Quadrivalent Human Papillomavirus Vaccine and High-Grade Vulvovaginal Lesions

What is the association between quadrivalent human papillomavirus (HPV) vaccination and high-grade vulvovaginal lesions?In this cohort study of 778 943 women, vaccinated women had a significantly lower incidence of high-grade vulvovaginal lesions than unvaccinated women, with a greater reduction among those vaccinated at ages 10 to 16 years than 17 years or older. A population-level incidence reduction was observed in birth cohorts covered by subsidized or catch-up vaccination programs compared with cohorts vaccinated opportunistically.In this study, quadrivalent HPV vaccination was associated with reduced risk of high-grade vulvovaginal lesions, suggesting that expanding vaccination, especially at younger ages, could help prevent high-grade vulvovaginal lesions.

Correspondence Author: Yunyang Deng, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, 171 77 Stockholm, Sweden (yunyang.deng@ki.se).

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