Research Letter

Pericardial Effusion and Bruton Tyrosine Kinase Inhibitors in B-Cell Malignant Disease

JAMA Oncology 10.1001/jamaoncol.2025.6605

February 19, 2026 at 11:00 AM EST

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This cohort study examines the association of bruton tyrosine kinase inhibitor therapy in B-cell malignant disease with increased risk of pericardial effusion and cardiovascular outcomes.

Corresponding Author: Ramzi Ibrahim, MD, Department of Cardiovascular Medicine, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259 (ibrahim.ramzi@mayo.edu).

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