Prostate-Specific Membrane Antigen PET-Guided Intensification of Salvage Radiotherapy After Radical Prostatectomy

Does prostate-specific membrane antigen positron emission tomography (PSMA-PET)–guided intensification of salvage radiotherapy (SRT) after radical prostatectomy (RP) improve failure-free survival (FFS) in patients with biochemical recurrence?In this phase 2 randomized clinical trial, including 64 patients in the treatment arm and 64 in the control group, PSMA-PET–guided intensification of SRT was associated with significantly improved FFS compared with standard-of-care SRT. The treatment was isotoxic, with comparable quality of life between groups.PSMA-PET may guide intensification of salvage radiotherapy after prostatectomy.

Corresponding Author: Cynthia Ménard, MD, Radiation Oncology, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), 1051 Rue Sanguinet Montréal, QC H2X 0C1, Canada (cynthia.menard@umontreal.ca).

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