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Dose-Dependent Effects of Cannabis Edibles on Simulated Driving Performance

JAMA Network Open 10.1001/jamanetworkopen.2026.31306

August 31, 2026 at 11:00 AM EDT

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In this crossover randomized clinical trial of driving performance after exposure to THC edibles, THC dose-dependently impaired simulated driving performance at blood THC concentrations below per se thresholds commonly used for roadside enforcement.

Related: This study has an accompanying commentary.

Corresponding Author: Bernard Le Foll, MD, PhD, 100 Stokes St, Toronto, ON M6J 1H4, Canada (Bernard.LeFoll@camh.ca).

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