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Gene Silencer Therapy in Transthyretin Amyloid Cardiomyopathy

JAMA 10.1001/jama.2026.17246

August 30, 2026 at 8:30 AM EDT

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The findings from this meta-analysis support TTR gene silencing for ATTR-CM. The attenuated benefit observed for patients receiving concomitant TTR stabilizer therapy may reflect residual differences in case mix, disease duration, or magnitude of TTR suppression or a true ceiling on additional benefit of gene silencing in the setting of background TTR stabilization.

Meeting Information: ESC 2026

This paper will be presented during European Society of Cardiology Congress in Munich, Germany.

Local Embargo Time: 14:30 (2:30 P.M.) CEST.

ESC Presentation: Julian Gillmore will simultaneously present the findings during the late-breaking clinical science session on cardiac amyloidosis in Ashgabat, Hall A3.

Corresponding Author: Scott D. Solomon, MD, Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115 (ssolomon@bwh.harvard.edu).

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