Original Investigation

Clinical Severity Staging System and Response to Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2025.4851

February 05, 2026 at 11:00 AM EST

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What baseline factors are associated with response to hypoglossal nerve stimulation in patients with obstructive sleep apnea (OSA)?In this retrospective cohort study of 119 patients with OSA, neck size, body mass index, apnea-hypopnea index scores, and comorbidity burden were associated with response and used to create a 4-category clinical severity staging system.This study presents a prognostic staging system that physicians may use to identify patients with OSA who have the highest chance of responding to hypoglossal nerve stimulation.

Corresponding Author: Jay F. Piccirillo, MD, Department of Otolaryngology–Head and Neck Surgery, Washington University in St Louis School of Medicine, 660 S Euclid Avenue, Campus Box 8115, St Louis, MO 63110 (piccirij@wustl.edu).

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