Editor's Pick Research Letter

Polypharmacy and Drug-Drug Interactions Among Older Adults

JAMA 10.1001/jama.2026.17268

September 24, 2026 at 11:00 AM EDT

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This study uses a nationally representative sample to estimate changes in the use and concurrent use of prescription and over-the-counter (OTC) medications and dietary supplements among older adults in the US between 2015-2016 and 2021-2023, including use of potentially major drug-drug interactions.

Corresponding Author: Dima Mazen Qato, PharmD, MPH, PhD, USC Mann School of Pharmacy, 1985 Zonal Ave, Los Angeles, CA 90089 (qato@usc.edu).

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