For The Media – JAMA Network

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 8, 2013 Media Advisory: To contact author Keith A. Vossel. M.D., M. Sc., call Anne D. Holden at 415-734-2534 or email Anne.Holden@gladstone.ucsf.edu. CHICAGO – Patients with epilepsy who had amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD) presented earlier with cognitive decline than patients who did…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 1, 2013   JAMA Neurology Viewpoint Highlights   The JAMA Specialty Journals are now publishing Viewpoint articles. Below are the Viewpoints to be published July 1 in JAMA Neurology.     Upcoming Challenges for Neurologists in the United States by Bruce Sigsbee, M.D., M.S., of Penobscot Bay…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 1, 2013 Media Advisory: To contact study author Shyam Prabhakaran, M.D., M.S., call Erin White at 847-491-4888 or email ewhite@northwestern.edu.   CHICAGO – Implementing an out-of hospital stroke policy in some Chicago hospitals was associated with significant improvements in emergency medical services use and increased intravenous tissue…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JUNE 17, 2013 Media Advisory: To contact corresponding author Suzanne Craft, Ph.D., call Bonnie Davis at 336-716-4977 or email bdavis@wakehealth.edu. To contact editorial author Deborah Blacker, M.D., Sc.D., call Michael Morrison at 617-724-6425 or email mdmorrison@partners.org. CHICAGO – The lipidation states (or modifications) in certain proteins in the…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JUNE 10, 2013 Media Advisory: To contact corresponding author Mirjam I. Geerlings, Ph.D., email m.geerlings@umcutrecht.nl. CHICAGO – Low baseline diastolic blood pressure (DBP) appears to be associated with brain atrophy in patients with arterial disease, whenever declining levels of blood pressure (BP) over time among patients who had…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JUNE 3, 2013 Media Advisory: To contact study author Hans-Peter Hartung, M.D., email HansPeter.Hartung2012@gmail.com. JAMA Neurology Study Highlights A study by Hans-Peter Hartung, M.D., of Heinrich-Heine-Universität, Düsseldoft, Germany, and colleagues examines the association between IL-17F and treatment response to interferon beta-1b among patients with relapsing-remitting multiple sclerosis. (Online…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MAY 6, 2013 Media Advisory: To contact study author Stephanie Cosentino, Ph.D., call Karin Eskenazi-Tzamarot at 212-305-3900 or email cumcnews@columbia.edu.     JAMA Neurology Study Highlights   Study Examines Cognitive Impairment in Families With Exceptional Longevity   A study by Stephanie Cosentino, Ph.D., of Columbia University, New York,…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, APRIL 15, 2013   JAMA Neurology Study Highlights   Study Suggests Glucocerebrosidase Gene Mutations Are Risk Factor For Dementia With Lewy Bodies   A study by Michael A. Nalls, Ph.D., of the National Institutes of Health, Bethesda, and colleagues suggests mutations in glucocerebrosidase (GBA1) are a risk factor…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 25, 2013 Media Advisory: To contact study author Kenn Freddy Pedersen, M.D., Ph.D., email kenfrp@online.no. To contact editorial author Brian J. Copeland, M.D., call Robert Cahill at 713-500-3030 or email Robert.cahill@uth.tmc.edu. CHICAGO – Mild cognitive impairment at the time of Parkinson disease (PD) diagnosis appears to be…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 18, 2013   JAMA Neurology Study Highlights   A study by Karen M. Rodrigue, Ph.D., of the University of Texas at Dallas, and colleagues suggests that patients with hypertension with at least one genetic risk factor for Alzheimer disease (an apolipoprotein E Ɛ4 allele) showed more β-amyloid…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 11, 2013   JAMA Neurology Study Highlights A study by Maureen Handoko, Ph.D., of the University of Minnesota, Minneapolis, and colleagues suggests that in cognitively intact older adults cerebrospinal fluid (CSF) amyloid-β trimers and Αβ*56  were elevated in patients at risk for Alzheimer disease (AD). (Online First)…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 11, 2013   JAMA Neurology Study Highlights A randomized clinical trial by E. Ray Dorsey, M.D., M.B.A.., of Johns Hopkins Medicine, Baltimore, and colleagues of 20 patients with Parkinson disease suggests that telemedicine visits could save patients, on average, 100 miles of travel and three hours of…

Editor’s Note: An author podcast will be available when the embargo lifts at http://bit.ly/MNucEu.   EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 11, 2013 JAMA Neurology Study Highlights   Yo-El S. Ju, M.D., and colleagues from the Washington University School of Medicine, St. Louis, suggest in a study that amyloid deposition in the preclinical…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, FEBRUARY 18, 2013   JAMA Neurology Study Highlights   Natalizumab Therapy Examined for Pediatric Multiple Sclerosis   A study by Barbara Kornek, M.D., of the Medical University of Vienna, Austria, suggests that natalizumab, a humanized monoclonal antibody, may be associated with reductions in average annualized relapse rates and…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, FEBRUARY 18, 2013   JAMA Neurology Study Highlights   Study Suggests White Matter Hyperintensities May Be Associated With Presentation of Alzheimer Disease   A study by Frank A. Provenzano, M.S., of Columbia University, New York, and colleagues suggests that Pittsburgh Compound B (PIB) positron-emission tomography-derived amyloid positivity and…

EMBARGOED FOR RELEASE: 3 P.M. (CT), THURSDAY, FEBRUARY 11, 2013   JAMA Neurology Study Highlights   Study Examines Vascular Injury, β-Amyloid Deposition and Cognition In a study of elderly patients, Natalie L. Marchant, Ph.D., of the University of California, Berkeley, and colleagues suggest there is no evidence that vascular brain injury (VBI) increases the likelihood…

EMBARGOED FOR RELEASE: 11 A.M. (CT), THURSDAY, FEBRUARY 7, 2013   JAMA Neurology Study Highlights   Study Examines Seizures, Epilepsy in Children with Intracerebral Hemorrhage In a study conducted at three tertiary care pediatric hospitals, Lauren A. Beslow, M.D., M.S.C.E., of the of the Yale University School of Medicine, New Haven, Conn., and colleagues examined…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, FEBRUARY 4, 2013 Media Advisory: To contact John Q. Trojanowski, M.D., Ph.D., call Kim Menard at 215-662-6183 or email kim.menard@uphs.upenn.edu. CHICAGO – A group of recipients of cadaver-derived human growth hormone (c-hGH) does not appear to be at increased risk for Alzheimer and Parkinson disease despite their likely…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JANUARY 28, 2013 Media Advisory: To contact Rosebud O. Roberts, M.B., Ch.B., M.S., call Nicholas Hanson at 507-284-5005 or email newsbureau@mayo.edu. CHICAGO – Cardiac disease was associated with increased risk, particularly for women, of nonamnestic mild cognitive impairment (naMCI), which may be a precursor of vascular and other…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JANUARY 7, 2013 Media Advisory: To contact John Hart Jr., M.D., call Shelly Kirkland at 972-883-3221 or email shelly.kirkland@utdallas.edu. To contact editorial author Ramon Diaz-Arrastia, M.D., Ph.D., call Sharon Willis at 301-295-3578 or email sharon.willis@usuhs.edu. CHICAGO – Cognitive deficits and depression may be more common in aging former…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, DECEMBER 31, 2012 Media Advisory: To contact study author José A. Luchsinger, M.D., M.P.H., call Elizabeth Streich at 212-305-3689 or email eas2125@columbia.edu. CHICAGO – Depression in a group of Medicare recipients ages 65 years and older appears to be associated with prevalent mild cognitive impairment and an increased…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, NOVEMBER 19, 2012 Archives of Neurology Study Highlights Patients with aspirin resistance are more likely to sustain a more severe stroke than patients without aspirin resistance, according to a study of 90 patients with acute stroke who previously received aspirin therapy (Online First). A genetic case-control association study…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact study author Lisa M. Shulman, M.D., call Sharon Boston at 410-328-8919 or email sboston@umm.edu. To contact corresponding editorial author E. Ray Dorsey, M.D., M.B.A., call Stephanie Desmon at 410-955-8665 or email sdesmon1@jhmi.edu. CHICAGO – Physical exercise, including treadmill, stretching and resistance…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, OCTOBER 29, 2012 Archives of Neurology Study Highlights A study of children with sickle cell anemia (SCA) screened by magnetic resonance imaging (MRI) for participation in a randomized controlled trial found that acute silent cerebral ischemic (a temporary shortage of oxygen caused by reduced blood flow) events were…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, OCTOBER 22, 2012 Media Advisory: To contact study authors call Tom Vasich at 949-824-6455 or email tmvasich@uci.edu.  CHICAGO– Poor physical performance on activities including walking was associated with increased odds of dementia in a study of individuals 90 years and older, according to a report published Online First…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, OCTOBER 15, 2012 Archives of Neurology Study Highlights While deep brain stimulation of the subthalamic nucleus has been associated with improvement in the symptoms of Parkinson disease (PD), including bradykinesia (a slowness of motion), a study of 24 patients with PD suggests that when stimulation was turned off…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, OCTOBER 1, 2012 Archives of Neurology Study Highlights A study of 84 patients with multiple sclerosis (MS) and 24 healthy controls that used a high-resolution imaging technique to measure retinal layer thickness suggests that those retinal measures reflect global central nervous system pathology in patients with MS. The…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, SEPTEMBER 24, 2012 Media Advisory: To contact corresponding author Michael D. Geschwind, M.D., Ph.D., call Jason Bardi at 415-502-4608 or email jason.bardi@ucsf.edu. To contact editorial author Richard J. Caselli, M.D., call Jim McVeigh at 480-301-4222 or email mcveigh.jim@mayo.edu. CHICAGO– A medical record review study of 97 patients with…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, SEPTEMBER 10, 2012 Archives of Neurology Study Highlights Treatment with angiotensin receptor blockers (ARBs; group of medications used in treatment of hypertension, diabetic nephropathy and congestive heart failure) among persons with hypertension is associated with less amyloid accumulation in the brain and a decreased likelihood of post-mortem neuropathologic…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, SEPTEMBER 3, 2012 Media Advisory: To contact corresponding author Lisa A. Cannon-Albright, Ph.D., call Kathy Wilets at 801-581-5717 or email kathy.wilets@hsc.utah.edu. To contact editorial author Walter A. Rocca, M.D., M.P.H., call Brian Kilen at 507-284-5005 or email newsbureau@mayo.edu. CHICAGO– A study that used a Utahgenealogic database and a…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, SEPTEMBER 3, 2012 Archives of Neurology Study Highlights A study that used a Utah genealogic database and a statewide cancer registry to examine the relationship between Parkinson disease (PD) and cancer suggests an increased risk of prostate cancer and melanoma in patients with PD and their relatives (Online…

  EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, AUGUST 27, 2012 Media Advisory: To contact Sara Hall, M.D., email sara.hall@med.lu.se or to contact corresponding author Oskar Hansson, M.D., Ph.D., email oskar.hansson@med.lu.se. To contact editorial author Richard J. Perrin, M.D., Ph.D., call Judy Martin Finch at 314-286-0105 or email martinju@wustl.edu. CHICAGO – A study of cerebrospinal…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, AUGUST 13, 2012 Archives of Neurology Study Highlights A phase 2 randomized study to determine the safety and tolerability of a medication called avagacestat (an oral γ-secretase inhibitor) for patients with Alzheimer disease found that in 209 patients with mild to moderate disease, the drug was well tolerated…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, AUGUST 6, 2012 Media Advisory: To contact Laura D. Baker, Ph.D., call Leila Gray at 206-685-0381 or email leilag@uw.edu. CHICAGO– Treatment with growth hormone-releasing hormone appears to be associated with favorable cognitive effects among both adults with mild cognitive impairment and healthy older adults, according to a randomized…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 23, 2012 Archives of Neurology Study Highlights Shortening of chromosomal telomeres, which provide a protective role for genetic material, is a consequence of cell division. The findings of a study of 1,983 people (average age 78.3 years) enrolled in a population-based study of aging and dementia in…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 16, 2012 Archives of Neurology Study Highlights A study describes a panel of plasma biomarkers that researchers suggest may distinguish patients with Alzheimer disease (AD), a progressive neurodegenerative disease, from cognitively healthy individuals. Researchers comment that the biomarkers identified in the analysis of data from the Australian…

  EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 9, 2012 Media Advisory: To contact William L. Palmer, M.A., M.Sc., email w.palmer07@imperial.ac.uk. CHICAGO– A study of patients with stroke admitted to English National Health Service public hospitals suggests that patients who were hospitalized on weekends were less likely to receive urgent treatments and had worse outcomes,…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 9, 2012 Archives of Neurology Study Highlights A study of patients with stroke admitted to English National Health Service public hospitals suggests that patients who were hospitalized on weekends were less likely to receive urgent treatments and had worse outcomes (Online First, see news release below). A…

EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 2, 2012 Media Advisory: To contact Ernst-Wilhelm Radue, M.D., email eradue@uhbs.ch. CHICAGO– The medication fingolimod reduced inflammatory lesion activity and reduced brain volume loss in patients with multiple sclerosis who participated in a two-year placebo-controlled clinical trial and were assessed by magnetic resonance imaging (MRI) measures, according…