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Original Investigation

Endothelial Cell Loss 1 Year After Successful DMEK in the Diabetes Endothelial Keratoplasty Study

JAMA Ophthalmology 10.1001/jamaophthalmol.2025.4261

October 17, 2025 at 9:30 AM EDT

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Are endothelial cell loss (ECL) and morphometric changes 1 year after successful Descemet membrane endothelial keratoplasty (DMEK) associated with the presence of diabetes in a cornea donor?In this randomized clinical trial including 1274 eyes of 982 recipients with graft success at 1 year and at least 1 analyzable postoperative image, there was no difference observed in ECL based on donor diabetes severity. Morphometric parameters also did not differ at 1 year.This study found that ECL and morphometry 1 year after DMEK were not affected by diabetes status of the cornea donor.

Corresponding Author: Jonathan H. Lass, MD, University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH 44106 (deks@case.edu).

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