JAMA:08202013

Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 20, 2013 Study Shows Gypsum Wallboard Does Not Keep Out Carbon Monoxide, Questioning CO Detector Exemptions For Certain Types of Residences “Carbon monoxide (CO) poisoning is a significant U.S. health problem, responsible for approximately 500 accidental deaths annually, and a risk of 18 percent to 35 percent…

Study Examines Genetic Associations for Gastrointestinal Condition in Infants

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 20, 2013 Media Advisory: To contact Bjarke Feenstra, Ph.D., email fee@ssi.dk. CHICAGO – Researchers have identified a new genome-wide significant locus (the place a gene occupies on a chromosome) for infantile hypertrophic pyloric stenosis (IHPS), a serious gastrointestinal condition associated with gastrointestinal obstruction, according to a study…

Lateral Wedge Insoles Not Associated With Improvement of Knee Pain in Osteoarthritis

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 20, 2013 Media Advisory: To contact Matthew J. Parkes, B.Sc., email matthew.parkes@manchester.ac.uk CHICAGO – Although a pooling of data from 12 studies showed a statistically significant association between use of lateral wedge insoles and lower pain in medial knee osteoarthritis, among trials comparing wedge insoles with neutral…

Higher Urinary Albumin Excretion Associated With Increased Risk of Coronary Heart Disease Among Black Adults

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 20, 2013 Media Advisory: To contact Orlando M. Gutierrez, M.D., M.M.Sc., call Tyler Greer at 205-934-2041 or email tgreer@uab.edu. To contact editorial co-author Wolfgang C. Winkelmayer, M.D., Sc.D., call Tracie White at 650-723-7628 or email traciew@stanford.edu. CHICAGO – In a large national study, higher levels of the…

Implementation of Multifaceted Hypertension Quality Improvement Program Associated With Increase in Blood Pressure Control Rates

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 20, 2013 Media Advisory: To contact Marc G. Jaffe, M.D., call Ann Marie Wallace at 510-390-3355 or email ann.m.wallace@kp.org; or call Joe Fragola at 415-902-3737 or email joe.c.fragola@kp.org. To contact editorial co-author Abhinav Goyal, M.D., M.H.S., call Jennifer Johnson McEwen at 404-727-5696 or email jrjohn9@emory.edu. CHICAGO –…

JAMA:08132013

Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 13, 2013 Study Examines Incidence of Sports-Related Sudden Death in France “Although screening programs prior to participation in sports have been used for many years for young competitive athletes, it has been suggested that screening programs might also be worthwhile in the general population. Description of the…

Earlier Surgical Correction of Heart Valve Disorder Associated With Greater Long-Term Survival, Lower Risk of Heart Failure Risk

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 13, 2013 Media Advisory: To contact Rakesh M. Suri, M.D., D.Phil., call Traci Klein at 507-284-5005 or email Klein.traci@mayo.edu. To contact editorial author Catherine M. Otto, M.D., call Leila Gray at 206-685-0381 or email leilag@uw.edu. CHICAGO – In a study that included patients with mitral valve regurgitation…

Study Identifies Characteristics of Heart Failure Patients More Likely to Benefit From Implantation of Cardiac Resynchronization Device

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 13, 2013 Media Advisory: To contact Pamela N. Peterson, M.D., M.S.P.H., call Jenny Bertrand at 303-520-9591 or email Jennifer.bertrand@dhha.org. CHICAGO – In a large population of Medicare beneficiaries with heart failure who underwent implantation of a cardiac resynchronization therapy defibrillator, patients who had the cardiac characteristics of…

JAMA:08062013

Also Appearing in This Violence/Human Rights Theme Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 6, 2013 Number of Scientific Publications on Firearms Shows Modest Increase in Recent Years “In January 1996, Congress passed an appropriations bill amendment prohibiting the U.S. Centers for Disease Control and Prevention (CDC) from using ‘funds made available for injury prevention … to advocate or promote gun…

Research Examines Importance of Identifying Need, Providing Delivery of Mental Health Services Following Community Disasters

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 6, 2013 Media Advisory: To contact Carol S. North, M.D., M.P.E., call Russell Rian at 214-648-3404 or email russell.rian@utsouthwestern.edu. CHICAGO – A review of articles on disaster and emergency mental health response interventions and services indicates that in postdisaster settings, a systematic framework of case identification, triage,…

Treatment for PTSD Does Not Appear to Increase Risk of Drinking Among Individuals With Alcohol Dependence and PTSD

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 6, 2013 Media Advisory: To contact Edna B. Foa, Ph.D., call Steve Graff at 215-349-5653 or email Stephen.Graff@uphs.upenn.edu. To contact editorial author Katherine Mills, Ph.D., email k.mills@unsw.edu.au. CHICAGO – In a trial that included patients with alcohol dependence and posttraumatic stress disorder (PTSD), treatment with the drug…

Mental Disorders But Not Deployment-Related Variables Associated With Suicide Risk Among Current and Former U.S. Military Personnel

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, AUGUST 6, 2013 Media Advisory: To contact Cynthia A. LeardMann, M.P.H., call Karl Van Orden at 619-553-9289 or email Karl.VanOrden@med.navy.mil. To contact editorial author Charles C. Engel, M.D., M.P.H., call Gwendolyn Smalls at 301-295-3981 or email gwendolyn.smalls@usuhs.edu. CHICAGO – In an examination of risk factors associated with suicide…

JAMA:07232013

Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 23, 2013 Increasing Incidence of Type 1 Diabetes Among Children in Finland Appears to Have Leveled Off “The incidence of type l diabetes (T1D), one of the most prevalent chronic diseases in children, has increased worldwide,” write Valma Harjutsalo, Ph.D., of the Diabetes Prevention Unit, Helsinki, Finland,…

Kidney Stones Associated With Modest Increased Risk of Coronary Heart Disease in Women, But Not Men

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 23, 2013 Media Advisory: To contact Pietro Manuel Ferraro, M.D., email manuel.ferraro@channing.harvard.edu.   CHICAGO – An analysis of data from three studies that involved a total of more than 240,000 participants found that a self-reported history of kidney stones was associated with a statistically significant increased risk…

Survey Assesses Views of Physicians Regarding Controlling Health Care Costs

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 23, 2013 Media Advisory: To contact Jon C. Tilburt, M.D., M.P.H., call Shelly Plutowski at 507-284-5005 or email newsbureau@mayo.edu. To contact editorial co-author Ezekiel J. Emanuel, M.D., Ph.D., call Katie Delach at 215-349-5964 or email Katie.Delach@uphs.upenn.edu. CHICAGO – In a survey of about 2,500 U. S. physicians…

Report Documents Organ Transplantation as Source of Fatal Rabies Virus Case

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 23, 2013 Media Advisory: To contact corresponding author Matthew J. Kuehnert, M.D., call Melissa Dankel at 404-639-4718 or email mdankel@cdc.gov. To contact editorial author Daniel R. Kaul, M.D., call Shantell Kirkendoll at 734-764-2220 or email smkirk@umich.edu. CHICAGO – An investigation into the source of a fatal case…

Difference in Breast Cancer Survival Between Black and White Women Has Not Changed Substantially

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 23, 2013 Media Advisory: To contact Jeffrey H. Silber, M.D., Ph.D., call Dana Mortensen at 267-426-6092 or email mortensen@email.chop.edu. To contact editorial co-author Jeanne S. Mandelblatt, M.D., M.P.H., call Karen Mallet at 215-514-9751 or email km463@georgetown.edu. CHICAGO – In an analysis of 5-year survival rates among black…

JAMA:07162013

Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 16, 2013 Survival Poor For Nursing Home Residents With Advanced Cognitive Impairment Who Undergo Multiple Hospitalizations For Infections or Dehydration “Multiple hospitalizations for complications from a terminal illness may be burdensome for elderly patients and reflect poor quality care,” write Joan M. Teno, M.D., M.S., of the…

Use of Androgen Deprivation Therapy For Treatment of Prostate Cancer Associ¬ated With Increased Risk of Acute Kidney Injury

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 16, 2013 Media Advisory: To contact corresponding author Samy Suissa, Ph.D., call Tod Hoffman at 514-340-8222, ext. 8661 or email thoffman@jgh.mcgill.ca. CHICAGO – In a study that included more than 10,000 men with nonmetastatic prostate cancer, use of androgen deprivation therapy (ADT) was associated with a significantly…

Combination Therapy May Help Improve Rate of Survival With Favorable Neurological Status Following Cardiac Arrest

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 16, 2013 Media Advisory: To contact Spyros D. Mentzelopoulos, M.D., email sdmentzelopoulos@yahoo.com. CHICAGO – Among patients who experienced in-hospital cardiac arrest requiring vasopressors (drugs that increase blood pressure), use of a combination therapy during cardiopulmonary resuscitation resulted in improved survival to hospital discharge with favorable neurological status,…

Study Examines Characteristics, Features of West Nile Virus Outbreaks

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 16, 2013 Media Advisory: To contact corresponding author Robert W. Haley, M.D., call Russell Rian at 214-648-3404 or email russell.rian@utsouthwestern.edu. To contact Lyle R. Petersen, M.D., M.P.H., call Candice Hoffmann at 404-639-7689 or email hqx5@cdc.gov. To contact editorial author Stephen M. Ostroff, M.D., email sostroff@verizon.net. CHICAGO –…

Longer Duration of Obesity Associated With Subclinical Coronary Heart Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 16, 2013 Media Advisory: To contact Jared P. Reis, Ph.D., call the NHLBI Communications Office at 301-496-4236 or email nhlbi_news@nhlbi.nih.gov. CHICAGO – In a study of adults recruited and followed up over the past 3 decades in the United States, longer duration of overall and abdominal obesity…

JAMA_OF:07102013

Major Study Finds That Overall Population Health in U.S. Has Improved, But Has Not Kept Pace With Other Wealthy Nations

EMBARGOED FOR EARLY RELEASE: 9 A.M. (CT) WEDNESDAY, JULY 10, 2013 Media Advisory: To contact Christopher J. L. Murray, M.D., D.Phil., call William Heisel at 206-897-2886 or email wheisel@uw.edu. To contact editorial author Harvey V. Fineberg, M.D., Ph.D., call Jennifer Walsh at 202-334-2183 or email JWalsh@nas.edu. CHICAGO – In a major study that includes data…

JAMA:07092013

Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 9, 2013 Dual Antiplatelet Therapy Following Coronary Stent Implantation is Associated With Improved Outcomes Emmanouil S. Brilakis, M.D., Ph.D., of the VA North Texas Health Care System and University of Texas Southwestern Medical Center at Dallas, and colleagues conducted a review of medical literature regarding optimal medical…

Research Examines Differences in Rates of Cardiac Catheterization Between New York State and Ontario

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 9, 2013 Media Advisory: To contact Dennis T. Ko, M.D., M.Sc., call Deborah Creatura at 416-480-4780 or email deborah.creatura@ices.on.ca. CHICAGO – The increased use of cardiac catheterization in New York relative to Ontario appears related to selecting more patients at low risk of obstructive coronary artery disease,…

Soy Protein Supplementation Does Not Reduce Risk of Prostate Cancer Recurrence After Radical Prostatectomy

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 9, 2013 Media Advisory: To contact Maarten C. Bosland, D.V.Sc., Ph.D., call Sherri McGinnis Gonzalez at 312-996-8277 or email smcginn@uic.edu. CHICAGO – Among men who had undergone radical prostatectomy, daily consumption of a beverage powder supplement containing soy protein isolate for 2 years did not reduce or…

Rates of Major Cardiovascular Procedures Differ Between Medicare Advantage and Fee-For-Service Beneficiaries

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 9, 2013 Media Advisory: To contact Daniel D. Matlock, M.D., M.P.H., call Mark Couch at 303-724-5377 or email Mark.Couch@ucdenver.edu. To contact editorial author Harlan M. Krumholz, M.D., S.M., call Karen Peart at 203-432-1326 or email karen.peart@yale.edu. CHICAGO – In a study that included nearly 6 million Medicare Advantage…

Association of Low Vitamin D Levels With Risk of Coronary Heart Disease Events Differs By Race, Ethnicity

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 9, 2013 Media Advisory: To contact corresponding author Ian H. de Boer, M.D., M.S., call Leila Gray at 206-685-0381 or email leilag@uw.edu. To contact corresponding author Keith C. Norris, M.D., call Rachel Champeau at 310-794-0777 or email Rchampeau@mednet.ucla.edu. CHICAGO – In a multiethnic group of adults, low…

JAMA:07022013

Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 2, 2013 The Paradox of Disease Prevention – Celebrated in Principle, Resisted in Practice In a Special Communication, Harvey V. Fineberg, M.D., Ph.D., of the Institute of Medicine, Washington, D.C., examines a number of the reasons that disease prevention in clinical medicine and public health is often…

Home-Based Walking Exercise Program Improves Speed and Endurance for Patients with PAD

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 2, 2013 Media Advisory: To contact Mary M. McDermott, M.D., call Erin White at 847-491-4888 or email ewhite@northwestern.edu. CHICAGO – In a trial that included nearly 200 participants with peripheral artery disease (PAD), a home-based exercise intervention with a group-mediated cognitive behavioral intervention component improved walking performance…

Study Examines Screening Using Peptide Level and Collaborative Care to Help Reduce Risk of Heart Failure

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 2, 2013 Media Advisory: To contact corresponding author Kenneth McDonald, M.D., email kenneth.mcdonald@ucd.ie or call 353-86-825-5428. To contact editorial author Adrian F. Hernandez, M.D., M.H.S., call Sarah Avery at 919-660-1306 or email sarah.avery@duke.edu. CHICAGO – Among patients at risk of heart failure, collaborative care based on screening…

Study Finds In Vitro Fertilization Associated With Small Increased Risk of Mental Retardation

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 2, 2013 Media Advisory: To contact Sven Sandin, M.Sc., email Sven.Sandin@ki.se. To contact editorial author Marcelle I. Cedars, M.D., call Karin Rush-Monroe at 415-502-NEWS or email Karin.Rush-Monroe@ucsf.edu. CHICAGO – In a study that included more than 2.5 million children born in Sweden, compared with spontaneous conception, any…

Intervention Helps Improve and Maintain Better Blood Pressure Control

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JULY 2, 2013 Media Advisory: To contact Karen L. Margolis, M.D., M.P.H., call Annelise Searle at 952-883-5308 or email Annelise.m.searle@healthpartners.com. To contact editorial co-author David J. Magid, M.D., M.P.H., call Amy Whited at 303-344-7518 or email amy.l.whited@kp.org. CHICAGO – An intervention that consisted of home blood pressure (BP)…

JAMA:06252013

JAMA:06242013

JAMA:06232013

Study Examines Prevalence, Characteristics of Traumatic Brain Injuries Among Adolescents

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 25, 2013 Media Advisory: To contact Gabriela Ilie, Ph.D., call Leslie Shepherd at 416-864-6094 or email shepherdl@smh.ca. “Traumatic brain injury (TBI) among adolescents has been identified as an important health priority. However, studies of TBI among adolescents in large representative samples are lacking. This information is important…

Gene Mutation May Have Effect on Benefit of Aspirin Use for Colorectal Cancer

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 25, 2013 Media Advisory: To contact corresponding author Andrew T. Chan, M.D., M.P.H., call Jessica Maki at 617-534-1603 or email jmaki3@partners.org; for corresponding author Shuji Ogino, M.D., Ph.D., M.S., call Anne Doerr at 617-632-5665 or email anne_doerr@dfci.harvard.edu. To contact editorial author Boris Pasche, M.D., Ph.D., call Beena…

Increase Seen in Use of Advanced Treatment Technologies For Prostate Cancer Among Men With Low-Risk Disease

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 25, 2013 Media Advisory: To contact corresponding author Brent K. Hollenbeck, M.D., M.S., call Justin Harris at 734-764-2220 or email juaha@umich.edu. CHICAGO – Use of advanced treatment technologies for prostate cancer, such as intensity-modulated radiotherapy and robotic prostatectomy, has increased among men with low-risk disease, high risk…

Ability to Lower Costs For Higher-Cost Medicare Patients Through Better Outpatient Care May Be Limited

EMBARGOED FOR EARLY RELEASE: 10:30 A.M. (CT) MONDAY, JUNE 24, 2013 Media Advisory: To contact Karen E. Joynt, M.D., M.P.H., call Marge Dwyer at 617-432-8416 or email mhdwyer@hsph.harvard.edu. To contact editorial co-author Aaron E. Carroll, M.D., M.S., call Mary Hardin at 317-274-5456 or email mhardin@iu.edu. CHICAGO – In an analysis that included a sample of…

Low-Income Uninsured Adults Who May Be Eligible For Medicaid Under the ACA Less Likely to Have Chronic Conditions Compared With Medicaid Enrollees

EMBARGOED FOR EARLY RELEASE: 8 A.M. (CT) SUNDAY, JUNE 23, 2013 Media Advisory: To contact Sandra L. Decker, Ph.D., call Jeff Lancashire at 301-458-4800 or email jhl1@cdc.gov. To contact co-author Genevieve M. Kenney, Ph.D., call 202-261-5568 or email jkenney@urban.org. CHICAGO – Compared with adults already enrolled in Medicaid, low-income uninsured adults who may be eligible…

JAMA:06182013

Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 18, 2013 Study Finds Need for Improvement on State Health Care Price Websites “With rising health care costs and 30 percent of privately insured adults enrolled in high-deductible health care plans, calls for greater health care price transparency are increasing. In response, health plans, consumer groups, and…

Study Evaluates Procedures for Diagnosing Sarcoidosis

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 18, 2013 Media Advisory: To contact corresponding author Jouke T. Annema, M.D., Ph.D., email j.t.annema@amc.nl. CHICAGO – Among patients with suspected stage I/II pulmonary sarcoidosis who were undergoing confirmation of the condition via tissue sampling, the use of the procedure known as endosonographic nodal aspiration compared with…

Markers of Beta-Cell Dysfunction Associated With High Rate of Progression to Type 1 Diabetes

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 18, 2013 Media Advisory: To contact Anette G. Ziegler, M.D., email anette-g.ziegler@helmholtz-muenchen.de. To contact editorial co-author Jay S. Skyler, M.D., call Lisa Worley at 305-243-5184 or email lworley2@med.miami.edu. CHICAGO – The majority of children at risk of type 1 diabetes who developed 2 or more diabetes-related autoantibodies…

MMR Booster Vaccine Does Not Appear to Worsen Disease Activity in Children With Juvenile Arthritis

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 18, 2013 Media Advisory: To contact Marloes W. Heijstek, M.D., email m.w.heijstek@umcutrecht.nl. CHICAGO – Among children with juvenile idiopathic arthritis (JIA) who had undergone primary immunization, the use of a measles-mumps-rubella (MMR) booster compared with no booster did not result in worse JIA disease activity, according to…

MRI Screening May Help Identify Spinal Infections From Contaminated Drug Injections

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 18, 2013 Media Advisory: To contact Anurag N. Malani, M.D., call Laura Blodgett at 734-712-4536 or email blodgetl@trinity-health.org. To contact editorial co-author Thomas F. Patterson, M.D., call Sheila Hotchkin at 210-567-3026 or email Hotchkin@uthscsa.edu. CHICAGO – Magnetic resonance imaging (MRI) at the site of injection of a…

Earlier Treatment Following Stroke Onset Associated With Reduced Risk of In-Hospital Death, Higher Rate of Discharge to Home

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 18, 2013 Media Advisory: To contact Jeffrey L. Saver, M.D., call Kim Irwin at 310-794-2262 or email kirwin@mednet.ucla.edu; or call Rachel Champeau at 310-794-2270 or email rchampeau@mednet.ucla.edu. CHICAGO – In a study that included nearly 60,000 patients with acute ischemic stroke, thrombolytic treatment (to help dissolve a…

JAMA:06112013

Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 11, 2013 Hearing Loss Associated With Hospitalization, Poorer Self-Reported Health “Hearing loss (HL) is a chronic condition that affects nearly 2 of every 3 adults aged 70 years or older in the United States. Hearing loss has broader implications for older adults, being independently associated with poorer…

Certain Inflammatory Biomarkers Associated With Increased Risk of COPD Exacerbations

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 11, 2013 Media Advisory: To contact corresponding author Borge G. Nordestgaard, D.M.Sc., email Boerge.Nordestgaard@regionh.dk. To contact editorial co-author Sanjay Sethi, M.D., call Ellen Goldbaum at 716-645-4605 or email goldbaum@buffalo.edu. CHICAGO – Simultaneously elevated levels of the biomarkers C-reactive protein, fibrinogen and leukocyte count in individuals with chronic…

Maternal Overweight and Obesity During Pregnancy Associated With Increased Risk of Preterm Delivery

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 11, 2013 Media Advisory: To contact Sven Cnattingius, M.D., Ph.D., email sven.cnattingius@ki.se. CHICAGO – In a study that included more than 1.5 million deliveries in Sweden, maternal overweight and obesity during pregnancy were associated with increased risk for preterm delivery, with the highest risks observed for extremely…

Study Finds Very High Prevalence of Chronic Health Conditions Among Adult Survivors of Childhood Cancer

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 11, 2013 Media Advisory: To contact Melissa M. Hudson, M.D., call Summer Freeman at 901-595-3061 or email summer.freeman@stjude.org. CHICAGO – In an analysis that included more than 1,700 adult survivors of childhood cancer, researchers found a very high percentage of survivors with 1 or more chronic health…

Intervention Results in Improved Adherence to Prescribing Guidelines for Bacterial Respiratory Tract Infections of Children

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 11, 2013 Media Advisory: To contact Jeffrey S. Gerber, M.D., Ph.D., call Rachel Salis-Silverman at 267-426-6063 or email Salis@email.chop.edu. To contact editorial author Jonathan A. Finkelstein, M.D., M.P.H., call Meghan Weber at 617-919-3656 or email Meghan.Weber@childrens.harvard.edu. CHICAGO – An intervention consisting of clinician education coupled with personalized…

JAMA:06042013

Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 4, 2013 Research Finds Retinal Vessel Leakage During High Altitude Exposure “Exposure to high altitude can cause acute mountain sickness (AMS) and, in severe cases, cerebral or pulmonary edema. Capillary leakage has been hypothesized to play a role in the pathogenesis of AMS, although the mechanism of…

Study Finds Little Evidence Supporting Use of Bariatric Surgical Procedures for Non-Morbidly Obese Adults With Diabetes or Glucose Intolerance

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 4, 2013 Media Advisory: To contact Melinda Maggard-Gibbons, M.D., M.S.H.S., call Warren Robak at 310-451-6913 or email robak@rand.org. CHICAGO – A review of more than 50 studies found limited evidence supporting the use of bariatric surgical procedures for non-morbidly obese adults (body mass index [BMI] 30-35) with…

Gastric Bypass Surgery May Help Manage Diabetes Risk Factors

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, JUNE 4, 2013 Media Advisory: To contact Sayeed Ikramuddin, M.D., call Matt DePoint at 612-625-4110 or email mdepoint@umn.edu. To contact editorial author Bruce M. Wolfe, M.D., call Mirabai Vogt at 503-494-7986 or email vogtmi@ohsu.edu. CHICAGO – Among mild to moderately obese patients with type 2 diabetes, adding gastric…

JAMA_OF:05202013

JAMA_OF:05212013

JAMA:05212013

Viewpoints in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 21, 2013 Advances in Regulatory Science at the Food and Drug Administration In this Viewpoint, Bruce M. Psaty, M.D., Ph.D., of the University of Washington, Seattle, and colleagues discuss advances in recent years at the U.S. Food and Drug Administration (FDA) to improve drug evaluation. “The mark…

Early Use of Tracheostomy For Mechanically Ventilated Patients Not Associated With Improved Survival

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 21, 2013 Media Advisory: To contact Duncan Young, D.M., email duncan.young@nda.ox.ac.uk. To contact editorial author Derek C. Angus, M.D., M.P.H., call Rick Pietzak at 412-864-4151 or email pietzakr@upmc.edu. CHICAGO – For critically ill patients receiving mechanical ventilation, early tracheostomy (within the first 4 days after admission) was…

Treatment With Antidepressant Results in Lower Rate of Mental Stress-Induced Cardiac Ischemia

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 21, 2013 Media Advisory: To contact Wei Jiang, M.D., call Rachel Harrison at 919-419-5069 or email rachel.harrison@duke.edu. CHICAGO – Among patients with stable coronary heart disease and mental stress-induced myocardial ischemia (MSIMI), 6 weeks of treatment with the antidepressant escitalopram, compared with placebo, resulted in a lower…

Genetic Variation Among Patients With Pulmonary Fibrosis Associated With Improved Survival

EMBARGOED FOR EARLY RELEASE: 1:00 P.M. (CT) TUESDAY, MAY 21, 2013 Media Advisory: To contact corresponding author David A. Schwartz, M.D., call Mark Couch at 303-724-5377 or email Mark.Couch@ucdenver.edu. CHICAGO – Variation in the gene MUC5B among patients with idiopathic pulmonary fibrosis was associated with improved survival, according to a study published online by JAMA….

Shorter Duration Steroid Therapy May Offer Similar Effectiveness In Reducing COPD Exacerbations

EMBARGOED FOR EARLY RELEASE: 1:00 P.M. (CT) TUESDAY, MAY 21, 2013 Media Advisory: To contact Jorg D. Leuppi, M.D., Ph.D., email joerg.leuppi@ksli.ch. To contact editorial co-author Don D. Sin, M.D., call Justin Karasick at 604-806-8460 or email jkarasick@providencehealth.bc.ca. CHICAGO – Among patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) requiring hospital admission, a…

Providing Intravenous Nutrition Within 24 Hours For Certain Critically Ill Patients Does Not Appear to Improve Survival or Reduce ICU Length of Stay

EMBARGOED FOR EARLY RELEASE: 1:00 P.M. (CT) MONDAY, MAY 20, 2013 Media Advisory: To contact Gordon S. Doig, Ph.D., email gdoig@med.usyd.edu.au. To contact editorial co-author Juan B. Ochoa Gautier, M.D., call Rick Pietzak at 412-864-4151 or email pietzakr@upmc.edu. CHICAGO – The early (within 24 hours of intensive care unit [ICU] admission) provision of intravenous nutrition…

Music Therapy Appears to Help Reduce Anxiety, Use of Sedatives For Patients Receiving Ventilator Support

EMBARGOED FOR EARLY RELEASE: 1:00 P.M. (CT) MONDAY, MAY 20, 2013 Media Advisory: To contact Linda L. Chlan, Ph.D., R.N., call Kathryn Kelley at 614-688-1062 or email kelley.81@osu.edu. To contact editorial co-author Elie Azoulay, M.D., Ph.D., email elie.azoulay@sls.aphp.fr. CHICAGO – Among intensive care unit patients receiving acute ventilatory support for respiratory failure, use of patient-preferred…

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Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 14, 2013 No Significant Change Seen in Overall Smokeless Tobacco Use Among U.S. Youths Tobacco use remains the leading preventable cause of death and disease in the United States. Declines in smoking among youths were observed from the late 1990s. “However, limited information exists on trends in…

Study Evaluates Long-Term Effectiveness of Surgery for Pelvic Organ Prolapse

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 14, 2013 Media Advisory: To contact Ingrid Nygaard, M.D., call Phil Sahm at 801-581-2517 or email phil.sahm@hsc.utah.edu. To contact editorial author Cheryl B. Iglesia, M.D., call Karen Mallet at 215-514-9751 or email km463@georgetown.edu. CHICAGO – Results after seven years of follow-up suggest that women considering abdominal sacrocolpopexy…

Dual Chamber ICDs Show Higher Risk of Complications

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 14, 2013 Media Advisory: To contact Pamela N. Peterson, M.D., M.S.P.H., call Jenny Bertrand at 303-602-4924 or email Jennifer.bertrand@dhha.org. CHICAGO – Even though patients receiving an implantable cardioverter-defibrillator (ICD) for primary prevention often receive a dual-chamber ICD, an analysis that included more than 32,000 patients receiving an…

Elective Cesarean Delivery Requested by Pregnant Women Requires Careful Consideration of Potential Benefits and Risks

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 7, 2013 Media Advisory:  To contact Jeffrey Ecker, M.D., call Susan McGreevey at 617-724-2764 or email: smcgreevey@partners.org   CHICAGO – A Clinical Crossroads review article in the May 8 issue of JAMA discusses the potential benefits and risks for pregnant women who request cesarean delivery without an…

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Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 7, 2013 Study Finds Increase in Fall-Related Traumatic Brain Injuries Among Elderly Men and Women “Traumatic brain injury (TBI) is a major cause of hospitalization, disability, and death-worldwide, and among older adults, falling is the most common cause of TBI,” writes Niina Korhonen, B.M., of the Injury…

Genetic Variations Associated With Susceptibility to Bacteria Linked to Stomach Disorders

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 7, 2013 Media Advisory: To contact corresponding author Markus M. Lerch, M.D., F.R.C.P., email lerch@uni-greifswald.de. To contact editorial author Emad M. El-Omar, M.D., email e.el-omar@abdn.ac.uk. CHICAGO – Two genome-wide association studies and a subsequent meta-analysis have found that certain genetic variations are associated with susceptibility to Helicobacter…

Study Evaluates Effect of Increasing Detection Intervals in ICDs on Pacing Function, ICD Shocks Delivered, and Inappropriate Shocks

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, MAY 7, 2013 Media Advisory: To contact Maurizio Gasparini, M.D., email maurizio.gasparini@humanitas.it. To contact editorial author Merritt H. Raitt, M.D., call Tamara Hargens-Bradley at 503-494-8231 or email hargenst@ohsu.edu. CHICAGO – Programming an implantable cardioverter-defibrillator (ICD) with a long-detection interval compared with a standard-detection interval resulted in a reduction…

Adding Omega-3 Fatty Acids and Lutein/Zeaxanthin to Formulation Does Not Further Reduce Risk of Progression to Advanced AMD

EMBARGOED FOR EARLY RELEASE: 6 P.M. (CT) SUNDAY, MAY 5, 2013 Media Advisory: To contact Emily Y. Chew, M.D., call Jean Horrigan at 301-496-5248 or email jh@nei.nih.gov. CHICAGO – In a large, multicenter, randomized clinical trial that included persons at high risk for progression to advanced age-related macular degeneration (AMD), adding the carotenoids lutein and…

Study Examines Effect of Different Oxygen Saturation Levels on Death or Disability in Extremely Preterm Infants

EMBARGOED FOR EARLY RELEASE: 8:15 A.M. (CT) SUNDAY, MAY 5, 2013 Media Advisory: To contact Barbara Schmidt, M.D., M.Sc., call Alison Fraser at 267-426-6054 or email FraserA1@email.chop.edu. To contact editorial co-author Eduardo Bancalari, M.D., call Lisa Worley at 305-243-5184 or email LWorley2@med.miami.edu. CHICAGO – In a randomized trial performed to help resolve the uncertainty about…

Risk of Death Has Decreased Substantially For Children Initially Treated With Dialysis for End-Stage Kidney Disease

EMBARGOED FOR EARLY RELEASE: 11:15 A.M. (CT) SATURDAY, MAY 4, 2013 Media Advisory: To contact corresponding author Bethany J. Foster, M.D., M.Sc., call Julie Robert at 514-934-1934 ext. 71381; or email julie.robert@muhc.mcgill.ca. CHICAGO – In a study that included more than 20,000 patients, there was a significant decrease in the United States in mortality rates…

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Other Articles in This Child Health Theme Issue of JAMA

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, APRIL 30, 2013 Antiretroviral Regimen Associated With Less Virological Failure Among HIV-Infected Children Elizabeth D. Lowenthal, M.D., M.S.C.E., of the University of Pennsylvania Perelman School of Medicine and Children’s Hospital of Philadelphia, and colleagues conducted a study to determine whether there was a difference in time to…

Shedding Light on the Long Shadow of Childhood Adversity

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, APRIL 30, 2013 Media Advisory: To contact David A. Brent, M.D., call Cristina Mestre at 412-586-9776 or email mestreca@upmc.edu. NEW YORK – Childhood adversity can lead to chronic physical and mental disability in adult life and have an effect on the next generation, underscoring the importance of…

Genetic Variants For Infants With Neonatal Abstinence Syndrome Associated With Shorter Hospital Stay, Less Treatment

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, APRIL 30, 2013 Media Advisory: To contact Jonathan M. Davis, M.D., call Julie Jette at 617-636-3265 or email jjette@tuftsmedicalcenter.org. NEW YORK – Among infants with neonatal abstinence syndrome (NAS; caused by in utero opioid exposure), variants in certain genes were associated with a shorter length of hospital…

Study Finds That 2 Doses of HPV Vaccine in Girls May Offer Similar Level of Infection Protection as 3 Doses in Young Women

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, APRIL 30, 2013 Media Advisory: To contact Simon R. M. Dobson, M.D., call Brian Lin at 604-822-2234 or email brian.lin@ubc.ca. To contact editorial co-author Jessica A. Kahn, M.D., M.P.H., call Nick Miller at 513-803-6035 or email nicholas.miller@cchmc.org. NEW YORK – With the number of doses and cost…

Optimal Vitamin D Dosage for Infants Uncertain

EMBARGOED FOR EARLY RELEASE: 10 A.M. (ET) TUESDAY, APRIL 30, 2013 Media Advisory: To contact Hope Weiler, R.D., Ph.D., email hope.weiler@mcgill.ca. To contact editorial author Steven A. Abrams, M.D., call Dipali Pathak at 713-798-4712 or email pathak@bcm.edu. NEW YORK – In a comparison of the effect of different dosages of vitamin D supplementation in breastfed…

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Also Appearing in This Issue of JAMA

EMBARGOED FOR RELEASE: 3 P.M. (CT) TUESDAY, APRIL 23, 2013 Study Examines Trends in Firearm Injuries Among Children and Adolescents “Given recent firearm-related fatalities combined with declining gun research funding, it is important to monitor firearm injuries in youths. Injury death rates are available but provide an incomplete picture of these potentially preventable injuries,” writes…