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Unsolicited Patient Complaints and Industry Payments for US Physicians
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Incidence, Prevalence, and Stability of Remission in Individuals With Clinical High Risk for Psychosis
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Rapid Access to Emergency Medical Services Within Historically Redlined Areas
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 5, 2025
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.25681?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=080525
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study, structural disparities in rapid emergency medical services (EMS) access were associated with historically redlined areas. Strategic resource allocation and system redesign are warranted to address these inequities in prehospital emergency care.
Corresponding Author: To contact the corresponding author, Cherisse Berry, MD, email cherisse.berry@rutgers.edu.
(doi:10.1001/jamanetworkopen.2025.25681)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Racial Differences in Screening Eligibility by Breast Density After State-Level Insurance Expansion
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, AUGUST 5, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that policies for insurance coverage of supplemental screening based on breast density may have limited ability to improve early detection for Black women.
Corresponding Author: To contact the corresponding author, Anne Marie McCarthy, ScM, PhD, email annemcc@pennmedicine.upenn.edu.
(doi:10.1001/jamanetworkopen.2025.25216)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Ecolabels and the Healthfulness and Carbon Footprint of Restaurant Meal Selections
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Medicaid Payments and Racial and Ethnic Disparities in Alzheimer Disease Special Care Units
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Adolescent BMI, Weight Trajectories to Adulthood, and Osteoporosis Risk
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Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression
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Glucagon-Like Peptide-1 Receptor Agonist Eligibility Among US Adolescents and Young Adults
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 4, 2025
Media advisory: The full study and editorial are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2025.2308?guestAccessKey=f2bc51d5-0648-430b-a9be-0407aedaa88c&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=080425
About The Study: This study found that nearly 17 million adolescents and young adults were eligible for glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy. One in 5 young adults eligible for GLP-1RAs were uninsured and one-third denied having a routine place for health care—a barrier to identifying, treating, and preventing cardio-kidney-metabolic diseases.
Corresponding Author: To contact the corresponding author, Ashwin K. Chetty, BS, email ashwin.chetty@yale.edu.
(doi:10.1001/jamapediatrics.2025.2308)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Oral Semaglutide in an East Asian Population With Overweight or Obesity, With or Without Type 2 Diabetes
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 4, 2025
Media advisory: The full study and editor’s note are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2025.3599?guestAccessKey=99e30b83-caf2-456c-a6d6-e5a95aa2c22a&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=080425
About The Study: In this randomized clinical trial, among East Asian adults with overweight or obesity, with or without type 2 diabetes, oral semaglutide, 50 mg, led to a superior and clinically meaningful reduction in body weight compared with placebo, with a safety profile consistent with the glucagon-like peptide-1 receptor agonist class.
Corresponding Authors: To contact the corresponding authors, email Takashi Kadowaki, MD, PhD, (t-kadowaki@toranomon.kkr.or.jp) and Kyoung-Kon Kim, MD, PhD, (zaduplum@gilhospital.com).
(doi:10.1001/jamainternmed.2025.3599)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Influenza With and Without Oseltamivir Treatment and Neuropsychiatric Events Among Children and Adolescents
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, AUGUST 4, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2025.1995?guestAccessKey=11df0d27-af92-4125-9b4f-79882c523cc7&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=080425
About The Study: In this cohort study, oseltamivir treatment during influenza episodes was associated with a reduced risk of serious neuropsychiatric events among children and adolescents. These findings support oseltamivir use for prevention of these influenza-related complications.
Corresponding Author: To contact the corresponding author, James W. Antoon, MD, PhD, MPH, email james.antoon@vumc.org.
(doi:10.1001/jamaneurol.2025.1995)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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New Research on Colorectal Cancer Incidence, Screening Among Younger US Adults
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, MONDAY, AUGUST 4, 2025
Media advisory: The full studies and editorial are linked to this news release.
About The Studies: This issue of JAMA includes three studies on colorectal cancer incidence and screening among younger U.S. adults. In summary:
Colorectal Cancer Incidence in US Adults After Recommendations for Earlier Screening
After a stable 15-year trend, local-stage colorectal cancer (CRC) incidence increased steeply in adults ages 45 to 49 during 2019-2022, including a 50% relative increase between 2021 and 2022. This trend contrasts with consistent increases of distant-stage diagnoses in this age group and likely reflects diagnosis of prevalent asymptomatic cancer through first-time screening due to recommendations for adults to begin screening at age 45 instead of age 50.
Corresponding Author: To contact the corresponding author, Elizabeth J. Schafer, MPH, email elizabeth.schafer@cancer.org.
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Trends in Colorectal Cancer Screening in US Adults Ages 45 to 49
From 2019 to 2023, CRC screening increased among U.S. adults ages 45 to 49, consistent with a previous report among certain commercially insured adults ages 45 to 49 in late 2021-2022. This trend is encouraging because screening reduces CRC mortality, mostly through the detection and removal of potentially precancerous lesions.
Corresponding Author: To contact the corresponding author, Jessica Star, MA, MPH, email jessica.star@cancer.org.
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Population Health Colorectal Cancer Screening Strategies in Adults Ages 45 to 49
In a randomized clinical trial to determine the most effective population health outreach strategy to promote colorectal cancer screening in adults ages 45 to 49, the 3 strategies requiring active choice through the electronic patient portal were significantly less effective than default unsolicited mailed fecal immunochemical test (FIT) outreach. Overall screening rates were low, underscoring the need for more effective strategies to engage this age group.
Corresponding Author: To contact the corresponding author, Folasade P. May, MD, PhD, MPhil, email fmay@mednet.ucla.edu.
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Editor’s Note: Please see the articles for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.
Projected Savings From Reducing Low-Value Services in Medicare
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Difference in the Cancer Burden and Current Funding of NCI-Designated Cancer Centers
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Implementation of a Statewide Fentanyl Possession Law and Opioid-Related Overdose Deaths
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Online Reviews of Health Care Facilities
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, AUGUST 1, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional analysis, negative patient experiences frequently centered on quality of communication and administrative issues. Negative feedback centered on unmet expectations, whereas positive reviews emphasized supportive staff interactions.
Corresponding author: To contact the corresponding author, Neil K.R. Sehgal, M.E., email neilsehgal99@gmail.com.
(doi: 10.1001/jamanetworkopen.2025.24505)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Smartphone Engagement During School Hours Among US Youths
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, AUGUST 1, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cross-sectional study found that when adolescents had their phones at school, they spent nearly an hour per school day on smartphones, with most of this time on social media. The results extend prior work indicating that smartphone use during instructional hours, especially social-specific use, is not trivial. These results also highlight developmental differences, with younger adolescents using smartphones and social media less than older adolescents.
Corresponding author: To contact the corresponding author, Scott H. Kollins, Ph.D., email scott@aura.com.
(doi: 10.1001/jamanetworkopen.2025.23991)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Reporting Guideline for Chatbot Health Advice Studies
JAMA Network Open
EMBARGOED FOR RELEASE: 7 A.M. ET, FRIDAY, AUGUST 1, 2025
Media advisory: The full article is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Article: The rise in chatbot health advice studies is accompanied by heterogeneity in reporting standards, impacting their interpretability. This article provides reporting recommendations for studies evaluating the performance of generative artificial intelligence (AI)–driven chatbots when summarizing clinical evidence and providing health advice. This article is being published jointly in Artificial Intelligence in Medicine, Annals of Family Medicine, BJS, BMC Medicine, BMJ Medicine, JAMA Network Open, The Lancet, NEJM-AI, and Surgical Endoscopy.
Corresponding Author: To contact the corresponding author, Bright Huo, MD, BScPharm, email brighthuo@dal.ca.
(doi:10.1001/jamanetworkopen.2025.30220)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Nationwide Analysis of Legal Barriers to Cancer Care
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Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring
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Proportional Sedation for Persistent Agitated Delirium in Palliative Care
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GLP-1 RAs and Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Older Patients With Diabetes
JAMA Ophthalmology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JULY 31, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2025.2299?guestAccessKey=42f1da5f-87cc-4855-bc01-b68f5185be01&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=073125
About The Study: This study of Medicare enrollees age 65 or older with type 2 diabetes found an association between semaglutide use and an increased risk of nonarteritic anterior ischemic optic neuropathy. There was risk variation among the glucagon-like peptide-1 receptor agonists (GLP-1 RAs); semaglutide and liraglutide were associated with higher risks.
Corresponding Author: To contact the corresponding author, Kin Wah Fung, MD, email kfung@mail.nih.gov.
(doi:10.1001/jamaophthalmol.2025.2299)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Impact of the MISSION Act on Quality and Outcomes of Major Cardiovascular Procedures Among Veterans
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, THURSDAY, JULY 31, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The U.S. Congress enacted the Maintaining Internal Systems and Strengthening Integrated Outside Networks (MISSION) Act with the goal of improving veterans’ access to health care services. This study found that MISSION Act implementation was associated with substantial decreases in travel times among veterans who became geographically eligible for non-Veterans Affairs care. For these patients undergoing percutaneous coronary intervention or coronary artery bypass grafting, MISSION Act implementation was also associated with worsened 30-day major adverse cardiovascular events rates.
Corresponding Author: To contact the corresponding author, Peter W. Groeneveld, MD, MS, email peter.groeneveld@va.gov.
(doi:10.1001/jama.2025.11661)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Control Group Outcomes in Trials of Psilocybin, SSRIs, or Esketamine for Depression
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Transgender-Affirming Hormone Therapies, QT Prolongation, and Cardiac Repolarization
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State E-Cigarette Flavor Restrictions and Tobacco Product Use in Youths and Adults
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Preserving and Promoting Clinical Trial Representativeness
JAMA Cardiology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 30, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2025.2421?guestAccessKey=ee4fc77b-e29b-40de-a00e-bd13c6f94536&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=073025
About The Study: This review synthesizes the latest policies and initiatives concerning representation in clinical research and provides a strategic framework to ensure scientific validity of clinical trials by operationalizing broad representation at all levels. A coordinated approach among stakeholders is needed to address the scientific value of trial representation of the intended use population.
Corresponding Author: To contact the corresponding author, Roxana Mehran, MD, email roxana.mehran@mountsinai.org.
(doi:10.1001/jamacardio.2025.2421)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Mortality Among Surgeons in the United States
JAMA Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 30, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Although nonsurgeon physicians have lower mortality rates than other highly educated professionals, this mortality benefit does not extend to surgeons. Because surgeons and nonsurgeon physicians have similar levels of health care knowledge and resources, higher mortality rates among surgeons might reflect differences related to work environment, professional demands, and lifestyle. The results of this study indicate that several causes of death (e.g., motor vehicle collisions), disproportionately affect surgeons, aligning with evidence that hazardous driving events associated with extended work hours are especially pronounced among surgeons.
Corresponding Author: To contact the corresponding author, Anupam B. Jena, MD, PhD, email jena@hcp.med.harvard.edu.
(doi:10.1001/jamasurg.2025.2482)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Stroke Center Certification and Within-Hospital Racial Disparities in Treatment
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 30, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.24027?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=073025
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, the likelihood of receiving stroke treatments increased for white but not Black patients within the same facility after the center was stroke certified as a primary stroke center or a thrombectomy-capable or comprehensive stroke center. These within-hospital racial differences serve as sobering evidence that racial disparities in stroke care persist despite increased access to care.
Corresponding Author: To contact the corresponding author, Renee Y. Hsia, MD, MSc, email renee.hsia@ucsf.edu.
(doi:10.1001/jamanetworkopen.2025.24027)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Psychopathology and Gaming Disorder in Adolescents
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Positive Childhood Experiences and Adult Health and Opportunity Outcomes in 4 US States
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Thermal and Perceptual Responses of Older Adults With Fan Use in Heat Extremes
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Influenza-Associated Acute Necrotizing Encephalopathy in US Children
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, JULY 30, 2025
Media advisory: The full study and editorial are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.11534?guestAccessKey=cf976c38-c219-4f1e-968a-5728eafd28e6&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=073025
About The Study: In this case series of children with influenza-associated acute necrotizing encephalopathy from the 2 most recent influenza seasons in the U.S., the condition was associated with high morbidity and mortality in this cohort of predominantly young and previously healthy children. The findings emphasize the need for prevention, early recognition, intensive treatment, and standardized management protocols.
Corresponding Author: To contact the corresponding author, Andrew Silverman, MD, MHS, email Aesilver@stanford.edu.
(doi:10.1001/jama.2025.11534)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
About The Editorial: Timothy M. Uyeki, MD, MPH, MPP, of the Centers for Disease Control and Prevention, wrote about the study in an Editorial.
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Demographic Data Supporting FDA Authorization of AI Devices for Alzheimer Disease and Related Dementias
JAMA
EMBARGOED FOR RELEASE: 9 A.M. ET, WEDNESDAY, JULY 30, 2025
Media advisory: The full study is linked to this news release. This study is being presented at the Alzheimer’s Association International Conference.
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About The Study: Transparency of evidence supporting Food and Drug Administration (FDA) authorization of artificial intelligence (AI)- and machine learning -based devices for Alzheimer disease and related dementias was limited, precluding effective evaluation of training and validation dataset representativeness. Disease status (i.e., dementia type and distribution), age, and sex were reported for fewer than half of devices, while race and ethnicity data were rarely disclosed, raising uncertainty about real-world generalizability and clinical accuracy in intended populations.
Corresponding Author: To contact the corresponding author, Ravi Gupta, MD, MSHP, email ravigupta@jhmi.edu.
(doi:10.1001/jama.2025.12779)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Medical and Nonmedical Use of Prescription Stimulants Among US Adolescents
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, TUESDAY, JULY 29, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Among U.S. adolescents, current medical use of prescription stimulants for attention-deficit/hyperactivity disorder (ADHD) increased between 2005 and 2023, while nonmedical use decreased. Lifetime nonmedical use was more prevalent than medical use in early cohorts but shifted to being less prevalent in recent cohorts. These findings are consistent with declines in peer-to-peer diversion among adolescents following COVID-related school closures and findings from adult studies.
Corresponding Author: To contact the corresponding author, Sean Esteban McCabe, PhD, email plius@umich.edu.
(doi:10.1001/jama.2025.11260)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Prevalence and Sources of Disability-Based Discrimination in a National Sample of Graduating Medical Students
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Germicidal UV Light and Incidence of Acute Respiratory Infection in Long-Term Care for Older Adults
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Global Prevalence of Hypertension in Children and Adolescents Younger Than 19 Years
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Trends Over Time in Cognitive Outcomes of Children Born Very Preterm
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Type 2 Diabetes and Financial Outcomes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JULY 28, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.23453?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=072825
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that patients with type 2 diabetes may experience substantially more adverse financial outcomes compared with patients without diabetes, highlighting the need to consider patient financial health when treating type 2 diabetes, particularly for patient groups at higher risk.
Corresponding Author: To contact the corresponding author, Cazilia Loibl, PhD, CFP, email loibl.3@osu.edu.
(doi:10.1001/jamanetworkopen.2025.23453)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Safety of JN.1-Updated mRNA COVID-19 Vaccines
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JULY 28, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this nationwide cohort study, no increased risk of 29 adverse events was observed after vaccination with the updated COVID-19 mRNA vaccine containing the SARS-CoV-2 Omicron JN.1 lineage in approximately 1 million adults.
Corresponding Author: To contact the corresponding author, Niklas Worm Andersson, MD, PhD, email nian@ssi.dk.
(doi:10.1001/jamanetworkopen.2025.23557)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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US POINTER Trial: Structured Lifestyle Intervention Delays Cognitive Decline
JAMA
EMBARGOED FOR RELEASE: 2 P.M. ET, MONDAY, JULY 28, 2025
Media advisory: The full study and editorial are linked to this news release. This study is being presented at the Alzheimer’s Association International Conference.
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About The Study: This randomized clinical trial found that among older adults at risk of cognitive decline and dementia, a structured, higher-intensity intervention of regular moderate-to-high-intensity physical exercise, adherence to the MIND diet, cognitive challenge and social engagement, and cardiovascular health monitoring had a statistically significant greater benefit on global cognition compared with an unstructured, self-guided intervention.
Known as the US Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (US POINTER) trial, this study was developed as a follow-up to the landmark 2015 Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) trial, which demonstrated significant cognitive benefit after two years of multidomain intervention in older adults at elevated risk of Alzheimer disease and related dementias. Specifically, the POINTER trial aimed to compare the effects of two multimodal lifestyle interventions on global cognitive function – structured and unstructured – in at least 2,000 at-risk older adults.
Authors: To contact the corresponding author, Laura D. Baker, PhD, email laura.d.baker@advocatehealth.org. Myra Wright, External Communications at Wake Forest University School of Medicine, can also assist with scheduling interviews. Myra can be reached at 336-830-1652 and mgwright@wakehealth.edu. To interview authors from the Alzheimer’s Association, email Niles Frantz, Director of News Media Engagement, at nfrantz@alz.org.
(doi:10.1001/jama.2025.12923)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
About The Editorial: Jonathan M Schott, MD, of the University College London Queen Square Institute of Neurology, wrote about the study in an Editorial.
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Global Estimates of Lives and Life-Years Saved by COVID-19 Vaccination During 2020-2024
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JULY 25, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This comparative effectiveness study found that COVID-19 vaccinations averted 2.5 million deaths
during 2020-2024 (sensitivity range estimates, 1.4-4.0 million). Estimates in this study are substantially more conservative than previous calculations focusing mostly on the first year of vaccination, but they still clearly demonstrate a major overall benefit from COVID-19 vaccination during the years 2020-2024. Most benefits in lives and life-years saved was secured for a portion of older persons, a minority of the global population.
Corresponding Author: To contact the corresponding author, John P. A. Ioannidis, M.D., D.Sc., email jioannid@stanford.edu.
(doi:10.1001/jamahealthforum.2025.2223)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Potential Trade-Offs of Proposed Cuts to the NIH
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JULY 25, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: The results of this qualitative analysis using systems modeling suggest that National Institutes of Health (NIH) budget reductions may have far-reaching implications for scientific progress, the biomedical innovation environment, and health care costs. Beyond immediate budgetary impacts, systemic interactions shaping long-term biomedical research and public health must be considered in funding policies.
Corresponding Author: To contact the corresponding author, Mohammad S. Jalali, Ph,D,, email msjalali@mgh.harvard.edu.
(doi: 10.1001/jamahealthforum.2025.2228)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Preexisting Depression and Prostate Cancer Survival
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Confounder Selection in Observational Studies in High-Impact Medical and Epidemiological Journals
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Patent Foramen Ovale and Stroke – A Review
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Lowering Drug Prices in the US—Look Within, Not Abroad
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Can AI Improve the Cost-Effectiveness of 3D Total-Body Photography?
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Diverticulitis – A Review
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Steroids and Cross-Linking for Ulcer Treatment
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Microbiota Transplantation Among Patients Receiving Long-Term Care
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Cardiovascular Events in Individuals Treated With Sulfonylureas or Dipeptidyl Peptidase 4 Inhibitors
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GLP-1RA Exposure and Nonarteritic Anterior Ischemic Optic Neuropathy Prevalence by Diabetes Status
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Defining Lifetime Risk Thresholds for Breast Cancer Surgical Prevention
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JULY 24, 2025
Media advisory: The full study is linked to this news release.
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About The Study: In this economic evaluation, undergoing risk-reducing mastectomy (RRM) appears cost-effective for women ages 30 to 55 with a lifetime breast cancer risk of 35% or higher. These results could have significant clinical implications to expand access to RRM beyond BRCA1/BRCA2/PALB2 pathogenic variant carriers. Future studies evaluating the acceptability, uptake, and long-term outcomes of RRM among these women are warranted.
Corresponding Author: To contact the corresponding author, Ranjit Manchanda, MD, PhD, email r.manchanda@qmul.ac.uk.
(doi:10.1001/jamaoncol.2025.2203)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Racial Differences in Care Quality Among Men With Newly Diagnosed Prostate Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JULY 24, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Among men with traditional Medicare, this study examined racial differences in 2 important measures of prostate cancer care quality that have contrasting relationships with utilization. Black men had lower odds of confirmatory testing among those on active surveillance, where utilization and quality are tightly aligned, indicating worse care. Conversely, Black men had lower odds of overtreatment, where utilization and quality are misaligned, suggesting better care in this dimension.
Corresponding Author: To contact the corresponding author, Arnav Srivastava, MD, MPH, MS, email srivasar@med.umich.edu.
(doi:10.1001/jamanetworkopen.2025.23038)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Smoking Cessation and Symptom Burden in Patients After Oncologic Surgery
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Distinct Patterns of Weight Gain, Age, and Subcortical Microstructure in Early Adolescence
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Optimizing Timing for RSV Prevention Interventions for Infants
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Difficulty With Binary Voting Among FDA Oncology Advisory Committee Members
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Long-Term Locoregional Outcomes in a Contemporary Cohort of Young Women With Breast Cancer
JAMA Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 23, 2025
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamasurgery/fullarticle/10.1001/jamasurg.2025.2324?guestAccessKey=9f5dc2dc-e0eb-4fca-aca1-2634fa90a7c6&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=072325
About The Study: In this contemporary cohort of women diagnosed with breast cancer at age 40 or younger, risk of isolated locoregional recurrence was relatively low (5.6%) at a median follow-up of 10.1 years, and significant differences were not seen by tumor subtype. Concerns for long-term risk of locoregional recurrence should not influence surgical decision-making with young women, irrespective of molecular subtype.
Corresponding Author: To contact the corresponding author, Laura Dominici, MD, email ldominici@bwh.harvard.edu.
(doi:10.1001/jamasurg.2025.2324)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trajectories of Physical Activity Before and After Cardiovascular Disease Events in CARDIA Participants
JAMA Cardiology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 23, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2025.2282?guestAccessKey=878928fc-5c4d-4665-bdbe-c81a7b5d9d7c&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=072325
About The Study: In this cohort and nested case-control study among CARDIA (Coronary Artery Risk Development in Young Adults; a prospective study) participants, moderate to vigorous–intensity physical activity (MVPA) declined from early adulthood to midlife then plateaued, with notable demographic differences; cases experienced steep declines before cardiovascular disease (CVD), and gaps compared to controls persisted afterward. Black women had the lowest MVPA across adulthood and the highest risk of low MVPA post-CVD, underscoring the need to support lifelong physical activity and address group differences.
Corresponding Author: To contact the corresponding author, Yariv Gerber, PhD, email yarivg@tauex.tau.ac.il.
(doi:10.1001/jamacardio.2025.2282)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Emergency Department Use Prior to Cancer Diagnosis and Mortality
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Childhood Suicide Risk in the Emergency Department
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Prescription and Nonprescription Drug Use Among People With Eating Disorders
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Psychological and Physical Health of a Preterm Birth Cohort at Age 35
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, JULY 22, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.22599?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=072225
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, preterm individuals had higher early life medical risk and faced increased mental health disorders, cardiometabolic issues, and body composition differences compared with full-term peers at age 35. Despite strong evidence linking preterm birth to long-term health consequences, many primary care clinicians in the U.S. remain unaware of these risks, often due to infrequent birth history inquiries in adult health care settings.
Corresponding Author: To contact the corresponding author, Amy L. D’Agata, PhD, RN, email amydagata@uri.edu.
(doi:10.1001/jamanetworkopen.2025.22599)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Telehealth and Online Cognitive Behavioral Therapy–Based Treatments for High-Impact Chronic Pain
JAMA
EMBARGOED FOR RELEASE: 11:00 A.M. ET, WEDNESDAY, JULY 23, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Remote, scalable cognitive behavioral therapy-based chronic pain treatments (delivered either via telehealth or self-completed modules online) resulted in modest improvements in pain and related functional/quality-of-life outcomes compared with usual care among individuals with high-impact chronic pain. These lower-resource cognitive behavioral therapy-based chronic pain treatments could improve availability of evidence-based nonpharmacologic pain treatments within health care systems.
Corresponding Author: To contact the corresponding author, Lynn DeBar, PhD, MPH, email lynn.debar@kpchr.org.
(doi:10.1001/jama.2025.11178)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Frequent Missed Opportunities for Earlier Diagnosis of Advanced-Stage Colorectal or Lung Cancer
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Neighborhood Incarceration Rates, Social Vulnerability, and Life Expectancy
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Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Individuals With Congenital Deafness
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Trends in Medical School Applications and Acceptances From Historically Black Colleges and Universities
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Estimated Out-of-Pocket Costs for Patients With Common Cancers and Private Insurance
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, JULY 21, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study of individuals with private insurance, patients faced high out-of-pocket costs (OOPCs) after an incident diagnosis of cancer, with patients with more advanced cancer having the highest OOPCs. Further research is needed to determine the clinical and financial effects of increased OOPCs for patients with cancer.
Corresponding Author: To contact the corresponding author, Liam Rose, PhD, email liamrose@stanford.edu.
(doi:10.1001/jamanetworkopen.2025.21575)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Patient Care Technology Disruptions Associated With the CrowdStrike Outage
JAMA Network Open
EMBARGOED FOR RELEASE: 10:50 A.M. ET, SATURDAY, JULY 19, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cross-sectional study of U.S. hospitals found that a widespread technology outage after a faulty cyber security software update on July 19, 2024, was associated with outages in patient-facing network services integral to care delivery. These findings suggest that internet measurement techniques may be useful for surveillance and study of critical digital health care infrastructure.
Corresponding Author: To contact the corresponding author, Jeffrey L. Tully, MD, email jtully@health.ucsd.edu.
(doi:10.1001/jamanetworkopen.2025.30226)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Ethical Obligations to Inform Patients About Use of AI Tools
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Ovarian Cancer – A Review
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Cancer Risk Concerns and Communication Gaps Regarding GLP-1 Medications
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Screening for Mental Health Problems in US Public Schools
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Trends in Physician Exit From Fee-for-Service Medicare
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, JULY 18, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: Over time, physician exit from traditional Medicare has increased. This result is consistent with earlier findings, but exits remained high even after the pandemic, which likely accelerated some physicians’ exit. The findings may reflect multiple factors, including the greater burden of new communication methods (e.g., portal messages) and demands for clinical documentation.
Corresponding Author: To contact the corresponding author, Hannah T. Neprash, PhD, email hneprash@umn.edu.
(doi:10.1001/jamahealthforum.2025.2267)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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GLP-1 RA Use and Survival Among Older Adults With Cancer and Type 2 Diabetes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, JULY 18, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In older patients with cancer and type 2 diabetes, glucagon-like peptide-1 receptor agonist (GLP-1RA) use was associated with lower all-cause mortality compared with dipeptidyl peptidase-4 inhibitor (DPP4i) use, with no significant difference relative to sodium-glucose cotransporter-2 inhibitor. The survival benefit over DPP4i persisted across age, sex, non-Hispanic white race, obesity status, and several cancer types (colorectal, lung, and breast).
Corresponding Author: To contact the corresponding author, Jingchuan Guo, MD, PhD, email guoj1@ufl.edu.
(doi:10.1001/jamanetworkopen.2025.21887)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Risk Factors for COVID-19–Related Hospitalization and Death in Patients With Cancer
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COVID-19 Pandemic and Posttreatment Breast Cancer Surveillance and Outcomes
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A Digital Asthma Self-Management Program for Adults
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Early-Onset Gastrointestinal Cancers
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Public Perception of Physicians Who Use AI
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, JULY 17, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In line with prior research, the results of this study indicate that the public has certain reservations about the integration of artificial intelligence (AI) in health care. While the present effect sizes are relatively small, in particular regarding AI use for administrative purposes, they may be highly relevant as trust in health care practitioners is closely linked to subjective treatment outcomes.
Corresponding Author: To contact the corresponding author, Moritz Reis, MSc, email moritz.reis@uni-wuerzburg.de.
(doi:10.1001/jamanetworkopen.2025.21643)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cannabis Use and Benign Salivary Gland Neoplasms
JAMA Otolaryngology–Head & Neck Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JULY 17, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The results of this study suggest an association between cannabis use disorder and benign salivary gland tumors. Future prospective research with large samples and data on cannabis dosing, method of use, and benign salivary gland neoplasm pathology is required to further assess and confirm this association.
Corresponding Author: To contact the corresponding author, Niels C. Kokot, MD, email niels.kokot@med.usc.edu.
(doi:10.1001/jamaoto.2025.1955)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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COVID-19 Vaccine Booster Uptake and Effectiveness Among US Adults With Cancer
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, JULY 17, 2025
Media advisory: The full study, editorial and related article are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2025.2020?guestAccessKey=e40a45e8-854f-4e6f-9dea-a9ccf39e8d35&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=071725
About The Study: In this retrospective cohort study, COVID-19 booster vaccinations were associated with significant protection against severe COVID-19, with a favorable number needed to vaccinate among persons with cancer. However, uptake of COVID-19 vaccine boosters was low, and interventions are therefore justified to increase COVID-19 vaccine uptake in this high-risk population.
Corresponding Author: To contact the corresponding author, Jacek Skarbinski, MD, email jacek.skarbinski@kp.org.
(doi:10.1001/jamaoncol.2025.2020)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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US Abortion Restrictions and the Neuropsychiatric Health of Pregnant Individuals and Families
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Cancer Incidence and Childhood Residence Near the Coldwater Creek Radioactive Waste Site
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Self-Reported Resilience During the COVID-19 Pandemic
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Access to Gender-Affirming Care and Alternatives to That Care Among Transgender Adults
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Prevalence of Extremely Severe Obesity and Metabolic Dysfunction Among US Children and Adolescents
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 16, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21170?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071625
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this nationally representative cross-sectional study of U.S. children and adolescents, prevalence of extremely severe obesity significantly increased over time, particularly among older adolescents and non-Hispanic Black participants. Extremely severe obesity was associated with severe metabolic and cardiovascular complications, including metabolic dysfunction–associated steatotic liver disease, prediabetes or diabetes, severe insulin resistance, and metabolic syndrome. These findings emphasize the urgent need for public health interventions and policies to address pediatric obesity broadly.
Corresponding Author: To contact the corresponding author, Phillipp Hartmann, MD, MAS, email phhartmann@health.ucsd.edu.
(doi:10.1001/jamanetworkopen.2025.21170)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.
Estimated Burden of Influenza and Direct and Indirect Benefits of Influenza Vaccination
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, JULY 16, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21324?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071625
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this analytical model study, influenza vaccination provided substantial benefit in reducing infections to both the vaccinated and unvaccinated portions of the population. Even when both vaccine effectiveness and vaccine uptake were low, vaccination showed marked reductions in disease burden for transmission levels characteristic of seasonal influenza. However, when the level of transmission was very high, even a highly effective vaccine did not protect unvaccinated individuals. These findings underscore the importance of vaccination in disease prevention and control and show that indirect benefits are limited in high transmission situations.
Corresponding Author: To contact the corresponding author, Mary G. Krauland, PhD, email mgk8@pitt.edu.
(doi:10.1001/jamanetworkopen.2025.21324)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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For more information, contact JAMA Network Media Relations at 312-464-JAMA (5262) or email media relations.
Projected Health System and Economic Impacts of 2025 Medicaid Policy Proposals
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, JULY 16, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2025.3187?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071625
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This analysis indicates that proposed Medicaid reforms would have far-reaching consequences beyond federal budget savings, including negative health outcomes, economic losses, and health care system disruptions, with rural and underserved communities disproportionately affected.
Corresponding Author: To contact the corresponding author, Sanjay Y. Basu, MD, PhD, email sanjay.basu@ucsf.edu.
(doi:10.1001/jamahealthforum.2025.3187)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Racial and Ethnic Factors and Opioid Use Disorder Treatment After an Emergency Department Visit
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Vaccination Intentions During Pregnancy and Among Parents of Young Children
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Cases, Hospitalization, and Mortality in COVID-19 and Influenza Among Veterans
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Concurrent Treatment of Posttraumatic Stress Disorder and Alcohol Use Disorder in Women
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Neurodegeneration and Stroke After GLP-1RAs in Diabetes and Obesity
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, JULY 15, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21016?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071525
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, the use of glucagon-like peptide 1 receptor agonists (GLP-1RAs) semaglutide and tirzepatide was associated with a lower risk of dementia, stroke, and all-cause mortality in adults with type 2 diabetes and obesity. These findings suggest potential neuroprotective and cerebrovascular benefits of GLP-1RAs beyond glycemic control, warranting further trials to confirm these outcomes.
Corresponding author: To contact the corresponding author, James Cheng-Chung Wei, M.D., Ph.D., email jccwei@gmail.com.
(doi: 10.1001/jamanetworkopen.2025.21016)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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