Serum Metabolomics for Prognostic Stratification in Resected Advanced-Stage Oral Cavity Cancer

Can serum metabolomics identify biomarkers predictive of relapse and survival in resected oral cavity squamous cell carcinoma (OCSCC)?In this cohort study including 228 patients with advanced-stage disease and a high prevalence of betel quid exposure, a novel serum metabolite-based prognostic scoring system was developed and validated. Patients with a high score (≥11) demonstrated worse 5-year local control, neck control, distant metastases, disease-free survival, and disease-specific survival compared with those with lower scores (<11).Serum metabolomic profiling enhances prognostic stratification in OCSCC and could inform personalized therapeutic decisions.

Corresponding Authors: Chun-Ta Liao, MD, Department of Otorhinolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital and Chang Gung University, No. 5, Fu-Hsing St, Kwei-Shan, Taoyuan, Taiwan (liaoct@cgmh.org.tw).

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