Nonexudative Macular Neovascularization in Age-Related Macular Degeneration

What is the prevalence of fellow-eye nonexudative macular neovascularization (neMNV) on optical coherence tomography angiography (OCT-A) in age-related macular degeneration (AMD) eyes with double-layer signs (DLS) on OCT among patients with unilateral new exudative AMD in the first eye?In this prospective cohort study, 1 in 5 fellow eyes had DLS. However, only 40% with DLS had neMNV on OCT-A.These results suggest DLS on OCT in fellow eyes of patients with new-onset exudative AMD in the first eye should not be used as a surrogate for neMNV in that fellow eye.

Corresponding Author: Sobha Sivaprasad, MD, Moorfields Clinical Research Facility, NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, 162 City Rd, London EC1V 2PD, United Kingdom (sobha.sivaprasad@nhs.net)

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