Tumor and Flap Reconstruction Volumes and Functional Outcomes after Glossectomy
JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2026.0099March 19, 2026 at 11:00 AM EDT
How are tumor volume, resection defect size, and tongue volume restoration associated with speech and swallowing outcomes of glossectomy?In this cohort study of 357 patients with squamous cell carcinoma undergoing tongue resection, preoperative tumor fraction greater than 31% and resection volume fraction greater than 67% were associated with gastrostomy tube dependence. Restoration of tongue volume with free-flap reconstruction to baseline preoperative volume was associated with improved oral intake.These findings suggest that quantitative knowledge of functional outcomes from incremental changes in tongue resection may contribute to patient counseling and improved functional outcomes.
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