Psilocybin Outside the Clinic

What are the public health implications of increased access to and use of unregulated psilocybin-containing mushrooms in the United States?This review synthesizes emerging data on psilocybin use trends, product variability, co-use with other substances, and adverse event reports. It highlights parallels with the cannabis legalization trajectory, showing that potency, product diversity, and unsupervised use are increasing while regulation and public education lag behind.Public health efforts must pivot from clinical trials to real-world psilocybin use, prioritizing harm reduction, product testing, and age-specific safety research.

Corresponding Author: Kent E. Hutchison, PhD, Department of Psychiatry, University of Colorado Anschutz Medical Campus, 1890 N Revere Ct, Ste 5180, Aurora, CO 80045 (kent.hutchison@cuanschutz.edu).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.