Research Letter

Characterizing Artificial Intelligence Psychosis in a Large Medical Setting

JAMA Psychiatry 10.1001/jamapsychiatry.2026.2923

October 07, 2026 at 11:00 AM EDT

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This cohort study estimates the prevalence of AI psychosis, characterizes affected patients, and defines the role of conversational AI in documented psychotic episodes.

Corresponding Author: Julia M. Sheffield, PhD, Vanderbilt University Medical Center, 1601 23rd Ave S, Nashville, TN 37212 (julia.sheffield@vumc.org).

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