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Ethical Framework for Weight Loss Medication Use in Youth

JAMA Pediatrics 10.1001/jamapediatrics.2025.4110

October 27, 2025 at 11:00 AM EDT

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This Viewpoint discusses a proposed ethical framework following the bioethical principles of autonomy, beneficence, justice, and nonmaleficence to guide decision-making that supports safe, equitable care while accounting for the complexity of decision-making in the pediatric population.

Corresponding Author: Mary Ellen Vajravelu, MD, MSHP, University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh, 4401 Penn Ave, Faculty Pavilion 6th Floor, Pittsburgh, PA 15224 (maryellen.vajravelu@pitt.edu).

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