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Comorbid Depression in Atopic Dermatitis—The Itch-to-Brain Circuitry Theory

JAMA Psychiatry 10.1001/jamapsychiatry.2026.0029

March 04, 2026 at 11:00 AM EST

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This Viewpoint explores the itch-to-brain circuitry theory, a model to better understand atopic dermatitis–generated comorbid depression mechanisms, which could help improve the care of individuals with these comorbid conditions.

Corresponding Author: Santosh Kumar Mishra, PhD, Department of Molecular Biomedical Sciences, North Carolina State University, 1060 William Moore Dr, Raleigh, NC 27697 (skmishra@ncsu.edu).

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