Processing Speed Impairment in Schizophrenia

Is there continued evidence of a central processing speed deficit for people with schizophrenia?In this systematic review and meta-analysis of 115 studies, symbol coding tests of processing speed remained among the most impaired cognitive tests for people with schizophrenia. Of the 49 other cognitive tests examined, symbol coding was reliably more impaired than 34 of them.This study suggests that processing speed continues to emerge as a particularly impaired cognitive domain, and findings indicate there may be an underlying mechanism driving global cognitive impairment, such as altered brain connectivity, that processing speed is especially sensitive to.

Corresponding Author: Danielle N. Pratt, PhD, Northwestern University, 1801 Maple Ave, Ste 3120, Evanston, IL 60201 (danielle.pratt@northwestern.edu).

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