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Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression

JAMA Psychiatry 10.1001/jamapsychiatry.2026.2658

September 02, 2026 at 11:00 AM EDT

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In TRBD, adjunctive IV ketamine was well tolerated and associated with significant antidepressant effects compared to midazolam.

Corresponding Author: Joshua D. Rosenblat, MD, MSc, University Health Network, 399 Bathurst St, Main Pavilion 7-424, Toronto, ON M5T 2S8, Canada (joshua.rosenblat@uhn.ca)

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