Program of Protected Time For Sleep Improves Morning Alertness For Medical Interns

Embargoed for Release: 3 p.m. CT Tuesday, December 4, 2012 Media Advisory: To contact Kevin G. Volpp, M.D., Ph.D., call Jessica Mikulski at 215-349-8369 or email jessica.mikulski@uphs.upenn.edu Kevin G. Volpp, M.D., Ph.D., of the Philadelphia Veterans Affairs Medical Center and University of Pennsylvania, Philadelphia, and colleagues conducted a study to determine whether a protected sleep…

Low Percentage of Medical Residents Plan to Practice General Internal Medicine

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, DECEMBER 4, 2012 Media Advisory: To contact Colin P. West, M.D., Ph.D., call Alyson Fleming at 507-284-5005 or email newsbureau@mayo.edu. Colin P. West, M.D., Ph.D., and Denise M. Dupras, M.D., Ph.D., of Mayo Clinic, Rochester, Minn., conducted a study to evaluate career plans of internal medicine residents. “General…

JAMA:11272012

Also Appearing in This Week’s JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 27, 2012 Earnings of U.S. Physicians Grow Less Than Other Health Professionals   “Understanding trends in physician earnings is important given health care cost growth and proposed Medicare physician fee reductions,” writes Seth A. Seabury, Ph.D., of the RAND Corporation, Santa Monica, Calif., and colleagues. National surveys…

Anticoagulation Treatment For Longer Than Three Months After Aortic Valve Replacement Associated With Decreased Risk of Cardiovascular Death

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 27, 2012 Media Advisory: To contact Charlotte Merie, M.D., email c.merie@mail.dk. To contact editorial co-author Shamir R. Mehta, M.D., M.Sc., call Veronica McGuire at 905-525-9140, ext. 22169, or email vmcguir@mcmaster.ca. CHICAGO – Although current guidelines recommend 3 months of anticoagulation treatment after bioprosthetic aortic valve replacement surgery,…

Risk of Pertussis Increases as Time Since Last Dose of DTaP Vaccine Lengthens

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 27, 2012 Media Advisory: To contact Lara K. Misegades, Ph.D., M.S., call Alison Patti at 404-639-3286 or email APatti@cdc.gov. To contact editorial co-author Eugene D. Shapiro, M.D., call Karen Peart at 203-432-1326 or email karen.peart@yale.edu. CHICAGO – In an examination of cases of childhood pertussis in California,…

Studies Examine Whether Therapies for Heart Failure Are Associated With Improved Survival

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 27, 2012 Media Advisory: To contact Adrian F. Hernandez, M.D., M.H.S., call Sarah Avery at 919-660-1306 or email sarah.avery@duke.edu. To contact Lars H. Lund, M.D., Ph.D., email lars.lund@alumni.duke.edu. To contact editorial author James C. Fang, M.D., call Mike Ferrari at 216-844-7239 or email Mike.Ferrari@uhhospitals.org. CHICAGO – An…

JAMA:11202012

Also Appearing in This Week’s JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 20, 2012 Study Finds That Older Persons With Positive Age Stereotypes More Likely to Recover From Severe Disability “Little research has been conducted on factors that account for why some older persons recover from disability and others do not. We considered a new culture-based explanatory factor: age…

Citicoline Does Not Improve Functional, Cognitive Status in Patients with Traumatic Brain Injury

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 20, 2012 Media Advisory: To contact Ross D. Zafonte, D.O., call Tim Sullivan at 617-573-2918 or email tsullivan11@partners.org. To contact editorial co-author Robert L. Ruff, M.D., Ph.D., call Jessica Studeny at 216-368-4692 or email jessica.studeny@case.edu. CHICAGO – Although approved for use for treating traumatic brain injury (TBI)…

Patients With Online Access to Clinicians, Medical Records Have Increased Use of Clinical Services

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 20, 2012 Media Advisory: To contact Ted E. Palen, M.D., Ph.D., M.S.P.H., call Amy Whited at 303-344-7518 or email Amy.L.Whited@kp.org. To contact editorial co-author David W. Bates, M.D., M.Sc., call Lori Schroth at 617-534-1604 or email Ljshanks@partners.org. CHICAGO – Patients with online access to their medical records…

JAMA:11132012

JAMA_OF:11122012

Also Appearing in This Week’s JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 13, 2012 Study Examines Brain White Matter Changes in Soccer Players “Soccer is the most popular sport in the world, with more than 250 million active players. It is the only sport in which the unprotected head is a primary point of contact when heading the ball….

Genetic Variation May Modify Associations Between Low Vitamin D Levels and Adverse Health Outcomes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 13, 2012 Media Advisory: To contact Gregory P. Levin, Ph.D., call Leila Gray at 206-685-0381 or email leilag@u.washington.edu. CHICAGO – Findings from a study suggest that certain variations in vitamin D metabolism genes may modify the association of low serum 25-hydroxyvitamin D concentrations with health outcomes such…

Having Migraines Associated With Higher Incidence of Brain Lesions Among Women; Effect on Health Uncertain

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, NOVEMBER 13, 2012 Media Advisory: To contact corresponding author Mark C. Kruit, M.D., Ph.D., email m.c.kruit@lumc.nl. To contact editorial co-author Deborah I. Friedman, M.D., M.P.H., call Jeff Carlton at 214-648-2876 or email Jeffrey.Carlton@utsouthwestern.edu. CHICAGO – After nearly 10 years of follow-up of study participants who experienced migraines and…

Patients With HBV-Related Liver Cancer Who Receive Antiviral Therapy Have Lower Risk of Tumor Recurrence

EMBARGOED FOR EARLY RELEASE: 2:45 P.M. (CT) MONDAY, NOVEMBER 12, 2012 Media Advisory: To contact Chun-Ying Wu, M.D., Ph.D., M.P.H., email chun@vghtc.gov.tw. To contact editorial author Anna S. F. Lok, M.D., call Nicole Fawcett at 734-764-2220 or email nfawcett@umich.edu. CHICAGO – Patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC; liver cancer) who received nucleoside…

JAMA_OF:11062012

JAMA_OF:11042012

JAMA_OF:11052012

JAMA_OF:11052012

JAMA:11052012

Study Examines Effect of Timing of Cell Therapy Following Heart Attack

FOR RELEASE: 2 P.M. (CT) MONDAY, NOVEMBER 5, 2012 Jay H. Traverse, M.D., of the Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, and colleagues investigated the influence of timing of cardiovascular cell delivery within the first week after a heart attack on improving left ventricular (LV) function following reperfusion. “Cell therapy may eventually become…

Study Evaluates Mesenchymal Stem Cell Therapies for Cardiac Patients

FOR RELEASE: 2 P.M. (CT) MONDAY, NOVEMBER 5, 2012 Joshua M. Hare, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine whether allogeneic (taken from a different individual) mesenchymal stem cells (MSCs) are as safe and effective as autologous (donor and recipient are the same person) MSCs…

Patients Who Cannot Tolerate Statins Achieve Reduction in LDL Cholesterol Levels With Administration of Monoclonal Antibody

EMBARGOED FOR EARLY RELEASE: 12:45 P.M. (CT) MONDAY, NOVEMBER 5, 2012 David Sullivan, M.D., of the Royal Prince Alfred Hospital, Camperdown, Australia, and colleagues conducted a phase 2 study to assess the efficacy and safety of subcutaneous (under the skin) administration of a human monoclonal antibody to the protein PCSK9, (the product is designated AMG145),…

Comparison of Anti-Clotting Drugs Finds Differences in Platelet Reactivity, Similar Clinical Outcomes

EMBARGOED FOR EARLY RELEASE: 5:30 P.M. (CT) SUNDAY, NOVEMBER 4, 2012 Paul A. Gurbel, M.D., of the Sinai Center for Thrombosis Research, Baltimore, and colleagues conducted a study to examine the differences in platelet reactivity and clinical outcomes among patients with acute coronary syndromes (ACS) being treated by the antiplatelet agents clopidogrel or prasugrel. From…

Pre-Operative and Post-Operative Fish Oil Supplementation Does Not Appear Effective in Reducing Atrial Fibrillation Following Heart Surgery

EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact corresponding author Dariush Mozaffarian, M.D., Dr.P.H., call Todd Datz at 617-432-8413 or email tdatz@hsph.harvard.edu. To contact corresponding author Roberto Marchioli, M.D., email marchioli@negrisud.it.   CHICAGO – Among patients undergoing cardiac surgery, supplementation with a n-3-polyunsaturated fatty acid (fish oil) before…

Other Studies Appearing in JAMA

EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Use of Corticosteroid During Cardiac Surgery Does Not Appear to Improve Outcomes Jan M. Dieleman, M.D., of the University Medical Center, Utrecht, the Netherlands and colleagues conducted a randomized clinical trial to quantify the effect of a single intraoperative dose of the corticosteroid dexamethasone…

Study Finds High Prevalence of Major Cardiovascular Disease Risk Factors Among U.S. Hispanic/Latino Adults

EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact Martha L. Daviglus, M.D., Ph.D., call Jeanne Galatzer-Levy at 312-996-1583 or email jgala@uic.edu. CHICAGO – In a study that involved more than 16,000 Hispanic/Latino men and women living in the United States, the prevalence of major cardiovascular disease (CVD) risk…

Risk of Fatal Coronary Heart Disease Higher Among Black Men and Women

EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact Monika M. Safford, M.D., call Jennifer Park Lollar at 205-934-3888 or email jpark@uab.edu. To contact editorial author Michael S. Lauer, M.D., call the NHLBI Office of Communications at 301-496-4236 or email nhlbi_news@nhlbi.nih.gov. CHICAGO – In an examination of the incidence…

Daily Multivitamin Use Among Men Does Not Reduce Risk of Major Cardiovascular Events

EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact Howard D. Sesso, Sc.D., M.P.H., call Tom Langford at 617-534-1605 or email tlangford@partners.org. To contact Eva M. Lonn, M.D., M.Sc., call Veronica McGuire at 905-525-9140, ext. 22169; or email vmcguir@mcmaster.ca. CHICAGO – In a randomized study that included nearly 15,000…

Lifetime Risk of Developing Cardiovascular Disease Substantial

EMBARGOED FOR EARLY RELEASE: 11 A.M. (CT) MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact John T. Wilkins, M.D., M.S., call Erin White at 847-491-4888 or email ewhite@northwestern.edu. CHICAGO – Even in men and women with an optimal cardiovascular disease (CVD) risk factor profile, the lifetime risk estimate for CVD is greater than 30 percent,…

JAMA_OF:10302012

Regardless of Age, Measures of Kidney Function Remain Predictors of Kidney Disease and Death

EMBARGOED FOR EARLY RELEASE: 2:00 P.M. (CT) TUESDAY, OCTOBER 30, 2012 Media Advisory: To contact corresponding author Josef Coresh, M.D., Ph.D., call Tim Parsons at 410-955-7619 or email tmparson@jhsph.edu. To contact editorial author Ian H. de Boer, M.D., M.S., call Clare LaFond at 206-685-1323 or email clareh@uw.edu. CHICAGO – In a large, collaborative study that…

JAMA_OF:10252012

Early Surgical Treatment of Low-Grade Glioma Brain Tumor Associated With Better Survival Than Watchful Waiting

EMBARGOED FOR EARLY RELEASE: 6:15 A.M. (CT) THURSDAY, OCTOBER 25, 2012 Media Advisory: To contact Asgeir S. Jakola, M.D., email asgeir.s.jakola@ntnu.no. To contact editorial author James M. Markert, M.D., call Bob Shepard at 205-934-8934 or email bshep@uab.edu. CHICAGO – In a comparison of strategies for treating low-grade gliomas (brain tumors), patients in Norway treated at…

JAMA:10232012

Also Appearing in This Week’s Issue

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 23, 2012 Molecular Prognostic Assay May Help Identify Patients at High Risk of Death Despite Small, Node-Negative Lung Tumors “Low-dose computed tomography screening may increase diagnoses of T1a node-negative non-small-cell lung cancers (NSCLC). One-quarter of these patients die within 5 years. Maximizing the benefit of screening requires…

Use of Mechanical Ventilation At Lower Level Among Patients Without Lung Injury Associated With Better Clinical Outcomes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 23, 2012 Media Advisory: To contact Ary Serpa Neto, M.D., M.Sc., email aryserpa@terra.com.br. To contact editorial author Niall D. Ferguson, M.D., M.Sc., call Leslie O’Leary at 416-586-4800, ext.8306; or email lo’leary2@mtsinai.on.ca. CHICAGO –Among patients without acute respiratory distress syndrome, protective mechanical ventilation with use of lower tidal…

Most Large Treatment Effects of Medical Interventions Come From Small Studies

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 23, 2012 Media Advisory: To contact corresponding author John P. A. Ioannidis, M.D., D.Sc., call Krista Conger at 650-725-5371 or email kristac@stanford.edu. To contact editorial author Andrew D. Oxman, M.D., email oxman@online.no. CHICAGO – In an examination of the characteristics of studies that yield large treatment effects…

Men With Certain Cardiovascular Risk Factors Appear to be At Increased Risk of Peripheral Artery Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 23, 2012 Media Advisory: To contact Michel M. Joosten, Ph.D., call Kelly Lawman at 617-667-7305 or email klawman@bidmc.harvard.edu. CHICAGO – Among nearly 45,000 men who were followed up for more than two decades, those with the risk factors of smoking, hypertension, high cholesterol, and type 2 diabetes…

JAMA_OF:10172012

Daily Sedation Interruption For Critically Ill Patients Does Not Improve Outcomes or Reduce Use of Mechanical Ventilation

EMBARGOED FOR EARLY RELEASE: 8:15 A.M. (CT) WEDNESDAY, OCTOBER 17, 2012 Media Advisory: To contact Sangeeta Mehta, M.D., call Nicole Bodnar at 416-978-5811 or email Nicole.bodnar@utoronto.ca. CHICAGO – For critically ill patients receiving mechanical ventilation, daily sedation interruption did not reduce the duration of mechanical ventilation or appear to offer any benefit to patients, and…

JAMA_OF:10172012

Tight Glucose Control For Critically Ill Children Does Not Appear to Impair Neurocognitive Development

EMBARGOED FOR EARLY RELEASE: 8:15 A.M. (CT) WEDNESDAY, OCTOBER 17, 2012 Media Advisory: To contact corresponding author Greet Van den Berghe, M.D., Ph.D., email greet.vandenberghe@med.kuleuven.be. To contact editorial author Robert C. Tasker, M.B.B.S., M.D., call Keri Stedman at 617-919-3114 or email keri.stedman@childrens.harvard.edu. CHICAGO – Although there is some concern that hypoglycemia may adversely affect the…

JAMA_OF:10182012

Norovirus Outbreaks in Nursing Homes Associated With Increase in Hospitalizations, Risk of Death

EMBARGOED FOR EARLY RELEASE: 11:15 A.M. (CT) THURSDAY, OCTOBER 18, 2012 Media Advisory: To contact Tarak K. Trivedi, B.S., call John Easton at 773-795-5225 or email john.easton@uchospitals.edu. CHICAGO – In a study that included more than 300 Medicare-certified nursing homes, rates of hospitalization and death were substantially increased during outbreaks of norovirus gastroenteritis vs. non-outbreak…

Multivitamin Use Among Middle-Aged, Older Men Results in Modest Reduction in Cancer

EMBARGOED FOR EARLY RELEASE: 9:30 A.M. (CT) WEDNESDAY, OCTOBER 17, 2012 Media Advisory: To contact J. Michael Gaziano, M.D., M.P.H., call Tom Langford at 617-534-1605 or email tlangford@partners.org. CHICAGO – In a randomized trial that included nearly 15,000 male physicians, long-term daily multivitamin use resulted in a modest but statistically significant reduction in cancer after…

JAMA:10162012

Also Appearing in This Week’s Issue

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Study Finds Association Between Pseudoephedrine Sales and Illicit Manufacture of Methamphetamine “The illicit production of methamphetamine [a highly addictive stimulant drug] from the precursor pseudoephedrine in clandestine laboratories fuels up to 35 percent of the domestic supply. Public health, law enforcement, and medical associations support…

High-Dose Multivitamin Supplementation Does Not Improve Outcomes For HIV Patients Receiving Antiretroviral Therapy

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Media Advisory: To contact Sheila Isanaka, Sc.D., call Marge Dwyer at 617-432-8416 or email mhdwyer@hsph.harvard.edu. CHICAGO – Among patients with human immunodeficiency virus (HIV) infection in Tanzania, high-dose multivitamin supplementation after beginning highly active antiretroviral therapy did not reduce the risk of HIV disease progression…

Lower Use of Chloride in Intravenous Fluids For Critically Ill Patients Associated With Decreased Risk of Kidney Injury

  EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Media Advisory: To contact corresponding author Rinaldo Bellomo, M.D., F.C.I.C.M., email rinaldo.bellomo@austin.org.au. To contact editorial co-author Sushrut S. Waikar, M.D., M.P.H., call Jessica Maki at 617-534-1603 or email jmaki3@partners.org. CHICAGO – In a pilot study assessing the effect of different levels of chloride in…

Study Identifies Strategy for Improved Screening for Type of Hereditary Colorectal Cancer

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Media Advisory: To contact corresponding author Antoni Castells, M.D., Ph.D., email castells@clinic.ub.es. To contact editorial co-author James M. Ford, M.D., call Krista Conger at 650-725-5371 or email kristac@stanford.edu. CHICAGO – In a comparison of strategies to identify individuals with Lynch syndrome, the most common form…

Cholesterol Levels Improving Among U.S. Adults

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 16, 2012 Media Advisory: To contact Margaret D. Carroll, M.S.P.H., call Karen Hunter at 404-639-3286 or email ksh7@cdc.gov. CHICAGO – An analysis of nationally-representative data indicates that between 1988 and 2010 there has been a trend of declining average levels of total cholesterol, non-high-density lipoprotein cholesterol, and…

JAMA:10092012

JAMA_OF:10082012

Also Appearing in This Week’s JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 9, 2012 Study Examines Off-Label Use of Bone Protein For Pediatric Spinal Surgery Arthrodesis (the surgical fixation of a joint to promote bone fusion) of the spine is frequently performed in children. Although nonunion occurs frequently in adults, children rarely experience nonunion. Bone morphogenetic proteins (BMPs) are…

Level of Hormone Associated With Increased Risk of Diabetes, Cardiovascular Disease, Breast Cancer and Death

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 9, 2012 Media Advisory: To contact Olle Melander, M.D., Ph.D., email olle.melander@med.lu.se. CHICAGO – Plasma levels of proneurotensin are associated with the development of diabetes, cardiovascular disease, cardiovascular and total mortality, and breast cancer in women during long-term follow-up, according to a study in the October 10…

Rates of Procedures Such as Angioplasty Lower in States With Public Reporting of Outcomes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 9, 2012 Media Advisory: To contact Karen E. Joynt, M.D., M.P.H., call Todd Datz at 617-432-8413 or email tdatz@hsph.harvard.edu.  To contact editorial author Maura Moscucci, M.D., M.B.A., call Lisa Worley at 305-243-5184 or email lworley2@med.miami.edu. CHICAGO – In an analysis that included nearly 100,000 Medicare patients who…

Vigorous Physical Activity May Increase Risk of Bleeding for Children With Hemophilia

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 9, 2012 Media Advisory: To contact Carolyn R. Broderick, M.B.B.S., email c.broderick@unsw.edu.au. To contact Marilyn J. Manco-Johnson, M.D., call Jacque Montgomery at 303-928-9093 or email Jacque.Montgomery@ucdenver.edu. CHICAGO – In children and adolescents with hemophilia, vigorous physical activity was associated with an elevated risk of bleeding, although it…

Use of Fresh Red Blood Cells for Transfusions for Premature Infants Does Not Improve Outcomes

EMBARGOED FOR EARLY RELEASE: 8 A.M. (CT) MONDAY, OCTOBER 8, 2012 Media Advisory: To contact Dean A. Fergusson, M.H.A., Ph.D., call Paddy Moore at 613-737-8899, ext. 73687, or email padmoore@ohri.ca. CHICAGO – Among premature, very low-birth-weight infants requiring a transfusion, use of fresh red blood cells (RBCs) compared with standard RBC transfusion practice did not…

JAMA:10022012

Viewpoints in This Week’s JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 2, 2012 Challenges at the Intersection of Team-Based and Patient-Centered Health Care – Insights From an IOM Working Group Matthew K. Wynia, M.D., M.P.H., of the American Medical Association, Chicago, and colleagues write that team-based health care may help the United States achieve improved health and improved…

Cardiac Medication May Help Reduce Stiffness Caused by Certain Muscle Diseases

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 2, 2012 Media Advisory: To contact corresponding author Richard J. Barohn, M.D., call C.J. Janovy at 913-588-2598 or email cjanovy@kumc.edu. To contact editorial co-author Eric P. Hoffman, Ph.D., call Paula Darte at 202-821-6357 or email pdarte@ChildrensNational.org. CHICAGO – Preliminary research finds that for patients with nondystrophic myotonias…

Patients With Rheumatoid Arthritis Appear To Be At Increased Risk For Blood Clots

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 2, 2012 Media Advisory: To contact Marie E. Holmqvist, M.D., Ph.D., email marie.holmqvist@ki.se. CHICAGO – A study that included more than 45,000 residents of Sweden with rheumatoid arthritis finds that individuals with this disease had an associated higher risk of venous thromboembolism (a blood clot that forms…

Beta-Blocker Use Not Associated With Lower Risk of Cardiovascular Events

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 2, 2012 Media Advisory: To contact Sripal Bangalore, M.D., M.H.A., call Allison Clair at 212-404-3753 or email allison.clair@nyumc.org. CHICAGO – Among patients with either coronary artery disease (CAD) risk factors only, known prior heart attack, or known CAD without heart attack, the use of beta-blockers was not…

Vitamin D Supplementation Does Not Reduce Rate or Severity of Colds

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, OCTOBER 2, 2012 Media Advisory: To contact David R. Murdoch, M.D., email david.murdoch@otago.ac.nz. To contact editorial author Jeffrey A. Linder, M.D., M.P.H., call Marjorie Montemayor-Quellenberg at 617-534-2208 or email mmontemayor-quellenberg@partners.org. CHICAGO – Although some data have suggested a possible inverse association between serum vitamin D levels and the…

JAMA:09252012

Viewpoints in This Week’s JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 25, 2012 Bringing Diagnosis Into the Quality and Safety Equations Mark L. Graber, M.D., of RTI International, St. James, N.Y., and colleagues suggest that cases of delayed, missed and incorrect diagnosis are common, with an incidence in the range of 10 percent to 20 percent, and that…

Use of Corticosteroid For Children Undergoing Tonsillectomy Does Not Appear to Increase Risk of Serious Bleeding

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 25, 2012 Media Advisory: To contact corresponding author Christopher J. Hartnick, M.D., call Mary Leach at 617-573-4170 or email Mary_Leach@meei.harvard.edu. CHICAGO – Administration of the corticosteroid dexamethasone to children during a tonsillectomy was not associated with excessive, serious bleeding events following surgery compared to patients who received…

Study Examines Usage, Outcomes of Knee Replacement Procedures Among Medicare Patients

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 25, 2012 Media Advisory: To contact Peter Cram, M.D., M.B.A., call Tom Moore at 319-356-3945 or email thomas-moore@uiowa.edu. To contact editorial co-author Joseph D. Zuckerman, M.D., call Craig Andrews at 212-404-3511 or email Craig.Andrews@nyumc.org. CHICAGO – There has been an increase in total knee arthroplasty (TKA; knee…

JAMA:09182012

Also Appearing in This Week’s Obesity Theme Issue

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, SEPTEMBER 18, 2012 Higher Amounts of Aerobic Exercise By Overweight Children Reduces Risk of Diabetes Child obesity and overweight are epidemic among U.S. children, with a third of elementary school-aged children being overweight or obese. Childhood obesity is associated with a number of adverse conditions formerly thought…

Government Can Play Important Role in Obesity Epidemic

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, SEPTEMBER 18, 2012 Media Advisory: To contact Thomas A. Farley, M.D., M.P.H., call Jean Weinberg at 347-396-4177 or email jweinberg@health.nyc.gov. NEW YORK – Addressing the obesity epidemic by preventing excess calorie consumption with government regulation of portion sizes is justifiable and could be an effective measure to…

Obese Adults With Excess Abdominal Fat and Insulin Resistance Appear to Have Higher Risk of Developing Type 2 Diabetes

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, SEPTEMBER 18, 2012 Media Advisory: To contact James A. de Lemos, M.D., call Lisa Warshaw at 214-648-9349 or email lisa.warshaw@utsouthwestern.edu. NEW YORK – Obese adults with excess visceral fat (fat located inside the abdominal cavity, around the body’s internal organs) and biomarkers of insulin resistance had an…

Over Long-Term, Gastric Bypass Surgery Associated With Higher Rate of Diabetes Remission, Improvement in Cardiovascular Risk Factors

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, SEPTEMBER 18, 2012 Media Advisory: To contact Ted D. Adams, Ph.D., M.P.H., call Jennifer Barrett at 801-408-2182 or email jennifer.barrett@imail.org. To contact editorial author Anita P. Courcoulas, M.D., M.P.H., call Amy Dugas Rose at 412-586-9776 or email dugasak@upmc.edu. NEW YORK – Severely obese patients who had Roux-en-Y…

Higher Levels of BPA in Children and Teens Associated With Obesity

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, SEPTEMBER 18, 2012 Media Advisory: To contact Leonardo Trasande, M.D., M.P.P., call Jessica Guenzel at 212-404-3591 or email Jessica.Guenzel@nyumc.org. NEW YORK – In a nationally representative sample of nearly 3,000 children and adolescents, those who had higher concentrations of urinary bisphenol A (BPA), a manufactured chemical found…

JAMA:09112012

Also Appearing in This Week’s JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 11, 2012 Study Analyzes Changes in Pharmaceutical Advertising Following Shift to OTC Status “The U.S. Food and Drug Administration (FDA) regulates prescription drug advertising, including requirements to provide consumers with a ‘fair balance’ of risks and benefits. When prescription drugs switch to over-the-counter (OTC) status, regulatory oversight…

Study Examines Cost-Savings of Physician Group Practice Program That is Similar to Proposed Programs of Accountable Care Organizations

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 11, 2012 Media Advisory: To contact Carrie H. Colla, Ph.D., call Annmarie Christensen at 603-653-0897 or email annmarie.christensen@dartmouth.edu. To contact editorial author Donald M. Berwick, M.D., M.P.P., email donberwick1@gmail.com. CHICAGO – In an analysis of the cost-savings achieved by an earlier pilot program, the Medicare Physician Group…

Technique Using Computed Tomography Associated With Improved Detection of Lymph Node Metastasis in Patients With Melanoma

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 11, 2012 Media Advisory: To contact corresponding author Joachim Klode, M.D., email joachim.klode@uk-essen.de. CHICAGO – Preoperative 3-dimensional visualization of sentinel lymph nodes (SLNs) with a technique known as single-photon emission computed tomography/computed tomography was associated with a higher rate of detection of positive SLNs and a higher…

Research Finds Little Difference in Outcomes Among Strategies to Adjust Asthma Therapy in Adults

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 11, 2012 Media Advisory: To contact William J. Calhoun, M.D., call Raul Reyes at 409-747-0794 or email rareyes@utmb.edu. To contact editorial co-author George T. O’Connor, M.D., M.S., call Gina DiGravio at 617-638-8480 or email gina.digravio@bmc.org. CHICAGO – Among adults with asthma controlled with low-dose inhaled corticosteroid therapy,…

Omega-3 Fatty Acid Supplementation Not Associated With Lower Risk of Major Cardiovascular Disease Events

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 11, 2012 Media Advisory: To contact corresponding author Moses S. Elisaf, M.D., Ph.D., F.A.S.A., F.R.S.H., email egepi@cc.uoi.gr. CHICAGO – In a study that included nearly 70,000 patients, supplementation with omega-3 polyunsaturated fatty acids was not associated with a lower risk of all-cause death, cardiac death, sudden death,…

JAMA:09042012

Also Appearing in This Week’s JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 4, 2012 Prone Position During Breast Cancer Radiation Therapy Associated With Reduced Amount of Irradiation to Lung, Heart Radiation therapy to the breast contributes to improved outcomes in breast cancer patients after breast preservation surgery. “However, whole breast radiotherapy is associated with damage to the heart and…

Study Evaluates Association Between Clopidogrel Use and Mortality Risk in Heart Attack Patients With Diabetes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 4, 2012 Media Advisory: To contact Charlotte Andersson, M.D., Ph.D., email ca@heart.dk. To contact editorial author Deepak L. Bhatt, M.D., M.P.H., call Lori Schroth at 617-534-1604 or email ljschroth@partners.org. CHICAGO – In a study that included nearly 60,000 patients with a first-time heart attack, patients with diabetes…

Use of Biologic Therapy for Rheumatoid Arthritis Not Significantly Associated With Increased Risk of Malignancy

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 4, 2012 Media Advisory: To contact corresponding author Maria E. Suarez-Almazor, M.D., Ph.D., call Julie Penne at 713-792-0662 or email jpenne@mdanderson.org. CHICAGO – Although there are concerns regarding the potential development of malignancies in patients with rheumatoid arthritis who are receiving treatment with biologic response modifiers (BRMs),…

Cardiac Study Evaluates Prevalence of Unrecognized Heart Attacks Among Older Adults

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 4, 2012 Media Advisory: To contact corresponding author Andrew E. Arai, M.D., call Nick Zagorski at 301-496-4236 or email nicholas.zagorski@nih.gov. CHICAGO – Using cardiac magnetic resonance imaging among older adults in Iceland, researchers estimated the prevalence of unrecognized heart attacks, which was associated with an increased risk…

Stiffening of Aortic Wall Linked With Increased Risk of High Blood Pressure

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, SEPTEMBER 4, 2012 Media Advisory: To contact corresponding author Gary F. Mitchell, M.D., call 781-255-6930 or email garyfmitchell@gmail.com. To contact editorial author Debabrata Mukherjee, M.D., M.S., call Laura Gallegos at 915-309-5647 or email laura.gallegos@ttuhsc.edu. CHICAGO – An analysis of the relationship between several vascular function measures and blood…

JAMA_OF:08272012

JAMA_OF:08262012

Study Examines Factors Associated With Improvement in Survival From Heart Attack in France

EMBARGOED FOR EARLY RELEASE: 1 A.M. (CT) MONDAY, AUGUST 27, 2012 Media Advisory: To contact corresponding author Nicolas Danchin, M.D., Ph.D., email nicolas.danchin@egp.aphp.fr. CHICAGO – The overall rate of death in patients hospitalized with ST-segment elevation myocardial infarction (STEMI; a certain pattern on an electrocardiogram following a heart attack) decreased from 1995 to 2010 in…

Diagnostic Test Shows Potential As Method to Noninvasively Identify Significant Coronary Artery Disease

EMBARGOED FOR EARLY RELEASE: 1 A.M. (CT) SUNDAY, AUGUST 26, 2012 Media Advisory: To contact James K. Min, M.D., call Sally Stewart at 310-423-4768 or email sally.stewart@cshs.org. To contact editorial author Manesh R. Patel, M.D., call Sarah Avery at 919-660-1306 or email sarah.avery@duke.edu. CHICAGO – Among patients with suspected or known coronary artery disease, use…

JAMA:08222012

Viewpoints in This Week’s JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 21, 2012 Preventing Patient Harms Through Systems of Care Peter J. Pronovost, M.D., Ph.D., of the Johns Hopkins Medical Institutions, Baltimore, and George W. Bo-Linn, M.D., M.H.A., of the Gordon and Betty Moore Foundation, Palo Alto, Calif., discuss the problem of preventable harms to patients, which include…

Addition of Carotid Artery Wall Thickness to Risk Model Associated With Small Improvement in Prediction of Heart Attack, Stroke

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 21, 2012 Media Advisory: To contact co-author Michiel L. Bots, M.D., Ph.D., email m.l.bots@umcutrecht.nl. CHICAGO – In an analysis of data from previously published studies that included more than 45,000 patients, the value of adding to the Framingham Risk Score a measure of the common carotid artery…

Statin Therapy Associated With Lower Risk of Pancreatitis

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 21, 2012 Media Advisory: To contact David Preiss, M.D., Ph.D., email david.preiss@glasgow.ac.uk. CHICAGO – Although some studies have suggested that use of lipid-lowering therapies may increase the risk of pancreatitis, an analysis that involved pooling of data from previous studies and included more than 150,000 participants found…

Use of Newer-Generation Drug-Releasing Stent Results in Lower Rate of Adverse Cardiac Events For Heart Attack Patients

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 21, 2012 Media Advisory: To contact corresponding author Stephan Windecker, M.D., email stephan.windecker@insel.ch. To contact editorial co-author Adnan Kastrati, M.D., email kastrati@dhm.mhn.de. CHICAGO – Compared with a bare-metal stent, the use of a stent with a biodegradable polymer that releases the drug biolimus resulted in a lower…

Measure of Coronary Artery Calcium Associated With Improved Prediction of Cardiovascular Disease Risk

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 21, 2012 Media Advisory: To contact Joseph Yeboah, M.D., M.S., call Marguerite Beck at 336-716-2415 or email marbeck@wakehealth.edu. To contact editorial co-author J. Michael Gaziano, M.D., M.P.H., call Lori Schroth at 617-534-1604 or email ljschroth@partners.org. CHICAGO – In a comparison of novel cardiovascular risk markers, coronary artery…