Multivariate Brain-Blood Signatures in Early-Stage Depression and Psychosis

Can combined peripheral inflammatory markers with whole-brain gray matter volume in a multivariate framework distinguish early-stage depression and psychosis?In this cross-sectional study of 678 individuals from the multicenter PRONIA study, sparse partial least squares isolated 2 distinct blood-brain signatures: one differentiating recent-onset psychosis from clinical high-risk states for psychosis and another separating recent-onset depression from healthy control individuals, each with different cytokine and gray matter volume patterns.The findings suggest that peripheral and neuroanatomical biomarkers may have the potential to support stage-specific differentiation and inform stratified approaches to psychiatric care.

Corresponding Authors: Rachel Upthegrove, MBE, MBBS, PhD, Department of Psychiatry, Oxford University, Warneford Hospital, Headington, Oxford, OX3 7JX, United Kingdom (rachel.upthegrove@psych.ox.ac.uk); David Popovic, MD, PhD, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany (david_popovic@psych.mpg.de).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.