Geographic Atrophy Multifocality in the Age-Related Eye Disease Study 2

What is the mean new geographic atrophy (GA) lesion incidence rate, and what risk factors are associated with a faster rate?In post hoc analyses of Age-Related Eye Disease Study 2 (AREDS2) including 689 eyes of 570 participants, mean lesion incidence rate was 1 lesion every 2.5 years. Independent risk factors for faster rates were GA lesion number, noncentral GA, greater GA proximity to fovea, reticular pseudodrusen, age, lower fish intake, and higher calorie intake.This study found that specific risk factors may help predict progression to more highly multifocal GA, which itself is associated with faster area-based progression; risk factors for first GA occurrence, subsequent GA lesion incidence rate, and area-based progression overlapped partially.

Corresponding Author: Tiarnán D. L. Keenan, BM BCh, PhD, Multidisciplinary Retinal Research Unit, Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bldg 10, CRC, Room 10D45, 10 Center Dr, MSC 1204, Bethesda, MD 20892-1204 (tiarnan.keenan@nih.gov).

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