Editor's Pick Original Investigation

Lifelong De Novo Aneurysm Risk After Aneurysmal Subarachnoid Hemorrhage in Young Survivors

JAMA Neurology 10.1001/jamaneurol.2026.2830

August 24, 2026 at 11:00 AM EDT

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This study found that young survivors of aSAH face a substantial lifetime risk of de novo aneurysm formation that does not plateau over 4 decades. Female sex, smoking status, and family history are independent risk factors; smoking cessation is a modifiable prevention target. These findings support lifelong surveillance and address current guideline gaps.

Corresponding Author: Peter Alpkvist, MD, Department of Neurosurgery, Karolinska University Hospital, 171 76 Stockholm, Sweden (peter.alpkvist@regionstockholm.se).

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