Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction

Does adjunctive rose bengal photodynamic therapy (RB-PDT) improve outcomes at 12 months in patients with infectious keratitis?In this randomized clinical trial including 330 participants with fungal, acanthamoeba, or smear/culture-negative keratitis, the primary outcome was best spectacle-corrected visual acuity (BSCVA) measured at 6 months. Overall, there was no difference in prespecified secondary outcomes of BSCVA, infiltrate/scar size, or adverse outcomes between the RB-PDT and sham control groups at 12 months.In this study, adjunctive RB-PDT did not appear to confer a long-term clinical benefit over standard antimicrobial therapy for these forms of infectious keratitis.

Corresponding Author: Jennifer Rose-Nussbaumer, MD, Byers Eye Institute, 2452 Watson Ct, Palo Alto, CA 94303 (rosej@stanford.edu).

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