Editor's Pick Review

Postural Orthostatic Tachycardia Syndrome (POTS)

JAMA 10.1001/jama.2026.14809

August 24, 2026 at 11:00 AM EDT

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POTS is a chronic autonomic disorder associated with functional impairment and reduced quality of life that is diagnosed based on characteristic orthostatic symptoms in the absence of orthostatic hypotension after excluding alternative causes of sinus tachycardia. Treatment involves nonpharmacological measures (such as increased fluid and sodium intake), lower-body compression garments, structured exercise training, and individualized pharmacological therapy.

Corresponding Author: Tae Hwan Chung, MD, Shirley Ryan AbilityLab, 355 E Erie St, Chicago, IL 60611 (tchung@sralab.org).

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