Brain Circuitry Loss May Be Sign of Cognitive Decline in Healthy Elderly
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, SEPTEMBER 9, 2013 Media Advisory: To contact author Evan Fletcher, Ph.D., call Phyllis Brown at 916-734-9023 or email phyllis.brown@ucdmc.ucdavis.edu. JAMA Neurology Study Highlights Brain Circuitry Loss May Be Sign of Cognitive Decline in Healthy Elderly White matter loss in an area of the brain known…
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JAMA Neurology Viewpoint Highlights
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, SEPTEMBER 2, 2013 JAMA Neurology Viewpoint Highlights The 11th Revision of the International Classification of Diseases (ICD)…The Neurological Perspective by Raad Shakir, F.R.C.P., of Charing Cross Hospital, London, United Kingdom, and Sanjeev Rajakulendran, M.D., Ph.D., of the UCL Institute of Neurology, London, United Kingdom, write, “Neurology as…
Following A Mediterranean Diet Not Associated With Delay To Clinical Onset Of Huntington Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, SEPTEMBER 2, 2013 Media Advisory: To contact study author Karen Marder, M.D., M.P.H., call Karin Eskenazi at 212-342-0508 or email ket2116@columbia.edu. JAMA Neurology Study Highlights Following A Mediterranean Diet Not Associated With Delay To Clinical Onset Of Huntington Disease Adhering to a Mediterranean-type diet…
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Study Examines Cerebrospinal Fluid Biomarkers In Early Parkinson Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, AUGUST 26, 2013 Media Advisory: To contact corresponding author Leslie M. Shaw, Ph.D., call Kim Menard at 215-662-6183 or email Kim.Menard@uphs.upenn.edu. JAMA Neurology Study Highlights Cerebrospinal fluid (CSF) levels of tau proteins, ɑ-synuclein, and β-amyloid 1-42 (Αβ1-42) appear to be associated with early stage Parkinson disease (PD) in…
Genome-Wide Survey Examines Recessive Alzheimer Disease Gene
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, AUGUST 26, 2013 Media Advisory: To contact corresponding author Ekaterina Rogaeva, Ph.D., call 416-946-7927 or email Ekaterina.Rogaeva@utoronto.ca. JAMA Neurology Study Highlights Runs of homozygosity (ROHs, regions of the genome where the copies inherited from parents are identical) may contribute to the etiology (origin) of Alzheimer disease (AD), according…
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Study Evaluates Relationship Between Spinal Fluid Biomarkers of Alzheimer Disease And Brain Functional Network Integrity On Imaging Studies
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, AUGUST 19, 2013 Media Advisory: To contact corresponding author Beau M. Ances, M.D., Ph.D., call Michael Purdy at 314-286-0122 or email purdym@wustl.edu. JAMA Neurology Study Highlights Study Evaluates Relationship Between Spinal Fluid Biomarkers of Alzheimer Disease And Brain Functional Network Integrity On Imaging Studies Both…
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Non-Responsive Patients May Use Selective Auditory Attention To Convey Ability To Follow Commands and Communicate
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, AUGUST 12, 2013 Media Advisory: To contact study author Lorina Naci, Ph.D., call Stephen Ledgley at 519-661-2111 or email sledgley@uwo.ca. JAMA Neurology Study Highlights Non-Responsive Patients May Use Selective Auditory Attention To Convey Ability To Follow Commands and Communicate A case study using functional magnetic…
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JAMA Neurology Viewpoint Highlights
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, AUGUST 5, 2013 JAMA Neurology Viewpoint Highlights Network for Excellence in Neuroscience Clinical Trials by Marissa Natelson Love, M.D., and Hassah Fathallh-Shaykh, M.D., Ph.D., of the University of Alabama at Birmingham, write: “The U.S. National Institute of Neurological Disorders and Stroke (NINDS) recently launched the…
Alzheimer Disease and Parkinson Disease Do Not Appear To Share Common Genetic Risk, Study Suggests
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, AUGUST 5, 2013 Media Advisory: To contact study author Valentina Moskvina, Ph.D., email moskvinav1@cf.ac.uk. JAMA Neurology Study Highlights Alzheimer Disease and Parkinson Disease Do Not Appear To Share Common Genetic Risk, Study Suggests A study by Valentina Moskvina, Ph.D., of the Cardiff University School of…
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Glucose Intolerance, Diabetes or Insulin Resistance Not Associated with Pathological Features of Alzheimer Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 29, 2013 Media Advisory: To contact author Richard J. O’Brien, M.D., Ph.D., call Stephanie Desmon at 410-955-8665 or email sdesmon1@jhmi.edu. Glucose Intolerance, Diabetes or Insulin Resistance Not Associated with Pathological Features of Alzheimer Disease CHICAGO – Glucose intolerance or insulin resistance do not appear to…
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Report on 3 Patients with Vascular Complications of Fungal Meningitis After Contaminated Spinal Injections
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 22, 2013 Media Advisory: To contact corresponding author Daniel O. Claassen, M.D., M.S., call 615-939-1007 or email Daniel.Claassen@Vanderbilt.edu. JAMA Neurology Study Highlights Report on 3 Patients with Vascular Complications of Fungal Meningitis After Contaminated Spinal Injections A case series by researchers at Vanderbilt University,…
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Seizures Late in Life May be an Early Sign of Alzheimer Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 8, 2013 Media Advisory: To contact author Keith A. Vossel. M.D., M. Sc., call Anne D. Holden at 415-734-2534 or email Anne.Holden@gladstone.ucsf.edu. CHICAGO – Patients with epilepsy who had amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD) presented earlier with cognitive decline than patients who did…
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JAMA Neurology Viewpoint Highlights
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 1, 2013 JAMA Neurology Viewpoint Highlights The JAMA Specialty Journals are now publishing Viewpoint articles. Below are the Viewpoints to be published July 1 in JAMA Neurology. Upcoming Challenges for Neurologists in the United States by Bruce Sigsbee, M.D., M.S., of Penobscot Bay…
Study Examines Out-Of hospital Stroke Policy at Chicago Hospitals
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JULY 1, 2013 Media Advisory: To contact study author Shyam Prabhakaran, M.D., M.S., call Erin White at 847-491-4888 or email ewhite@northwestern.edu. CHICAGO – Implementing an out-of hospital stroke policy in some Chicago hospitals was associated with significant improvements in emergency medical services use and increased intravenous tissue…
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Study of Dietary Intervention Examines Proteins in Brain
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JUNE 17, 2013 Media Advisory: To contact corresponding author Suzanne Craft, Ph.D., call Bonnie Davis at 336-716-4977 or email bdavis@wakehealth.edu. To contact editorial author Deborah Blacker, M.D., Sc.D., call Michael Morrison at 617-724-6425 or email mdmorrison@partners.org. CHICAGO – The lipidation states (or modifications) in certain proteins in the…
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Low Diastolic Blood Pressure May Be Associated With Brain Atrophy
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JUNE 10, 2013 Media Advisory: To contact corresponding author Mirjam I. Geerlings, Ph.D., email m.geerlings@umcutrecht.nl. CHICAGO – Low baseline diastolic blood pressure (DBP) appears to be associated with brain atrophy in patients with arterial disease, whenever declining levels of blood pressure (BP) over time among patients who had…
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Interleukin 17F Level and Interferon Beta Response in Patients With Multiple Sclerosis
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JUNE 3, 2013 Media Advisory: To contact study author Hans-Peter Hartung, M.D., email HansPeter.Hartung2012@gmail.com. JAMA Neurology Study Highlights A study by Hans-Peter Hartung, M.D., of Heinrich-Heine-Universität, Düsseldoft, Germany, and colleagues examines the association between IL-17F and treatment response to interferon beta-1b among patients with relapsing-remitting multiple sclerosis. (Online…
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Study Examines Cognitive Impairment in Families With Exceptional Longevity
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MAY 6, 2013 Media Advisory: To contact study author Stephanie Cosentino, Ph.D., call Karin Eskenazi-Tzamarot at 212-305-3900 or email cumcnews@columbia.edu. JAMA Neurology Study Highlights Study Examines Cognitive Impairment in Families With Exceptional Longevity A study by Stephanie Cosentino, Ph.D., of Columbia University, New York,…
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Study Suggests Glucocerebrosidase Gene Mutations Are Risk Factor For Dementia With Lewy Bodies
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, APRIL 15, 2013 JAMA Neurology Study Highlights Study Suggests Glucocerebrosidase Gene Mutations Are Risk Factor For Dementia With Lewy Bodies A study by Michael A. Nalls, Ph.D., of the National Institutes of Health, Bethesda, and colleagues suggests mutations in glucocerebrosidase (GBA1) are a risk factor…
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Mild Cognitive Impairment at Parkinson Disease Diagnosis Associated with Increased Risk for Early Dementia
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 25, 2013 Media Advisory: To contact study author Kenn Freddy Pedersen, M.D., Ph.D., email kenfrp@online.no. To contact editorial author Brian J. Copeland, M.D., call Robert Cahill at 713-500-3030 or email Robert.cahill@uth.tmc.edu. CHICAGO – Mild cognitive impairment at the time of Parkinson disease (PD) diagnosis appears to be…
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Study Suggests Combination of Hypertension, Genetic Risk Factor for Alzheimer Disease May be Associated with Increased Brain Amyloid Deposits in Cognitively Normal Adults
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 18, 2013 JAMA Neurology Study Highlights A study by Karen M. Rodrigue, Ph.D., of the University of Texas at Dallas, and colleagues suggests that patients with hypertension with at least one genetic risk factor for Alzheimer disease (an apolipoprotein E Ɛ4 allele) showed more β-amyloid…
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Study Examines Cerebrospinal Fluid Markers in Relation to Alzheimer Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 11, 2013 JAMA Neurology Study Highlights A study by Maureen Handoko, Ph.D., of the University of Minnesota, Minneapolis, and colleagues suggests that in cognitively intact older adults cerebrospinal fluid (CSF) amyloid-β trimers and Αβ*56 were elevated in patients at risk for Alzheimer disease (AD). (Online First)…
Telemedicine Saves Travel and Time for Patients with Parkinson Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 11, 2013 JAMA Neurology Study Highlights A randomized clinical trial by E. Ray Dorsey, M.D., M.B.A.., of Johns Hopkins Medicine, Baltimore, and colleagues of 20 patients with Parkinson disease suggests that telemedicine visits could save patients, on average, 100 miles of travel and three hours of…
Study Suggests Possible Marker of Alzheimer Disease Associated With Worse Sleep Quality
Editor’s Note: An author podcast will be available when the embargo lifts at http://bit.ly/MNucEu. EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, MARCH 11, 2013 JAMA Neurology Study Highlights Yo-El S. Ju, M.D., and colleagues from the Washington University School of Medicine, St. Louis, suggest in a study that amyloid deposition in the preclinical…
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Natalizumab Therapy Examined for Pediatric Multiple Sclerosis
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, FEBRUARY 18, 2013 JAMA Neurology Study Highlights Natalizumab Therapy Examined for Pediatric Multiple Sclerosis A study by Barbara Kornek, M.D., of the Medical University of Vienna, Austria, suggests that natalizumab, a humanized monoclonal antibody, may be associated with reductions in average annualized relapse rates and…
Study Suggests White Matter Hyperintensities May Be Associated With Presentation of Alzheimer Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, FEBRUARY 18, 2013 JAMA Neurology Study Highlights Study Suggests White Matter Hyperintensities May Be Associated With Presentation of Alzheimer Disease A study by Frank A. Provenzano, M.S., of Columbia University, New York, and colleagues suggests that Pittsburgh Compound B (PIB) positron-emission tomography-derived amyloid positivity and…
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Study Examines Vascular Injury, β-Amyloid Deposition and Cognition
EMBARGOED FOR RELEASE: 3 P.M. (CT), THURSDAY, FEBRUARY 11, 2013 JAMA Neurology Study Highlights Study Examines Vascular Injury, β-Amyloid Deposition and Cognition In a study of elderly patients, Natalie L. Marchant, Ph.D., of the University of California, Berkeley, and colleagues suggest there is no evidence that vascular brain injury (VBI) increases the likelihood…
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Study Examines Seizures, Epilepsy in Children with Intracerebral Hemorrhage
EMBARGOED FOR RELEASE: 11 A.M. (CT), THURSDAY, FEBRUARY 7, 2013 JAMA Neurology Study Highlights Study Examines Seizures, Epilepsy in Children with Intracerebral Hemorrhage In a study conducted at three tertiary care pediatric hospitals, Lauren A. Beslow, M.D., M.S.C.E., of the of the Yale University School of Medicine, New Haven, Conn., and colleagues examined…
Study Examines Potential Transmission of Alzheimer, Parkinson Disease Protein in Cadaver Human Growth Hormone
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, FEBRUARY 4, 2013 Media Advisory: To contact John Q. Trojanowski, M.D., Ph.D., call Kim Menard at 215-662-6183 or email kim.menard@uphs.upenn.edu. CHICAGO – A group of recipients of cadaver-derived human growth hormone (c-hGH) does not appear to be at increased risk for Alzheimer and Parkinson disease despite their likely…
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Cardiac Disease Associated With Increased Risk of Nonamnestic Cognitive Impairmen
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JANUARY 28, 2013 Media Advisory: To contact Rosebud O. Roberts, M.B., Ch.B., M.S., call Nicholas Hanson at 507-284-5005 or email newsbureau@mayo.edu. CHICAGO – Cardiac disease was associated with increased risk, particularly for women, of nonamnestic mild cognitive impairment (naMCI), which may be a precursor of vascular and other…
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Cognitive Deficits, Depression May be More Common in Aging Football Players
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, JANUARY 7, 2013 Media Advisory: To contact John Hart Jr., M.D., call Shelly Kirkland at 972-883-3221 or email shelly.kirkland@utdallas.edu. To contact editorial author Ramon Diaz-Arrastia, M.D., Ph.D., call Sharon Willis at 301-295-3578 or email sharon.willis@usuhs.edu. CHICAGO – Cognitive deficits and depression may be more common in aging former…
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Late-Life Depression Associated with Prevalent Mild Cognitive Impairment, Increased Risk of Dementia
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, DECEMBER 31, 2012 Media Advisory: To contact study author José A. Luchsinger, M.D., M.P.H., call Elizabeth Streich at 212-305-3689 or email eas2125@columbia.edu. CHICAGO – Depression in a group of Medicare recipients ages 65 years and older appears to be associated with prevalent mild cognitive impairment and an increased…
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Archives of Neurology Study Highlights
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, NOVEMBER 19, 2012 Archives of Neurology Study Highlights Patients with aspirin resistance are more likely to sustain a more severe stroke than patients without aspirin resistance, according to a study of 90 patients with acute stroke who previously received aspirin therapy (Online First). A genetic case-control association study…
ARCHNEUR_OF:11052012
Physical Exercise Improves Gait Speed, Muscle Strength, Fitness in Patients with Parkinson Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, NOVEMBER 5, 2012 Media Advisory: To contact study author Lisa M. Shulman, M.D., call Sharon Boston at 410-328-8919 or email sboston@umm.edu. To contact corresponding editorial author E. Ray Dorsey, M.D., M.B.A., call Stephanie Desmon at 410-955-8665 or email sdesmon1@jhmi.edu. CHICAGO – Physical exercise, including treadmill, stretching and resistance…
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Archives of Neurology Study Highlights
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, OCTOBER 29, 2012 Archives of Neurology Study Highlights A study of children with sickle cell anemia (SCA) screened by magnetic resonance imaging (MRI) for participation in a randomized controlled trial found that acute silent cerebral ischemic (a temporary shortage of oxygen caused by reduced blood flow) events were…
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Study of Patients Ages 90 and Older Links Poor Physical Performance, Increased Odds of Dementia
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, OCTOBER 22, 2012 Media Advisory: To contact study authors call Tom Vasich at 949-824-6455 or email tmvasich@uci.edu. CHICAGO– Poor physical performance on activities including walking was associated with increased odds of dementia in a study of individuals 90 years and older, according to a report published Online First…
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Archives of Neurology Study Highlights
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, OCTOBER 15, 2012 Archives of Neurology Study Highlights While deep brain stimulation of the subthalamic nucleus has been associated with improvement in the symptoms of Parkinson disease (PD), including bradykinesia (a slowness of motion), a study of 24 patients with PD suggests that when stimulation was turned off…
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Archives of Neurology Study Highlights
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, OCTOBER 1, 2012 Archives of Neurology Study Highlights A study of 84 patients with multiple sclerosis (MS) and 24 healthy controls that used a high-resolution imaging technique to measure retinal layer thickness suggests that those retinal measures reflect global central nervous system pathology in patients with MS. The…
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Study Examines Delayed, Misdiagnosis of Sporadic Jakob-Creutzfeldt Disease
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, SEPTEMBER 24, 2012 Media Advisory: To contact corresponding author Michael D. Geschwind, M.D., Ph.D., call Jason Bardi at 415-502-4608 or email jason.bardi@ucsf.edu. To contact editorial author Richard J. Caselli, M.D., call Jim McVeigh at 480-301-4222 or email mcveigh.jim@mayo.edu. CHICAGO– A medical record review study of 97 patients with…
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Archives of Neurology Study Highlights
EMBARGOED FOR RELEASE: 3 P.M. (CT), MONDAY, SEPTEMBER 10, 2012 Archives of Neurology Study Highlights Treatment with angiotensin receptor blockers (ARBs; group of medications used in treatment of hypertension, diabetic nephropathy and congestive heart failure) among persons with hypertension is associated with less amyloid accumulation in the brain and a decreased likelihood of post-mortem neuropathologic…