Diagnostic Performance of Prespecified OCT Rules for Glaucomatous Optic Neuropathy in Nonpathologic Myopia

Can prespecified optical coherence tomography (OCT) rules accurately detect glaucoma in eyes with nonpathologic moderate and high myopia (spherical equivalent ≤−3.0 diopters or axial length ≥24.5 mm, excluding staphyloma or severe maculopathy)?In this multicenter diagnostic study of 1525 eyes, a qualitative OCT rule identifying a temporal-superior-inferior-nasal-temporal (TSNIT) curve dip or depression achieved sensitivity of 0.93 and specificity of 0.93 in an external cohort. A quantitative rule using inferior peripapillary retinal nerve fiber layer or inferotemporal macular ganglion cell–inner plexiform layer thinning demonstrated high diagnostic accuracy (0.90 sensitivity, 0.93 specificity).Results indicate these prespecified OCT rules may serve as effective decision-support tools to help clinicians distinguish early glaucoma from physiological myopic variations.

Corresponding Authors: Xiulan Zhang, MD, PhD, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-sen University, No. 7 Jinsui Rd, Guangzhou 510060, China (zhangxl2@mail.sysu.edu.cn); Carol Y. Cheung, PhD, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 4/F Hong Kong Eye Hospital, 147K Argyle St, Kowloon, Hong Kong Special Administrative Region, China (carolcheung@cuhk.edu.hk).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.