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Metformin and the Development of Age-Related Macular Degeneration

JAMA Ophthalmology 10.1001/jamaophthalmol.2025.3070

September 18, 2025 at 11:00 AM EDT

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Is there an association of metformin prescription with the development of any age-related macular degeneration (AMD) or with progression of AMD to geographic atrophy and neovascular AMD?In this cohort study with more than 1.6 million participants, no difference in AMD development or progression was found between groups exposed and unexposed to metformin.In this study, participants prescribed metformin had generally comparable risk of developing AMD or having progression of their AMD compared with participants not prescribed metformin.

Corresponding Author: Katherine E. Talcott, MD, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, i32, Cleveland, OH 44195 (talcotk@ccf.org).

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