The Role of Energy Homeostasis in Depression Pathophysiology and Its Heterogeneity

Are dysregulations in energy homeostasis involved in the manifestation of distinct symptom profiles in major depressive disorder?The genetic liability of a homeostatic system encompassing metabolic, interoceptive, and motivational pathways was modeled. A polygenic score capturing this shared genetic liability was more strongly associated with a higher likelihood of manifesting increased appetite and sleep during depression in more than 5000 participants.Altered energy homeostasis is associated with the expression of a specific symptom profile during depression; this bioclinical profile could identify patients with depression at higher metabolic risk and pave the way for the development of targeted treatments.

Corresponding Author: Yuri Milaneschi, PhD, Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Oldenaller 1, 1081 HL Amsterdam, the Netherlands (y.milaneschi@amsterdamumc.nl).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.