Biological Sex and Chronic Rhinosinusitis Diagnosis and Biomarkers

Is biological sex associated with a diagnosis of chronic rhinosinusitis (CRS)?In this cross-sectional study of a nationwide US database including 258 245 participants, female sex was associated with up to 44% increased odds of CRS without nasal polyps (CRSsNP); but a 37% reduced odds of CRS with nasal polyps (CRSwNP). Female participants also had lower levels of serum eosinophils and IgE compared to male participants.These findings indicate that there is an increased likelihood of CRSsNP diagnosis and decreased likelihood of CRSwNP diagnosis among female compared to male participants, with biomarkers indicating a possible female disposition toward nontype 2 inflammation.

Corresponding Author: Richard G. Chiu, BS, Department of Otolaryngology, College of Medicine, University of Illinois Chicago, 1853 W Polk St, Chicago, IL 60612 (rchiu8@uic.edu).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.