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Trends Over Time in Cognitive Outcomes of Children Born Very Preterm
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Type 2 Diabetes and Financial Outcomes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JULY 28, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.23453?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=072825
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that patients with type 2 diabetes may experience substantially more adverse financial outcomes compared with patients without diabetes, highlighting the need to consider patient financial health when treating type 2 diabetes, particularly for patient groups at higher risk.
Corresponding Author: To contact the corresponding author, Cazilia Loibl, PhD, CFP, email loibl.3@osu.edu.
(doi:10.1001/jamanetworkopen.2025.23453)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Safety of JN.1-Updated mRNA COVID-19 Vaccines
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JULY 28, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.23557?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=072825
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this nationwide cohort study, no increased risk of 29 adverse events was observed after vaccination with the updated COVID-19 mRNA vaccine containing the SARS-CoV-2 Omicron JN.1 lineage in approximately 1 million adults.
Corresponding Author: To contact the corresponding author, Niklas Worm Andersson, MD, PhD, email nian@ssi.dk.
(doi:10.1001/jamanetworkopen.2025.23557)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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US POINTER Trial: Structured Lifestyle Intervention Delays Cognitive Decline
JAMA
EMBARGOED FOR RELEASE: 2 P.M. ET, MONDAY, JULY 28, 2025
Media advisory: The full study and editorial are linked to this news release. This study is being presented at the Alzheimer’s Association International Conference.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.12923?guestAccessKey=6d3f2f02-03db-4f9a-87af-bf467976588d&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=072825
About The Study: This randomized clinical trial found that among older adults at risk of cognitive decline and dementia, a structured, higher-intensity intervention of regular moderate-to-high-intensity physical exercise, adherence to the MIND diet, cognitive challenge and social engagement, and cardiovascular health monitoring had a statistically significant greater benefit on global cognition compared with an unstructured, self-guided intervention.
Known as the US Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (US POINTER) trial, this study was developed as a follow-up to the landmark 2015 Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) trial, which demonstrated significant cognitive benefit after two years of multidomain intervention in older adults at elevated risk of Alzheimer disease and related dementias. Specifically, the POINTER trial aimed to compare the effects of two multimodal lifestyle interventions on global cognitive function – structured and unstructured – in at least 2,000 at-risk older adults.
Authors: To contact the corresponding author, Laura D. Baker, PhD, email laura.d.baker@advocatehealth.org. Myra Wright, External Communications at Wake Forest University School of Medicine, can also assist with scheduling interviews. Myra can be reached at 336-830-1652 and mgwright@wakehealth.edu. To interview authors from the Alzheimer’s Association, email Niles Frantz, Director of News Media Engagement, at nfrantz@alz.org.
(doi:10.1001/jama.2025.12923)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
About The Editorial: Jonathan M Schott, MD, of the University College London Queen Square Institute of Neurology, wrote about the study in an Editorial.
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Global Estimates of Lives and Life-Years Saved by COVID-19 Vaccination During 2020-2024
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JULY 25, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This comparative effectiveness study found that COVID-19 vaccinations averted 2.5 million deaths
during 2020-2024 (sensitivity range estimates, 1.4-4.0 million). Estimates in this study are substantially more conservative than previous calculations focusing mostly on the first year of vaccination, but they still clearly demonstrate a major overall benefit from COVID-19 vaccination during the years 2020-2024. Most benefits in lives and life-years saved was secured for a portion of older persons, a minority of the global population.
Corresponding Author: To contact the corresponding author, John P. A. Ioannidis, M.D., D.Sc., email jioannid@stanford.edu.
(doi:10.1001/jamahealthforum.2025.2223)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Potential Trade-Offs of Proposed Cuts to the NIH
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JULY 25, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2025.2228?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=072525
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: The results of this qualitative analysis using systems modeling suggest that National Institutes of Health (NIH) budget reductions may have far-reaching implications for scientific progress, the biomedical innovation environment, and health care costs. Beyond immediate budgetary impacts, systemic interactions shaping long-term biomedical research and public health must be considered in funding policies.
Corresponding Author: To contact the corresponding author, Mohammad S. Jalali, Ph,D,, email msjalali@mgh.harvard.edu.
(doi: 10.1001/jamahealthforum.2025.2228)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Preexisting Depression and Prostate Cancer Survival
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Confounder Selection in Observational Studies in High-Impact Medical and Epidemiological Journals
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Patent Foramen Ovale and Stroke – A Review
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Lowering Drug Prices in the US—Look Within, Not Abroad
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Can AI Improve the Cost-Effectiveness of 3D Total-Body Photography?
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Diverticulitis – A Review
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Steroids and Cross-Linking for Ulcer Treatment
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Microbiota Transplantation Among Patients Receiving Long-Term Care
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Cardiovascular Events in Individuals Treated With Sulfonylureas or Dipeptidyl Peptidase 4 Inhibitors
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GLP-1RA Exposure and Nonarteritic Anterior Ischemic Optic Neuropathy Prevalence by Diabetes Status
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Defining Lifetime Risk Thresholds for Breast Cancer Surgical Prevention
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JULY 24, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2025.2203?guestAccessKey=cdb465a6-c7a9-4b2b-b96c-ccafe41f4d03&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=072425
About The Study: In this economic evaluation, undergoing risk-reducing mastectomy (RRM) appears cost-effective for women ages 30 to 55 with a lifetime breast cancer risk of 35% or higher. These results could have significant clinical implications to expand access to RRM beyond BRCA1/BRCA2/PALB2 pathogenic variant carriers. Future studies evaluating the acceptability, uptake, and long-term outcomes of RRM among these women are warranted.
Corresponding Author: To contact the corresponding author, Ranjit Manchanda, MD, PhD, email r.manchanda@qmul.ac.uk.
(doi:10.1001/jamaoncol.2025.2203)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Racial Differences in Care Quality Among Men With Newly Diagnosed Prostate Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JULY 24, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Among men with traditional Medicare, this study examined racial differences in 2 important measures of prostate cancer care quality that have contrasting relationships with utilization. Black men had lower odds of confirmatory testing among those on active surveillance, where utilization and quality are tightly aligned, indicating worse care. Conversely, Black men had lower odds of overtreatment, where utilization and quality are misaligned, suggesting better care in this dimension.
Corresponding Author: To contact the corresponding author, Arnav Srivastava, MD, MPH, MS, email srivasar@med.umich.edu.
(doi:10.1001/jamanetworkopen.2025.23038)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Smoking Cessation and Symptom Burden in Patients After Oncologic Surgery
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Distinct Patterns of Weight Gain, Age, and Subcortical Microstructure in Early Adolescence
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Optimizing Timing for RSV Prevention Interventions for Infants
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Difficulty With Binary Voting Among FDA Oncology Advisory Committee Members
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Long-Term Locoregional Outcomes in a Contemporary Cohort of Young Women With Breast Cancer
JAMA Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 23, 2025
Media advisory: The full study and commentary are linked to this news release.
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About The Study: In this contemporary cohort of women diagnosed with breast cancer at age 40 or younger, risk of isolated locoregional recurrence was relatively low (5.6%) at a median follow-up of 10.1 years, and significant differences were not seen by tumor subtype. Concerns for long-term risk of locoregional recurrence should not influence surgical decision-making with young women, irrespective of molecular subtype.
Corresponding Author: To contact the corresponding author, Laura Dominici, MD, email ldominici@bwh.harvard.edu.
(doi:10.1001/jamasurg.2025.2324)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trajectories of Physical Activity Before and After Cardiovascular Disease Events in CARDIA Participants
JAMA Cardiology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 23, 2025
Media advisory: The full study is linked to this news release.
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About The Study: In this cohort and nested case-control study among CARDIA (Coronary Artery Risk Development in Young Adults; a prospective study) participants, moderate to vigorous–intensity physical activity (MVPA) declined from early adulthood to midlife then plateaued, with notable demographic differences; cases experienced steep declines before cardiovascular disease (CVD), and gaps compared to controls persisted afterward. Black women had the lowest MVPA across adulthood and the highest risk of low MVPA post-CVD, underscoring the need to support lifelong physical activity and address group differences.
Corresponding Author: To contact the corresponding author, Yariv Gerber, PhD, email yarivg@tauex.tau.ac.il.
(doi:10.1001/jamacardio.2025.2282)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Emergency Department Use Prior to Cancer Diagnosis and Mortality
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Childhood Suicide Risk in the Emergency Department
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Prescription and Nonprescription Drug Use Among People With Eating Disorders
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Psychological and Physical Health of a Preterm Birth Cohort at Age 35
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, JULY 22, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.22599?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=072225
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, preterm individuals had higher early life medical risk and faced increased mental health disorders, cardiometabolic issues, and body composition differences compared with full-term peers at age 35. Despite strong evidence linking preterm birth to long-term health consequences, many primary care clinicians in the U.S. remain unaware of these risks, often due to infrequent birth history inquiries in adult health care settings.
Corresponding Author: To contact the corresponding author, Amy L. D’Agata, PhD, RN, email amydagata@uri.edu.
(doi:10.1001/jamanetworkopen.2025.22599)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Telehealth and Online Cognitive Behavioral Therapy–Based Treatments for High-Impact Chronic Pain
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, JULY 23, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Remote, scalable cognitive behavioral therapy-based chronic pain treatments (delivered either via telehealth or self-completed modules online) resulted in modest improvements in pain and related functional/quality-of-life outcomes compared with usual care among individuals with high-impact chronic pain. These lower-resource cognitive behavioral therapy-based chronic pain treatments could improve availability of evidence-based nonpharmacologic pain treatments within health care systems.
Corresponding Author: To contact the corresponding author, Lynn DeBar, PhD, MPH, email lynn.debar@kpchr.org.
(doi:10.1001/jama.2025.11178)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Frequent Missed Opportunities for Earlier Diagnosis of Advanced-Stage Colorectal or Lung Cancer
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Neighborhood Incarceration Rates, Social Vulnerability, and Life Expectancy
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Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Individuals With Congenital Deafness
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2025.2053?guestAccessKey=b5777a49-5b7c-43eb-be45-eaec58ec8312&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=072125
Trends in Medical School Applications and Acceptances From Historically Black Colleges and Universities
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Estimated Out-of-Pocket Costs for Patients With Common Cancers and Private Insurance
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JULY 21, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21575?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=072125
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study of individuals with private insurance, patients faced high out-of-pocket costs (OOPCs) after an incident diagnosis of cancer, with patients with more advanced cancer having the highest OOPCs. Further research is needed to determine the clinical and financial effects of increased OOPCs for patients with cancer.
Corresponding Author: To contact the corresponding author, Liam Rose, PhD, email liamrose@stanford.edu.
(doi:10.1001/jamanetworkopen.2025.21575)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Patient Care Technology Disruptions Associated With the CrowdStrike Outage
JAMA Network Open
EMBARGOED FOR RELEASE: 10:50 A.M. ET, SATURDAY, JULY 19, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.30226?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071925
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cross-sectional study of U.S. hospitals found that a widespread technology outage after a faulty cyber security software update on July 19, 2024, was associated with outages in patient-facing network services integral to care delivery. These findings suggest that internet measurement techniques may be useful for surveillance and study of critical digital health care infrastructure.
Corresponding Author: To contact the corresponding author, Jeffrey L. Tully, MD, email jtully@health.ucsd.edu.
(doi:10.1001/jamanetworkopen.2025.30226)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Ethical Obligations to Inform Patients About Use of AI Tools
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Ovarian Cancer – A Review
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Cancer Risk Concerns and Communication Gaps Regarding GLP-1 Medications
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Screening for Mental Health Problems in US Public Schools
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Trends in Physician Exit From Fee-for-Service Medicare
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JULY 18, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2025.2267?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071825
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: Over time, physician exit from traditional Medicare has increased. This result is consistent with earlier findings, but exits remained high even after the pandemic, which likely accelerated some physicians’ exit. The findings may reflect multiple factors, including the greater burden of new communication methods (e.g., portal messages) and demands for clinical documentation.
Corresponding Author: To contact the corresponding author, Hannah T. Neprash, PhD, email hneprash@umn.edu.
(doi:10.1001/jamahealthforum.2025.2267)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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GLP-1 RA Use and Survival Among Older Adults With Cancer and Type 2 Diabetes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JULY 18, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In older patients with cancer and type 2 diabetes, glucagon-like peptide-1 receptor agonist (GLP-1RA) use was associated with lower all-cause mortality compared with dipeptidyl peptidase-4 inhibitor (DPP4i) use, with no significant difference relative to sodium-glucose cotransporter-2 inhibitor. The survival benefit over DPP4i persisted across age, sex, non-Hispanic white race, obesity status, and several cancer types (colorectal, lung, and breast).
Corresponding Author: To contact the corresponding author, Jingchuan Guo, MD, PhD, email guoj1@ufl.edu.
(doi:10.1001/jamanetworkopen.2025.21887)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Risk Factors for COVID-19–Related Hospitalization and Death in Patients With Cancer
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COVID-19 Pandemic and Posttreatment Breast Cancer Surveillance and Outcomes
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A Digital Asthma Self-Management Program for Adults
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Early-Onset Gastrointestinal Cancers
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Public Perception of Physicians Who Use AI
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JULY 17, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21643?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071725
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In line with prior research, the results of this study indicate that the public has certain reservations about the integration of artificial intelligence (AI) in health care. While the present effect sizes are relatively small, in particular regarding AI use for administrative purposes, they may be highly relevant as trust in health care practitioners is closely linked to subjective treatment outcomes.
Corresponding Author: To contact the corresponding author, Moritz Reis, MSc, email moritz.reis@uni-wuerzburg.de.
(doi:10.1001/jamanetworkopen.2025.21643)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cannabis Use and Benign Salivary Gland Neoplasms
JAMA Otolaryngology–Head & Neck Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JULY 17, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The results of this study suggest an association between cannabis use disorder and benign salivary gland tumors. Future prospective research with large samples and data on cannabis dosing, method of use, and benign salivary gland neoplasm pathology is required to further assess and confirm this association.
Corresponding Author: To contact the corresponding author, Niels C. Kokot, MD, email niels.kokot@med.usc.edu.
(doi:10.1001/jamaoto.2025.1955)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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COVID-19 Vaccine Booster Uptake and Effectiveness Among US Adults With Cancer
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JULY 17, 2025
Media advisory: The full study, editorial and related article are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2025.2020?guestAccessKey=e40a45e8-854f-4e6f-9dea-a9ccf39e8d35&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=071725
About The Study: In this retrospective cohort study, COVID-19 booster vaccinations were associated with significant protection against severe COVID-19, with a favorable number needed to vaccinate among persons with cancer. However, uptake of COVID-19 vaccine boosters was low, and interventions are therefore justified to increase COVID-19 vaccine uptake in this high-risk population.
Corresponding Author: To contact the corresponding author, Jacek Skarbinski, MD, email jacek.skarbinski@kp.org.
(doi:10.1001/jamaoncol.2025.2020)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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US Abortion Restrictions and the Neuropsychiatric Health of Pregnant Individuals and Families
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Cancer Incidence and Childhood Residence Near the Coldwater Creek Radioactive Waste Site
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Self-Reported Resilience During the COVID-19 Pandemic
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Access to Gender-Affirming Care and Alternatives to That Care Among Transgender Adults
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Prevalence of Extremely Severe Obesity and Metabolic Dysfunction Among US Children and Adolescents
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 16, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21170?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071625
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this nationally representative cross-sectional study of U.S. children and adolescents, prevalence of extremely severe obesity significantly increased over time, particularly among older adolescents and non-Hispanic Black participants. Extremely severe obesity was associated with severe metabolic and cardiovascular complications, including metabolic dysfunction–associated steatotic liver disease, prediabetes or diabetes, severe insulin resistance, and metabolic syndrome. These findings emphasize the urgent need for public health interventions and policies to address pediatric obesity broadly.
Corresponding Author: To contact the corresponding author, Phillipp Hartmann, MD, MAS, email phhartmann@health.ucsd.edu.
(doi:10.1001/jamanetworkopen.2025.21170)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Estimated Burden of Influenza and Direct and Indirect Benefits of Influenza Vaccination
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 16, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21324?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071625
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this analytical model study, influenza vaccination provided substantial benefit in reducing infections to both the vaccinated and unvaccinated portions of the population. Even when both vaccine effectiveness and vaccine uptake were low, vaccination showed marked reductions in disease burden for transmission levels characteristic of seasonal influenza. However, when the level of transmission was very high, even a highly effective vaccine did not protect unvaccinated individuals. These findings underscore the importance of vaccination in disease prevention and control and show that indirect benefits are limited in high transmission situations.
Corresponding Author: To contact the corresponding author, Mary G. Krauland, PhD, email mgk8@pitt.edu.
(doi:10.1001/jamanetworkopen.2025.21324)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Projected Health System and Economic Impacts of 2025 Medicaid Policy Proposals
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 16, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2025.3187?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071625
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This analysis indicates that proposed Medicaid reforms would have far-reaching consequences beyond federal budget savings, including negative health outcomes, economic losses, and health care system disruptions, with rural and underserved communities disproportionately affected.
Corresponding Author: To contact the corresponding author, Sanjay Y. Basu, MD, PhD, email sanjay.basu@ucsf.edu.
(doi:10.1001/jamahealthforum.2025.3187)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Racial and Ethnic Factors and Opioid Use Disorder Treatment After an Emergency Department Visit
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Vaccination Intentions During Pregnancy and Among Parents of Young Children
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Cases, Hospitalization, and Mortality in COVID-19 and Influenza Among Veterans
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Concurrent Treatment of Posttraumatic Stress Disorder and Alcohol Use Disorder in Women
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Neurodegeneration and Stroke After GLP-1RAs in Diabetes and Obesity
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JULY 15, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21016?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071525
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, the use of glucagon-like peptide 1 receptor agonists (GLP-1RAs) semaglutide and tirzepatide was associated with a lower risk of dementia, stroke, and all-cause mortality in adults with type 2 diabetes and obesity. These findings suggest potential neuroprotective and cerebrovascular benefits of GLP-1RAs beyond glycemic control, warranting further trials to confirm these outcomes.
Corresponding author: To contact the corresponding author, James Cheng-Chung Wei, M.D., Ph.D., email jccwei@gmail.com.
(doi: 10.1001/jamanetworkopen.2025.21016)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Pediatric COVID-19 Hospitalization Trends by Race and Ethnicity, 2020-2023
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JULY 15, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21009?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071525
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This study found that among pediatric patients hospitalized with COVID-19, Black and Hispanic children were disproportionately more likely to be hospitalized for COVID-19 and experience severe disease compared with white and Asian or Pacific Islander children. A higher proportion of hospitalized Black children had underlying medical conditions. This study underlines the need for targeted interventions, particularly for children with underlying medical conditions, and the need for equitable access and use of vaccines and therapeutics for disproportionately affected populations.
Corresponding author: To contact the corresponding author, Onika Anglin, MPH, email quk3@cdc.gov.
(doi: 10.1001/jamanetworkopen.2025.21009)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Clinical Decision Support System for Primary Care of Opioid Use Disorder
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Oncology “Me-Too” Drugs Compared With Original Drugs in Randomized Clinical Trials
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I Am Taking a GLP-1 Weight-Loss Medication—What Should I Know?
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Behavioral Compared With Drug Therapy for Overactive Bladder Symptoms in Parkinson Disease
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Delayed Hypertension Diagnosis and Its Association With Cardiovascular Treatment and Outcomes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JULY 14, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.20498?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071425
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that delays in hypertension diagnosis were common and significantly associated with delays in treatment initiation and adverse cardiovascular outcomes, underscoring the need for earlier identification and intervention.
Corresponding Author: To contact the corresponding author, John E. Brush Jr, MD, email jebrush@sentara.com.
(doi:10.1001/jamanetworkopen.2025.20498)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Integrating Diet and Physical Activity When Prescribing GLP-1s—Lifestyle Factors Remain Crucial
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JULY 14, 2025
Media advisory: The full article and a Patient Page are linked to this news release.
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About The Article: This article provides practical strategies for symptom management for patients receiving glucagon-like peptide-1 and dual receptor agonists (GLP-1 RAs) to manage weight and suggests interventions supporting muscle and nutrient preservation during GLP-1 RA treatment.
Corresponding Author: To contact the corresponding author, JoAnn E. Manson, MD, DrPH, email jmanson@bwh.harvard.edu.
(doi:10.1001/jamainternmed.2025.1794)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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GLP-1 Receptor Agonists in Idiopathic Intracranial Hypertension
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JULY 14, 2025
Media advisory: The full study and editorial are linked to this news release.
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About The Study: Glucagon-like peptide 1 receptor agonist (GLP-1 RA) therapy in idiopathic intracranial hypertension is associated with significant reductions in medication use, symptoms/signs, and procedural interventions, suggesting its potential as a management strategy. Further prospective studies are warranted to confirm these findings.
Corresponding Author: To contact the corresponding author, Dennis J. Rivet II, MD, email dennis.rivet@vcuhealth.org.
(doi:10.1001/jamaneurol.2025.2020)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Lower Urinary Tract Symptoms in Men
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Regulatory and Clinical Outcomes of Nononcology Accelerated Approvals
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Documented Firearm Access Before Suicide Among Psychiatric Emergency Service Patients
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Long-Term Obesity and Biological Aging in Young Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JULY 11, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this multiple-events case-control study, long-term obesity was associated with the expression of biochemical aging markers in adults ages 28 to 31, consistent with epigenetic alterations, telomere attrition, chronic inflammation, impaired nutrient sensing, mitochondrial stress, and compromised intercellular communication. In young adults, chronic health issues may emerge from accelerated biological aging associated with long-term obesity.
Corresponding Authors: To contact the corresponding authors, email Paulina Correa-Burrows, PhD, (paulina.correa@inta.uchile.cl) and Christian Gonzalez-Billault, PhD, (chrgonza@uchile.cl).
(doi:10.1001/jamanetworkopen.2025.20011)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Use of Tobacco and Cannabis Following State-Level Cannabis Legalization
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JULY 11, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this longitudinal cohort study, recreational cannabis legalization was associated with more cannabis and electronic nicotine delivery systems use after 5 years and no significant change in cigarette use. Furthermore, cannabis use increased over time, underscoring the importance of studying commercialization policy going forward. Based on the present results, it is unlikely recreational cannabis legalization has been associated with a large increase in cigarette use, but increases in use of cannabis and vaped nicotine bear close monitoring as retail cannabis rapidly expands.
Corresponding Author: To contact the corresponding author, Andrew S. Hyatt, MD, email ashyatt@challiance.org.
(doi:10.1001/jamanetworkopen.2025.20093)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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State Gun Laws and Firearm-Related Homicides and Suicides
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JULY 11, 2025
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study, stronger gun laws correlated with decreased overall firearm mortality, with the strongest correlations for decreased suicides. For firearm suicide, this analyses lend support to policies that regulate firearm sales, transfers, and permitting laws. While some gun law categories were correlated with decreased firearm homicide, sociodemographic factors, such as unemployment, poverty, and insurance status, correlated with larger changes, suggesting policies that address root causes of violence through economic mobility and access to robust social, health, and educational services may be associated with a greater reduction in homicides.
Corresponding Author: To contact the corresponding author, Chethan Sathya, MD, MSc, email chethan.sathya@gmail.com.
(doi:10.1001/jamanetworkopen.2025.19955)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Differential Obesity Trends in Asian and Native Hawaiian or Other Pacific Islander US Adults
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, THURSDAY, JULY 10, 2025
Media advisory: The full study and editorial are linked to this news release.
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About The Study: In a large California health care system, the contemporary burden of obesity varied substantially across disaggregated Asian American, Native Hawaiian, and Pacific Islander subgroups ages 30 to 49, affecting more than half of Native Hawaiian and Other Pacific Islander adults (body mass index [BMI] 30 or greater). Rapid temporal increases in high BMI were seen among Filipino and other Southeast Asian subpopulations where nearly 50% of females and 60% of males had a BMI greater than or equal to 27.5.
Corresponding Author: To contact the corresponding author, Joan C. Lo, MD, email Joan.C.Lo@kp.org.
(doi:10.1001/jama.2025.9901)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Systemic Strategies to Prevent Nonbeneficial Treatments Near the End of Life
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Lawsuits for Unpaid Medical Bills and the Role of Physician Groups
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Incorporating Ethics in Clinical Guidelines in Infectious Diseases
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Cumulative Anticholinergic Exposure and Change in Gait Speed and Grip Strength in Older Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JULY 10, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, higher anticholinergic exposure was associated with accelerated decline in physical performance, consistent with clinically meaningful decline. These findings suggest that minimizing anticholinergic medications is important for healthy aging.
Corresponding Author: To contact the corresponding author, Shelly L. Gray, PharmD, MS, email slgray@uw.edu.
(doi:10.1001/jamanetworkopen.2025.19819)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Incidence and Nature of Antidepressant Discontinuation Symptoms
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Profiles of Genetic Risks for Psychotic Disorders
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First-Trimester Antibiotic Use for Urinary Tract Infection and Risk of Congenital Malformations
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BMI in Children Before, During, and After the COVID-19 Pandemic
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 9, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cross-sectional study including 426,000 children in Denmark found that body mass index (BMI) outcomes of COVID-19 pandemic–related control policies and restrictions were not exclusively observed among children with obesity, which suggests that pandemic-related mitigation policies targeting children and adolescents in all BMI categories are warranted. The findings of this study highlight differences among children of varying ages and BMI classes.
Corresponding Author: To contact the corresponding author, Frederik Kirkemann Jensen, MPH, email kirkemannjensen@outlook.com.
(doi:10.1001/jamanetworkopen.2025.19528)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Morning vs Bedtime Dosing and Nocturnal Blood Pressure Reduction in Patients With Hypertension
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 9, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this randomized clinical trial of antihypertensive chronotherapy, bedtime dosing provided better control of nocturnal blood pressure and improved the circadian rhythm, without reducing the efficacy on mean daytime or 24-hour blood pressure, or increasing the risk of nocturnal hypotension. These findings support the potential advantages of bedtime administration and offer new evidence to guide future research on antihypertensive chronotherapy.
Corresponding Author: To contact the corresponding author, Xiaoping Chen, MD, email xiaopingchen15@126.com.
(doi:10.1001/jamanetworkopen.2025.19354)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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RSV Hospital Admissions During the First 2 Seasons Among Children With Chronic Medical Conditions
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Consumer Identification of Processed Foods and Their Health Effects
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Postoperative Delirium in Older Adults Undergoing Noncardiac Surgery
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Hepatitis C Screening in Emergency Departments
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, JULY 9, 2025
Media advisory: The full study and editor’s note are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.10563?guestAccessKey=9a43df15-f842-4bb3-911f-26d66bc0cafb&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=070925
About The Study: In this multicenter randomized clinical trial, a nontargeted screening approach was superior to targeted screening for identifying new hepatitis C virus infections among patients seen in 3 urban emergency departments. The substantial decrease in patients who went from diagnosis to sustained virologic response at 12 weeks highlights an urgent need for innovative models of hepatitis C virus treatment.
Corresponding Author: To contact the corresponding author, Jason Haukoos, MD, MSc, email jason.haukoos@dhha.org.
(doi:10.1001/jama.2025.10563)
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The Failure of Life Expectancy to Fully Rebound to Pre-Pandemic Levels
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, JULY 9, 2025
Media advisory: The full study is linked to this news release.
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About The Study: This study found that California life expectancy remained lower in 2024 than in 2019, due primarily to non–COVID-19 causes. COVID-19 accounted for 12.8% of the deficit in 2024. Although a prior analysis of California data reported that the life expectancy–income gradient increased during 2020-2021, by 2024 the gap between Q1 and Q4 returned to pre-pandemic levels. Life expectancy in the Black population was much lower than in other racial and ethnic populations, and Black and Hispanic populations experienced the largest deficits.
Corresponding Author: To contact the corresponding author, Hannes Schwandt, PhD, email schwandt@northwestern.edu.
(doi:10.1001/jama.2025.10439)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Eastern Equine Encephalitis in the US
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, JULY 9, 2025
Media advisory: The full article is linked to this news release.
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About The Article: This JAMA Insights examines the epidemiology, diagnosis, and management of eastern equine encephalitis virus (EEEV) disease in the U.S. following a recent increase in reported cases. This virus is the cause of a rare mosquito-borne disease in the U.S. that causes substantial morbidity and mortality. People at highest risk of EEEV infection are those living in or visiting endemic forested areas near swamps or marshes and those whose occupations (e.g., agricultural work) or hobbies (e.g., camping, gardening) involve outdoor exposure.
Corresponding Author: To contact the corresponding author, J. Erin Staples, MD, PhD, email auv1@cdc.gov.
(doi:10.1001/jama.2025.9073)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Threats to Patient Safety From Cybersecurity Flaws—A New Never Event
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Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy
JAMA
EMBARGOED FOR RELEASE: 3 A.M. ET, SATURDAY, JULY 5, 2025
Media advisory: The full study is linked to this news release. This study is being presented at the 11th Annual Conference of the Chinese Stroke Association & Tiantan International Stroke Conference 2025.
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About The Study: In patients with acute large vessel occlusion presenting between 4.5 and 24 hours of symptom onset, intra-arterial tenecteplase after successful thrombectomy had a greater likelihood of excellent neurological outcome at 90 days without increasing the risk of symptomatic intracranial hemorrhage or mortality. However, because none of the secondary efficacy analyses supported the primary finding, further trials are needed to confirm the results.
Corresponding Authors: To contact the corresponding authors, email Xiaochuan Huo, PhD, (huoxiaochuan@126.com) and Bernard Yan, MD, (bernard.yan@mh.org.au).
(doi:10.1001/jama.2025.10800)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.
West Nile Virus
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Higher Educational Attainment and Accelerated Tau Accumulation in Alzheimer Disease
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Firearm Storage and Firearm Suicide
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Knowledge of Interpreter Rights and Health Care Access
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Cannabidiol and Liver Enzyme Level Elevations in Healthy Adults
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, JULY 7, 2025
Media advisory: The full study and editorial are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2025.2366?guestAccessKey=79997ab2-e714-4534-a34c-b0a63fd074a6&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=070725
About The Study: In this randomized double-blind clinical trial of healthy adults administered cannabidiol (CBD), 5 mg/kg/d for 28 days, 8 (5.6%) experienced liver enzyme level elevations and 7 (4.9%) met protocol defined criteria for potential drug-induced liver injury. Participants did not experience clinical symptoms related to liver function during this 28-day study and hepatic enzymes returned to normal within 1 to 2 weeks following discontinuation. The findings of this study underscore the need for further investigation on the long-term effects of CBD use, its impact on various populations, and the safety of lower doses commonly used by consumers.
Corresponding Author: To contact the corresponding author, Jeffry Florian, PhD, email jeffry.florian@fda.hhs.gov.
(doi:10.1001/jamainternmed.2025.2366)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.
Trends in US Children’s Mortality, Chronic Conditions, Obesity, Functional Status, and Symptoms
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, MONDAY, JULY 7, 2025
Media advisory: The full study and editorial are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.9855?guestAccessKey=3a37e5b1-731a-44f5-b0b9-f553484974b7&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=070725
About The Study: The health of U.S. children has worsened across a wide range of health indicator domains over the past 17 years. The broad scope of this deterioration highlights the need to identify and address the root causes of this fundamental decline in the nation’s health.
Corresponding Author: To contact the corresponding author, Christopher B. Forrest, MD, PhD, email forrestc@chop.edu.
(doi:10.1001/jama.2025.9855)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.