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Editor's Pick Preliminary Communication

Daily Zinc Supplementation for Infection Prevention in Children With Sickle Cell Anemia

JAMA 10.1001/jama.2026.14190

August 19, 2026 at 11:00 AM EDT

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Zinc supplementation at 20 mg per day reduced all-cause infection in children with sickle cell anemia younger than 5 years in Uganda. Multisite clinical trials are needed to validate these findings and to assess effectiveness in older children.

Corresponding Author: Chandy C. John, MD, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, 705 Riley Hospital Dr, RI5900, Indianapolis, IN 46202 (chjohn@iu.edu).

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