Authors: David L. Guyton, M.D., of the Johns Hopkins University Hospital in Baltimore, is the corresponding author.

(doi:10.1001/jamaophthalmol.2019.4603)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Is Slight Hearing Loss in Children Associated With Behavioral Problems, School Performance?

Posted November 25, 2019 by Jim Michalski

JAMA Otolaryngology-Head & Neck Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, NOVEMBER 27, 2019

Media advisory: The full study and commentary are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2019.3585?guestAccessKey=24afca04-23a4-4be1-aced-68486f66d1b0&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112719

What The Study Did: Researchers in this observational study investigated whether slight to mild hearing loss was associated with behavioral problems and performance on a standardized test among 4,700 children between the ages of 9 to 11 in the Netherlands.

Authors: Carlijn M.P. le Clercq, M.D., of Erasmus University Medical Center in Rotterdam, the Netherlands, is the corresponding author.

(doi:10.1001/jamaoto.2019.3585)

Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.

Examining Work Schedules of Hospitalists, Patient Outcomes

Posted November 21, 2019 by Jim Michalski

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, NOVEMBER 25, 2019

Media Advisory: The full study and podcast are linked to this news release.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2019.5193?guestAccessKey=1a74171c-5635-4dee-b362-59fe361bdca2&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112519

What The Study Did: This observational study investigated whether the continuity of hospitalists’ work schedules, such as working more days consecutively compared to intermittently, was associated with outcomes for patients admitted to Texas hospitals.

Authors: James S. Goodwin, M.D., of the University of Texas Medical Branch at Galveston, is the corresponding author.

(doi:10.1001/jamainternmed.2019.5193)

Editor’s Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

# # #

For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.