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Lung Function Trajectory Using Race-Specific vs Race-Neutral Global Lung Function Initiative Coefficients
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Geographic Variation of Racial and Ethnic Differences in Uterine Cancer Survival
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Public Coverage of Postpartum Services for Immigrants
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
State and Sociodemographic Trends in US Cigarette Smoking With Future Projections
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, APRIL 25, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.6834?guestAccessKey=c0957767-f5eb-4d6d-88a4-15c747418b57&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=042525
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of these repeated cross-sectional surveys suggest that the difference in cigarette smoking prevalence between historically high vs low prevalence states will shrink by 2035, primarily from much faster declines among young adults in the traditionally highest prevalence states. Slower prevalence declines among older adults are likely to slow the decline in health consequences in these states.
Corresponding Author: To contact the corresponding author, John P. Pierce, PhD, email jppierce@health.ucsd.edu.
(doi:10.1001/jamanetworkopen.2025.6834)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Fiscal Impact of Expanded Medicare Coverage for GLP-1 Receptor Agonists to Treat Obesity
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, APRIL 25, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama-health-forum/fullarticle/10.1001/jamahealthforum.2025.0905?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=042525
About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This economic evaluation estimates that expanded Medicare coverage for glucagon-like peptide-1 receptor agonists (GLP-1RAs) would increase access and reduce obesity-related comorbidities but impose substantial costs over 10 years. Even with a moderate scenario (5% uptake, 20% adherence, and 30% additional price discount), net spending was still projected to reach $8 billion over a decade, underscoring the need for further price reductions, lower-cost strategies to prevent weight regain, and reductions in spending on low-value care.
Corresponding Author: To contact the corresponding author, David D. Kim, PhD, email david.kim@bsd.uchicago.edu.
(doi:10.1001/jamahealthforum.2025.0905)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US
JAMA
EMBARGOED FOR RELEASE: 11:15 A.M. ET, THURSDAY, APRIL 24, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Based on estimates from this modeling study, declining childhood vaccination rates will increase the frequency and size of outbreaks of previously eliminated vaccine-preventable infections, eventually leading to their return to endemic levels. The timing and critical threshold for returning to endemicity will differ substantially by disease, with measles likely to be the first to return to endemic levels and may occur even under current vaccination levels without improved vaccine coverage and public health response. These findings support the need to continue routine childhood vaccination at high coverage to prevent resurgence of vaccine-preventable infectious diseases in the U.S.
Corresponding Author: To contact the corresponding author, Nathan C. Lo, MD, PhD, email nathan.lo@stanford.edu.
(doi:10.1001/jama.2025.6495)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Race, Ethnicity, and Outcomes Among Adults With Atrial Fibrillation Treated With Drug Therapy vs Ablation
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Characteristics of Medical Cannabis Patients and Clinicians in 7 US States
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Patient-Centered Research Through AI to Identify Priorities in Cancer Care
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Intravenous Magnesium and Cisplatin-Associated Acute Kidney Injury
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Herpes Zoster Vaccination and Dementia Occurrence
JAMA
EMBARGOED FOR RELEASE: 4:40 P.M. ET, WEDNESDAY, APRIL 23, 2025
Media advisory: The full study is linked to this news release. This study is being presented at the World Vaccine Congress.
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About The Study: By taking advantage of a quasi-experiment and corroborating findings from Wales in a different population, this study provides evidence of the potential benefits of herpes zoster vaccination for dementia that is more likely to be causal than that of more commonly conducted associational studies.
Corresponding Author: To contact the corresponding author, Pascal Geldsetzer, ScD, MBChB, MPH, email pgeldsetzer@stanford.edu.
(doi:10.1001/jama.2025.5013)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity
JAMA
EMBARGOED FOR RELEASE: 7:45 P.M. ET, THURSDAY, APRIL 24, 2025
Media advisory: The full study is linked to this news release. This study is being presented at the Osteoarthritis Research Society International World Congress.
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About The Study: The results of this randomized clinical trial support use of metformin for treatment of symptomatic knee osteoarthritis in people with overweight or obesity. Because of the modest sample size, confirmation in a larger clinical trial is warranted.
Corresponding Author: To contact the corresponding author, Flavia M. Cicuttini, PhD, email flavia.cicuttini@monash.edu.
(doi:10.1001/jama.2025.3471)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Mental Health Diagnoses Among Publicly Insured Children
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, APRIL 24, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The percentage of publicly insured children receiving any mental health or neurodevelopmental disorder diagnosis significantly increased between 2010 and 2019, with increases observed for most diagnostic categories examined. These findings highlight the need for access to appropriate services in safety net systems and other settings that serve this population.
Corresponding Author: To contact the corresponding author, Janet R. Cummings, PhD, email jrcummi@emory.edu.
(doi:10.1001/jama.2025.4605)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Health Care Cost Concerns and Hardships for Families of Children With Disabilities
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, APRIL 24, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This study contributes to the existing literature by identifying that while insurance coverage is higher among children with disabilities, their families had higher adjusted odds for all of the financial hardships evaluated, compared with families of children without disabilities. This finding suggests that insurance is inadequate for disabled children. These data demonstrate a need to structure health insurance policies to ensure that children with disabilities have their needed medical care covered in a way that is not financially burdensome to families.
Corresponding Author: To contact the corresponding author, Amy J. Houtrow, MD, PhD, MPH, email houtrow@upmc.edu.
(doi:10.1001/jamanetworkopen.2025.7826)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cumulative Life’s Essential 8 Scores and Cardiovascular Disease Risk
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Distinct Convergent Brain Alterations in Sleep Disorders and Sleep Deprivation
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Long-Term Postoperative Outcomes by Surgeon Gender and Patient-Surgeon Gender Concordance in the US
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Cannabis Use and Misuse Following Recreational Cannabis Legalization
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Sense of Belonging and Intent to Leave Among Medical School Faculty
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Cognitive and Functional Decline Among Long-Term Care Residents
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 23, 2025
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.5635?guestAccessKey=c0957767-f5eb-4d6d-88a4-15c747418b57&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=042325
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study, severe permanent impairment in function and cognition were common and often present near the end of life for long-term care residents, but a minority of residents lived in these states for years. These results suggest that building shared understanding and open communication about the natural course of frailty trajectories for long-term care residents may support resident-centered medical decision-making.
Corresponding Author: To contact the corresponding author, Daniel Kobewka, MD, MSc, email dkobewka@toh.ca.
(doi:10.1001/jamanetworkopen.2025.5635)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Screening and Response for Adverse Social Determinants of Health in US Emergency Departments
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 23, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: Despite the high prevalence of adverse social determinants of health (SDOH) in emergency department (ED) populations, in this survey study of 232 EDs, less than one-third performed screening, and one-fifth did not have policies requiring a response to positive screens. Bridging this gap may require expanding adverse SDOH screening practices while also ensuring that EDs have the resources and infrastructure to respond appropriately to identified social needs. Future research might explore advanced technological solutions to enhance screening and responses in these resource-constrained settings.
Corresponding Author: To contact the corresponding author, Melanie F. Molina, MD, MAS, email melanie.molina@ucsf.edu.
(doi:10.1001/jamanetworkopen.2025.7951)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Alcohol Use and Abusive or Neglectful Behaviors Among Family Caregivers of Patients With Dementia
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, APRIL 22, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this microlongitudinal cohort study of family caregivers of relatives with dementia, hazardous drinking and daily alcohol consumption were significantly and independently associated with increased odds of abusive and neglectful behaviors, highlighting the need for personalized interventions that address caregiving complexities and alcohol use patterns.
Corresponding author: To contact the corresponding author, Carolyn E. Z. Pickering, Ph.D., R.N., email pickering@uth.tmc.edu.
(doi: 10.1001/jamanetworkopen.2025.6211)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Nurse Staffing Configurations and Nurse Absence Due to Sickness
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Prevalence of Impairing Substance Use in Injured Drivers
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Patterns in Symptoms Preceding Acute Care in Patients With Cancer
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Childhood Exposure to Air Pollution, BMI Trajectories, and Insulin Resistance Among Young Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, APRIL 22, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.6431?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=042225
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of young adults, the long-term association between traffic-related air pollution and insulin resistance may be partially explained by higher body mass index (BMI) and accelerated BMI growth from early adolescence into young adulthood. These findings highlight the importance of weight management in children, particularly those residing in highly polluted areas.
Corresponding author: To contact the corresponding author, Shohreh F. Farzan, Ph.D., email sffarzan@usc.edu.
(doi: 10.1001/jamanetworkopen.2025.6431)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Varenicline for Youth Nicotine Vaping Cessation
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 23, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.3810?guestAccessKey=8c0aa836-0f6d-465e-86ea-178fe0d81e70&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=042325
About The Study: In this 12-week randomized clinical trial, varenicline, combined with behavioral counseling, increased vaping abstinence in youth who vape nicotine and do not regularly smoke tobacco.
Corresponding Author: To contact the corresponding author, A. Eden Evins, MD, email aeevins@mgh.harvard.edu.
(doi:10.1001/jama.2025.3810)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Cytisinicline for Smoking Cessation
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Genomic and Developmental Models to Predict Cognitive and Adaptive Outcomes in Autistic Children
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Obstetrician and Gynecologist Physicians’ Practice Locations Before and After the Dobbs Decision
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Surgical Outcomes and Patient Expectations and Satisfaction in Spine Surgery Stratified by Surgeon Age
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Medication for Opioid Use Disorder and Treatment Retention Among Pregnant Individuals
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Trends in Mental and Physical Health Among Youths
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, APRIL 21, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2025.0556?guestAccessKey=39cacfb2-9054-4750-a142-6a7353a21871&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=042125
About The Study: In this large, nationally representative sample of U.S. youths, the proportions of youths with anxiety or depression increased from 2016 to 2022. In contrast, youth physical health conditions like asthma and severe headache or migraine decreased, while behavioral or conduct problems and heart conditions were consistent. These findings suggest that deterioration in youth health was specific to depression and anxiety but not select physical health conditions. This study aimed to characterize trends in youth health in the U.S., but more work is needed to identify factors associated with observed trends and mechanisms associated with changes.
Corresponding Author: To contact the corresponding author, Marie E. Heffernan, PhD, email mheffernan@luriechildrens.org.
(doi:10.1001/jamapediatrics.2025.0556)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Transcranial Pulsed Current Stimulation and Social Functioning in Children With Autism
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, APRIL 21, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.5776?guestAccessKey=c0957767-f5eb-4d6d-88a4-15c747418b57&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=042125
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this randomized clinical trial of prefrontal-cerebellar transcranial pulsed current stimulation in children ages 3 to 14 with autism spectrum disorder, 20 sessions over 4 weeks improved social functioning and sleep. These findings suggest that transcranial pulsed current stimulation may serve as a viable nonpharmacologic alternative for autism spectrum disorder.
Corresponding Author: To contact the corresponding author, Zhenhuan Liu, MD, PhD, email lzh1958424@163.com.
(doi:10.1001/jamanetworkopen.2025.5776)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Burnout Trends Among US Health Care Workers
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, APRIL 21, 2025
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.5954?guestAccessKey=c0957767-f5eb-4d6d-88a4-15c747418b57&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=042125
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this survey study of Veterans Health Administration (VHA) health care workers, burnout and professional stress decreased on average following the pandemic, but burnout levels remain elevated compared with prepandemic levels. The VHA has made several efforts to reduce burnout and stress, and results showed some promise, but exploration of ways to reduce burnout to prepandemic levels is needed.
Corresponding Author: To contact the corresponding author, David C. Mohr, PhD, email david.mohr2@va.gov.
(doi:10.1001/jamanetworkopen.2025.5954)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Non–Risk-Based Lung Cancer Screening With Low-Dose Computed Tomography
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Development and Assessment of a Patient-Reported Outcome Instrument for Gender-Affirming Care
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Mental and Physical Health-Related Risk Factors Among Females Who Died by Firearm Suicide
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Genetic and Nongenetic Risk Factors for Breast Cancer Risk Estimation
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Medical Debt and Forgone Mental Health Care Due to Cost Among Adults
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, APRIL 18, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: In this survey study, more than 1 in 7 adults reported carrying medical debt in 2023, of whom 1 in 3 forwent mental health care in the subsequent year. Medical debt may exacerbate the treatment gap by potentially (1) raising the threshold for seeking care, (2) eroding patient trust in the health system, or (3) being denied care due to outstanding debts.
Corresponding Author: To contact the corresponding author, Catherine K. Ettman, PhD, email cettman1@jh.edu.
(doi:10.1001/jamahealthforum.2025.0383)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Legalizing Youth-Friendly Cannabis Edibles and Extracts and Adolescent Cannabis Use
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, APRIL 18, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.5819?guestAccessKey=c0957767-f5eb-4d6d-88a4-15c747418b57&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=041825
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this serial cross-sectional study of adolescents in grades 7 to 11, legalization of cannabis edibles and extracts was associated with an increase not only in edible cannabis use and cannabis smoking, but also in the overall prevalence of cannabis use and co-use of alcohol and cannabis, highlighting the need for stricter policy measures to curb adolescents’ access to cannabis edibles and extracts and greater awareness among adolescents about harms of cannabis use.
Corresponding Author: To contact the corresponding author, Hai V. Nguyen, PhD, email hvnguyen@mun.ca.
(doi:10.1001/jamanetworkopen.2025.5819)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis
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Disparities in Digital Health Care Use in 2022
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Health-Related Quality of Life in the US Territories of Puerto Rico, Guam, and the Virgin Islands
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Inequity in Assessment Among Pediatric Residents
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Population Attributable Fraction of Incident Dementia Associated With Hearing Loss
JAMA Otolaryngology–Head & Neck Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, APRIL 17, 2025
Media advisory: The full study is linked to this news release.
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About The Study: The results of this cohort study suggest that treating hearing loss might delay dementia for a large number of older adults. Public health interventions targeting clinically significant audiometric hearing loss might have broad benefits for dementia prevention. Future research quantifying population attributable fractions should carefully consider which measures are used to define hearing loss, as self-reporting may underestimate hearing-associated dementia risk.
Corresponding Author: To contact the corresponding author, Jason R. Smith, ScM, email jsmit491@jhu.edu.
(doi:10.1001/jamaoto.2024.0192)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Prevalence of Obesity With and Without Confirmation of Excess Adiposity Among US Adults
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, APRIL 17, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Among U.S. adults ages 20 to 59, the prevalence of obesity by body mass index (BMI) only was nearly identical with the obesity prevalence after confirmation of excess adiposity. Approximately 98% of individuals identified as having obesity based on BMI had excess adiposity.
Corresponding Author: To contact the corresponding author, Michael Fang, PhD, MHS, email mfang9@jh.edu.
(doi:10.1001/jama.2025.2704)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Digital Photography Guide for Dermatologists With Special Considerations for Diverse Populations
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Cognitive Behavior Therapy for Mental Disorders in Adults
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Negative Effects During Placebo Treatment
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Preferences for Communication About Prognosis Among Children With Cancer, Parents, and Oncologists
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AI–Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms
JAMA Cardiology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, APRIL 16, 2025
Media advisory: The full study is linked to this news release.
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About The Study: Across multinational cohorts, a noise-adapted artificial intelligence (AI)-electrocardiogram (ECG) model estimated heart failure risk using lead I ECGs, suggesting a potential heart failure risk-stratification strategy requiring prospective study using wearable and portable ECG devices.
Corresponding Author: To contact the corresponding author, Rohan Khera, MD, MS, email rohan.khera@yale.edu.
(doi:10.1001/jamacardio.2025.0492)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Immediate Skin-to-Skin Contact in Very Preterm Neonates and Early Childhood Neurodevelopment
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 16, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this randomized clinical trial, 2 hours of mother-neonate skin-to-skin contact (SSC) in the delivery room did not enhance neurodevelopmental outcomes at 2 to 3 years of age. However, the SSC group demonstrated improved breastfeeding practices up to 12 months compared with standard care, suggesting that the feasible and low-cost SSC intervention should be encouraged in clinical practice.
Corresponding Author: To contact the corresponding author, Laila Kristoffersen, RN, PhD, email laila.kristoffersen@ntnu.no.
(doi:10.1001/jamanetworkopen.2025.5467)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Social Risk at Individual vs Neighborhood Levels and Health Care Use in Medicaid Enrollees
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Plastic Waste and COVID-19 Incidence Among Hospital Staff After Deescalation in PPE Use
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Rurality and Area Deprivation and Outcomes After Out-of-Hospital Cardiac Arrest
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Screening History, Stage at Diagnosis, and Mortality in Screen-Detected Breast Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, APRIL 15, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of older women with screen-detected estrogen receptor–positive or human epidermal growth factor receptor 2–negative breast cancer, prior screening mammography was associated with earlier stage at breast cancer diagnosis and lower breast cancer mortality. These findings support the potential for routine screening to improve breast cancer outcomes. As with all observational studies, this study is limited by the potential effects of other differences between the screening and nonscreening groups.
Corresponding Author: To contact the corresponding author, Michaela A. Dinan, PhD, email michaela.dinan@yale.edu.
(doi:10.1001/jamanetworkopen.2025.5322)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Sex-Based Differences in Binge and Heavy Drinking Among US Adults
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 16, 2025
Media advisory: The full study is linked to this news release.
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About The Study: This analysis found that past-month binge drinking among young adult females in 2021-2023 was higher than males, reversing 2017-2019 patterns, whereas males in other age groups continued to binge and heavy drink at higher rates. These findings may be due to more rapid decreases in binge drinking over time among young adult males relative to females, or to plateauing or increases in binge drinking among females. Further investigation using other nationally representative surveys is needed to elucidate these explanations.
Corresponding Author: To contact the corresponding author, Bryant Shuey, MD, MPH, email bryant.shuey@pitt.edu.
(doi:10.1001/jama.2025.2726)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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A Digital Depression Treatment Program for Adults Treated in Primary Care
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Prevalence of Motor Milestone Delays in Autistic Children
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Patterns in Nonfatal Self-Harm Among Adolescents
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Adolescent Disparities in Exposure to Adverse Childhood Experiences by Gender Identity
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Incidence of Pancreas and Colorectal Adenocarcinoma in the US
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, APRIL 14, 2025
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.4682?guestAccessKey=c0957767-f5eb-4d6d-88a4-15c747418b57&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=041425
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this cohort study suggest that the incidence of pancreatic adenocarcinoma has increased among all age groups, whereas that of colorectal adenocarcinoma has increased among younger age groups. Clinicians should be aware of this trend when evaluating younger patients with relevant symptoms.
Corresponding Author: To contact the corresponding author, Arvind J. Trindade, MD, email arvind.trindade@gmail.com.
(doi:10.1001/jamanetworkopen.2025.4682)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Gestational Age and Cognitive Development in Childhood
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, APRIL 14, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study of children ages 9 to 10, moderately preterm birth was associated with long-term cognitive problems independent of socioeconomic status, genetics, and other risk factors. These findings underscore the need for continued follow-up of all preterm children, with particular focus on those born before 34 weeks’ gestational age, because they may face greater developmental challenges over time.
Corresponding Author: To contact the corresponding author, Samson Nivins, PhD, email samson.nivins@ki.se.
(doi:10.1001/jamanetworkopen.2025.4580)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Projected Lifetime Cancer Risks From Current Computed Tomography Imaging
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, APRIL 14, 2025
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About The Study: This study found that at current utilization and radiation dose levels, computed tomography examinations in 2023 were projected to result in approximately 103,000 future cancers over the course of the lifetime of exposed patients. If current practices persist, computed tomography-associated cancer could eventually account for 5% of all new cancer diagnoses annually.
Corresponding Author: To contact the corresponding author, Rebecca Smith-Bindman, MD, email rebecca.smith-bindman@ucsf.edu.
(doi:10.1001/jamainternmed.2025.0505)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Use of Life Support and Outcomes Among Patients Admitted to Intensive Care Units
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Drug Decriminalization in British Columbia and Changes in Drug Crime and Opioid and Stimulant Harms
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Interventions for Childhood Central Obesity
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Responses to the Gaza-Israel Conflict by Specialty Medical Societies
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Risk Factors for Severe Disease Among Children Hospitalized With RSV
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, APRIL 11, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of children hospitalized with respiratory syncytial virus (RSV) in 2022 and 2023, severe RSV disease was more likely among those age 2 or older with pulmonary and neurologic, neuromuscular, or developmental conditions. For children younger than 2 years, age younger than 6 months and prematurity were the main risk factors. These findings support prevention strategies for all younger children, including premature infants, with potential benefit for children age 2 or older in specific high-risk groups.
Corresponding Author: To contact the corresponding author, Peter J. Gill, MD, DPhil, MSc, email peter.gill@sickkids.ca.
(doi:10.1001/jamanetworkopen.2025.4666)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Kidney Function Following COVID-19 in Children and Adolescents
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, APRIL 11, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this large U.S. cohort study of children and adolescents, SARS-CoV-2 infection was associated with a higher risk of adverse postacute kidney outcomes, particularly among those with preexisting chronic kidney disease or acute kidney injury, suggesting the need for vigilant long-term monitoring.
Corresponding Author: To contact the corresponding author, Yong Chen, PhD, email ychen123@pennmedicine.upenn.edu.
(doi:10.1001/jamanetworkopen.2025.4129)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Olfactory Deficits and Mortality in Older Adults
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Childcare Barriers and Appointment Nonadherence Among Women in a Safety-Net Health System
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Stigma Experiences of Sexual and Gender Minority Parents and Offspring Mental Health
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Neighborhood Characteristics and Mental Health From Childhood to Adolescence
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, APRIL 10, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of children and adolescents, associations between neighborhood characteristics and mental health evolved from childhood through adolescence. These findings suggest that targeted interventions in disadvantaged neighborhoods and strategies to protect young children from air pollution are essential. A comprehensive approach is recommended to incorporate air pollution, green space, and socioeconomic status not only in residential neighborhoods but also in other settings, such as schools.
Corresponding Author: To contact the corresponding author, Niloofar Shoari, PhD, email n.shoari@ucl.ac.uk.
(doi:10.1001/jamanetworkopen.2025.4470)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Influenza Vaccination Among People With Medicare by Race and Ethnicity, Education, and Rurality
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, APRIL 10, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional survey study, although overall influenza vaccination rates changed little from 2019 to 2022, they increased substantially for Black and Hispanic older adults, particularly those in rural areas, and decreased for some groups of white older adults. Determining the reasons for these divergent changes in influenza vaccination rates is a high priority for future research.
Corresponding Author: To contact the corresponding author, Marc N. Elliott, PhD, email elliott@rand.org.
(doi:10.1001/jamanetworkopen.2025.4462)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Automating the Addiction Behaviors Checklist for Problematic Opioid Use Identification
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Convergence of Cannabis and Psychosis on the Dopamine System
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Clinician Suicide Risk Assessment for Prediction of Suicide Attempt in a Large Health Care System
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Concordance of 30-Day Mortality and In-Hospital Mortality or Hospice Discharge After Sepsis
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Cardioprotective Glucose-Lowering Agents and Dementia Risk
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, APRIL 7, 2025
Media advisory: The full study and editorial are linked to this news release.
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About The Study: While cardioprotective glucose-lowering therapies were not associated with an overall reduction in all-cause dementia, this meta-analysis of randomized clinical trials found that glucose lowering with glucagon-like peptide-1 receptor agonists (GLP-1RAs) was associated with a statistically significant reduction in all-cause dementia.
Corresponding Author: To contact the corresponding author, Catriona Reddin, MD, email reddin.catriona@gmail.com.
(doi:10.1001/jamaneurol.2025.0360)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Opioid Cap Laws and Opioid Prescriptions After Total Joint Replacements in Older Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 9, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that the New York opioid restriction law was associated with reductions in opioid quantities in the immediate total joint replacement postoperative period. Additional refinements may further reduce opioid prescribing in New York, and these findings may serve as a foundation for refining laws in other states that may not achieve their intended targets or have not implemented similar laws.
Corresponding Author: To contact the corresponding author, Caroline P. Thirukumaran, MBBS, MHA, PhD, email caroline.thirukumaran@northwestern.edu.
(doi:10.1001/jamanetworkopen.2025.4448)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Pregnancy-Related Deaths in the US, 2018-2022
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 9, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional analysis of pregnancy-related deaths in the U.S., rates increased during 2018 to 2022, with large variations by state and race and ethnicity. The concerning rates in the U.S. should be an urgent public health priority.
Corresponding Author: To contact the corresponding author, Yingxi Chen, MD, PhD, email yingxi.chen@nih.gov.
(doi:10.1001/jamanetworkopen.2025.4325)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Mortality Among Veterans With Opioid Use Disorder After Medical Hospitalization
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Hospital Addiction Consultation Service and Opioid Use Disorder Treatment
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Antenatal Opioid Exposure and Global and Regional Brain Volumes in Newborns
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Implications of Abortion Restrictions for Adolescents
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GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related Dementias
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, APRIL 7, 2025
Media advisory: The full study and editorial are linked to this news release.
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About The Study: In people with type 2 diabetes, both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) were statistically significantly associated with decreased risk of Alzheimer disease and related dementias compared with other glucose-lowering drugs, and no difference was observed between both drugs.
Corresponding Author: To contact the corresponding author, Jingchuan Guo, MD, PhD, email guoj1@ufl.edu.
(doi:10.1001/jamaneurol.2025.0353)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Neighborhood Disadvantage, Individual Experiences of Racism, and Breast Cancer Survival
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, APRIL 7, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort of Black women, living in disadvantaged neighborhoods was associated with a higher mortality from breast cancer, even after accounting for stage at diagnosis, treatments, and individual-level lifestyle factors. Community-level interventions to reduce environmental stressors and improve conditions in disadvantaged neighborhoods, including access to high-quality cancer care, may be critical to reducing racial disparities in breast cancer survival.
Corresponding Author: To contact the corresponding author, Etienne X. Holder, PhD, MPH, email exholder@bu.edu.
(doi:10.1001/jamanetworkopen.2025.3807)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Implementation of an Organization-Based Couples Health Promotion Program to Improve Physician Well-Being
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Mediterranean Diet, Physical Activity, and Bone Health in Older Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, APRIL 8, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In the PREDIMED-Plus trial, an energy-reduced Mediterranean diet and physical activity lifestyle intervention mitigated weight loss– and age-related bone mineral density decline among older women with metabolic syndrome compared with conventional ad libitum Mediterranean diet recommendations. Weight-loss lifestyle interventions with longer follow-up are warranted in the future to confirm these results in relation to bone health.
Corresponding author: To contact the corresponding authors, email Jesús F. García-Gavilán, Ph.D. (jesusfrancisco.garcia@urv.cat), and Jordi Salas-Salvadó, M.D., Ph.D. (jordi.salas@urv.cat).
(doi: 10.1001/jamanetworkopen.2025.3710)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Repeated Access to Patient Portal While Awaiting Test Results and Patient-Initiated Messaging
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Psychological Therapy Outcomes and Engagement in People of Different Religions
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Yoga or Strengthening Exercise for Knee Osteoarthritis
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Health Care Practitioner Bias and Access to Inpatient Rehabilitation Services Among Survivors of Violence
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, APRIL 8, 2025
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this mixed-methods qualitative study of hospital patients discharged to rehabilitation centers, significant disparities in denials for admission were observed among survivors of violence, who were disproportionally Black or Hispanic. Stigmatizing language found in medical records suggested that bias within the referral process may have contributed to these disparities. These findings underscore the need for reformed clinical documentation practices and enhanced oversight of rehabilitation referral processes to promote equitable access to care.
Corresponding author: To contact the corresponding author, Megan R. Georges, M.S., email megan.georges@bmc.org.
(doi: 10.1001/jamanetworkopen.2025.4074)
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