Prostaglandin EP2 Receptor and Cystoid Macular Edema in Phakic Posttrabeculectomy Eyes

Can cystoid macular edema (CME) develop in phakic eyes treated with the prostaglandin EP2 receptor agonist omidenepag isopropyl (OMDI)?Among 836 patients from 1 institution, 8 phakic eyes (6 patients), all with a history of trabeculectomy, developed CME 6 to 11 months after initiating OMDI. CME resolved in all cases within 28 to 91 days after discontinuing OMDI, either without (3 cases) or with topical or systemic anti-inflammatory drugs.These results demonstrate associations between OMDI and CME in phakic eyes posttrabeculectomy; additional studies might provide more precise estimates of the magnitude of this association and associated risk factors.

Corresponding Author: De-Kuang Hwang, Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Sec 2, Shipai Rd, Beitou Dist, Taipei City 112201, Taiwan (ROC) (m95gbk@gmail.com); Catherine Jui-Ling Liu, Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wenchang Rd, Shilin Dist, Taipei City 111045, Taiwan (ROC) (cjlliu317@gmail.com).

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