EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 22, 2013 Media Advisory: To contact corresponding author Joanne Lynn, M.D., M.A., M.S., call Ken Schwartz at 571-733-5709 or email Ken.Schwartz@altarum.org. To contact editorial author Mark V. Williams, M.D., call Marla Paul at 312-503-8928 or email marla-paul@northwestern.edu. CHICAGO – Communities in which quality improvement initiatives for care…
Research Finds Substantial Variation in Readmission Rate Among Children’s Hospitals
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 22, 2013 Media Advisory: To contact Jay G. Berry, M.D., M.P.H., call Meghan Weber at 617-919-3110 or email meghan.weber@childrens.harvard.edu. To contact editorial co-author Rajendu Srivastava, M.D., F.R.C.P.C., M.P.H., call Phil Sahm at 801-581-2517 or email phil.sahm@hsc.utah.edu. CHICAGO – In a national sample of 72 children’s hospitals, 6.5…
Emergency Department Use Within 30 Days of Hospital Discharge Common
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 22, 2013 Media Advisory: To contact Anita A. Vashi, M.D., M.P.H., call Karen Peart at 203-432-1326 or email karen.peart@yale.edu. CHICAGO – In a study that included more than 4 million patients, nearly 20 percent of hospitalizations resulted in at least 1 acute care encounter within the 30…
JAMA:01152013
Viewpoints in This Issue of JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 15, 2013 Mega-Trials for Blockbusters John P. A. Ioannidis, M.D., D.Sc., of the Stanford University School of Medicine, Stanford, Calif., writes that mega-trials (very large, simple trials) should be conducted for licensed interventions with annual sales that exceed $1 billion, i.e., a blockbuster. These blockbusters “should have…
Absence of Monitoring of Stomach Fluid Volume for Patients on Ventilator and Feeding Tube Does Not Increase Risk of Pneumonia; May Improve Feeding
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 15, 2013 Media Advisory: To contact Jean Reignier, M.D., Ph.D., email jean.reignier@chd-vendee.fr. To contact editorial author Todd W. Rice, M.D., M.Sc., call Craig Boerner at 615-322-4747 or email craig.boerner@vanderbilt.edu. CHICAGO – Patients undergoing mechanical ventilation and receiving nutrition via a feeding tube who did not receive monitoring…
Higher Quality Rating For Medicare Advantage Plan Associated With Increased Likelihood of Plan Enrollment
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 15, 2013 Media Advisory: To contact corresponding author William H. Shrank, M.D., M.S.H.S., call Brian Cook or Isabella Leung of the CMS Press Office at 202-690-6145 or email press@cms.hhs.gov. To contact editorial author Jack Hoadley, Ph.D., call Lauren Mullins at 202-687-2269 or email lm973@georgetown.edu. CHICAGO – In…
Advanced Airway Procedures for Out-of-Hospital Cardiac Arrest Associated With Poorer Neurological Outcomes
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 15, 2013 Media Advisory: To contact Kohei Hasegawa, M.D., M.P.H., call Kristen Stanton at 617-643-3907 or email kstanton3@partners.org. To contact editorial co-author Donald M. Yealy, M.D., call Rick Pietzak at 412-864-4151 or email pietzakr@upmc.edu. CHICAGO – In patients with out-of-hospital cardiac arrest, cardiopulmonary resuscitation with advanced airway…
JAMA:01082013
Viewpoints in This Issue of JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 8, 2013 How to Decide Whether a Clinical Practice Guideline Is Trustworthy David F. Ransohoff, M.D., of the University of North Carolina School of Medicine, Chapel Hill, and colleagues discuss concerns about the process of developing clinical practice guidelines and the standards for developing practice guidelines created…
Post-Operative Intravenous Acetaminophen May Help Reduce Use of Morphine In Infants
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 8, 2013 Media Advisory: To contact co-author Dick Tibboel, M.D., Ph.D., email d.tibboel@erasmusmc.nl. To contact editorial author Kanwaljeet J. S. Anand, M.B.B.S., D.Phil., F.R.C.P.C.H., call Sheila Champlin at 901-448-4957 or email schampli@uthsc.edu. CHICAGO – Among infants undergoing major surgery, postoperative use of intermittent intravenous paracetamol (acetaminophen) for…
Study Documents Failure Rate of Antibiotic Treatment for Gonorrhea
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 8, 2013 Media Advisory: To contact Vanessa G. Allen, M.D., M.P.H., call Nicole Helsberg at 647-260-7466 or email nicole.helsberg@oahpp.ca. To contact editorial author Robert D. Kirkcaldy, M.D., M.P.H., call the NCHHSTP Media Office at 404-639-8895 or email NCHHSTPMediaTeam@cdc.gov. CHICAGO – In an examination of the effectiveness of…
Vitamin D Supplementation Does Not Reduce Knee Pain, Cartilage Loss in Patients With Osteoarthritis
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 8, 2013 Media Advisory: To contact Timothy McAlindon, D.M., M.P.H., call Julie Jette at 617-636-3265 or email jjette@tuftsmedicalcenter.org. CHICAGO – In a two year randomized trial, patients with symptomatic knee osteoarthritis who received vitamin D supplementation did not have a significant difference in knee pain or cartilage…
JAMA:01012013
Viewpoints in This Week’s JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 1, 2013 How and Why U.S. Health Care Differs From That in Other OECD Countries Victor R. Fuchs, Ph.D., of Stanford University, Stanford, Calif., compares U.S. health care to that in other countries of the Organization for Economic Co-operation and Development (OECD), and “reaches one inescapable conclusion—U.S….
Maintenance Therapy With Calcium-Channel Blocker to Suppress Premature Labor Does Not Significantly Reduce Adverse Perinatal Outcomes
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 1, 2013 Media Advisory: To contact Carolien Roos, M.D., email c.roos@obgyn.umcn.nl. CHICAGO – In women with threatened (symptoms of) preterm labor, maintenance therapy to suppress labor with the calcium-channel blocker nifedipine for 12 days did not result in a significant reduction in adverse perinatal (just before and…
Study Finds No Significant Difference in Survival Between Patients Who Receive ICDs in Clinical Practice vs. Clinical Trials
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 1, 2013 Media Advisory: To contact Sana M. Al-Khatib, M.D., M.H.S., call Sarah Avery at 919-660-1306 or email sarah.avery@duke.edu. CHICAGO – Comparing the largest registry of implantable cardioverter-defibrillator (ICD) implants in the United States with 2 primary prevention randomized clinical trials, researchers found that patients who met…
Use of Anti-Depressants During Pregnancy Not Associated With Increased Risk of Stillbirth, Infant Death
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 1, 2013 Media Advisory: To contact Olof Stephansson, M.D., Ph.D., email olof.stephansson@ki.se. CHICAGO – In a study that included nearly 30,000 women from Nordic countries who had filled a selective serotonin reuptake inhibitor (SSRI) prescription during pregnancy, researchers found no significant association between use of these medications…
Imaging Study Examines Effect of Fructose on Brain Regions That Regulate Appetite
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 1, 2013 Media Advisory: To contact corresponding author Robert S. Sherwin, M.D., call Helen Dodson at 303-436-3984 or email helen.dodson@yale.edu. To contact editorial co-author Jonathan Q. Purnell, M.D., call Mirabai Vogt at 503-494-7986 or email vogtmi@ohsu.edu. CHICAGO – In a study examining possible factors regarding the associations…
Higher Levels of Obesity Associated With Increased Risk of Death; Being Overweight Associated With Lower Risk of Death
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JANUARY 1, 2013 Media Advisory: To contact Katherine M. Flegal, Ph.D., call Karen Hunter at 404-639-3286 or email ksh7@cdc.gov. To contact editorial co-author Steven B. Heymsfield, M.D., email Steven.heymsfield@pbrc.edu. CHICAGO – In an analysis of nearly 100 studies that included approximately 3 million adults, relative to normal weight,…
JAMA_OF:12212012
JAMA:12252012
Also Appearing in This Issue of JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 25, 2012 Obesity May Be Declining Among Preschool-Aged Children Living in Low-Income Families “Obesity and extreme obesity in childhood, which are more prevalent among minority and low-income families, have been associated with other cardiovascular risk factors, increased health care costs, and premature death. Obesity and extreme obesity…
Sustained Virological Response Associated With Improved Survival For Certain Patients With Chronic Hepatitis C Virus Infection
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 25, 2012 Media Advisory: To contact corresponding author Harry L. A. Janssen, M.D., Ph.D., email h.janssen@erasmusmc.nl. CHICAGO – Among patients with chronic hepatitis C virus infection and advanced hepatic fibrosis (development of excess fibrous connective tissue), sustained virological response (SVR) to interferon-based treatment was associated with a…
Autopsy-Based Study Examines Prevalence of Atherosclerosis Among U.S. Service Members
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 25, 2012 Media Advisory: To contact Bryant J. Webber, M.D., call Sharon Willis at 301-295-3578 or email sharon.willis@usuhs.edu. To contact editorial author Daniel Levy, M.D., call the NHLBI press office at 301-496-4236 or email nhlbi_news@nhlbi.nih.gov. CHICAGO – Among deployed U.S. service members who died of combat or…
JAMA:12182012
Viewpoints in This Week’s JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 18, 2012 Iodine Supplementation During Pregnancy and Lactation Alex Stagnaro-Green, M.D., M.H.P.E., of the George Washington University School of Medicine and Health Sciences, Washington, D.C., and colleagues discuss the possible adverse effects of iodine deficiency and the importance of supplementation during pregnancy and while breastfeeding. “The status…
Administration of Clopidogrel Prior to PCI Associated With Reduction in Major Cardiac Events, But Not Improved Survival
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 18, 2012 Media Advisory: To contact corresponding author Gilles Montalescot, M.D., Ph.D., email gilles.montalescot@psl.aphp.fr. CHICAGO – Among patients scheduled for a percutaneous coronary intervention (PCI; procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries), pretreatment with the antiplatelet agent clopidogrel was not…
Intensive Weight-Loss Intervention Associated With Increased Likelihood of Partial Remission From Diabetes, Although Improvement in Rate Modest
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 18, 2012 Media Advisory: To contact Edward W. Gregg, Ph.D., call Karen Hunter at 404-639-3286 or email ksh7@cdc.gov. To contact editorial co-author David E. Arterburn, M.D., M.P.H., call Joan DeClaire at 206-287-2653 or email declaire.j@ghc.org. CHICAGO – Among overweight adults, participation in an intensive lifestyle intervention (that…
Regular Aspirin Use 10 or More Years Ago Associated With Increased Risk of Type of Age-Related Macular Degeneration
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 18, 2012 Media Advisory: To contact Barbara E. K. Klein, M.D., M.P.H., call Susan Lampert Smith at 608-262-7335 or email slsmith2@wisc.edu. CHICAGO – Among nearly 5,000 study participants, regular aspirin use reported ten years prior was associated with a small but statistically significant increase in the risk…
World Trade Center Rescue and Recovery Workers Have Had Increased Incidence of Certain Types of Cancer
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 18, 2012 Media Advisory: To contact co-author Steven D. Stellman, Ph.D., M.P.H., call Jean Weinberg at 347-396-4177 or email jweinberg@health.nyc.gov; or Marcus Liem at 347-396-2919 or email mliem@health.nyc.gov. CHICAGO – Among rescue and recovery workers exposed to the dust, debris, and fumes following the World Trade Center…
JAMA:12112012
Also Appearing in This Issue of JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 11, 2012 Study Finds Association Between Weight of Pancreas and Potential Diabetes Biomarker Autopsy and imaging studies suggest that among adults with type 1 diabetes (T1D), their pancreas is smaller and weighs less than the pancreas of adults without the disease. However, it is unknown when pancreatic…
Combination Therapy May Help Decrease Sleep Apnea Symptoms at Higher Altitudes
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 11, 2012 Media Advisory: To contact corresponding author Konrad E. Bloch, M.D., email konrad.bloch@usz.ch. CHICAGO – For individuals with obstructive sleep apnea traveling to higher altitudes (which may exacerbate symptoms), use of a combination therapy resulted in improvement in symptoms including reduced insomnia and better control of…
Prevalence of Visual Impairment in U.S. Increases
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 11, 2012 Media Advisory: To contact corresponding author David S. Friedman, M.D., M.P.H., Ph.D., call John Lazarou at 410-502-8902 or email jlazaro1@jhmi.edu. To contact editorial co-author David C. Musch, Ph.D., M.P.H., call Betsy Nisbet at 734-647-5586 or email bsnisbet@umich.edu. CHICAGO – The prevalence of nonrefractive visual impairment…
JAMA:12042012
Viewpoints in This Week’s JAMA
Embargoed for Release: 3 p.m. CT Tuesday, December 4, 2012 Overcoming the Obstacles to Research During Residency – What Does It Take? Michael B. Rothberg, M.D., M.P.H., of the Cleveland Clinic, writes that “although most physicians work as clinicians and never perform research, the Accreditation Council for Graduate Medical Education requires that residents ‘participate in…
Study Examines Attitudes of Medical Students’ Toward Industry Following COI Disclosures by Preclinical Lecturers
Embargoed for Release: 3 p.m. CT Tuesday, December 4, 2012 Media Advisory: To contact corresponding author Deborah Korenstein, M.D., call Kevin Orozovich at 212-241-9200 or email newsmedia@mssm.edu. Azalea Kim, M.P.A., of the Mount Sinai School of Medicine, New York, and colleagues studied the association between routine conflicts of interest (COI) disclosure with preclinical medical students…
Bias May Exist in Rating of Medical Trainees
Embargoed for Release: 3 p.m. CT Tuesday, December 4, 2012 Media Advisory: To contact Peter Yeates, M.B.B.S., M.Clin.Ed., email peter.yeates@manchester.ac.uk. Peter Yeates, M.B.B.S., M.Clin.Ed., of the University of Manchester, United Kingdom, and colleagues conducted a study to examine whether observations of the performance of postgraduate year 1 physicians influence raters’ scores of subsequent performances. “The…
Research Evaluates Possible Benefit of Multiple Mini-Interviews as Part of Medical School Admission Process
Embargoed for Release: 3 p.m. CT Tuesday, December 4, 2012 Media Advisory: To contact Kevin W. Eva, Ph.D., call Brian Kladko at 604-827-3301 or email brian.kladko@ubc.ca. Kevin W. Eva, Ph.D., of the University of British Columbia, Vancouver, and colleagues conducted a study to determine whether students deemed acceptable through a revised admissions protocol using a…
Clinically Integrated E-Learning of Evidence-Based Medicine Improves Knowledge, Skills in Resource-Limited Countries
Embargoed for Release: 3 p.m. CT Tuesday, December 4, 2012 Media Advisory: To contact corresponding author Khalid S. Khan, M.B.B.S., M.Sc., email k.s.khan@qmul.ac.uk. Regina Kulier, M.D., of the World Health Organization, Geneva, Switzerland, and colleagues conducted a study to evaluate the effects of a clinically integrated e-learning evidence-based medicine (EBM) course on knowledge, skills, and…
Shorter Rotation for Attending Physicians Does Not Appear to Have Adverse Effects on Patients; May Decrease Physician Burnout
Embargoed for Release: 3 p.m. CT Tuesday, December 4, 2012 Media Advisory: To contact Brian P. Lucas, M.D., M.S., call Nancy Di Fiore at 312-942-5159 or email Nancy_DiFiore@rush.edu. Brian P. Lucas, M.D., M.S., of the Cook County Health and Hospitals System and Rush Medical College, Chicago, and colleagues conducted a study to compare the effects…
Program of Protected Time For Sleep Improves Morning Alertness For Medical Interns
Embargoed for Release: 3 p.m. CT Tuesday, December 4, 2012 Media Advisory: To contact Kevin G. Volpp, M.D., Ph.D., call Jessica Mikulski at 215-349-8369 or email jessica.mikulski@uphs.upenn.edu Kevin G. Volpp, M.D., Ph.D., of the Philadelphia Veterans Affairs Medical Center and University of Pennsylvania, Philadelphia, and colleagues conducted a study to determine whether a protected sleep…
Low Percentage of Medical Residents Plan to Practice General Internal Medicine
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 4, 2012 Media Advisory: To contact Colin P. West, M.D., Ph.D., call Alyson Fleming at 507-284-5005 or email newsbureau@mayo.edu. Colin P. West, M.D., Ph.D., and Denise M. Dupras, M.D., Ph.D., of Mayo Clinic, Rochester, Minn., conducted a study to evaluate career plans of internal medicine residents. “General…
JAMA:11272012
Also Appearing in This Week’s JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 27, 2012 Earnings of U.S. Physicians Grow Less Than Other Health Professionals “Understanding trends in physician earnings is important given health care cost growth and proposed Medicare physician fee reductions,” writes Seth A. Seabury, Ph.D., of the RAND Corporation, Santa Monica, Calif., and colleagues. National surveys…
Anticoagulation Treatment For Longer Than Three Months After Aortic Valve Replacement Associated With Decreased Risk of Cardiovascular Death
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 27, 2012 Media Advisory: To contact Charlotte Merie, M.D., email c.merie@mail.dk. To contact editorial co-author Shamir R. Mehta, M.D., M.Sc., call Veronica McGuire at 905-525-9140, ext. 22169, or email vmcguir@mcmaster.ca. CHICAGO – Although current guidelines recommend 3 months of anticoagulation treatment after bioprosthetic aortic valve replacement surgery,…
Risk of Pertussis Increases as Time Since Last Dose of DTaP Vaccine Lengthens
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 27, 2012 Media Advisory: To contact Lara K. Misegades, Ph.D., M.S., call Alison Patti at 404-639-3286 or email APatti@cdc.gov. To contact editorial co-author Eugene D. Shapiro, M.D., call Karen Peart at 203-432-1326 or email karen.peart@yale.edu. CHICAGO – In an examination of cases of childhood pertussis in California,…
Studies Examine Whether Therapies for Heart Failure Are Associated With Improved Survival
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 27, 2012 Media Advisory: To contact Adrian F. Hernandez, M.D., M.H.S., call Sarah Avery at 919-660-1306 or email sarah.avery@duke.edu. To contact Lars H. Lund, M.D., Ph.D., email lars.lund@alumni.duke.edu. To contact editorial author James C. Fang, M.D., call Mike Ferrari at 216-844-7239 or email Mike.Ferrari@uhhospitals.org. CHICAGO – An…
JAMA:11202012
Also Appearing in This Week’s JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 20, 2012 Study Finds That Older Persons With Positive Age Stereotypes More Likely to Recover From Severe Disability “Little research has been conducted on factors that account for why some older persons recover from disability and others do not. We considered a new culture-based explanatory factor: age…
Citicoline Does Not Improve Functional, Cognitive Status in Patients with Traumatic Brain Injury
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 20, 2012 Media Advisory: To contact Ross D. Zafonte, D.O., call Tim Sullivan at 617-573-2918 or email tsullivan11@partners.org. To contact editorial co-author Robert L. Ruff, M.D., Ph.D., call Jessica Studeny at 216-368-4692 or email jessica.studeny@case.edu. CHICAGO – Although approved for use for treating traumatic brain injury (TBI)…
Patients With Online Access to Clinicians, Medical Records Have Increased Use of Clinical Services
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 20, 2012 Media Advisory: To contact Ted E. Palen, M.D., Ph.D., M.S.P.H., call Amy Whited at 303-344-7518 or email Amy.L.Whited@kp.org. To contact editorial co-author David W. Bates, M.D., M.Sc., call Lori Schroth at 617-534-1604 or email Ljshanks@partners.org. CHICAGO – Patients with online access to their medical records…
JAMA:11132012
JAMA_OF:11122012
Also Appearing in This Week’s JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 13, 2012 Study Examines Brain White Matter Changes in Soccer Players “Soccer is the most popular sport in the world, with more than 250 million active players. It is the only sport in which the unprotected head is a primary point of contact when heading the ball….
Genetic Variation May Modify Associations Between Low Vitamin D Levels and Adverse Health Outcomes
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 13, 2012 Media Advisory: To contact Gregory P. Levin, Ph.D., call Leila Gray at 206-685-0381 or email leilag@u.washington.edu. CHICAGO – Findings from a study suggest that certain variations in vitamin D metabolism genes may modify the association of low serum 25-hydroxyvitamin D concentrations with health outcomes such…
Having Migraines Associated With Higher Incidence of Brain Lesions Among Women; Effect on Health Uncertain
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 13, 2012 Media Advisory: To contact corresponding author Mark C. Kruit, M.D., Ph.D., email m.c.kruit@lumc.nl. To contact editorial co-author Deborah I. Friedman, M.D., M.P.H., call Jeff Carlton at 214-648-2876 or email Jeffrey.Carlton@utsouthwestern.edu. CHICAGO – After nearly 10 years of follow-up of study participants who experienced migraines and…
Patients With HBV-Related Liver Cancer Who Receive Antiviral Therapy Have Lower Risk of Tumor Recurrence
EMBARGOED FOR EARLY RELEASE: 2:45 P.M. (CT) MONDAY, NOVEMBER 12, 2012 Media Advisory: To contact Chun-Ying Wu, M.D., Ph.D., M.P.H., email chun@vghtc.gov.tw. To contact editorial author Anna S. F. Lok, M.D., call Nicole Fawcett at 734-764-2220 or email nfawcett@umich.edu. CHICAGO – Patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC; liver cancer) who received nucleoside…
JAMA_OF:11062012
JAMA_OF:11042012
JAMA_OF:11052012
JAMA_OF:11052012
JAMA:11052012
Study Examines Effect of Timing of Cell Therapy Following Heart Attack
FOR RELEASE: 2 P.M. (CT) MONDAY, NOVEMBER 5, 2012 Jay H. Traverse, M.D., of the Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, and colleagues investigated the influence of timing of cardiovascular cell delivery within the first week after a heart attack on improving left ventricular (LV) function following reperfusion. “Cell therapy may eventually become…
Study Evaluates Mesenchymal Stem Cell Therapies for Cardiac Patients
FOR RELEASE: 2 P.M. (CT) MONDAY, NOVEMBER 5, 2012 Joshua M. Hare, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine whether allogeneic (taken from a different individual) mesenchymal stem cells (MSCs) are as safe and effective as autologous (donor and recipient are the same person) MSCs…
Patients Who Cannot Tolerate Statins Achieve Reduction in LDL Cholesterol Levels With Administration of Monoclonal Antibody
EMBARGOED FOR EARLY RELEASE: 12:45 P.M. (CT) MONDAY, NOVEMBER 5, 2012 David Sullivan, M.D., of the Royal Prince Alfred Hospital, Camperdown, Australia, and colleagues conducted a phase 2 study to assess the efficacy and safety of subcutaneous (under the skin) administration of a human monoclonal antibody to the protein PCSK9, (the product is designated AMG145),…
Comparison of Anti-Clotting Drugs Finds Differences in Platelet Reactivity, Similar Clinical Outcomes
EMBARGOED FOR EARLY RELEASE: 5:30 P.M. (CT) SUNDAY, NOVEMBER 4, 2012 Paul A. Gurbel, M.D., of the Sinai Center for Thrombosis Research, Baltimore, and colleagues conducted a study to examine the differences in platelet reactivity and clinical outcomes among patients with acute coronary syndromes (ACS) being treated by the antiplatelet agents clopidogrel or prasugrel. From…
Pre-Operative and Post-Operative Fish Oil Supplementation Does Not Appear Effective in Reducing Atrial Fibrillation Following Heart Surgery
EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact corresponding author Dariush Mozaffarian, M.D., Dr.P.H., call Todd Datz at 617-432-8413 or email tdatz@hsph.harvard.edu. To contact corresponding author Roberto Marchioli, M.D., email marchioli@negrisud.it. CHICAGO – Among patients undergoing cardiac surgery, supplementation with a n-3-polyunsaturated fatty acid (fish oil) before…
Other Studies Appearing in JAMA
EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Use of Corticosteroid During Cardiac Surgery Does Not Appear to Improve Outcomes Jan M. Dieleman, M.D., of the University Medical Center, Utrecht, the Netherlands and colleagues conducted a randomized clinical trial to quantify the effect of a single intraoperative dose of the corticosteroid dexamethasone…
Study Finds High Prevalence of Major Cardiovascular Disease Risk Factors Among U.S. Hispanic/Latino Adults
EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact Martha L. Daviglus, M.D., Ph.D., call Jeanne Galatzer-Levy at 312-996-1583 or email jgala@uic.edu. CHICAGO – In a study that involved more than 16,000 Hispanic/Latino men and women living in the United States, the prevalence of major cardiovascular disease (CVD) risk…
Risk of Fatal Coronary Heart Disease Higher Among Black Men and Women
EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact Monika M. Safford, M.D., call Jennifer Park Lollar at 205-934-3888 or email jpark@uab.edu. To contact editorial author Michael S. Lauer, M.D., call the NHLBI Office of Communications at 301-496-4236 or email nhlbi_news@nhlbi.nih.gov. CHICAGO – In an examination of the incidence…
Daily Multivitamin Use Among Men Does Not Reduce Risk of Major Cardiovascular Events
EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact Howard D. Sesso, Sc.D., M.P.H., call Tom Langford at 617-534-1605 or email tlangford@partners.org. To contact Eva M. Lonn, M.D., M.Sc., call Veronica McGuire at 905-525-9140, ext. 22169; or email vmcguir@mcmaster.ca. CHICAGO – In a randomized study that included nearly 15,000…
Lifetime Risk of Developing Cardiovascular Disease Substantial
EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact John T. Wilkins, M.D., M.S., call Erin White at 847-491-4888 or email ewhite@northwestern.edu. CHICAGO – Even in men and women with an optimal cardiovascular disease (CVD) risk factor profile, the lifetime risk estimate for CVD is greater than 30 percent,…
JAMA_OF:10302012
Regardless of Age, Measures of Kidney Function Remain Predictors of Kidney Disease and Death
EMBARGOED FOR EARLY RELEASE: 2:00 P.M. (CT) TUESDAY, OCTOBER 30, 2012 Media Advisory: To contact corresponding author Josef Coresh, M.D., Ph.D., call Tim Parsons at 410-955-7619 or email tmparson@jhsph.edu. To contact editorial author Ian H. de Boer, M.D., M.S., call Clare LaFond at 206-685-1323 or email clareh@uw.edu. CHICAGO – In a large, collaborative study that…
JAMA_OF:10252012
Early Surgical Treatment of Low-Grade Glioma Brain Tumor Associated With Better Survival Than Watchful Waiting
EMBARGOED FOR EARLY RELEASE: 6:15 A.M. (CT) THURSDAY, OCTOBER 25, 2012 Media Advisory: To contact Asgeir S. Jakola, M.D., email asgeir.s.jakola@ntnu.no. To contact editorial author James M. Markert, M.D., call Bob Shepard at 205-934-8934 or email bshep@uab.edu. CHICAGO – In a comparison of strategies for treating low-grade gliomas (brain tumors), patients in Norway treated at…
JAMA:10232012
Also Appearing in This Week’s Issue
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 23, 2012 Molecular Prognostic Assay May Help Identify Patients at High Risk of Death Despite Small, Node-Negative Lung Tumors “Low-dose computed tomography screening may increase diagnoses of T1a node-negative non-small-cell lung cancers (NSCLC). One-quarter of these patients die within 5 years. Maximizing the benefit of screening requires…
Use of Mechanical Ventilation At Lower Level Among Patients Without Lung Injury Associated With Better Clinical Outcomes
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 23, 2012 Media Advisory: To contact Ary Serpa Neto, M.D., M.Sc., email aryserpa@terra.com.br. To contact editorial author Niall D. Ferguson, M.D., M.Sc., call Leslie O’Leary at 416-586-4800, ext.8306; or email lo’leary2@mtsinai.on.ca. CHICAGO –Among patients without acute respiratory distress syndrome, protective mechanical ventilation with use of lower tidal…
Most Large Treatment Effects of Medical Interventions Come From Small Studies
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 23, 2012 Media Advisory: To contact corresponding author John P. A. Ioannidis, M.D., D.Sc., call Krista Conger at 650-725-5371 or email kristac@stanford.edu. To contact editorial author Andrew D. Oxman, M.D., email oxman@online.no. CHICAGO – In an examination of the characteristics of studies that yield large treatment effects…
Men With Certain Cardiovascular Risk Factors Appear to be At Increased Risk of Peripheral Artery Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 23, 2012 Media Advisory: To contact Michel M. Joosten, Ph.D., call Kelly Lawman at 617-667-7305 or email klawman@bidmc.harvard.edu. CHICAGO – Among nearly 45,000 men who were followed up for more than two decades, those with the risk factors of smoking, hypertension, high cholesterol, and type 2 diabetes…
JAMA_OF:10172012
Daily Sedation Interruption For Critically Ill Patients Does Not Improve Outcomes or Reduce Use of Mechanical Ventilation
EMBARGOED FOR EARLY RELEASE: 8:15 A.M. (CT) WEDNESDAY, OCTOBER 17, 2012 Media Advisory: To contact Sangeeta Mehta, M.D., call Nicole Bodnar at 416-978-5811 or email Nicole.bodnar@utoronto.ca. CHICAGO – For critically ill patients receiving mechanical ventilation, daily sedation interruption did not reduce the duration of mechanical ventilation or appear to offer any benefit to patients, and…
JAMA_OF:10172012
Tight Glucose Control For Critically Ill Children Does Not Appear to Impair Neurocognitive Development
EMBARGOED FOR EARLY RELEASE: 8:15 A.M. (CT) WEDNESDAY, OCTOBER 17, 2012 Media Advisory: To contact corresponding author Greet Van den Berghe, M.D., Ph.D., email greet.vandenberghe@med.kuleuven.be. To contact editorial author Robert C. Tasker, M.B.B.S., M.D., call Keri Stedman at 617-919-3114 or email keri.stedman@childrens.harvard.edu. CHICAGO – Although there is some concern that hypoglycemia may adversely affect the…
JAMA_OF:10182012
Norovirus Outbreaks in Nursing Homes Associated With Increase in Hospitalizations, Risk of Death
EMBARGOED FOR EARLY RELEASE: 11:15 A.M. (CT) THURSDAY, OCTOBER 18, 2012 Media Advisory: To contact Tarak K. Trivedi, B.S., call John Easton at 773-795-5225 or email john.easton@uchospitals.edu. CHICAGO – In a study that included more than 300 Medicare-certified nursing homes, rates of hospitalization and death were substantially increased during outbreaks of norovirus gastroenteritis vs. non-outbreak…
Multivitamin Use Among Middle-Aged, Older Men Results in Modest Reduction in Cancer
EMBARGOED FOR EARLY RELEASE: 9:30 A.M. (CT) WEDNESDAY, OCTOBER 17, 2012 Media Advisory: To contact J. Michael Gaziano, M.D., M.P.H., call Tom Langford at 617-534-1605 or email tlangford@partners.org. CHICAGO – In a randomized trial that included nearly 15,000 male physicians, long-term daily multivitamin use resulted in a modest but statistically significant reduction in cancer after…
JAMA:10162012
Also Appearing in This Week’s Issue
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Study Finds Association Between Pseudoephedrine Sales and Illicit Manufacture of Methamphetamine “The illicit production of methamphetamine [a highly addictive stimulant drug] from the precursor pseudoephedrine in clandestine laboratories fuels up to 35 percent of the domestic supply. Public health, law enforcement, and medical associations support…
High-Dose Multivitamin Supplementation Does Not Improve Outcomes For HIV Patients Receiving Antiretroviral Therapy
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Media Advisory: To contact Sheila Isanaka, Sc.D., call Marge Dwyer at 617-432-8416 or email mhdwyer@hsph.harvard.edu. CHICAGO – Among patients with human immunodeficiency virus (HIV) infection in Tanzania, high-dose multivitamin supplementation after beginning highly active antiretroviral therapy did not reduce the risk of HIV disease progression…
Lower Use of Chloride in Intravenous Fluids For Critically Ill Patients Associated With Decreased Risk of Kidney Injury
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Media Advisory: To contact corresponding author Rinaldo Bellomo, M.D., F.C.I.C.M., email rinaldo.bellomo@austin.org.au. To contact editorial co-author Sushrut S. Waikar, M.D., M.P.H., call Jessica Maki at 617-534-1603 or email jmaki3@partners.org. CHICAGO – In a pilot study assessing the effect of different levels of chloride in…
Study Identifies Strategy for Improved Screening for Type of Hereditary Colorectal Cancer
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Media Advisory: To contact corresponding author Antoni Castells, M.D., Ph.D., email castells@clinic.ub.es. To contact editorial co-author James M. Ford, M.D., call Krista Conger at 650-725-5371 or email kristac@stanford.edu. CHICAGO – In a comparison of strategies to identify individuals with Lynch syndrome, the most common form…
Cholesterol Levels Improving Among U.S. Adults
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Media Advisory: To contact Margaret D. Carroll, M.S.P.H., call Karen Hunter at 404-639-3286 or email ksh7@cdc.gov. CHICAGO – An analysis of nationally-representative data indicates that between 1988 and 2010 there has been a trend of declining average levels of total cholesterol, non-high-density lipoprotein cholesterol, and…
JAMA:10092012
JAMA_OF:10082012
Also Appearing in This Week’s JAMA
EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 9, 2012 Study Examines Off-Label Use of Bone Protein For Pediatric Spinal Surgery Arthrodesis (the surgical fixation of a joint to promote bone fusion) of the spine is frequently performed in children. Although nonunion occurs frequently in adults, children rarely experience nonunion. Bone morphogenetic proteins (BMPs) are…