Effect of Colchicine on Biomarkers and Clinical Outcomes in Patients Hospitalized With COVID-19

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 24, 2020

Media advisory: The full study and commentary are linked to this news release.

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: This randomized clinical trial evaluates the effect of treatment with colchicine on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with COVID-19.

Authors: Spyridon G. Deftereos, M.D., Ph.D., of the National and Kapodistrian University of Athens in Greece, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.13136)

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Management of Patients With Severe Mental Illness During the COVID-19 Pandemic

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 24, 2020

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What The Article Says: How to best treat patients with severe mental illness during the COVID-19 pandemic is detailed in this article.

Authors: Kai G. Kahl, M.D., of the Hannover Medical School in Hannover, Germany, is the corresponding author.

 

(doi:10.1001/jamapsychiatry.2020.1701)

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COVID-19 Outbreak and Mental Health

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 24, 2020

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What The Viewpoint Says: The use of online platforms to guide effective consumption of information, facilitate social support and continue mental health care delivery during the COVID-19 pandemic is discussed in this Viewpoint.

Authors: Yuval Neria, Ph.D., of the Columbia University Irving Medical Center in New York, is the corresponding author.

 

(doi:10.1001/jamapsychiatry.2020.1730)

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Rethinking Regional Neurologic Care in COVID-19 Era

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 29, 2020

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What The Viewpoint Says: Ways to reduce over-triage for patients with neurologic disease and finding ways to care for patients at a distance during the COVID-19 pandemic are discussed in this Viewpoint.

Authors: Benjamin P. George, M.D., M..PH., and Adam G. Kelly, M.D., of the University of Rochester Medical Center in Rochester, New York, are the authors.

 

(doi:10.1001/jamaneurol.2020.1956)

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Staying Apart During a Pandemic

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 29, 2020

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What The Perspective Says: The loss of human connection caused by the social and physical distancing of the COVID-19 pandemic is lamented in this piece.

Authors: Nathaniel P. Morris, M.D., of Stanford University School of Medicine in California, is the corresponding author.

 

(doi:10.1001/jamainternmed.2020.2505)

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Simulation of Pool Testing Strategies to Identify Patients With COVID-19

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 23, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: The feasibility of using pool testing to identify patients with COVID-19 in a setting with limited testing availability was examined in this decision analytical model study.

Authors: Alhaji Cherif, Ph.D., of the Renal Research Institute in New York, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.13075)

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Examining Association of Despair With Suicidal Thoughts, Substance Misuse Among Young Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 23, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: Researchers looked at whether despair among young adults was associated with suicidal thoughts and behavior and alcohol and drug misuse.

Authors: William E. Copeland, Ph.D., of the University of Vermont College of Medicine in Burlington, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.8627)

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Attitudes, Psychological Factors Associated With Behaviors Among Adolescents During COVID-19

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 29, 2020

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What The Study Did: Psychological factors associated with adolescents’ behaviors during the COVID-19 pandemic are examined in this survey study.

Authors: Benjamin Oosterhoff, Ph.D., of Montana State University in Bozeman, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2020.1876)

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Out-of-Hospital Cardiac Arrests and Resuscitations During COVID-19 Pandemic in New York

JAMA Cardiology

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 19, 2020

Media advisory: The full study and editor’s note are linked to this news release.

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What The Study Did: This study describes the characteristics associated with outpatient cardiac arrests and death during the COVID-19 pandemic in New York.

Authors: David J. Prezant, M.D., of the Fire Department of the City of New York in Brooklyn, is the corresponding author.

 

(doi:10.1001/jamacardio.2020.2488)

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Assessment of COVID-19 Community Containment Strategies in China

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 22, 2020

Media advisory: The full study is linked to this news release.

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: Measures implemented in a community in China to restrict the spread of COVID-19 are examined in this case series.

Authors: Wen-Wu Zhang, B.Med., and Qing-Li Dou, Ph.D., of The People’s Hospital of Baoan Shenzhen in China, are the corresponding authors.

 

(doi:10.1001/jamanetworkopen.2020.12934)

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Variation in Ventilator Allocation Guidelines by State During COVID-19 Pandemic

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 19, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: State guidelines for ventilator allocation decision-making during the COVID-19 pandemic are examined in this review.

Authors: Gina M. Piscitello, M.D., of Rush University in Chicago, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.12606)

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Studies Examine Association Between Recreational Marijuana Legalization, Changes in Traffic Fatality Rates

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 22, 2020

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What The Studies Did: These studies looked at changes in the rate of traffic fatalities in states that have legalized the use of recreational cannabis.

 

Authors: Julian Santaella-Tenorio, Dr.P.H., of the New York University School of Medicine, is the corresponding author of the original investigation.

(doi:10.1001/jamainternmed.2020.1757)

Authors: Russell S. Kamer, M.D., of New York Medical College in White Plains, New York, is the corresponding author of the research letter.

(doi:10.1001/jamainternmed.2020.1769)

 

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Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 17, 2020

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What The Study Did: Whether the prone position is associated with improved oxygenation and decreased risk for intubation in spontaneously breathing patients with severe COVID-19 hypoxemic respiratory failure is investigated in this observational study.

Authors: Sanja Jelic, M.D., of the Columbia University Vagelos College of Physicians and Surgeons in New York, is the corresponding author.

 

(doi:10.1001/jamainternmed.2020.3030)

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How Common Are Taste, Smell Dysfunction in COVID-19 Patients

JAMA Otolaryngology–Head & Neck Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JUNE 18, 2020

Media advisory: The full study is linked to this news release.

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What The Study Did: This survey study of patients with COVID-19 investigates how common the ability to taste and smell was reduced at the onset of the disease.

Authors: Fabio Ferreli, M.D., of the Humanitas Clinical and Research Center in Milan, Italy, is the corresponding author.

 

(doi:10.1001/jamaoto.2020.1155)

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Disparities in COVID-19 Reported Incidence, Knowledge, Behavior Among US Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JUNE 18, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: The association of sociodemographic characteristics with reported incidence, knowledge and behavior regarding COVID-19 among U.S. adults is examined in this survey study.

Authors: David Cutler, Ph.D., of Harvard University in Cambridge, Massachusetts, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.12403)

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Design, Analyses of Oncology Trials During COVID-19 Pandemic

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JUNE 18, 2020

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What The Viewpoint Says: The challenges associated with conducting and assessing results of clinical trials during the COVID-19 pandemic are discussed in this Viewpoint.

Authors: Chaya S. Moskowitz, Ph.D., of the Memorial Sloan Kettering Cancer Center in New York, is the corresponding author.

 

(doi:10.1001/jamaoncol.2020.2370)

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Factors Associated With Decision to Withdraw Life-Supporting Treatment in Patients With Severe Traumatic Brain Injury

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 17, 2020

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What The Study Did: Researchers examined what demographic and clinical factors are associated with the decision to withdraw life-supporting treatment in patients with severe traumatic brain injury using data from more than 825 trauma centers in the U.S.

Authors: Theresa Williamson, M.D., of Duke University Medical Center in Durham, North Carolina, is the corresponding author.

 

(doi:10.1001/jamasurg.2020.1790)

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Examining Association Between Common Antibiotic Use, Risk of Cardiovascular Death

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 17, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: This observational study examined the risk of cardiovascular death and sudden cardiac death associated with use of the antibiotic azithromycin compared with amoxicillin.

Authors: Jonathan G. Zaroff, M.D., of Kaiser Permanente Northern California in Oakland, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.8199)

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Characteristics of Patients With COVID-19 in Detroit

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 16, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: Clinical characteristics and outcomes of patients with COVID-19 at a health system in Detroit are described in this case series, which also provides a comparative analysis of hospitalized and ambulatory patient populations.

Authors: Geehan Suleyman, M.D., of the Henry Ford Hospital in Detroit, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.12270)

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How Commonly Do Patients Develop Persistent Opioid Use After Cardiac Surgery?

JAMA Cardiology

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 17, 2020

Media advisory: The full study and commentary are linked to this news release.

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What The Study Did: A large, national database was used to determine how common it was for patients who hadn’t used opioids before undergoing a coronary artery bypass grafting or heart valve procedure to subsequently develop persistent opioid use after surgery.

Authors: Nimesh D. Desai, M.D., Ph.D., of the Hospital of the University of Pennsylvania in Philadelphia, is the corresponding author.

 

(doi:10.1001/jamacardio.2020.1445)

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Asthma Among Children With Developmental Disabilities

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 16, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: How common asthma was among children with various developmental disabilities (including attention-deficit/hyperactivity disorder, autism spectrum disorder and vision, hearing or speech delay) was compared to children without disabilities in this survey study.

Authors: Sarah E. Messiah, Ph.D., M.P.H., of the Children’s Health System of Texas in Dallas, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.7728)

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N95, KN95, and Surgical Mask Filtration Efficiency After Sterilization

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 15, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: This is a quality improvement study that examines the effects of sterilization with hydrogen peroxide and chlorine dioxide on the filtration efficiency of N95, KN95 and surgical face masks.

Authors: Changjie Cai, Ph.D., of the University of Oklahoma Health Sciences Center in Oklahoma City, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.12099)

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Perceived Harm of e-Cigarettes vs Cigarettes after Outbreak of Vaping-Associated Lung Injury

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 15, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: This survey study looked at perceptions of the harms of electronic cigarettes compared to regular cigarettes among current smokers in England before and after the U.S. outbreak of vaping-associated lung injury in 2019. Misperceptions that e-cigarettes are at least as harmful to health as regular cigarettes may dissuade smokers who are unable or unwilling to stop using nicotine from switching to e-cigarettes.

Authors: Harry Tattan-Birch, M.Sc., of University College London, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.6981)

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Examining the Association Between Healthy Eating Patterns and Risk of Cardiovascular Disease

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 15, 2020

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What The Study Did: Whether several recommended healthy eating patterns that combine various nutrients and foods are associated with long-term risk of cardiovascular disease, including heart disease and stroke, was the focus of this observational study that used data from three large study groups with up to 32 years of follow-up. Few studies have examined whether adherence to different dietary patterns could be associated with a lower risk of cardiovascular disease.

Authors: Frank B. Hu, M.D., Ph.D., of the Harvard T.H. Chan School of Public Health in Boston, is the corresponding author.

 

(doi:10.1001/jamainternmed.2020.2176)

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Patient-Collected Lower Nasal Specimens for SARS-CoV-2 Testing

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 12, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: This study compares the diagnostic equivalence of patient-collected lower nasal specimens with that of health care worker–collected oropharyngeal specimens for SARS-CoV-2 testing.

Authors: Jonathan Altamirano, M.S., of the Stanford University School of Medicine in California, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.12005)

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Treating Relapsing Multiple Sclerosis with Hookworm Infection

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 15, 2020

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What The Study Did: This randomized clinical trial assessed the effect of treating patients with relapsing multiple sclerosis with a therapeutic hookworm infection compared with placebo. Some studies have suggested that gut worms induce immune responses that can protect against multiple sclerosis.

Authors: Cris S. Constantinescu, M.D., Ph.D., and David I. Pritchard, Ph.D., of the University of Nottingham in Nottingham, England, are the corresponding authors.

 

(doi:10.1001/jamaneurol.2020.1118)

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Temperature, Humidity, Latitude Analysis to Estimate Potential Spread, Seasonality of COVID-19

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JUNE 11, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: The association between climate and the spread of COVID-19 is examined in this observational study.

Authors: Mohammad M. Sajadi, M.D., of the University of Maryland School of Medicine in Baltimore, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.11834)

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Prevalence of Gastrointestinal Symptoms, Fecal Viral Shedding in Patients With COVID-19

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JUNE 11, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: How commonly reported gastrointestinal symptoms were in patients with COVID-19 and viral RNA shedding was detected in these patients’ stool are examined in this systematic review and meta-analysis.

Authors: Sravanthi Parasa, M.D., of Swedish Medical Center in Seattle, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.11335)

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Comparing Life Expectancy Between Insured Adults With or Without HIV

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 15, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: Researchers estimated the difference in overall life expectancy and years free from major chronic illnesses between individuals with HIV infection with access to care and similar uninfected adults from the same health care system from 2000 to 2016. Antiretroviral therapy has increased life expectancy for individuals with HIV, but recent data comparing life span between individuals with or without the disease are lacking.

Authors: Julia L. Marcus, Ph.D., M.P.H., of Harvard Medical School in Boston, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.7954)

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Outcomes of COVID-19 in Countries With Different Income Levels

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JUNE 11, 2020

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What The Viewpoint Says: Possible outcomes of the COVID-19 pandemic on low- and middle-income countries are described.

Authors: Daniel Vigo, M.D., Lic. Psych., Dr.P.H., of the University of British Columbia in Vancouver, Canada, is the corresponding author.

 

(doi:10.1001/jamapsychiatry.2020.2174)

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Changes in Frequency of Sex Among US Adults

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 12, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: This survey study of U.S. adults ages 18 to 44 looked at changes in the reported frequency of sexual activity, the number of sexual partners and factors associated with frequency and numbers of partners.

Authors: Peter Ueda, M.D., Ph.D., of the Karolinska Institutet in Stockholm, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.3833)

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Comparing Survival After Minimally Invasive Hysterectomy or Open Surgery for Early-Stage Cervical Cancer

JAMA Oncology

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JUNE 11, 2020

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What The Study Did: This study combined the results of 15 observational studies with 9,500 patients who underwent radical hysterectomy for early-stage cervical cancer to compare the risk of cancer recurrence and death associated with receiving minimally invasive versus open radical hysterectomy.

Authors: Alexander Melamed, M.D., M.P.H., of the Columbia University Vagelos College of Physicians and Surgeons in New York, is the corresponding author.

 

(doi:10.1001/jamaoncol.2020.1694)

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Palliative Care in Emergency Departments During COVID-19 Pandemic

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 5, 2020

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What The Study Did: The clinical characteristics and outcomes of patients who received intervention by a COVID-19 palliative care response team are examined in this case series.

Authors: Shunichi Nakagawa, M.D., of the Columbia University Medical Center in NewYork, is the corresponding author.

 

(doi:10.1001/jamainternmed.2020.2713)

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Investigational Treatments of COVID-19 in Children

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 5, 2020

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What The Study Did: This pharmacokinetic simulation study estimates appropriate pediatric-specific dosing regimens for hydroxychloroquine and remdesivir in the treatment of pediatric patients with COVID-19.

Authors: Michael Cohen-Wolkowiez, M.D., Ph.D., of the Duke University School of Medicine in Durham, North Carolina, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2020.2422)

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USPSTF Recommendation on Screening for Unhealthy Drug Use

JAMA

EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JUNE 9, 2020

Media advisory: To contact the U.S. Preventive Services Task Force, email the Media Coordinator at Newsroom@USPSTF.net or call 202-572-2044. The full report and related articles are linked to this news release.

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Bottom Line: The U.S. Preventive Services Task Force (USPSTF) recommends screening for unhealthy drug use in adults 18 or older by asking questions about such use when services for diagnosis, treatment, and care can be offered or referred. Unhealthy drug use includes using illegal drugs or using a prescription drug in ways that are not recommended by a doctor. The USPSTF routinely makes recommendations about the effectiveness of preventive care services and this is a new recommendation, replacing the 2008 statement that found insufficient evidence at the time. Evidence continues to be insufficient regarding screening for unhealthy drug use in adolescents. Drug use is one of the most common causes of preventable death, injuries and disability. In 2017, unhealthy drug use caused more than 70,000 fatal overdoses.

 

(doi:10.1001/jama.2020.8020)

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Note: More information about the U.S. Preventive Services Task Force, its process, and its recommendations can be found on the newsroom page of its website.

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Rate Over Time of Stroke Caused by Brain Bleeding

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 8, 2020

Media advisory: The full study is linked to this news release.

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What The Study Did: This observational study looked at the rate and risk factors of stroke caused by bleeding within the brain (intracerebral hemorrhage) between 1948 and 2016 among 10,000 participants in the Framingham Heart Study. There have been conflicting results in other studies on whether the rate of this often deadly type of stroke is changing.

Authors: Vasileios-Arsenios Lioutas, M.D., of Beth Israel Deaconess Medical Center and Harvard Medical School in Boston, is the corresponding author.

 

(doi:10.1001/jamaneurol.2020.1512)

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COVID-19 in Pediatric Surgical Patients At 3 U.S. Children’s Hospitals

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JUNE 4, 2020

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What The Study Did:This study assessed how many pediatric patients presenting for surgery at three tertiary care children’s hospitals across the U.S. had COVID-19.

Authors: Apurva S. Shah, M.D., M.B.A., of the Children’s Hospital of Philadelphia, is the corresponding author.

 

(doi:10.1001/jamasurg.2020.2588)

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Is e-Cigarette Use Associated With Relapse Among Former Smokers?

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 5, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: Whether use of electronic cigarettes among former cigarette smokers was associated with an increased risk of smoking relapse was examined with the use of nationally representative survey data.

Authors: Wilson M. Compton, M.D., M.P.E., of the National Institute on Drug Abuse in Bethesda, Maryland, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.4813)

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Epidemiology, Clinical Features, Disease Severity in Pediatric Patients With COVID-19

JAMA Pediatrics

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 3, 2020

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What The Study Did: Epidemiology, clinical and laboratory features of 50 children hospitalized with COVID-19 in New York are examined in this case series.

Authors: Philip Zachariah, M.D., M.Sc., of Columbia University Irving Medical Center in New York, is the corresponding author.

 

(doi:10.1001/jamapediatrics.2020.2430)

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Comparing New Use of Flavored vs Unflavored e-Cigarettes With Starting, Quitting Smoking

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JUNE 5, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: This survey study looked at the association between starting to use flavored or unflavored e-cigarettes and subsequently starting or quitting smoking among adolescents and adults.

Authors: Abigail S. Friedman, Ph.D., of the Yale School of Public Health in New Haven, Connecticut, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.3826)

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Clinical, Immune Features of Hospitalized Pediatric Patients With COVID-19

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JUNE 3, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: The immunologic features of mild and moderate COVID-19 in pediatric patients is described and compared in this case series.

Authors: Yun Xiang, Ph.D., and Jianbo Shao, Ph.D., of the Wuhan Children’s Hospital in China, are the corresponding authors.

 

(doi:10.1001/jamanetworkopen.2020.10895)

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Mental Health of Young Physicians in China During COVID-19 Outbreak

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 1, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: Anxiety, depression, mood and fear of workplace violence were assessed in a group of young physicians in China before and during the COVID-19 outbreak.

Authors: Weidong Li, M.D., Ph.D., of Shanghai Jiao Tong University in Shanghai, China, and Srijan Sen, M.D., Ph.D., of the University of Michigan in Ann Arbor, are the corresponding authors.

 

(doi:10.1001/jamanetworkopen.2020.10705)

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Association of COVID-19 Outbreak With Enrollment in Cancer Clinical Trials

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JUNE 1, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: How the COVID-19 pandemic is associated with national enrollment in cancer clinical trials is investigated in this study.

Authors: Joseph M. Unger, Ph.D., of the SWOG Statistics and Data Management Center and the Fred Hutchinson Cancer Research Center in Seattle, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.10651)

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Neuropathogenesis, Neurologic Manifestations of Coronaviruses

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MAY 29, 2020

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What The Study Did:  Potential tissue targets and routes of entry of SARS-CoV-2 into the central nervous system and reported neurological complications of COVID-19 are identified in this narrative review.

Authors: Serena Spudich, M.D., of the Yale University School of Medicine in New Haven, Connecticut, is the corresponding author.

(doi:10.1001/jamaneurol.2020.2065)

Editor’s Note: The article includes conflict of interest disclosures. Please see the articles for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.

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Images in Neurology: Brain of Patient With COVID-19, Smell Loss

JAMA Neurology

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MAY 29, 2020

Media advisory: The full article is linked to this news release. The images are below.

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What The Study Did: This case report describes a 25-year-old female radiographer with no significant medical history who had been working in a COVID-19 ward who presented with a mild dry cough that lasted for one day, followed by persistent severe anosmia (loss of smell) and dysgeusia (an impaired sense of taste).

Authors: Letterio S. Politi, M.D., of the IRCCS Istituto Clinico Humanitas in Rozzano, Italy, is the corresponding author.

 

Brain MRI Alterations in a Patient With COVID-19 Presenting With Anosmia 4 Days From Symptom Onset

 

Follow-up MRI Study in the Same Patient 28 Days From Symptom Onset

 

(doi:10.1001/jamaneurol.2020.2125)

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Venous Thrombosis Among Critically Ill Patients With COVID-19

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MAY 29, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: A systematic assessment of deep vein thrombosis among patients in an intensive care unit in France with severe COVID-19 is reported in this case series.

Authors: Tristan Morichau-Beauchant, M.D., of the Centre Cardiologique du Nord in Saint-Denis, France, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.10478)

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Recurrent Positive RT-PCR Results for COVID-19 in Discharged Patients

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 28, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: Patients with COVID-19 who were discharged from the hospital and had recurrent positive reverse transcriptase–polymerase chain reaction (RT-PCR) results were the focus of this case series.

Authors: Zhixia Jiang, M.S., of the Affiliated Hospital of Zunyi Medical University in Zunyi, China, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.10475)

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Mental Health Outcomes Among Health Care Workers During COVID-19 Pandemic in Italy

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MAY 28, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: Symptoms of posttraumatic stress disorder, depression, anxiety and insomnia among health care workers in Italy during the COVID-19 pandemic are reported in this observational study.

Authors: Rodolfo Rossi, M.D., of the University of Rome Tor Vergata in Italy, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.10185)

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Describing Clinical Characteristics of Patients With Asymptomatic vs Symptomatic COVID-19 in China

JAMA Network Open

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 27, 2020

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About JAMA Network Open: JAMA Network Open is the new online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

 

What The Study Did: Clinical characteristics of patients with asymptomatic or symptomatic COVID-19 are described in this case series from Wuhan, China.

Authors: Yong Xiong, Ph.D., of Wuhan University in China, is the corresponding author.

 

(doi:10.1001/jamanetworkopen.2020.10182)

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An Imperative for Psychiatrists to Act Now

JAMA Psychiatry

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 27, 2020

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What The Viewpoint Says: How psychiatrists can contribute to diminish the effects of the COVID-19 pandemic is discussed.

Authors: Jurjen J. Luykx, M.D., Ph.D., of University Medical Center Utrecht and Utrecht University in the Netherlands, is the corresponding author.

 

(doi:10.1001/jamapsychiatry.2020.1225)

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Diversity of Applicants to Surgical Residency, Fellowship Programs

JAMA Surgery

EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MAY 27, 2020

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What The Study Did: Researchers looked at trends in diversity by sex and race/ethnicity among applicants to U.S. surgical residency and fellowship programs from 2008-2018 to see if diversity was increasing.

Authors: Issam Koleilat, M.D., of the Montefiore Medical Center in New York, is the corresponding author.

 

(doi:10.1001/jamasurg.2020.1018)

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